Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Integrated analysis of multimodal single-cell data

Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453

UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

McInnes, L., Healy, J., & Melville, J. (2018) · arXiv · doi:10.48550/arxiv.1802.03426 · Cited by 7,101

Scenic: single-cell regulatory network inference and clustering.

Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520

Dimensionality reduction for visualizing single-cell data using UMAP

Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

A spatial map of human macrophage niches reveals context-dependent macrophage functions in colon and breast cancer.Preprint

Matusiak, M., Hickey, J. W., Luca, B. A., Lu, G., Kidziński, Ł., Zhu, S., Colburg, D. R. C., Phillips, D. J., Brubaker, S. W., Charville, G. W., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2393443/v1 · Cited by 23

Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastomaPreprint

Albiach, A. M., Janusauskas, J., Jacobsen, J. K., Kapustová, I., Karamzadeh, R., Kvedaraite, E., Hu, L., Franck, M. C. M., Mannens, C. C. A., Codeluppi, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.01.555882 · Cited by 23

Gene-Expression Profiling to Decipher Breast Cancer Inter- and Intratumor HeterogeneityPreprint

Swarbrick, A., Fernández-Martínez, A., & Perou, C. M. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041320 · Cited by 23

Monocyte Single-Cell Multimodal Profiling in Cardiovascular Disease Risk States

Bashore, A. C., Xue, C., Kim, E., Yan, H., Zhu, L. Y., Pan, H., Kissner, M. D., Ross, L. S., Zhang, H., Li, M., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.324457 · Cited by 26

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

David, B. A., Andreata, F., Blériot, C., Ginhoux, F., Kubes, P., & Iannacone, M. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01288-0 · Cited by 25

Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways

Filiberti, S., Russo, M., Lonardi, S., Bugatti, M., Vermi, W., Tournier, C., & Giurisato, E. (2022) · Biomedicines · doi:10.3390/biomedicines10112709 · Cited by 25

Low molecular weight cytotoxic components (DAMPs) form the post-COVID-19 syndrome

Klimova, E. M., Божков, А. И., Lavinska, O. V., Drozdova, L. A., & Kurhuzova, N. I. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152316 · Cited by 26

Single-cell RNA sequencing in dissecting microenvironment of age-related macular degeneration: Challenges and perspectives

Tan, Y., Jianguo, H., Li, D., Zou, C., Liu, D., & Qin, B. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102030 · Cited by 22

Lenvatinib, Toripalimab plus FOLFOX Chemotherapy in Hepatocellular Carcinoma Patients with Extrahepatic Metastasis: A Biomolecular Exploratory, Phase II Trial (LTSC)

He, M., Huang, Y., Du, Z., Lai, Z., Ouyang, H., Shen, J., Wen, D., Li, Q., Zhang, Y., Wei, W., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0060 · Cited by 22

Heterogeneity and origins of myeloid cells

Yáñez, A., Bono, C., & Goodridge, H. S. (2022) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000716 · Cited by 22

Systematic identification of biomarker-driven drug combinations to overcome resistance

Rees, M. G., Brenan, L., DoCarmo, M., Duggan, P., Bajrami, B., Arciprete, M., Boghossian, A. S., Vaimberg, E. W., Ferrara, S. J., Lewis, T. A., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-00996-7 · Cited by 22

Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics

Chu, X., Zhang, Y., & Cheng, S. (2022) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2022.06.01 · Cited by 21

Single-cell transcriptomics reveals the interaction between peripheral CD4+ CTLs and mesencephalic endothelial cells mediated by IFNG in Parkinson's disease

Yan, S., Si, Y., Zhou, W., Cheng, R., Wang, P., Wang, D., Ding, W., Shi, W., Jiang, Q., Yang, F., et al. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106801 · Cited by 24

Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

Wang, Y., Yu, Y., Li, L., Zheng, M., Zhou, J., Gong, H., Feng, B., Wang, X., Meng, X., Cui, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40565-7 · Cited by 23

TREM2-Expressing Multinucleated Giant Macrophages Are a Biomarker of Good Prognosis in Head and Neck Squamous Cell Carcinoma

Gessain, G., Anzali, A.-A., Lerousseau, M., Mulder, K., Bied, M., Auperin, A., Stockholm, D., Signolle, N., Sassi, F., Costa, M. E. M. D., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0018 · Cited by 27

Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade in classic Hodgkin lymphoma

Paczkowska, J., Tang, M., Wright, K., Song, L., Luu, K., Shanmugam, V., Welsh, E. L., Weirather, J. L., Besson, N. R., Olszewski, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54512-7 · Cited by 21

Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing

Valcárcel, G., López-Rubio, A. V., Lazarenkov, A., Berenguer, C., Calafell-Segura, J., Rodríguez‐Ubreva, J., Ballestar, E., & Sardina, J. L. (2025) · Science Advances · doi:10.1126/sciadv.adt1644 · Cited by 23

Distinct responses of newly identified monocyte subsets to advanced gastrointestinal cancer and COVID-19

Rigamonti, A., Castagna, A., Viatore, M., Colombo, F., Terzoli, S., Peano, C., Marchesi, F., & Locati, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.967737 · Cited by 18

Niclosamide targets the dynamic progression of macrophages for the resolution of endometriosis in a mouse model

Zhao, L., Shi, M., Winuthayanon, S., MacLean, J. A., & Hayashi, K. (2022) · Communications Biology · doi:10.1038/s42003-022-04211-0 · Cited by 22

Tissue-resident macrophages — early passengers or drivers in the tumor niche?

Vogel, A., & Weichhart, T. (2023) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2023.102984 · Cited by 21

Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis

Huang, Y., Cao, D., Zhang, M., Yang, Y., Niu, G., Tang, L., Shen, Z., Zhang, Z., Bai, Y., Min, D., et al. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00949-3 · Cited by 20

Astragalus polysaccharides inhibits tumor proliferation and enhances cisplatin sensitivity in bladder cancer by regulating the PI3K/AKT/FoxO1 axis

Chen, R., Li, Y., Zuo, L., Xiong, H., Sun, R., Song, X., & Liu, H. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143739 · Cited by 20

High-throughput sequencing unravels the cell heterogeneity of cerebrospinal fluid in the bacterial meningitis of children

Xiao, H., Xiao, H., Zhang, Y., Guo, L., Dou, Z., Liu, L., Zhu, L., Feng, W., Liu, B., Hu, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872832 · Cited by 19

Multinucleation resets human macrophages for specialized functions at the expense of their identity

Ahmadzadeh, K., Pereira, M., Vanoppen, M., Bernaerts, E., Ko, J., Mitera, T., Maksoudian, C., Manshian, B. B., Soenen, S. J., Rosé, C. D., et al. (2023) · EMBO Reports · doi:10.15252/embr.202256310 · Cited by 22

Subverted macrophages in the triple-negative breast cancer ecosystem

Shang, L., Zhong, Y., Yao, Y., Liu, C., Wang, L., Zhang, W., Liu, J., Wang, X., & Sun, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115414 · Cited by 21

The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis

de la Calle‐Fabregat, C., Rodríguez‐Ubreva, J., Ciudad, L., Ramirez, J. R., Celis, R., Azuaga, A., Cuervo, A. M., Graell, E., Pérez-García, C., Díaz‐Torné, C., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158783 · Cited by 18

Fallopian tube single cell analysis reveals myeloid cell alterations in high-grade serous ovarian cancer

Brand, J., Haro, M., Lin, X., Rimel, B. J., McGregor, S. M., Lawrenson, K., & Dinh, H. Q. (2024) · iScience · doi:10.1016/j.isci.2024.108990 · Cited by 19

Identification of SPP1+ macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomics

Jin, H., Kim, W., Yuan, M., Li, X., Yang, H., Li, M., Shi, M., Türkez, H., Uhlén, M., Zhang, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1446453 · Cited by 23

CD137 agonism enhances anti-PD1 induced activation of expanded CD8+ T cell clones in a neoadjuvant pancreatic cancer clinical trial

Montagne, J. M., Mitchell, J. T., Tandurella, J. A., Christenson, E. S., Danilova, L., Deshpande, A. M., Loth, M., Sidiropoulos, D. N., Davis-Marcisak, E. F., Bergman, D. R., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111569 · Cited by 19

Differences in glycolytic metabolism between tissue-resident alveolar macrophages and recruited lung macrophages

Woods, P. S., & Mutlu, G. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1535796 · Cited by 21

Cancer Immunotherapies Based on Genetically Engineered Macrophages

Cannac, M., Nikolić, J., & Benaroch, P. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-22-0030 · Cited by 18

Systematic single-cell dissecting reveals heterogeneous oncofetal reprogramming in the tumor microenvironment of gastric cancer

Mo, S., Shen, X., Wang, Y., Liu, Y., Sugasawa, T., Yang, Z., Gu, W., & Nakajima, T. (2023) · Human Cell · doi:10.1007/s13577-023-00856-z · Cited by 20

Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma

Tomolonis, J., Xu, X. Y., Dholakia, K. H., Zhang, C., Guo, L., Courtney, A. N., Wang, S., Balzeau, J. C., Barragán, G. A., Tian, G., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005478 · Cited by 18

Glycolysis regulation in tumor‐associated macrophages: Its role in tumor development and cancer treatment

Jiang, G., Hong, J., Sun, L., Wei, H., Gong, W., Wang, S., & Zhu, J. (2023) · International Journal of Cancer · doi:10.1002/ijc.34711 · Cited by 18

MAFB shapes human monocyte–derived macrophage response to SARS-CoV-2 and controls severe COVID-19 biomarker expression

Simón‐Fuentes, M., Ríos, I., Herrero, C., Lasala, F., Labiod, N., Luczkowiak, J., Roy‐Vallejo, E., de Córdoba‐Oñate, S. F., Delgado‐Wicke, P., Bustos, M., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.172862 · Cited by 18

Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer

Elfstrum, A. K., Bapat, A. S., & Schwertfeger, K. L. (2024) · Cancer Medicine · doi:10.1002/cam4.7053 · Cited by 22

Macrophage re-programming by JAK inhibitors relies on MAFB

López-Navarro, B., Simón‐Fuentes, M., Ríos, I., Schiaffino, M. T., Sánchez, A., Torres‐Torresano, M., Nieto‐Valle, A., Castrejón, I., & Puig‐Kröger, A. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05196-1 · Cited by 20

Myeloid-T cell interplay and cell state transitions associated with checkpoint inhibitor response in melanoma

Schlenker, R., Schwalie, P. C., Dettling, S., Huesser, T., Irmisch, A., Mariani, M., Gómez, J. M. M., Ribeiro, A., Limani, F., Herter, S., et al. (2024) · Med · doi:10.1016/j.medj.2024.03.015 · Cited by 19

Dynamic changes in peripheral blood monocytes early after anti-PD-1 therapy predict clinical outcomes in hepatocellular carcinoma

Jeon, S. H., Lee, Y. J., Kim, H., Nam, H., Ryoo, B., Park, S., Yoo, C., & Shin, E. (2022) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-022-03258-6 · Cited by 16

Myeloid cells in chronic liver inflammation

Patseas, D., El-Masry, A., Liu, Z., Ramachandran, P., & Triantafyllou, E. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01324-4 · Cited by 20

CCL17 acts as an antitumor chemokine in micromilieu‐driven immune skewing

Li, Y., Cao, H., Jiang, Z., Yan, K., Shi, J., Wang, S., Wang, F., Wang, W., Li, X., Sun, N., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110078 · Cited by 17

Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway

Huang, L., Chen, W., Tan, Z., Huang, Y., Gu, X., Liu, L., Zhang, H., Shi, Y., Ding, J., Zheng, C., et al. (2024) · Theranostics · doi:10.7150/thno.89174 · Cited by 17

Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results

Lévy, A., Morel, D., Texier, M., Rodriguez-Ruiz, M. E., Bouarroudj, L., Bouquet, F., Bustillos, A., Quevrin, C., Clémenson, C., Mondini, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02173-3 · Cited by 17

Cytotoxic IgG: Mechanisms, functions, and applications

Wöhner, M., & Nimmerjahn, F. (2025) · Immunity · doi:10.1016/j.immuni.2025.05.008 · Cited by 18

Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: Implications for atherogenic, tumorigenic, and obesogenic processes

Lee‐Rueckert, M., Jauhiainen, M., Kovanen, P. T., & Escolá‐Gil, J. C. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.008 · Cited by 16

The single-cell landscape of the human vein after arteriovenous fistula creation and implications for maturation failure

Martinez, L., Stoyell‐Conti, F. F., Tabbara, M., Rojas, M. G., Pereira‐Simon, S., Falcon, N. S., Lopez, R. H., Galtes, D., Kosanovic, C., Griswold, A. J., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.08.024 · Cited by 18

The role of NK cells in regulating tumorimmunity: current state, challenges and future strategies

Zhu, W., Fan, C., Zhao, Y., Li, W., Niu, J., Dong, S., Yang, Z., & Zhou, W. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03980-y · Cited by 17

SLC2A1+ tumour-associated macrophages spatially control CD8+ T cell function and drive resistance to immunotherapy in non-small-cell lung cancer

Wang, L., Chu, H., Chen, D., Wei, Y., Jia, J., Li, L., He, L., Peng, L., Liu, F., Huang, S., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-025-01840-5 · Cited by 16

Guidelines for mouse and human DC functional assays

Clausen, B. E., Amon, L., Backer, R. A., Berod, L., Bopp, T., Brand, A., Burgdorf, S., Chen, L., Da, M., Distler, U., et al. (2022) · European Journal of Immunology · doi:10.1002/eji.202249925 · Cited by 16

Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation

Han, S., Li, X., Xia, N. L., Zhang, Y., Yu, W., Li, J., Jiao, C., Wang, Z., & Pu, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076348 · Cited by 16

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

Cheng, K., Seita, Y., Whelan, E. C., Yokomizo, R., Hwang, Y. S., Rotolo, A., Krantz, I. D., Ginsberg, J. P., Kolon, T. F., Lal, P., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114323 · Cited by 15

Single-cell dissection of multifocal bladder cancer reveals malignant and immune cells variation between primary and recurrent tumor lesions

Liu, S., Feng, C., Tan, L., Zhang, D., Li, Y., Han, Y., & Wang, C. (2024) · Communications Biology · doi:10.1038/s42003-024-07343-7 · Cited by 18

FOLR2+ macrophage depletion from intestinal metaplasia to early gastric cancer: single-cell sequencing insight into gastric cancer progression

He, Y., Wang, J., Deng, Z., Feng, H., Du, M., Zhang, D., Zhang, G., Shi, T., & Chen, W. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03245-y · Cited by 16

Atractylenolide II regulates the proliferation, ferroptosis, and immune escape of hepatocellular carcinoma cells by inactivating the TRAF6/NF-κB pathway

Lin, Y., Chen, K., Zhu, M., Song, W., Wu, G., & Pan, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03046-2 · Cited by 15

Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection

Inoue, T., Emoto, T., Yamanaka, K., Chomei, S., Miyahara, S., Takahashi, H., Shinohara, R., Kondo, T., Taniguchi, M., Furuyashiki, T., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65931-3 · Cited by 15

Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics

Ahamed, F., Eppler, N., Jones, E., & Zhang, Y. (2024) · Livers · doi:10.3390/livers4030033 · Cited by 17

IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma

Yang, W., Guo, Z., Ju, H., Lu, Y., Fei, Y., Yin, Y., Ren, G., Yan, M., Han, C., & Hu, J. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-011474 · Cited by 15

An islet-resident macrophage antioxidant program preserves β cell physiology

Grosjean, A., Jalon, A., Leveau, C., Diedisheim, M., Bejarano, D. A., Cuenco, J., Mulder, K., Liu, Z., Guernic, A. L., Island, M., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adz5181 · Cited by 19

Human resident liver myeloid cells protect against metabolic stress in obesity

Barreby, E., Strunz, B., Nock, S., Naudet, L., Shen, J. X., Johansson, H., Sönnerborg, I., Ma, J., Urgard, E., Pallett, L. J., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00834-7 · Cited by 14

Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma

Sun, X., Meng, F., Nong, M.-Y., Fang, H., Lu, C., Wang, Y., & Zhang, P. (2023) · Aging · doi:10.18632/aging.205306 · Cited by 15

Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets

Cao, S. “., Nguyen, K. M., Ma, K., Du, X., Liu, X., Antonova, A. U., Rood, R. P., Gremida, A. K., Chen, C.-H., Gutierrez, A. M., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.07.025 · Cited by 15

On the Biology and Therapeutic Modulation of Macrophages and Dendritic Cells in Cancer

Park, M. D., Belabed, M., Chen, S. T., Hamon, P., Hegde, S., Mattiuz, R., Marron, T. U., & Mérad, M. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061521-085949 · Cited by 15

C1QA is an invariant biomarker for tissue macrophagesPreprint

Horowitz, A., Yu, H., Pandey, S., Mishra, B., & Sahoo, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.26.577475 · Cited by 15

Dissecting the liver inflammation ecosystem identifies annexin A1 as a pro-resolving target for liver failure

Yu, X., Tian, W., Bao, X., Li, Z., Tu, H., Xu, X., Chen, J., Zhang, Q., Chen, J., Liu, C., et al. (2026) · Hepatology · doi:10.1097/hep.0000000000001427 · Cited by 14

Emerging therapeutics targeting tumor-associated macrophages for the treatment of solid organ cancers

Li, D., & Rudloff, U. (2025) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2025.2504376 · Cited by 15

Multiomics integration analysis identifies tumor cell-derived MIF as a therapeutic target and potentiates anti-PD-1 therapy in osteosarcoma

Chen, W., Liao, Y., Yao, H., Zou, Y., Ji, F., Zhang, J., Guo, Z., Tu, J., Chen, J., Huo, Z., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011091 · Cited by 17

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

Block, A. V., Liu, X., Zhang, D., & Adebowale, K. (2026) · npj Biomedical Innovations. · doi:10.1038/s44385-026-00072-y · Cited by 16

Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Suzuki, Y., Emoto, T., Sato, S., Yoshida, T., Shoda, M., Endoh, H., Nagao, M., Hamana, T., Inoue, T., Hayashi, T., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07308-w · Cited by 15

Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation

Turiel, G., Desgeorges, T., Masschelein, E., Fan, Z., Lussi, D., Capelle, C., Bernardini, G., Ardicoglu, R., Schönberger, K., Birrer, M., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00709-y · Cited by 15

Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia

Dooling, L. J., Anlaş, A. A., Tobin, M. P., Ontko, N. M., Marchena, T., Wang, M., Andrechak, J. C., & Discher, D. E. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2425452122 · Cited by 15

JMJD3 downregulates IL4i1 aggravating lipopolysaccharide‐induced acute lung injury via H3K27 and H3K4 demethylation

Gao, Y. K., Wang, N., & Jia, D. (2022) · Environmental Toxicology · doi:10.1002/tox.23725 · Cited by 13

BRD4 Inhibition Enhances the Antitumor Effects of Radiation Therapy in a Murine Breast Cancer Model

Kim, S.-M., Jeon, S. H., Han, M. G., Kang, M. H., & Kim, I. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713062 · Cited by 13

Bexmarilimab Activates Human Tumor-Associated Macrophages to Support Adaptive Immune Responses in Interferon-Poor Immune Microenvironments

Rannikko, J. H., Bono, P., Hynninen, J., & Hollmén, M. (2023) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-0350 · Cited by 13

Immunity in malignant brain tumors: Tumor entities, role of immunotherapy, and specific contribution of myeloid cells to the brain tumor microenvironment

Kienzler, J. C., & Becher, B. (2023) · European Journal of Immunology · doi:10.1002/eji.202250257 · Cited by 13

Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification

Haag, S. M., Xie, S., Eidenschenk, C., Fortin, J., Callow, M. G., Costa, M., Lun, A. T. L., Cox, C., Wu, S. Z., Pradhan, R., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01962-w · Cited by 13

Age-Associated Modulation of TREM1/2-Expressing Macrophages Promotes Melanoma Progression and Metastasis

Scortegagna, M., Murad, R., Bina, P., Feng, Y., Porritt, R. A., Terskikh, A. V., Tian, X., Adams, P. D., Vuori, K., & Ronai, Z. A. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4317 · Cited by 13

Investigating the spatial interaction of immune cells in colon cancer

Mirzaei, N. M., Hao, W., & Shahriyari, L. (2023) · iScience · doi:10.1016/j.isci.2023.106596 · Cited by 11

Population-level single-cell genomics reveals conserved gene programs in systemic juvenile idiopathic arthritis

Verweyen, E. L., Thakkar, K., Dhakal, S., Baker, E. K., Chetal, K., Schnell, D., Canna, S., Grom, A. A., Salomonis, N., & Schulert, G. S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci166741 · Cited by 13

Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities

Dai, C., Zhang, H., Zheng, Z., Li, C. G., Ma, M., Gao, H., Zhang, Q., Cui, X., & Jiang, F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1309739 · Cited by 13

A spatiotemporal comparative analysis on tumor immune microenvironment characteristics between neoadjuvant chemotherapy and preoperative immunotherapy for ESCC

Zhou, Z., Zhang, H., Du, J., Yang, J., Pan, W., Zhang, Q., Wang, H., Tang, P., Ba, Y., & Zhang, H. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06986-y · Cited by 12

Single-cell sequencing in diffuse large B-cell lymphoma: C1qC is a potential tumor-promoting factor

Gao, G., Sun, N., Zhang, Y., Li, J., Jiang, Y., Chen, N., Tang, Y., & Shi, W. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113319 · Cited by 12

Tissue‐Resident Macrophages in Cancer: Friend or Foe?

Chi, J., Gao, Q., & Liu, D. (2024) · Cancer Medicine · doi:10.1002/cam4.70387 · Cited by 13

Advances on the role of lung macrophages in the pathogenesis of chronic obstructive pulmonary disease in the Era of Single-Cell Genomics

Li, X., Zhang, H., Chi, X., Ruan, W., Meng, X., Deng, J., Pan, M., Ma, T., & Zhang, J. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.100160 · Cited by 13

Lung tumor immunity: redirecting macrophages through infection-induced inflammation

Aktay-Cetin, Ö., Pullamsetti, S. S., Herold, S., & Savai, R. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.04.004 · Cited by 14

Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

Meng, C., Lin, K., Shi, W., Teng, H., Wan, X., DeBruine, A., Wang, Y., Liang, X., Leo, J., Chen, F., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59381-2 · Cited by 14

Microbial-induced trained immunity for cancer immunotherapy

Vuscan, P., Kischkel, B., Joosten, L. A. B., & Netea, M. G. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100074 · Cited by 14

The Underexplored Landscape of Hypoxia-Inducible Factor 2 Alpha and Potential Roles in Tumor Macrophages: A Review

Steinberger, K. J., & Eubank, T. D. (2023) · Oxygen · doi:10.3390/oxygen3010005 · Cited by 15

Functional specialization of short-lived and long-lived macrophage subsets in human tonsils

Alaoui, L., Villar, J., Leclère, R., Gallou, S. L., Relouzat, F., Michaud, H., Tarte, K., Teissier, N., Favier, B., Roussel, M., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230002 · Cited by 11

Inflammation across tissues: can shared cell biology help design smarter trials?

Hosack, T., Thomas, T. R., Ravindran, R. P., Uhlig, H. H., Travis, S. P. L., & Buckley, C. D. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01007-2 · Cited by 12

Single-Cell Transcriptomics Reveals CCL3+ Classical Monocyte Subset Linked to Autoimmune Pathogenesis

Xu, H., Yuan, K., Chen, G., Luo, J., Yan, A., Huang, H., Yu, X., Tao, Q., Huang, G., & Xu, A. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s547283 · Cited by 11

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Wang, Z., Xu, W., Zhao, L., Zhong, L., Yu, W., Wang, S., Sun, L., Guo, T., Li, F., Li, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202513606 · Cited by 12

CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming

Liu, S., Zhang, S., Dong, H., Jin, X., Sun, J., Zhou, H., Jin, Y., Li, Y., & Wu, G. (2024) · BMC Cancer · doi:10.1186/s12885-024-12472-7 · Cited by 11

Human genital dendritic cell heterogeneity confers differential rapid response to HIV-1 exposure

Parthasarathy, S., de Lara, L. M., Carrillo-Salinas, F. J., Werner, A., Borchers, A., Iyer, V. V., Vogell, A. B., Fortier, J. M., Wira, C. R., & Rodríguez‐García, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1472656 · Cited by 11

Decision level integration of unimodal and multimodal single cell data with scTriangulate

Li, G., Song, B., Singh, H., Prasath, V. B. S., Grimes, H. L., & Salomonis, N. (2023) · Nature Communications · doi:10.1038/s41467-023-36016-y · Cited by 10

A spatial map of human macrophage niches links tissue location with functionPreprint

Matusiak, M., Hickey, J., Luca, B., Lu, G., Kidzinski, L., Shu, S., Colburg, D., Phillips, D., Brubaker, S. W., Charville, G., et al. (2022) · bioRxiv · doi:10.1101/2022.08.18.504434 · Cited by 8

Transcriptional programs underlying human monocyte differentiation and diversity

Komaravolu, R. K., Araujo, D. J., Hedrick, C. C., & Alimadadi, A. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf058 · Cited by 15

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

Bao, W., Qu, X., Wang, Y., Huang, D., Zhang, H., Dong, M., Sun, H., Yang, Z., & Li, X. (2026) · MedComm · doi:10.1002/mco2.70599 · Cited by 13

Macrophage heterogeneity and plasticity: mechanism and therapeutics

Li, S., Yang, Y., Qiu, H., & Pang, L. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.02.002 · Cited by 10

Decoding the CAF–TAM axis: multi-omics dissection and therapeutic targeting of stromal–immune crosstalk in the tumor microenvironment

Fu, Y., Li, M., Wu, S., Wang, J., & Wang, S. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08685-2 · Cited by 11

The synthetic phospholipid C8-C1P determines pro-angiogenic and pro-reparative features in human macrophages restraining the proinflammatory M1-like phenotype

Wilczyñski, J. M. O., Mena, H. A., Ledesma, M. M., Olexen, C. M., Podaza, E., Schattner, M. A., Negrotto, S., Errasti, A. E., & Silva, E. A. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1162671 · Cited by 10

Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics

Loke, P., & Lin, J.-D. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo4652 · Cited by 24

Abstract 7280: Pan-cancer single-cell RNA sequencing analysis refines multiorigin monocyte and macrophage lineages

Nguyen, T. D., Lee, A., Park, H. J., Shah, N., Mandzhieva, B., Lee, D., Jung, I., & Park, W.-Y. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-7280

A spatial map of human macrophage niches links tissue location with functionPreprint

Matusiak, M., Hickey, J., Luca, B., Lu, G., Kidzinski, L., Shu, S., Colburg, D., Phillips, D., Brubaker, S. W., Charville, G., et al. (2022) · bioRxiv · doi:10.1101/2022.08.18.504434 · Cited by 8

Antiproliferative effect of IL-1 and alpha interferon in melanoma cells

Alvino, E. (1992) · Pharmacological Research · doi:10.1016/1043-6618(92)91297-t

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Wang, W., Chen, Z., Huang, Y., Hu, Z., Zhu, P., Huang, Z., Lv, J., Liao, Z., Zheng, Y., Wei, C., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70608 · Cited by 4