The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression
Open accessAbstract
&NA; Tumor‐associated macrophages (TAMs) are essential components of the cancer microenvironment and play critical roles in the regulation of tumor progression. Optimal therapeutic intervention requires in‐depth understanding of the sources that sustain macrophages in malignant tissues. In this study, we investigated the ontogeny of TAMs in murine pancreatic ductal adenocarcinoma (PDAC) models. We identified both inflammatory monocytes and tissue‐resident macrophages as sources of TAMs. Unexpectedly, significant portions of pancreas‐resident macrophages originated from embryonic development and expanded through in situ proliferation during tumor progression. Whereas monocyte‐derived TAMs played more potent roles in antigen presentation, embryonically derived TAMs exhibited a pro‐fibrotic transcriptional profile, indicative of their role in producing and remodeling molecules in the extracellular matrix. Collectively, these findings uncover the heterogeneity of TAM origin and functions and could provide therapeutic insight for PDAC treatment. Graphical Abstract Figure. No caption available. HighlightsTAMs in PDAC are derived from both monocytes and embryonic macrophagesTissue‐resident embryonic macrophages promote PDAC progressionEmbryonically derived tissue‐resident TAMs expand in PDAC via in situ proliferationEmbryonically derived TAMs exhibit unique pro‐fibrotic activities &NA; Zhu et al. identify tissue‐resident macrophages of embryonic origin as a source of tumor‐associated macrophages in pancreatic ductal adenocarcinoma. These cells expand through in situ proliferation during tumor progression and demonstrate a unique pro‐fibrotic transcriptional profile distinct from that of their monocyte‐derived counterparts.
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Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Self-citationCCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 2×
“…emerging evidence suggests that various types of tissue-resident macrophages are established during embryonic development, persist into adulthood, and self-maintain independently of the adult hematopoietic system (Ginhoux and Guilliams, 2016; Gomez Perdiguero et al., 2015; Schulz et al., 2012).”
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Inflammation and cancer: triggers, mechanisms, and consequences
Greten, F. R., & Grivennikov, S. I. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.025 · Cited by 3,806
Diversity, Mechanisms, and Significance of Macrophage Plasticity
Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199
Targeting macrophages: therapeutic approaches in cancer
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Macrophages and metabolism in the tumor microenvironment
Vitale, I., Manic, G., Coussens, L. M., Kroemer, G., & Galluzzi, L. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.001 · Cited by 1,837
Metadata
- Authors
- Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J., Bearden, A. R., Lavine, K. J., Yokoyama, W. M., Hawkins, W. G., Fields, R. C., Randolph, G. J., & DeNardo, D. G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 47
- Issue
- 2
- Pages
- 323-338.e6
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2749550628
- Cited by
- 801
- References
- 60
- FWCI
- 22.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J., Bearden, A. R., Lavine, K. J., Yokoyama, W. M., Hawkins, W. G., Fields, R. C., Randolph, G. J., & DeNardo, D. G. (2017). Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression. Immunity. https://doi.org/10.1016/j.immuni.2017.07.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
