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Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life
Open accessAbstract
&NA; Although the fetal immune system is considered tolerogenic, preterm infants can suffer from severe intestinal inflammation, including necrotizing enterocolitis (NEC). Here, we demonstrate that human fetal intestines predominantly contain tumor necrosis factor‐&agr; (TNF‐&agr;)+CD4+CD69+ T effector memory (Tem) cells. Single‐cell RNA sequencing of fetal intestinal CD4+ T cells showed a T helper 1 phenotype and expression of genes mediating epithelial growth and cell cycling. Organoid co‐cultures revealed a dose‐dependent, TNF‐&agr;‐mediated effect of fetal intestinal CD4+ T cells on intestinal stem cell (ISC) development, in which low T cell numbers supported epithelial development, whereas high numbers abrogated ISC proliferation. CD4+ Tem cell frequencies were higher in inflamed intestines from preterm infants with NEC than in healthy infant intestines and showed enhanced TNF signaling. These findings reveal a distinct population of TNF‐&agr;‐producing CD4+ T cells that promote mucosal development in fetal intestines but can also mediate inflammation upon preterm birth. Graphical Abstract Figure. No caption available. HighlightsHuman fetal intestinal CD4+ Tem cells preferentially produce TNF‐&agr;Fetal intestinal TNF‐&agr;+CD4+ Tem cells are present from the end of the first trimesterFetal TNF‐&agr;+CD4+ Tem cells promote intestinal epithelial tissue growthPremature birth can result in TNF‐&agr;‐mediated intestinal tissue damage &NA; The fetal immune system is considered anti‐inflammatory; nonetheless, preterm infants are at risk for necrotizing enterocolitis (NEC), a severe intestinal inflammatory disease. Schreurs et al. demonstrate that fetal TNF‐&agr;+CD4+ T cells promote gut development early in life. However, in preterm babies these TNF&agr;+CD4+ T cells can mediate intestinal inflammation, providing a potential mechanism for NEC.
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Metadata
- Authors
- Schreurs, R. R. C. E., Baumdick, M. E., Sagebiel, A. F., Kaufmann, M., Mokry, M., Klarenbeek, P. L., Schaltenberg, N., Steinert, F. L., van Rijn, J. M., Drewniak, A., The, S.-M. M. L., Bakx, R., Derikx, J. P. M., de Vries, N., Corpeleijn, W. E., Pals, S. T., Gagliani, N., Friese, M. A., Middendorp, S., Nieuwenhuis, E. E. S., Reinshagen, K., Geijtenbeek, T. B. H., van Goudoever, J. B., & Bunders, M. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 50
- Issue
- 2
- Pages
- 462-476.e8
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2913661510
- Cited by
- 205
- References
- 12
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schreurs, R. R. C. E., Baumdick, M. E., Sagebiel, A. F., Kaufmann, M., Mokry, M., Klarenbeek, P. L., Schaltenberg, N., Steinert, F. L., van Rijn, J. M., Drewniak, A., The, S.-M. M. L., Bakx, R., Derikx, J. P. M., de Vries, N., Corpeleijn, W. E., Pals, S. T., Gagliani, N., Friese, M. A., Middendorp, S., . . . Bunders, M. J. (2019). Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life. Immunity. https://doi.org/10.1016/j.immuni.2018.12.010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
