Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Integrated analysis of multimodal single-cell data

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Comprehensive Integration of Single-Cell Data

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UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

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Scenic: single-cell regulatory network inference and clustering.

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

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Tumour-educated macrophages promote tumour progression and metastasis

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Research trends of tumor-associated macrophages in colorectal cancer: a bibliometric analysis

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A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer

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Non-enzymatic Rnaseh2c orchestrates proliferating macrophage-driven immunosuppression and HCC progression via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8 + T ex infiltration: a novel therapeutic paradigm with “Rnaseh2c-In1” inhibitor

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Integrated Single-Cell and Spatial Transcriptomics Analyses Delineate a BAG3-Associated Macrophage Program with Microenvironmental and Prognostic Relevance in Hepatocellular Carcinoma

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Intrathecal Allogeneic B7-H3–Targeted CAR γδ T Cells for Leptomeningeal Metastasis from Solid Tumors: Safety, Efficacy, and Immunologic Dynamics in a Phase I Trial

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Tumour‐Derived Extracellular Vesicles Reprogramme Tumour‐Associated Macrophages Into Immunosuppressive Phenotype via NOD1 Signalling in Clear Cell Renal Cell Carcinoma

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From islet to blood: macrophage remodeling signatures for diagnosis and risk stratification in type 1 diabetes

Chen, Y., Zhou, Y., Li, S., Chen, Y., Liu, J., Yang, C., Zhao, H., Su, Z., Bian, L., Chen, S. Y., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1832672 · Cited by 1

Host-directed antimicrobial peptide biomaterials for combating Gram-negative bacterial infections

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Extracellular vesicles in the tumor microenvironment: Diverse origins, multifaceted functions, and emerging therapeutic opportunities

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Molecular changes during AT/RT progression associated with epithelial–mesenchymal transition and extracellular matrix changes

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Beyond density: mapping the functional landscapes of macrophage-T lymphocyte niches in the tumor microenvironment

Zilio, S., Rouault, A., Seradj, M., Marigo, I., Prévost‐Blondel, A., Peranzoni, E., & Bercovici, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1851873 · Cited by 1

Spatially fractionated radiotherapy for liver metastases: two cases of intrahepatic response dissociation

Zhao, Y., Li, C., Guo, S., Zhang, B., Wu, D., Wei, Q., & Zhang, T. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1867630 · Cited by 1

Integrated single-cell and spatial transcriptomic atlas of multi-etiology acute lung injury reveals etiology-dependent neutrophil fate decisions and a prognostic neutrophil–monocyte/macrophage interaction signature

Chen, L., Gao, X., Jiang, L., Lin, W., He, M., Li, X., Xu, J., & Shang, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117182 · Cited by 1

Bile acids in cancer: From metabolism to immunomodulation

Fang, Q., & Schneider, K. M. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.003 · Cited by 2

Molecular innate immune programs of tumor-associated macrophages in immune checkpoint blockade resistance: a staged framework from suppressive circuitry to translational bottlenecks

Huang, Y., Zhang, J., Tu, K., Ye, W., Zou, S., Tang, Z., & Zeng, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1881958 · Cited by 1

Metabolic inflammation, obesity, and cancer

Alzaïd, F., Blériot, C., Anagnostopoulos, G., Chakarov, S., Venteclef, N., & Ginhoux, F. (2026) · Immunity · doi:10.1016/j.immuni.2026.07.020 · Cited by 1

Macrophage-directed therapeutic strategies in cancer

Joshi, S., & Varner, J. A. (2026) · Trends in cancer · doi:10.1016/j.trecan.2026.08.006 · Cited by 1

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Hinterleitner, C., Barthet, V. J. A., Goldberg, H. V., Vogt, K. C., Perea, A. M., Hillger, L. R., Ruiz, S. B., McHugh, D., Ho, Y.-J., Perez, A. C., et al. (2026) · Science · doi:10.1126/science.aeg4791 · Cited by 1

Roles of Tumor-Associated Macrophages in Tumor Environment and Strategies for Targeting Therapy

Liu, M., Zhang, J., & Zhu, J. (2023) · Pharmaceutical Fronts · doi:10.1055/s-0043-1777704 · Cited by 1

Single‐cell RNA sequencing data identify a conserved population of metallothionein‐expressing macrophages that may be ubiquitous in vital human organs

Daccache, J. A., Eng, F. J., Cao, L., Ma, N., Ward, S. C., Schiano, T. D., Miller, M., Herron, D. M., Azzara, A. V., Pullen, S. S., et al. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.348 · Cited by 1

HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients

Talarico, G., Franceschini, A., Raveane, A., Falvo, P., Mazzara, S., Melle, F., Motta, G., Orecchioni, S., Tenore, A., Gregato, G., et al. (2024) · Discover Oncology · doi:10.1007/s12672-024-01657-y · Cited by 1

Association of nociception index with postoperative immune status: a prospective observational study

Zhang, Y., Zha, A., Shen, W., & Dai, R. (2025) · Anesthesiology and Perioperative Science · doi:10.1007/s44254-025-00104-7 · Cited by 1

Spatial and molecular profiling of the classic Hodgkin lymphoma microenvironment reveals an immunosuppressive mononuclear phagocyte networkPreprint

Stewart, B. J., Fergie, M., Young, M. D., Jones, C., Sachdeva, A., Blain, A. E., Bacon, C. M., Rand, V., Ferdinand, J. R., James, K. R., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1233380/v1 · Cited by 1

Interferon-induced lysosomal membrane permeabilization and death cause cDC1-deserts in tumorsPreprint

Aerakis, E., Chatzigeorgiou, A., Alvanou, M., Matthaiakaki-Panagiotaki, M., Angelidis, I., Koumadorakis, D. E., Γαλάρας, Α., Hatzis, P., Kerdidani, D., Makridakis, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.14.484263 · Cited by 2

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancersPreprint

Al‐Eryani, G., Bartoniček, N., Chan, C., Anderson, A., Harvey, K., Wu, S. Z., Roden, D., Wang, T., Reeves, J., Yeung, B. Z., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.31.494081 · Cited by 1

Identification of novel myeloid-derived cell states with implication in cancer outcomePreprint

Guimarães, G. R., Maklouf, G. R., Teixeira, C. E., Santos, L. D. O., Tessarollo, N. G., Pretti, M. A. M., de Toledo, N. E., da Cruz, J. G. V., Falchetti, M., Dimas, M. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.04.522727 · Cited by 1

Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineagesPreprint

Park, W., Nguyen, T. D. T., Park, H. J., Lee, D., Shah, N., & Mandzhieva, B. (2023) · Research Square · doi:10.21203/rs.3.rs-3229780/v1 · Cited by 1

Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated responsePreprint

Nyirenda, J., Hardy, O. M., Silva‐Filho, J. L., Herder, V., Attipa, C., Ndovi, C., Siwombo, M., Namalima, T. R., Suwedi-Kapesa, L. C., Nyasulu, W., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.16.566964 · Cited by 1

Spatial Transcriptomic Characterization of Novel Pathologic Niches in IPFPreprint

Mayr, C. H., Santacruz, D., Jarosch, S., Lempp, C., Neubert, L., Rath, B., Kamp, J. C., Jonigk, D. D., Kühnel, M., Schlueter, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.13.571464 · Cited by 1

Single-cell transcriptomics reveals altered myeloid cell profiles associated with the early establishment of leishmania reservoirsPreprint

Estaquier, J., Picard, M., Boutrais, S., Rodrigues, V., Fortier, Y., Borde, C., Soundaramourty, C., Clain, J. A., Beauparlant, C. J., Racine, G., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3931457/v1 · Cited by 1

A “ tug-of-war ” between the NuRD and SWI/SNF chromatin remodelers regulates the coordinated activation of Epithelial-Mesenchymal Transition and inflammation in oral cancerPreprint

Stabile, R., Tucci, F. A., Verhagen, M. P., Embregts, C. W. E., van den Bosch, T. P. P., Joosten, R., Herdt, M. J. D., van der Steen, B., Nigg, A. L., Koljenović, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.05.588102 · Cited by 1

Single-Cell Analysis of Microglia and Monocyte Dynamics Uncover Distinct TNF-α-driven Neuroimmune Signatures after Intracerebral HemorrhagePreprint

Kawamura, Y., Johnson, C. W., DeLong, J. H., Camillo, L. P. D. L., Velazquez, S. E., Takahashi, M., Beatty, H. E., Herbert, R., Cord, B. J., Matouk, C. C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.24.630187 · Cited by 1

Path of differentiation defines human macrophage identityPreprint

Frenis, K., Badalamenti, B., Mamigonian, O., Weng, C., Wang, D., Fierstein, S., Côté, P., Khong, H., Li, H., da Rocha, E. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634694 · Cited by 2

Re-programming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulationPreprint

Ríos, I., Herrero, C., Torres‐Torresano, M., López-Navarro, B., Schiaffino, M. T., Diaz-Crespo, F. J., Nieto‐Valle, A., Samaniego, R., Sierra‐Palomares, Y., Oliver, E., et al. (2025) · eLife · doi:10.7554/elife.102659.1 · Cited by 1

Nonredundant roles of the HDAC3 corepressor complex subunits SMRT and NCOR in controlling inflammatory and metabolic macrophage pathwaysPreprint

Efthymiadou, A., Gu, C., Wang, C., Wang, H., Li, Z., García‐Irigoyen, O., Fan, R., Treuter, E., & Huang, Z. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.13.653058 · Cited by 1

Deep immune profiling pinpoints cellular and molecular drivers of lupus immunopathologyPreprint

Nakano, M., Kono, M., Asahara, K., Katsuyama, T., Kubo, S., Katsuyama, E., Fujita, Y., Nishino, T., Inokuchi, H., Arakawa, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.08.693110 · Cited by 1

Development of the Early Childhood Duodenum across Ancestry, Geography and EnvironmentPreprint

Casal, J. D. S., Raghunathan, K., Asare, C., Plone, A., Moradinasab, N., Iqbal, J., Wood, L., Ngwa, E. M., Chen, X., Rhoads, S. F., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.15.694427 · Cited by 2

Cell landscape of cerebrospinal fluid and neuroinflammatory signatures in the bacterial meningitis through high-throughput sequencing and meta-analysisPreprint

Wen, T., Xiao, H., Xiao, H., Zhang, Y., Guo, L., Dou, Z., Liu, L., Zhu, L., Feng, W., Liu, B., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1290782/v1

Spatial and molecular profiling of classic Hodgkin lymphoma reveals an immunosuppressive mononuclear phagocyte networkPreprint

Stewart, B. J., Fergie, M., Young, M. D., Jones, C., Sachdeva, A., Blain, A. E., Bacon, C. M., Rand, V., Ferdinand, J. R., James, K. R., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1233380/v2

Proliferation drives quorum sensing of microbial products in human macrophage populationsPreprint

Rajab, N., Gearing, L. J., Lyu, R., Prawer, Y. D. J., Angel, P. W., Grimmond, S. M., Laslett, A. L., McCarthy, D. J., & Wells, C. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.12.491598

急性冠症候群を引き起こすプラークのシングルセル解析

江本, 拓., 山下, 智., & Hirata, K. (2022) · Journal of JCS Cardiologists · doi:10.1253/jjcsc.31.0_11

Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells

Goff, P. H., Riolobos, L., LaFleur, B., Spraker, M. B., Seo, Y. D., Smythe, K. S., Campbell, J. S., Pierce, R. H., Zhang, Y., He, Q., et al. (2023) · doi:10.1158/1078-0432.c.6532685.v1

Supplementary Data from Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti–PD-1 Therapy

Wang, K., Patkar, S., Lee, J. S., Gertz, E. M., Robinson, W., Schischlik, F., Crawford, D. R., Schäffer, A. A., & Ruppin, E. (2023) · doi:10.1158/2159-8290.22541149.v1

Supplementary Data from Deconvolving Clinically Relevant Cellular Immune Cross-talk from Bulk Gene Expression Using CODEFACS and LIRICS Stratifies Patients with Melanoma to Anti–PD-1 Therapy

Wang, K., Patkar, S., Lee, J. S., Gertz, E. M., Robinson, W., Schischlik, F., Crawford, D. R., Schäffer, A. A., & Ruppin, E. (2023) · doi:10.1158/2159-8290.22541149

Defining macrophages in the lactating murine mammary gland and human milk

(2023) · Nature Immunology · doi:10.1038/s41590-023-01531-z

Human fallopian tube single-cell analysis reveals monocytic transcriptional and interaction changes in high-grade serous ovarian cancersPreprint

Brand, J., Haro, M., Lin, X., McGregor, S. M., Lawrenson, K., & Dinh, H. Q. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.14.549073

Heme oxygenase-1 expressing omental macrophages as a therapeutic target in ovarian high grade serous carcinomaPreprint

Spear, S., Saux, O. L., Mirza, H., Tyson, K., Bickel, J. K., Freile, F. G., Siskos, A., Balcells, C. D., Walton, J. B., Woodman, C. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.18.549474

High dimensional mass cytometry analysis unravels distinct profiles of peripheral blood mononuclear cells in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disease or in healthPreprint

Yao, M., Wang, W., Sun, J., Guo, T., Bian, J., Xiao, F., Li, Y., Cong, H., Wei, Y., Zhang, X., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3191309/v1

Microenvironment of Adjacent Non-Neoplastic Regions Determines Prognostic Outcomes in Locally Advanced Colorectal Cancer after Surgical Resection: A Multi-Center & Multi-Omics studyPreprint

Park, W., Bang, Y. H., Choi, J. H., Park, K., Lim, J., Lee, B., Han, K. Y., Pyo, D. H., Cho, Y. B., Kim, T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3375190/v1

A spatiotemporal comparative analysis on tumor immune microenvironment characteristics between neoadjuvant chemotherapy and preoperative immunotherapy for ESCCPreprint

Ba, Y., Zhou, Z., Zhang, H., Yang, J., Wang, T., Pan, W., Zhang, Q., Wang, H., Tang, P., & Zhang, H. (2023) · Research Square · doi:10.21203/rs.3.rs-3584990/v1

Étude du phénotype de la réponse musculaire au cours des syndrome des anti-synthétases par transcriptomique spatiale : implication de l’IFN-II et des macrophages dans la survie des lymphocytes B

Malartre, S., Cin, J. D., Anquetil, C., Seilhean, D., Letournel, F., Madelaine, A., Léonard-Louis, S., Allenbach, Y., & Benvéniste, O. (2023) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2023.10.080

Integrated Metabolic-Transcriptomic Network Identifies Novel Immunometabolic Modulations in Human MacrophagesPreprint

Chen, H., Vappiani, J., Griffith, G. R., Booty, L. M., van Roomen, C. P. A. A., Kuiper, J., den Dunnen, J., de Jonge, W. J., Prinjha, R. K., Mander, P. K., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4647290

Identification of a distinct cluster of GDF15 high macrophages exhibiting anti-inflammatory activitiesPreprint

Dai, C., Zhang, H., Zheng, Z., Li, C. G., Ma, M., Gao, H., Zhang, Q., Cui, X., & Jiang, F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.11.575315

Single-cell multimodal profiling of monocytes reveals diverse phenotypes and alterations linked to cardiovascular disease risksPreprint

Bashore, A. C., Xue, C., Kim, E., Yan, H., Zhu, L. Y., Pan, H., Kissner, M. D., Ross, L. S., Zhang, H., Li, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.18.580913

Additional file 1 of Integrated transcriptional analysis reveals macrophage heterogeneity and macrophage-tumor cell interactions in the progression of pancreatic ductal adenocarcinoma

Yang, K., Yang, T., Yu, J., Li, F., & Zhao, X. (2023) · Figshare · doi:10.6084/m9.figshare.22601713

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modificationPreprint

Haag, S. M., Xie, S., Eidenschenk, C., Fortin, J., Callow, M. G., Costa, M., Lun, A. T. L., Cox, C., Wu, S. Z., Pradhan, R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.12.589122

Macrophage niches as conserved functional tissue building blocks

Matusiak, M., Trinh, A. T., & van de Rijn, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-14064-8.00003-5

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid ArthritisPreprint

MacDonald, L., Elmesmari, A., Somma, D., Frew, J., Mario, C. D., Madhu, R., Paoletti, A., Simakou, T., Hardy, O. M., Tolusso, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.17.600758

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

Ríos, I., Herrero, C., Torres‐Torresano, M., López-Navarro, B., Schiaffino, M. T., Diaz-Crespo, F. J., Nieto‐Valle, A., Samaniego, R., Sierra‐Palomares, Y., Oliver, E., et al. (2025) · eLife · doi:10.7554/elife.102659.3

A Multi-Machine Learning Consensus Model Based on Clinical Features Reveals That Interleukin-10 Derived from Monocytes Leads to a Poor Prognosis in Patients with Coronavirus Disease-2019

Yu, J., Zhang, Y., Ye, Z., Tang, K., Ma, Y., Fu, L., Cui, T., Kang, H., Yuan, Y., & Pan, W. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s472099

Biomarkers for modeling of cancer-specifc tumorassociated macrophages ex vivo

Sudarskikh, T., Larionova, I., Rakina, M. A., & Kzhyshkowska, J. G. (2024) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2024-23-4-54-65

Perspective Chapter: Targeting the Myeloid Compartment – Innovative Immunotherapy Strategies for Malignant Brain Tumors

Kienzler, J. C. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006937

Single-cell Landscape of Immune Cells in Blood and Skin in PsoriasisPreprint

Deng, J., Nordkamp, M. A. M. O., Ye, S., Ye, J., Balak, D., Yu, W., Radstake, T. R. D. J., Borghans, J. A. M., Lu, C., Pandit, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613463

Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages

Anagnostopoulos, G., Blériot, C., Venteclef, N., & Ginhoux, F. (2024) · Results and problems in cell differentiation · doi:10.1007/978-3-031-65944-7_3

Enucleated Mesenchymal Stem Cell Carriers Enhance Therapeutic Effect on Rheumatoid Arthritis Rats Through Regulation of Joint SynoviumPreprint

Sui, Y., Pu, Z., Yang, N., Luo, Y., Sa, Y., Qi, Q., Yan, Y., Ji, W., & Si, W. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.5032649

Exploring radiation resistance-related genes in pancreatic cancer and their impact on patient prognosis and treatment

Dai, D., Wang, S., Li, J., & Zhao, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1524798

Identifying Key Cells for Fibrosis by Systematically Calling Cell Type–Phenotype Associations across Massive Heterogenous DatasetsPreprint

Chen, X., Ding, Y., Yang, S., Lin, W., Chu, M., Tang, H., Kong, L., Zhou, Y., & Gao, G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.23.644786

Re-programming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulationPreprint

Ríos, I., Herrero, C., Torres‐Torresano, M., López-Navarro, B., Schiaffino, M. T., Diaz-Crespo, F. J., Nieto‐Valle, A., Samaniego, R., Sierra‐Palomares, Y., Oliver, E., et al. (2025) · eLife · doi:10.7554/elife.102659.2

Type I IFN-activated lung monocytes and macrophages as initiators and drivers of fibrosis at the alveolar barrier in IPFPreprint

Nathwani, V., Weeratunga, P. N., Woo, J., Denney, L., Vuppusetty, C., Hu, T., Zulfikar, S., Achaiah, A., Parker, H., Chuang, H.-W., et al. (2025) · medRxiv · doi:10.1101/2025.05.09.25326523

IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19Preprint

Ramón-Vázquez, A., Skowyra, A., Crowley, T., Velmurugan, J., Lee, C. M., Lindsay, A. J., Woznicki, J. A., Stamou, P., Nelson, O., Jeffery, I. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656795

The cellular diversity of human cerebrospinal fluid following intraventricular hemorrhage revealed by single-nucleus RNA sequencingPreprint

Malaiya, S., Serra, R., Cortes-Gutierrez, M., Wilhelmy, B. E., Jusuf, E., Somalinga, M., Peprah, D., Nambiar, H., Kim, K. T., Saadon, J. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.05.657834

Drug-induced metabolic remodeling of immune cell repertoire generates an effective broad-range antimicrobial effectPreprint

Prusty, B. K., Hollmann, C., Park, E. C., Liu, Z., Nourollahi, F., Nikolayshvili, G., Dietz, J., Basens, E. E., Vora, M., Waghmare, T. S., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7077811/v1

Integrative Omics Identifies Candidate Plasma Biomarkers and Cellular Targets Associated with Thoracic Aortic AneurysmPreprint

Bashore, A. C., Radkevich, E., Roudko, V., Chen, Z., Nie, K., Rizakos, T., Morgenroth-Rebin, J., D’Souza, D., Filimonov, A. K., Gyasi, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.25.666909

IL4i1-sourced oncometabolites promote neuroblastoma cell survivalPreprint

Guyot, C., de Velde, L.-A. V., Kainacher, L., Ruoff, J., Bici, A., Peterson, N. B., Allen, E. K., Steigenberger, B. A., Yeroslaviz, A., Yang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.07.669062

POSTER PRESENTATIONS

Damgaard, A. J., Mogard, E., Primdahl, J., Bremander, A., Dures, E., Lindqvist, E., Krarup, H. F., Graversgaard, J., Beckman, A., & Knak, K. L. (2025) · Scandinavian Journal of Rheumatology · doi:10.1080/03009742.2025.2533698

Single-Cell Transcriptomic Analysis Reveals Cell Heterogeneity and Altered Signaling Pathways in Jellyfish Sting Patients

Qin, Z., Hao, Z., Wang, C., Lu, N., Qiu, P., Wang, S., & Yu, R. (2025) · Marine Drugs · doi:10.3390/md23090358

Tissue-level division of labor is coordinated across organs through universal programs and context-specific adaptations

Yonassi, S., Goldenberg, N., Walfisch, A., Cohen, E., Tamar, E. S., Zhou, X., & Adler, M. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117851

Single-cell RNA sequencing and large-scale bulk combination with machine learning reveal gastric cancer-related macrophage heterogeneityPreprint

Gong, S., Zhao, Y., Yang, S., Liu, T., Li, C. Y., Zhou, Y., & Liang, G. (2025) · SSRN Electronic Journal · doi:10.1101/2025.10.17.683046

Additional file 2 of Integrated transcriptional analysis reveals macrophage heterogeneity and macrophage-tumor cell interactions in the progression of pancreatic ductal adenocarcinoma

Yang, K., Yang, T., Yu, J., Li, F., & Zhao, X. (2023) · Figshare · doi:10.6084/m9.figshare.22601716

Phenotypic plasticity mediates colorectal cancer metastasisPreprint

Efremova, M., Ogden, S., Metic, N., Smith, E. A., Berner, A., Baker, A.-M., Uddin, I., Chelala, C., Ullah, D., Saad, A. B., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3846377/v1

Additional file 2 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946108

Additional file 7 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946123

Additional file 3 of CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming

Liu, S., Zhang, S., Dong, H., Jin, X., Sun, J., Zhou, H., Jin, Y., Li, Y., & Wu, G. (2024) · Figshare · doi:10.6084/m9.figshare.26730799

Additional file 1 of CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming

Liu, S., Zhang, S., Dong, H., Jin, X., Sun, J., Zhou, H., Jin, Y., Li, Y., & Wu, G. (2024) · Figshare · doi:10.6084/m9.figshare.26730793

Additional file 6 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946120

Additional file 4 of CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming

Liu, S., Zhang, S., Dong, H., Jin, X., Sun, J., Zhou, H., Jin, Y., Li, Y., & Wu, G. (2024) · Figshare · doi:10.6084/m9.figshare.26730802

Additional file 3 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946111

Additional file 1 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946105

Additional file 5 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946117

Additional file 4 of Single-cell transcriptional atlas of tumor-associated macrophages in breast cancer

Zhang, Y., Zhong, F., & Liu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26946114

Genomic expression of MSR1 in solid tumors associates with response to anti-PD1 and anti-CTLA4 therapiesPreprint

Sanvicente, A., Díaz-Tejeiro, C., Nieto-Jiménez, C., Paniagua‐Herranz, L., López-Cade, I., Győrffy, B., Moreno, V., Pérez-Segura, P., Calvo, E., & Ocana, A. (2023) · Research Square · doi:10.21203/rs.3.rs-3005010/v1

Additional file 5 of CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming

Liu, S., Zhang, S., Dong, H., Jin, X., Sun, J., Zhou, H., Jin, Y., Li, Y., & Wu, G. (2024) · Figshare · doi:10.6084/m9.figshare.26730805

Additional file 2 of CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming

Liu, S., Zhang, S., Dong, H., Jin, X., Sun, J., Zhou, H., Jin, Y., Li, Y., & Wu, G. (2024) · Figshare · doi:10.6084/m9.figshare.26730796

Antiviral inhalation medicinal product based on interferon alpha-2b: A study of efficacy, subchronic toxicity, and toxicokinetics in rodents

Pankova, N. V., Ленева, И. А., Falynskova, I. N., Ivanina, A. V., Сергеевна, К. Е., Khuttunen, О. E., Kiryanova, A. S., Sheremet’ev, S. V., & Lonshakov, D. V. (2025) · Biological Products Prevention Diagnosis Treatment · doi:10.30895/2221-996x-2025-25-4-448-460

Modeling Tumor-Associated Macrophages In Vitro: The Role of Secreted Factors in Tumor Microenvironment Dynamics

Risnik, D., Lava, M. C., Silva, E. A. C., & Errasti, A. E. (2025) · Journal of Visualized Experiments · doi:10.3791/69406

Decoding IL4I1: The Core role of metabolism-driven immune regulation and new perspectives on disease targeting

Zhang, M., Dai, X., Huang, B., Zheng, S., Liu, H., Zhao, L., Liu, P., & Gao, Y. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109544

YAP/TEAD drives treatment-induced adaptive immunosuppression in EGFR-mutant lung cancerPreprint

Honkanen, M., Baumgarten, J., Dibus, N., Rannikko, J. H., Gojković, M., Cejas, P., Xie, Y., Ortutay, Z., Merilahti, J. A. M., Tienhaara, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.22.701073

Macrophages target PVR/CD155 on colorectal cancer cells via REVERBαPreprint

Kato, D., Han, Y., Helm, L., Herweck, F., Schichta, N., Malz, L., Herrmann, K., Farooq, M. S., Hauber, V., Gutting, T., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.29.702476

IL4I1+ macrophages drive hepatocellular carcinoma progression by responding to biomechanical cues

Zhou, S., Liang, R., Lu, P., Wang, W., Li, X., Yuan, H., He, T., & Ai, Z. (2026) · JHEP Reports · doi:10.1016/j.jhepr.2026.101782

Stabilin-1+ lipid-associated macrophages promote lung adenocarcinoma liver metastasis and osimertinib resistance through impairing macrophage phagocytosis via SIRPα-CD47 axis

Wang, Q., Zhou, J., Li, X., Zhao, C., Cheng, L., Wang, L., Chen, J., Chen, C., Li, C., & Su, C. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101379

Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics

Loke, P., & Lin, J.-D. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo4652 · Cited by 24

Abstract 7280: Pan-cancer single-cell RNA sequencing analysis refines multiorigin monocyte and macrophage lineages

Nguyen, T. D., Lee, A., Park, H. J., Shah, N., Mandzhieva, B., Lee, D., Jung, I., & Park, W.-Y. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-7280

A spatial map of human macrophage niches links tissue location with functionPreprint

Matusiak, M., Hickey, J., Luca, B., Lu, G., Kidzinski, L., Shu, S., Colburg, D., Phillips, D., Brubaker, S. W., Charville, G., et al. (2022) · bioRxiv · doi:10.1101/2022.08.18.504434 · Cited by 8

Antiproliferative effect of IL-1 and alpha interferon in melanoma cells

Alvino, E. (1992) · Pharmacological Research · doi:10.1016/1043-6618(92)91297-t

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Wang, W., Chen, Z., Huang, Y., Hu, Z., Zhu, P., Huang, Z., Lv, J., Liao, Z., Zheng, Y., Wei, C., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70608 · Cited by 4