Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Integrated analysis of multimodal single-cell data

Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453

UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

McInnes, L., Healy, J., & Melville, J. (2018) · arXiv · doi:10.48550/arxiv.1802.03426 · Cited by 7,101

Scenic: single-cell regulatory network inference and clustering.

Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520

Dimensionality reduction for visualizing single-cell data using UMAP

Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

The myeloid SRC family kinase HCK regulates breast cancer growth by activating tumor-associated macrophage-led invasion and inhibiting cytotoxic T cell activity

Murrey, M. W., Poh, A. R., Steer, J. H., Rinaldi, C., Mouchemore, K. A., Dwyer, A. R., Denisenko, E., Kuznetsova, I., Yeow, Y. L., Jones, M. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1709102

A lipid-laden macrophage niche drives immunosuppression in primary central nervous system lymphomaPreprint

Hong, L., Joshi, S., Liu, M., Sridhar, S., Revuelta, M. V., Ong, Z. Y. C., Tay, N. S. C., Lai, W. X. C., Tipgomut, C., Jaynes, P. W., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.705289

SuperCell2.0 enables semi-supervised construction of multimodal metacell atlasesPreprint

Hérault, L., Gabriel, A. A., Duc, B., Dolfi, B., Shah, A., Joyce, J. A., & Gfeller, D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706848

Monocytes acquire a tumor-associated IL1B program upon encountering patient-derived colon cancer organoids

Balzasch, B. M., von Kries, A., Hüll, S., Shaltiël, I. A., Boonekamp, K. E., Ast, V., Burgermeister, E., Betge, J., Ebert, M., Boutros, M., et al. (2026) · OncoImmunology · doi:10.1080/2162402x.2026.2633012

Animal component-free differentiation of human pluripotent stem cells into macrophages

van den Berk, L., Popović, N. Z., Wijmenga, R. H., Cao, X., Mummery, C. L., Orlova, V. V., & Davis, R. P. (2026) · Stem Cell Research · doi:10.1016/j.scr.2026.103957

Clec4e is associated with macrophage inflammatory responses in LPS-induced acute lung injury

Zhao, B., Chang, Z., & Huo, M. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102479

Innovative immunotherapeutic strategies for thyroid cancer: challenges and opportunities

Cui, J., Fang, H., & 曲昌华 (2026) · Clinical & Translational Oncology · doi:10.1007/s12094-026-04299-4

CD5L insufficiency exacerbates skeletal joint damage in rheumatoid arthritis

Bicho, D., Erlandsson, M. C., Svensson, D., Comas, E., Silva, M. C., Chandrasekaran, V., Lundgren, V., Santos, R. F., Oliveira, L., Bokarewa, M. I., et al. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01456-x

Host Prior Exposure Augments Gene Expression Heterogeneity of Both Host and Pathogen During In Vivo Infection

Pérez‐Umphrey, A. A., Miller, J., Tulman, E. R., Garrett-Larsen, J., Vinkler, M., Langwig, K. E., Geary, S. J., Adelman, J. S., & Hawley, D. M. (2026) · Molecular Ecology · doi:10.1111/mec.70319

A high-resolution single-nucleus RNA sequencing reveals conserved macrophage activation trajectories across muscle regeneration and dystrophy.Preprint

Baek, J.-H., Byun, W. S., Bang, E.-C., & Shim, Y.-G. (2026) · Research Square · doi:10.21203/rs.3.rs-9129034/v1

Rôle des lymphocytes B et de l'enzyme IL4-induced gene 1 (IL4I1) dans le contexte du mélanome métastatique chez la souris

Bekkat, F. (2021) · theses.fr (ABES) · doi:10.70675/342b7d41z2d8ez45d9z91aezbb2697862f74

Single-Cell RNA Sequencing of Lung Tissue in a Rat Model of Acute Respiratory Distress Syndrome

Wang, B., Wang, Y., & Li, Y. (2026) · Journal of Visualized Experiments · doi:10.3791/70491

Caractérisation de l’hétérogénéité moléculaire des sarcomes épithélioïdes par analyse multi-omique et transcriptomique sur cellule unique

Ngo, C. (2024) · theses.fr (ABES) · doi:10.70675/b0599c56z6ccez4fb4z849dz8cddf7f16113

Mapping the immune microenvironment of non-small cell lung cancer

Ge, X., Cai, M., Nie, J., Wang, L., Li, Y., Hu, Y., Meng, J., Liu, H., Geng, L., 花宝金, et al. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105335

ANPEP governs macrophage lipid metabolism and macrophage foam cell formation in large-artery atherosclerotic stroke

Bai, F., Hu, Y., Wang, Z., Guo, Y., Bie, P., Shi, Z., Li, X., Li, D., Zhao, C., & Xu, Q. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1747321

Quand la tumeur dialogue avec la moelle osseuse

Hamon, P. (2026) · médecine/sciences · doi:10.1051/medsci/2026044

ADAR1 Controls Macrophage Scavenging and Lipid‐Buffering Programs in Metabolic Tissues

Fardellas, A., Barreby, E., Brice, M., Nock, S., Russick, J., Vankova, A., Edberg, C., Robertsen, I., Hertel, J. K., Stål, P., et al. (2026) · European Journal of Immunology · doi:10.1002/eji.70189 · Cited by 1

Kupffer cells and monocyte-derived macrophages in the pathogenesis and treatment of hepatocellular carcinoma

Voumvouraki, A., Tsomidis, I., & Kouroumalis, E. (2026) · Hepatoma Research · doi:10.20517/2394-5079.2025.75

Epidermal PPARγ Signaling as a Suppressor of Toll-like Receptor-Mediated Inflammation and Fibrosis: Relevance to Cutaneous Squamous Cell Carcinoma

Konger, R. L., & Derr-Yellin, E. C. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27094136

Impact of pro-inflammatory monocyte subsets and their microRNAs regulation after an ischemia/reperfusion myocardial injuryPreprint

Bevilacqua, E., Falcón, D., Galeano-Otero, I., Morón-Civanto, F., Barón‐Esquivias, G., Valverde, I., Ordóñez-Fernández, A., Smani, T., & Toro, R. D. (2026) · Research Square · doi:10.21203/rs.3.rs-9448122/v1

Immune microenvironment and strategy of immunotherapy in acral melanoma

Minowa, T., Murata, K., Watowich, S. S., Gubin, M. M., & Hirohashi, Y. (2026) · Immunological Medicine · doi:10.1080/25785826.2026.2670041

Monocyte-Macrophage Lineages in Cancer: Biology, Plasticity, and Therapeutic Targeting

Owusu, C., & Moles, R. (2026) · Cancer Biome and Targeted Therapy · doi:10.66505/cbtt.v1i2.23

IL4i1 activity generates oncometabolites that rescue neuroblastoma cells from oxidative death

Guyot, C., de Velde, L.-A. V., Kainacher, L., Ruoff, J., Bici, A., Peterson, N. B., Ogger, P. P., Allen, E. K., Steigenberger, B. A., Yeroslaviz, A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117441

Molecular adaptations of activated T-cells in an inflammation-associated schizophrenia sub-groupPreprint

Salem, D., O’Hara-Payne, R. K., Clark, S., Cortes-Gutierrez, M., Singh, N. J., Roche, D. J. O., Kelly, D. L., & Ament, S. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.22.727194

Monocyte-derived macrophages promote intraepithelial infiltration of effector memory CD8 + T cells in tumors regressing after STING agonist treatmentPreprint

Vermare, A., Ventura, A., Rouault, A., Simula, L., Seradj, M., Lhuillier, L., Weber-Delacroix, E., Mulder, K., Vimeux, L., Espie, D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.28.728475

Cellular and spatial continuum of TAM functional states governs immune exclusion and dictates immune checkpoint resistance in melanoma

Chakraborty, S., Corrales, E., Godbole, I., Madkhali, N., Das, T., Krolla, C., Nystroem, A., Meiß, F., Rafei-Shamsabadi, D. A., Bengsch, B., et al. (2026) · Genome Medicine · doi:10.21203/rs.3.rs-9692259/v1

Associations Between Plasma Lipoprotein(a) Levels and Circulating Monocyte Subsets Differ across PopulationsPreprint

Bashore, A. C., Halmos, B., Groenen, A. G., Matveyenko, A., Matienzo, N., Zhu, L. Y., Mosquera-Restrepo, S. F., Li, Y., Zhang, H., Westerterp, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.729444

Tumor-Associated Macrophages in Hepatocellular Carcinoma: From Ontogeny and Heterogeneity to Immune Evasion and Therapeutic Targeting

Su, Y., Liang, Y., Zhong, D., Chen, Y., Ma, S. S., & Huang, X. (2026) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s616101

Regulation and function of macrophages in Toxocara canis infection

Abou-El-Naga, I. F. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108654

Association of IL4I1+ M2-like macrophages in tumor microenvironment with poor prognosis in hepatocellular carcinoma: insights from bioinformatics and experimental validation

Yang, T., Lu, Y., Li, Y., Bao, X.-H., Lu, H., & Xiong, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1872272

Macrophages in MASLD: from inflammatory and metabolic crosstalk to exercise intervention

Sun, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1894884 · Cited by 1

Immunity and Beyond: Emerging Roles of Monocytes and Macrophages in Cancer

Tomás, A., & Pojo, M. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_7

Tumor-associated macrophages and lineage plasticity in prostate cancer: from established myeloid programs to emerging spatial hypotheses

Li, J., Li, J., Zhao, Y., Yu, Y., & Cui, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1853196

A versatile distance-based approach for gene expression selection across diverse biological systems

Ye, Q., Macedo, R., Martinez‐Verbo, L., Plekaviciute, V., Navarro, J. V., García, E., Pagès-Oliveras, J., Lozano, J. J., Cabrera, C., Perramon‐Malavez, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1843796

Cytokine-mediated mechanisms of TAM in driving cancer progression

Jamali, M. C., Al-Samawi, R. I., Patel, A. A., Mekkey, S. M., Mallick, A. K., Dawood, S. A., Sadikan, M. Z., Mustafa, A. E. M., Mansuri, N., Qureshi, M. A., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117125 · Cited by 1

Disruption of macrophage migration inhibitory factor signaling induces major tumor-associated macrophage phenotypes in human M2 macrophages

Klaver, D., Gander, H., Frena, B., Martin, M., Amato, M., Richter, J., Pichler, R., & Thurnher, M. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00515-3

Tissue-reactive zonation of mesenchymal-like phenotypes in human glioblastoma

Albiach, A. M., Janusauskas, J., Jacobsen, J. K., Kapustová, I., Karamzadeh, R., Kvedaraite, E., Hu, L., Franck, M. C. M., García, M. R., Fernández-García, D., et al. (2026) · Med · doi:10.1016/j.medj.2026.101228

Uni-TINT: Unifying T and Innate Lymphoid Cell Taxonomy with a high resolution, pan-disease and pan-tissue single-cell transcriptomic atlasPreprint

Chuah, S., Li, M., Ang, K. S., Gascoigne, N. R. J., & Chen, J. K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.20.739448

IL-19 limits macrophage-driven inflammation in acetaminophen-induced liver injury

Jia, D., & Iwakiri, Y. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2026.07.015

FAP-derived CCL2 is required for adequate monocyte/macrophage infiltration to support acute skeletal muscle injury repair

Wang, X., Wang, Y., Yuan, R., Smith, G. R., Ruf-Zamojski, F. M., Homma, S. T., Sealfon, S. C., & Zhou, L. (2026) · iScience · doi:10.1016/j.isci.2026.116933

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF 312

DeLong, J. H., Díaz-Pérez, S., Sheth, K. N., Cha, J., Malanga, C. J., Wagner, P., Pezous, N., Hanin, A., Walsh, K. B., Hinson, H. E., et al. (2026) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.70485

Cancer immunotherapy targeting murine myeloid cells requires endosomal pattern recognition

Pan, Y., Pei, S., Liang, H., Westberg, K., Nitschke, L., Chen, X., Yu, Y., He, N., Lin, Q., Lei, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75543-2

Single-cell foundation modeling with species-native protein tokens links regenerative competence across frog and mousePreprint

Cang, H., & Sun, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.27.740807

Single-cell transcriptomic analysis of cutaneous squamous cell carcinoma identifies an NR1H3-associated angiogenic macrophage state

He, Y., Tian, T., Li, L., Qian, L., Tian, T., Wang, X., Li, Y., & Jiang, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1837479

Inhibition of fatty acid-binding protein 4 alleviates psoriasis-like skin inflammation by modulating macrophage polarization

Kang, B. M., Choi, H. S., Kim, B. R., Youn, S. W., Kwon, H. J., Lee, J., Joh, C. S.-Y., Nam, H. J., Jeong, S., Kim, H. W., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1830077

scRNA ‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Gong, S., Zhao, Y., Yang, S., Liu, T., Li, C., Zhou, Y., & Liang, G. (2026) · Cancer Science · doi:10.1111/cas.70495 · Cited by 1

Macrophage heterogeneity in human secondary lymphoid organs

Segura, É. (2026) · Clinical Science · doi:10.1042/cs20250086

Bidirectional regulation between ferroptosis and tumor-associated macrophages: mechanisms, strategies, and therapeutic perspectives

Yu, X., Li, H., Liu, S., Ai, Z., Wang, L., & Jian, L. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1905711

Harnessing macrophage signaling pathways and scalable engineering for next-generation immunotherapies

Paasch, D., Haake, K., Kan, C., Ulpiano, C., Nikolouli, E., Jang, M.-S., Klassen, M.-C., Epstein, M., Sugimura, R., & Lachmann, N. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02907-x · Cited by 1

Mechanisms and clinical research progress of IL-6-mediated crosstalk between the alveolar microenvironment and the immune system in patients with severe pneumonia undergoing mechanical ventilation

Xiao, J., Xu, L., Li, Y., Tan, K., & Qi, S. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1915511

Type I interferon-activated myeloid states are associated with less fibrotic stages in idiopathic pulmonary fibrosis

Nathwani, V., Weeratunga, P., Woo, J., Denney, L., Vuppusetty, C., Hu, T. H., Zulfikar, S., Achaiah, A., Baghaarabani, L., Parker, H., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117881

Continuous tissue fields organize immune composition in pancreatic cancerPreprint

Wang, W., Sarkar, S., Hasselluhn, M. C., Lui-Leung, N., Coka, L. D., Siolas, D., Марченко, Н. В., Escobar‐Hoyos, L. F., Egeblad, M., Sherman, M. H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.22.746444

Multimodal spatial profiling reveals distinct myeloid-defined ENKTL subgroups and tumor-myeloid cooperativity within prognostic inflammatory niche

Deng, L., Liu, M., Linton, R. E., Hu, K., Sridhar, S., Bertolazzi, G., Leong, S. M., Ding, L., Syn, N., Fan, S., et al. (2026) · Leukemia · doi:10.1038/s41375-026-03118-7

Remodeling the tumor immune microenvironment: mechanisms of crosstalk between regulated cell death macrophages

Duan, X., Ma, P., Ao, X., Li, X., Huang, J., & Song, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1933734

Tumor-associated macrophages: Ontogeny, plasticity, spatial ecosystems, and therapeutic targeting

Elnaggar, A., & Elnaggar, A. (2026) · Advances in cancer research · doi:10.1016/bs.acr.2026.06.002

IFIT1+ Tumor-Associated Macrophages Suppress Cancer Stemness and Enhance Chemosensitivity via the TNFSF10–TNFRSF10B Axis in Epithelial Ovarian Cancer

Liu, R., Fang, Y., Zheng, R., Lin, L., Huang, D., Zhai, L., He, Q., Zhang, Z., Zhou, J., & Zhang, X. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl52801

Role of myeloid cell abnormalities in the pathogenesis of aplastic anemia:a review of research advances

Wang, M., Haichen, L. I. N., & Zhu, X. (2026) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2025-0881

Mechanisms of regeneration and maladaptive repair in acute kidney injury

Seibt, T., Hoeft, K., Schaefer, G. J. L., Wahida, A., Kurzrock, R., Conrad, M., & Kramann, R. (2026) · Nature Reviews Nephrology · doi:10.1038/s41581-026-01115-8

A pro-inflammatory metastasis-associated macrophage subset induces tumor-promoting mesothelial cell conversion in ovarian cancer via IL-1α secretion

Heidemann, S., Finkernagel, F., Steitz, A. M., Könnecke, J., Werner, F., Beutgen, V. M., Szymanski, W. G., Graumann, J., Teply‐Szymanski, J., Nist, A., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09280-1

Exploratory single‐nucleus multiomics analysis of myeloid cell states associated with neoadjuvant chemotherapy response in pancreatic ductal adenocarcinoma

Ojetunde, M. M., Ma, L., Pratt, H. G., Stevens, A. M., Mizener, A. D., Pistilli, E. E., Ott, S., Abdilleh, K., Szomolay, B., Hu, G., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70810

The Silent Vehicle: Validating the Biological Signals and Noises of Baculovirus Vectors in Macrophage-Targeted Vaccines

Ridwan, B., Salmanida, F. P., Wahyuningtyas, R., Lai, Y., Wu, M., Chung, W., Chang, C.-T., & Chang, K. (2026) · Vaccines · doi:10.3390/vaccines14090816

Conditional myeloid-specific deletion of Ube2n hinders YUMM1.7 melanoma growth

Schiavone, K., Pecoraro, A., Khawar, A., Zhang, K., Jain, V., Gregory, S., Starczynowski, D. T., & Zhang, J. Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1932270

NINJ1 Defines a Hyperinflammatory Monocyte State Associated with Severe COVID-19

Yu, F., Ma, H., Li, M., Zhang, H., & Yang, Y. (2026) · Biomedicines · doi:10.3390/biomedicines14102203

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Palma, A. (2026) · Immunology · doi:10.1111/imm.70208

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

Yang, S., Li, R., Yu, C., Li, J., & Zhou, X. (2026) · MedComm · doi:10.1002/mco2.71031

Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo

Martínez‐Muriana, A., Fattorelli, N., Wolfs, L., Jutz, L., Pasciuto, E., Denton, H., van Hoek, M., Premereur, J., Zen, G., Bijnens, B., et al. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.09.005

Reprogramming the myeloid–T cell ecosystem through engineered oncolytic viruses for durable antitumor immunity

Wu, C., Gu, W., 秦安东, Liu, H., Zheng, W., Pan, X., Zhang, Y., Shen, B., Sun, R., Shen, D., et al. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105638

Curcumin Nanodelivery for Tumor-Associated Macrophage Reprogramming and Immune-Checkpoint Sensitization: Engineering the Tumor Immune Microenvironment

Rana, J. N., & Mumtaz, S. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101295

A Double-Edged Sword: The Dichotomous Roles of Dendritic Cell Subsets in Shaping CD8+ T Cell Immunity and Tolerance Within the Tumor Microenvironment

Gao, G., & Chen, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27209064

Stemness overcomes IFNγ-induced antitumour exhaustion in human macrophagesPreprint

Nitsche, J., Busch, C. J., Subburayalu, J., Favret, J., Swiersy, A., Hertrich, M., Rost, F., Ivan, D., Benjamin, J., Franco, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.06.756629

A self-amplifying IL-1β–CCL2 circuit between macrophages and cancer-associated fibroblasts drives colorectal cancer progression

Wang, Y., Bao, W., Li, J., Jiang, R., Jiang, C., & Li, S. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218896

Embracing macrophage complexity for research and translation

Ginhoux, F., Mulder, K., Arcila-Barrera, S., & Amit, I. (2026) · Immunity · doi:10.1016/j.immuni.2026.09.015

A single-cell atlas of human neutrophils reveals neutrophil heterogeneity across health and disease

Zheng, H., Maestri, E., Moore, A. R., Ganesan, A., Enriquez, J., Durán, V., Einav, S., van der Poll, T., Bouma, H. R., Atreya, M. R., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02671-8

Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab

Nomura, K., Fukami, T., Kato, S., Tanaka, S., Fukuda, A., Koike, Y., Kondo, M., Kumagai, K., Irie, T., Okumura, G., et al. (2026) · Cancer Cell · doi:10.1016/j.ccell.2026.09.016

Multi-omics analysis of high-grade serous ovarian cancers reveals heterogeneity and distinct immunological patterns based upon clinico-genomic status

Qian, J., Bassiouni, R., Jin, Y., Rajpara, S., Neuman, M. K., Khetan, V. U., Salhia, B., Craig, D. W., Carlson, J. W., Roman, L. D., et al. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012355

A single-cell atlas of the human respiratory system identifies a monocyte-centered HSPA1B+ inflammatory primed state associated with WTAP

Wang, Y., Zhu, L., 朱业晋, & Chen, G. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1950659

A Reproducible CD36-Enriched Lipid-Associated Macrophage State in Lung Adenocarcinoma and Its Spatial Relationship to Exhausted CD8+ T Cells

Ma, Q., Liang, J., Li, J., & Li, J. (2026) · Biomedicines · doi:10.3390/biomedicines14112454

Macrophage biology and immunoregulation in health and disease

Zhao, H., Chou, Y.-J., & Huang, S. C. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01486-9

Tumour assembloids recapitulate tumour–CAF–T cell crosstalk in renal cancer

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