The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Mechanisms and Therapeutic Relevance of Neuro-immune Communication
Open accessAbstract
Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the inflammatory reflex and other neuro-immune interactions have greatly advanced understanding immunity, and identified new therapeutic possibilities in inflammatory and autoimmune diseases. Recent successful clinical trials using bioelectronic devices that modulate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel disease provide a path for using electrons as a therapeutic modality to target molecular mechanisms of immunity. Here we review mechanisms of peripheral sensory neuronal function modulation in response to immune challenges and neural regulation of immunity and inflammation, and discuss the therapeutic implications of this mechanistic insight.
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Citations
Cites
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Cited by
The Sleep-Immune Crosstalk in Health and Disease
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“The cholinergic innervation of immune organs is still a matter of debate (206, 400), yet a non-neuronal cholinergic system in T cells can locally provide acetylcholine release in the periphery (99, 203).”
BackgroundMolecular and functional neuroscience in immunity
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Self-citationCurrent understanding of osteoarthritis pathogenesis and relevant new approaches
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Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
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Therapeutic options for targeting inflammatory osteoarthritis pain
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Metadata
- Authors
- Chavan, S. S., Pavlov, V. A., & Tracey, K. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 46
- Issue
- 6
- Pages
- 927-942
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2698307513
- Cited by
- 663
- References
- 34
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
