Cited by 480Immune responses and vaccinationsNeonatal and Maternal InfectionsImmune Response and Inflammation

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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

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Kollmann, Tobias R., Kampmann, Beate, Mazmanian, Sarkis K., Marchant, Arnaud, Levy, Ofer·2017·Immunity

DOI 10.1016/j.immuni.2017.03.009

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Abstract

Infections in the first year of life are common and often severe. The newborn host demonstrates both quantitative and qualitative differences to the adult in nearly all aspects of immunity, which at least partially explain the increased susceptibility to infection. Here we discuss how differences in susceptibility to infection result not out of a state of immaturity, but rather reflect adaptation to the particular demands placed on the immune system in early life. We review the mechanisms underlying host defense in the very young, and discuss how specific developmental demands increase the risk of particular infectious diseases. In this context, we discuss how this plasticity, i.e. the capacity to adapt to demands encountered in early life, also provides the potential to leverage protection of the young against infection and disease through a number of interventions.

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The protective role of maternal genetic immunization on maternal‐fetal health and welfare
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Breastfeeding and Neonatal Age Influence Neutrophil‐Driven Ontogeny of Blood Cell Populations in the First Week of Human Life
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Per Os to Protection – Targeting the Oral Route to Enhance Immune-mediated Protection from Disease of the Human Newborn
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Describing Biological Vulnerability in Small, Vulnerable Newborns in Urban Burkina Faso (DenBalo): Gut Microbiota, Immune System, and Breastmilk Assembly
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In Depth Viral Diversity Analysis in Atypical Neurological and Neonatal Chikungunya Infections in Rio de Janeiro, Brazil
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Maternal immunization with pneumococcal surface protein A provides the immune memories of offspring against pneumococcal infection
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Type 3 immune response protects against Salmonella Typhimurium infection in the small intestine of neonatal rats
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Rational adjuvant selection for the neonatal period shapes unique and lasting immune polarization in mice
Chen, C., Benson, O. E., Simmons, T., Dorsett, C. L., Janczak, K. W., Wiest, M. J., Farazuddin, M., Baker, J. R., Wong, P. T., & O’Konek, J. J. (2025) · npj Vaccines · doi:10.1038/s41541-025-01227-5 · Cited by 3
“Moreover, while vaccines are administered with the greatest frequency in the ﬁ rst year of life, the speci ﬁ c immune effects of vaccination and adjuvants during early life have not been well de ﬁ ned 5 .”
Biomarkers of immune dysregulation and posttreatment inflammation in spinal muscular atrophy
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An influenza HA mRNA-LNP vaccine induces potent responses in newborn nonhuman primates that enhance protection from challenge
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“It is clear that the immune system steadily evolves over the ﬁ rst year of life 76 .”
Integrating exposures and multi-omics in the Boston Birth Cohort to elucidate immune development across the life course: rationale and study design
Hong, X., Frischmeyer‐Guerrerio, P. A., Wang, G., Pearson, C., Adam, W. G., Larman, H. B., Ji, H., & Wang, X. (2025) · Precision Nutrition · doi:10.1097/pn9.0000000000000097 · Cited by 3

Authors: Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O.
Affiliations: University of British Columbia (CA)
MRC Unit the Gambia (GM)
California Institute of Technology (US)
Université Libre de Bruxelles (BE)
Boston Children's Hospital (US)
Corresponding author: Kollmann, Tobias R.
Levy, Ofer
ORCID: Kollmann, Tobias R.
Kampmann, Beate
Mazmanian, Sarkis K.
Marchant, Arnaud
Levy, Ofer
Venue: Immunity
Publisher: Elsevier BV
Published: 2017-03
Volume: 46
Issue: 3
Pages: 350-363
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2017.03.009
OpenAlex: W2599501186
Semantic Scholar: e51f9b517003c880df24898208e6d4d93bb7cc87
Cited by: 478
References: 200
Citations by year: 2026: 62 · 2025: 45 · 2024: 54 · 2023: 51 · 2022: 40 · 2021: 67 · 2020: 69 · 2019: 39 · 2018: 36 · 2017: 15
FWCI: 4.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
Funders: Medical Research Council (MR/R005990/1)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: immune ontogeny, neonatal immunity, host defense, immune plasticity, neonatal infection
MeSH terms: Animals, Communicable Diseases, Disease Susceptibility, Humans, Immune System, Infant, Infant, Newborn

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Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

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