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The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
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Several members of the AD-specific miR-132 predicted targetome (TRIM44, NUCKS1, NFE2L2, LYN, ZEB2, SPRED1, ABHD5, RASA1, NAP1L1) have known roles in inflammation and/or microglial cell states/function.
“In addition to these critical effectors, several members of the AD-specific miR-132 predicted targetome that we identified, e.g. TRIM44, NUCKS1, NFE2L2, LYN, ZEB2, SPRED1, ABHD5, RASA1, and NAP1L1 [143, 147–154], have known roles in inflammation and/or microglial cell states/function.”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [150]
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Cites
Regulatory networks defining EMT during cancer initiation and progression
Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487
Self-citationthe Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972
Restoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · cited 3×
“REAGENT or RESOURCE SOURCE IDENTIFIER RNeasy Micro Plus kit QIAGEN 74034 Sensifast cDNA synthesis kit Bioline BIO-65054 Allin Red Taq HighQu HQ.HSM0305 CSF1fc David Hume/Clare Pridans (Gow et al., 2014) Deposited Data RAW and analyzed data GEO GSE117081 Experimental Models: Organisms/Strains Mouse: Zeb2fl/fl Huylebroe…”
Bain, C. C., Bravo-Blas, A., Scott, C. L., Gomez Perdiguero, E., Geissmann, F., Henri, S., Malissen, B., Osborne, L. C., Artis, D., & Mowat, A. M. (2014) · Nature Immunology · doi:10.1038/ni.2967 · Cited by 1,178
Self-citationSpecification of tissue-resident macrophages during organogenesis
Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Günther, P., Crozet, L., Jacome-Galarza, C. E., Händler, K., Klughammer, J., Kobayashi, Y., et al. (2016) · Science · doi:10.1126/science.aaf4238 · Cited by 891
An improved Flp deleter mouse in C57Bl/6 based on Flpo recombinase
Kranz, A., Fu, J., Duerschke, K., Weidlich, S., Naumann, R., Stewart, A. F., & Anastassiadis, K. (2010) · genesis · doi:10.1002/dvg.20641 · Cited by 153
Flagged first, then by citations
Research works printed but not linked: 35
- A-Gonzalez, 2013, The nuclear receptor LXRα controls the functional specialization of splenic macrophages, Nat. Immunol., 14, 831, 10.1038/ni.2622 · DOI
- Bain, 2013, Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors, Mucosal Immunol., 6, 498, 10.1038/mi.2012.89 · DOI
- Brabletz, 2010, The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?, EMBO Rep., 11, 670, 10.1038/embor.2010.117 · DOI
- Cain, 2013, Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages, J. Immunol., 191, 4665, 10.4049/jimmunol.1300581 · DOI
- Caton, 2007, Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen, J. Exp. Med., 204, 1653, 10.1084/jem.20062648 · DOI
- Dominguez, 2015, The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection, J Exp Med, 212, 10.1084/jem.20150186 · DOI
- Durai, 2016, Functions of Murine Dendritic Cells, Immunity, 45, 719, 10.1016/j.immuni.2016.10.010 · DOI
- Ginhoux, 2016, Tissue-Resident Macrophage Ontogeny and Homeostasis, Immunity, 44, 439, 10.1016/j.immuni.2016.02.024 · DOI · Paper page
- Gosselin, 2014, Environment drives selection and function of enhancers controlling tissue-specific macrophage identities, Cell, 159, 1327, 10.1016/j.cell.2014.11.023 · DOI · Paper page
- Gow, 2014, Characterisation of a novel Fc conjugate of macrophage colony-stimulating factor, Mol. Ther., 22, 1580, 10.1038/mt.2014.112 · DOI
- Guilliams, 2017, Does niche competition determine the origin of tissue-resident macrophages?, Nat. Rev. Immunol., 17, 451, 10.1038/nri.2017.42 · DOI · Paper page
- Guilliams, 2016, Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species, Immunity, 45, 669, 10.1016/j.immuni.2016.08.015 · DOI
- Higashi, 2002, Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse, Genesis, 32, 82, 10.1002/gene.10048 · DOI
- Hume, 1988, The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo, J. Immunol., 141, 3405, 10.4049/jimmunol.141.10.3405 · DOI
- Lavin, 2014, Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment, Cell, 159, 1312, 10.1016/j.cell.2014.11.018 · DOI · Paper page
- Luche, 2007, Faithful activation of an extra-bright red fluorescent protein in “knock-in” Cre-reporter mice ideally suited for lineage tracing studies, Eur. J. Immunol., 37, 43, 10.1002/eji.200636745 · DOI · Paper page
- Lun, 2016, A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor, F1000Res., 5, 2122
- Lynch, 2018, An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias, J. Leukoc. Biol., 95, 2157
- Monticelli, 2017, Transcriptional determination and functional specificity of myeloid cells: making sense of diversity, Nat. Rev. Immunol., 17, 595, 10.1038/nri.2017.51 · DOI
- Okabe, 2014, Tissue-specific signals control reversible program of localization and functional polarization of macrophages, Cell, 157, 832, 10.1016/j.cell.2014.04.016 · DOI · Paper page
- Okabe, 2016, Tissue biology perspective on macrophages, Nat. Immunol., 17, 9, 10.1038/ni.3320 · DOI
- Omilusik, 2015, Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection, J Exp Med, 212, 10.1084/jem.20150194 · DOI
- Pettitt, 2009, Agouti C57BL/6N embryonic stem cells for mouse genetic resources, Nat. Methods, 6, 493, 10.1038/nmeth.1342 · DOI
- Schneider, 2014, Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages, Nat. Immunol., 15, 1026, 10.1038/ni.3005 · DOI
- Scott, 2015, CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells, Mucosal Immunol., 8, 327, 10.1038/mi.2014.70 · DOI
- Scott, 2016, The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2, J. Exp. Med., 213, 897, 10.1084/jem.20151715 · DOI
- Scott, 2016, Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells, Nat. Commun., 7, 10321, 10.1038/ncomms10321 · DOI · Paper page
- Tagliani, 2011, Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1, J. Exp. Med., 208, 1901, 10.1084/jem.20110866 · DOI
- Tamoutounour, 2012, CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis, Eur. J. Immunol., 42, 3150, 10.1002/eji.201242847 · DOI
- van de Laar, 2016, Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages, Immunity, 44, 755, 10.1016/j.immuni.2016.02.017 · DOI
- van Helden, 2015, Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection, J. Exp. Med., 212, 2015, 10.1084/jem.20150809 · DOI
- Vandewalle, 2009, The role of the ZEB family of transcription factors in development and disease, Cell. Mol. Life Sci., 66, 773, 10.1007/s00018-008-8465-8 · DOI
- Wang, 2012, IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia, Nat. Immunol., 13, 753, 10.1038/ni.2360 · DOI · Paper page
- Wu, X., Briseño, C.G., Grajales-Reyes, G.E., Haldar, M., Iwata, A., and Kretzer, N.M. KC, W., Tussiwand, R., Higashi, Y., Murphy, T.L., et al. (2016). Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate. Proceedings of the National Academy of Sciences 113, 14775–14780. · DOI
- Zhang, 2012, Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice, J. Clin. Invest., 122, 1688, 10.1172/JCI59817 · DOI
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Metadata
- Authors
- Scott, C. L., T’Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., De Prijck, S., Vandamme, N., Cannoodt, R., Saelens, W., Vanneste, B., Toussaint, W., De Bleser, P., Takahashi, N., Vandenabeele, P., Henri, S., Pridans, C., Hume, D. A., Lambrecht, B. N., De Baetselier, P., Milling, S. W. F., Van Ginderachter, J. A., Malissen, B., Berx, G., Beschin, A., Saeys, Y., & Guilliams, M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 49
- Issue
- 2
- Pages
- 312-325.e5
- ISSN
- 1074-7613
- PMC
- PMC6104815
- Cited by
- 299
- References
- 6
- Language
- en
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