Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Integrated analysis of multimodal single-cell data

Hao, Y., Hao, S., Andersen-Nissen, E., Mauck, W. M., Zheng, S., Butler, A., Lee, M. J., Wilk, A. J., Darby, C., Zagar, M., et al. (2020) · doi:10.1101/2020.10.12.335331 · Cited by 15,508

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453

UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction

McInnes, L., Healy, J., & Melville, J. (2018) · arXiv · doi:10.48550/arxiv.1802.03426 · Cited by 7,101

Scenic: single-cell regulatory network inference and clustering.

Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520

Dimensionality reduction for visualizing single-cell data using UMAP

Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175

Full-length RNA-seq from single cells using Smart-seq2

Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413

M-1/M-2 Macrophages and the Th1/Th2 Paradigm

Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287

Transcriptional states of lung cancer microenvironment reveal macrophage subtype dynamics linked to disease progression

Keremitçi, D., Tuna, Ö., Houdjedj, A., Kazan, H., & Kaymaz, Y. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf253 · Cited by 4

Integrative multi-omics reveals energy metabolism–related prognostic signatures and immunogenetic landscapes in lung adenocarcinoma

Xie, L., Zhou, Y., Hu, Z., Zhang, W., & Zhang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1679464 · Cited by 4

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Pan, W., Yong, Y., Li, Y., Shi, G., Zhang, M., Wan, L., Zhao, Y., Zhan, W., Lin, Y., Qin, Q., et al. (2025) · Advanced Science · doi:10.1002/advs.202512799 · Cited by 4

Tryptophan metabolism in tumor microenvironment and therapeutic implications

Wen, J., Jiang, J., Ma, X., Wei, W., Wu, X., Yu, Y., & Xia, L. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.12.049 · Cited by 6

The Identification of LA-tumor associated macrophages in immune modulation via amyloid-beta precursor protein/CD74 signal pathway in gastric cancer: a predictive module and machine learning

Wang, J.-P., An, C.-C., Wang, Z.-N., Wei, Z.-J., & Dai, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2025.1752562 · Cited by 4

Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy

Zeng, W., Fan, Y., Wang, C., Yang, S., Xu, J., Wang, C., Chang, H., Luo, Y., Liu, S., & He, Z. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102528 · Cited by 4

Colorectal microenvironment determines the prognosis of colorectal cancer

Bang, Y. H., Choi, J. H., Park, K., Lee, B., Han, K. Y., Pyo, D. H., Cho, Y. B., Kim, T. M., Park, K. J., Ryoo, S., et al. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01599-7 · Cited by 4

Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation

Dhariwala, M. O., Carale, R. O., DeRogatis, A. M., Rodriguez-Valbuena, H., Okoro, J. N., Ekstrand, C. A., Weckel, A., Tran, V. M., Habrylo, I., Barrere‐Cain, R., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.01.005 · Cited by 8

Leveraging macrophage plasticity for precision-targeted tumor immunotherapy

Li, S., Wang, X., Li, L., Chen, L., & Sun, Z.-J. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168176 · Cited by 5

Tumor-associated macrophages: orchestrators of the tumor microenvironment

Echols, J. B., Meehan, A. W., Marotto, K., Ordonez, V., & Hildreth, B. E. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00834.2025 · Cited by 4

The gene regulatory networks shaping macrophage plasticity and altered function in fibrosis

Kolostyák, Z., & Nagy, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1767954 · Cited by 5

Pareto optimality reveals an atlas of cellular archetypes

Crowley, G., Alon, U., & Quake, S. R. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2530194123 · Cited by 4

The role of the triggering receptor expressed on myeloid cells family in metabolic syndrome: A review

Li, Y., Wang, Y., Li, H., Gao, R., Zhang, W., & Yang, X. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112509 · Cited by 4

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response.

Currenti, J., Mishra, A., Wallace, M., George, J., & Sharma, A. (2023) · PubMed Central · doi:10.1042/bst20220157 · Cited by 5

Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding

Qu, H., Liang, Y., Guo, Q., Lu, L., Yang, Y., Xu, W., Zhang, Y., & Qin, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-54837-9 · Cited by 4

Analysis of the causal relationship between immune cells and rheumatoid arthritis from the perspective of genetic variation: a bidirectional two-sample Mendelian randomization study

Cheng, F., Zhu, Y., Liu, X., Zhang, R., Xia, F., & Ge, L. (2024) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-024-00425-4 · Cited by 4

Choroidal macrophages in homeostasis, aging and age-related macular degeneration

Khan, A. H., & Mulfaul, K. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110159 · Cited by 4

Single-cell transcriptomic analysis identifies tissue-specific fibroblasts as the main modulators of myeloid cells in peritoneal metastasis of different origin

Gerakopoulos, V., Ramos, C., Müller, C., Walterskirchen, N., Vintila, S., Zotter, C., Ilg, M., Pap, A., Riss, S., Bergmann, M. M., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217678 · Cited by 4

The platelet-related genes associated with the prognosis of HCC by regulating cycling T cell and prolif-TAMs

Peng, C., Wang, Y., Zhang, H., & Chen, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26798 · Cited by 4

SPP1+ macrophages: A malignant macrophage subset in the colorectal cancer microenvironment revealed by single-cell sequencingPreprint

Zheng, J., Xie, Z., Niu, L., Zheng, G., Li, R., Dan, H., Duan, L., Wu, H., Ren, G., Dou, X., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1984416/v1 · Cited by 5

Commensal myeloid crosstalk in neonatal skin regulates cutaneous type 17 inflammationPreprint

Dhariwala, M. O., Carale, R. O., DeRogatis, A. M., Rodriguez-Valbuena, H., Okoro, J. N., Ekstrand, C., Weckel, A., Tran, V. M., Habrylo, I., Barrere‐Cain, R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.29.560039 · Cited by 4

Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1 + macrophagesPreprint

Yu, J., Thomas, J. R., Haub, J., Pizarro, C., Zhang, M., Biener, L., Becker, M., Zhang, L., Kapellos, T. S., Schulte, W., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.06.569201 · Cited by 4

Sopa: a technology-invariant pipeline for analyses of image-based spatial-omicsPreprint

Blampey, Q., Mulder, K., Dutertre, C., Gardet, M., André, F., Ginhoux, F., & Cournède, P.-H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.22.571863 · Cited by 4

Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulationPreprint

Ríos, I., Herrero, C., Torres‐Torresano, M., López-Navarro, B., Schiaffino, M. T., Diaz-Crespo, F. J., Nieto‐Valle, A., Samaniego, R., Sierra‐Palomares, Y., Oliver, E., et al. (2025) · eLife · doi:10.7554/elife.102659 · Cited by 4

The nucleosome remodeling and deacetylase-SWItch/sucrose non-fermentable antagonism regulates the coordinated activation of epithelial-to-mesenchymal transition and inflammation in oral cancer

Stabile, R., Tucci, F. A., Verhagen, M. P., Embregts, C. W. E., van den Bosch, T. P. P., Joosten, R., Herdt, M. J. D., van der Steen, B., Nigg, A. L., Koljenović, S., et al. (2025) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaf065 · Cited by 4

Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia

Sibbertsen, F., Dress, R. J., Weidemann, S. A., Möller, K., Herden, U., Fischer, L., Paul, K., Oh, J. S., Tolosa, E., Schulz‐Jürgensen, S., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1567645 · Cited by 3

Targeting age-related cell-free DNA for prevention, early diagnosis and treatment of rheumatoid arthritis

Ma, N., Xu, Y., Zhang, D., Zhang, H., Luo, W., Cao, Y., & Wong, V. K. W. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103961 · Cited by 4

Tissue signatures of human macrophages during homeostasis and activation

Caron, D. P., Specht, W. L., Nargund, S., Chen, D., Wells, S. B., Hwu, J., Szabo, P. A., Sims, P. A., & Färber, D. L. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf317 · Cited by 3

Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease

Fenton, T. M., Wulff, L., Väänänen, V. A., Jones, G., Lemvigh, C. K., Riis, L. B., Wewer, M. D., Vandamme, J., Jørgensen, P. B., Bain, C. C., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adz8650 · Cited by 3

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Wang, T., Zhao, H., Sun, X., Ding, Y., Zhu, Z., Yu, X., Zhu, R., Wang, D., Li, K., Liu, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.202521265 · Cited by 4

A Single-Cell Analysis Reveals Macrophage Heterogeneity Driving Plaque Vulnerability in Coronary and Carotid Arteries

Yoshida, T., Emoto, T., Yamamoto, H., Takaya, T., Sawada, T., Murphy, S. L., Shoda, M., Nakamura, K., Taniguchi, M., Sasaki, N., et al. (2026) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.65991 · Cited by 3

Perspectives for novel therapeutic concepts in hepatocellular carcinoma targeting the stromal and innate immune microenvironment

Rennert, C., Lang‐Meli, J., Gromak, M., Hofmann, M., Thimme, R., & Roehlen, N. (2022) · Liver Cancer International · doi:10.1002/lci2.70 · Cited by 3

Restimulation by macrophages exhausts T cells

Fernández-García, F., & Maier, B. B. (2025) · Immunity · doi:10.1016/j.immuni.2024.12.010 · Cited by 3

Cross-disease integration of single-cell RNA sequencing data from lung myeloid cells reveals TAM signature in in vitro model

Pinto, C., Widawski, J., Zahalka, S., Thaler, B., Schuster, L. C., Lukowski, S. W., Ramírez, F., & Tirapu, I. (2025) · OncoImmunology · doi:10.1080/2162402x.2025.2502278 · Cited by 3

Macrophage heterogeneity in autoimmune diseases

Li, S., Zhou, X., Song, Y., Liu, Z., Sun, M., Si, Z., & Zhu, W. (2025) · Cellular Immunology · doi:10.1016/j.cellimm.2025.104993 · Cited by 4

SPATIALLY‐RESOLVED TRANSCRIPTOMICS DEFINE CLINICALLY RELEVANT SUBSETS OF MACROPHAGES IN DIFFUSE LARGE B‐CELL LYMPHOMA

Liu, M., Bertolazzi, G., Mulder, K., Sridhar, S., Lee, R. X., Jaynes, P., Hoppe, M. M., Fan, S., Peng, Y., Thng, J., et al. (2023) · Hematological Oncology · doi:10.1002/hon.3163_147 · Cited by 3

The heterogeneity of tumor-associated macrophages and strategies to target it

LV, H., ZHU, B., & Chen, D. (2024) · Biocell · doi:10.32604/biocell.2023.046367 · Cited by 3

Decoding changes in tumor‐infiltrating leukocytes through dynamic experimental models and single‐cell technologies

Lee, C. Y. C., Clatworthy, M. R., & Withers, D. R. (2024) · Immunology and Cell Biology · doi:10.1111/imcb.12787 · Cited by 3

FastIntegration: a fast and high-capacity version of Seurat Integration for large-scale integration of single-cell dataPreprint

Chen, J., Li, M., Zhang, X., & Ang, K. S. (2022) · Research Square · doi:10.21203/rs.3.rs-1643794/v1 · Cited by 3

FastIntegration: a versatile R package for accessing and integrating large-scale single-cell RNA-seq dataPreprint

Li, M., Zhang, X., Ang, K. S., & Chen, J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.10.491296 · Cited by 4

Single-cell transcriptomics reveal distinct subsets of activated dendritic cells in the tumor microenvironmentPreprint

To, T. K. J., Devalaraja, S., Folkert, I. W., Zhai, L., Lobel, G. P., & Haldar, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.13.507746 · Cited by 3

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in inflammatory bowel diseasePreprint

Garrido-Trigo, A., Corraliza, A. M., Veny, M., Dotti, I., Melón-Ardanaz, E., Rill, A., Crowell, H. L., Corbí, A. L., Gudiño, V., Esteller, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.28.518139 · Cited by 3

Cancer cell phagocytosis induces an anti-inflammatory gene regulatory program in macrophagesPreprint

Zhang, C. R., Xiong, L., Gu, M., Yeh, C. Y., Jerby‐Arnon, L., Kundaje, A. B., Greenleaf, W. J., & Bassik, M. C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.18.670953 · Cited by 3

Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cellsPreprint

Wiencke, J., Nissen, E. D., Koestler, D., Tamaki, S., Tamaki, C., Hansen, H. M., Warrier, G., Hadad, S., Mccoy, L. S., Rice, T., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3793353/v1 · Cited by 3

Integrating single‐cell RNA sequencing data to decipher heterogeneity and function of macrophages in various organs and diseases

Xu, X., Wu, Z., Zeng, Z., Cao, J., & Chen, L. (2024) · Clinical and Translational Discovery · doi:10.1002/ctd2.70005 · Cited by 2

The Microenvironment in DCIS and Its Role in Disease Progression

Roozitalab, R., Prekete, N., Allen, M. D., Grose, R. P., & Jones, J. L. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-70875-6_12 · Cited by 2

Palmitoylation-driven immune dysregulation and prognostic signature in low-grade glioma: a multi-omics and functional validation study

Wang, Z., Yu, T., Liu, Y., Wu, Y., & Hu, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1586921 · Cited by 2

Adverse prognosis of GM-CSF expression in human cutaneous melanoma

García‐Martínez, E., Nieto‐Valle, A., Barrio‐Alonso, C., López-Navarro, B., Avilés-Izquierdo, J. A., Parra‐Blanco, V., Gutiérrez‐Seijo, A., Sánchez‐Mateos, P., & Samaniego, R. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101240 · Cited by 2

Platelet Releasate Reprograms Synovial Macrophages In Vitro: A New Approach in the Treatment of Hemophilic Synovitis

Oneto, P., Landro, M. E., Ledesma, M. M., Etulain, J., Daffunchio, C., Cambiaggi, G., Schattner, M. A., Errasti, A. E., Caviglia, H. A., & Silva, E. A. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110616 · Cited by 2

“Monocytes in B-Cell Malignancies: Their Role in Disease Progression and Therapy Resistance”

Marhelava, K., Jakubowska, J., Pastorczak, A. K., & Firczuk, M. (2025) · Current Oncology Reports · doi:10.1007/s11912-025-01732-9 · Cited by 2

Targeting hepatocytic TβRI ameliorates liver metastatic outcomes by revitalizing stem-like CD8+ Tex subsets

Wang, H., Zhou, Y., Tu, Y., You, J., Gao, B., Yuan, K., Zhong, S., Huang, C., Han, Q., Dai, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65615-0 · Cited by 3

Engineering CCR2/IFN-γ overexpression in enucleated mesenchymal stem cells enhances therapy for rheumatoid arthritis

Sui, Y., Pu, Z., Yang, N., Luo, Y., Sa, Y., Qi, Q., Tan, L., Yan, Y., & Si, W. (2025) · Communications Biology · doi:10.1038/s42003-025-09248-5 · Cited by 2

Cutaneous diffuse large B-cell lymphoma induces a macrophage immunosuppressive phenotype through IL-10 secretion

Galtier, J., Peanne, R., Morvan, V. L., Blondy, T., Mélane, M., Bidon, A., Chopin, A., Prochazkova‐Carlotti, M., Poglio, S., Merlio, J., et al. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025016492 · Cited by 2

Single‐Cell Transcriptomic Analysis Reveals an Inflammatory Antigen‐Presenting Macrophages Subtype Drive Vitiligo Pathogenesis Through STAT1‐Mediated Dual Mechanisms

Qi, R., Huang, M., Lin, Z., Deng, H., Sa, R., Chen, Y., Chen, G., & Duan, X. (2025) · Mediators of Inflammation · doi:10.1155/mi/8878698 · Cited by 2

A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages

Palmer, O., Perreard, L., Kolling, F., Pioli, P. A., & Goods, B. A. (2025) · BMC Biotechnology · doi:10.1186/s12896-025-01071-4 · Cited by 2

An integrative model of pro- and anti-inflammatory signaling pathways in macrophage differentiation: the role of NF-κB and CREB

Martínez-Méndez, D., Aguilar-Elguea, I. Z., Castelán-Pacheco, L. S., Jiménez-Álvarez, L. A., Cruz‐Lagunas, A., Zúñiga, J., Villarreal, C., & Huerta, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639005 · Cited by 2

Conditional IL4I1 Inactivation Triggers Tumor-Associated Macrophage Reprogramming and CD8+ T-cell Reactivation to Control Melanoma Progression

Seradj, M., Kari, S., Llebaria-Fabrias, A., Rouault, A., Herrmann, A., Lengagne, R., Kato, M., Castellano, F., Molinier‐Frenkel, V., Llebaria, A., et al. (2026) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-24-1159 · Cited by 2

Pan-cancer epigenetic landscape of human tumor-associated macrophages reveals crucial enhancers governing their heterogenous formation by Pol II pausing modulation

Xiong, C., Ning, H., Wang, X., Xie, Y., Liu, Z., Hu, D., & Gao, X. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.01.048 · Cited by 2

Macrophage Infiltration, Activation, and Therapeutic Implication in Skeletal Muscle Injury and Repair

Wang, X., & Zhou, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031332 · Cited by 2

Monocytes from inflammatory arthritis patients accumulate methotrexate and their transcriptome predicts methotrexate clinical response

Ríos, I., Schiaffino, M. T., López-Navarro, B., Triguero‐Martínez, A., Lin, M., Torres‐Torresano, M., Struys, E. A., Álvarez, S., Román, M., Abad‐Santos, F., et al. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06162-9 · Cited by 2

Pan-cancer analysis of single-cell profiles with polygenic signals reveals genetic influences on tumor immunity across cancers

Deng, C., Ka, L., Ma, Y., Li, J., Li, Y. Z., Su, M., Zhou, Y., Zhang, Y., Su, J., & Zhang, Y. (2026) · Communications Biology · doi:10.1038/s42003-026-10158-3 · Cited by 2

Targeting macrophage-driven NK cell immunosuppression to improve cancer immunotherapy

Redavid, A. R., Cifaldi, L., Bei, R., de Billy, E., & Fruci, D. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2026-014840 · Cited by 2

Immune Landscape and Tumour Heterogeneity in Ovarian Cancer: Insights From Single‐Cell RNA Sequencing

Chen, S., Elhessewi, G. M. S., Cai, H., Alawad, W. M., Mishra, M. K., & Sayed, U. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71235 · Cited by 2

Melanoma cell states shape spatial tumor-immune ecosystems to dictate the efficacy of anti-PD1 immunotherapy

Pham, F., Dufeu, M., Benboubker, V., Grimont, M., LHORISSON, A., Berthet, J., Donzel, M., Schneider, R., Tonon, L., Doffin, A., et al. (2026) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2025-014030 · Cited by 4

Metabolic Reprogramming and Immunometabolic Dysregulation in Diabetic Kidney Disease: From Pathogenesis to Precision Multi-target Therapies

Zhang, Z., Qu, Y., Wang, X., Ji, Y., Yao, J., Deng, W., Sun, G., Xu, H., Chen, X., & Hong, Q. (2026) · Research · doi:10.34133/research.1386 · Cited by 2

Challenges for CAR-T cell therapy in multiple myeloma: overcoming the tumor microenvironment

Cui, J., An, G., & Qiu, L. (2023) · Hematology and Oncology Discovery · doi:10.15212/hod-2022-0008 · Cited by 2

Differential early response of monocyte/macrophage subsets to intra-operative corticosteroid administration in lung transplantation

Glorion, M., Pascale, F., Huriet, M., Estephan, J., Gouin, C., Urien, C., Bourge, M., Egidy, G., Richard, C., Gelin, V., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1281546 · Cited by 2

From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy

Wang, X., Chen, J., & Jia, G. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0370 · Cited by 4

Coniferyl ferulate alleviate xylene-caused hematopoietic stem and progenitor cell toxicity by Mgst2

Yin, Z., Ou, R., Zhu, Y., Liu, Z., Huang, J., Zhong, Q., Li, G., Zhang, Q., & Liu, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1334445 · Cited by 2

In Silico Transcriptomic Expression of MSR1 in Solid Tumors Is Associated with Responses to Anti-PD1 and Anti-CTLA4 Therapies

Sanvicente, A., Díaz‐Tejeiro, C., Nieto‐Jiménez, C., Paniagua‐Herranz, L., López-Cade, I., Győrffy, B., Moreno, V., Pérez‐Segura, P., Calvo, E., & Ocaña, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073987 · Cited by 3

Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity

Singh, S. S., Calvo, R., Kumari, A., Sable, R. V., Fang, Y., Tao, D., Hu, X., Castle, S. G., Nahar, S., Li, D., et al. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0790 · Cited by 2

Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Xie, Y., Chen, C., Wu, F., Peng, Y., Su, J., Zhao, Y., Huang, H., Li, Z. A., Pei, Y., Li, W., et al. (2025) · Advanced Science · doi:10.1002/advs.202415835 · Cited by 3

Joining Forces in Basic Science: ITS Meeting 2.0

Pilat, N., Issa, F., Luo, X., Chong, A. S., Bromberg, J. S., & Kotsch, K. (2022) · Transplant International · doi:10.3389/ti.2022.10843 · Cited by 3

Consequences of training data composition for deep learning models in single-cell biologyPreprint

Nadig, A., Thoutam, A., Hughes, M., Gupta, A., Navia, A. W., Fusi, N., Raghavan, S., Winter, P. S., Amini, A. P., & Crawford, L. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.19.639127 · Cited by 5

Spatial Heterogeneity of Macrophages in the Human LungPreprint

Hume, P. S., Lyn-Kew, K. H., Wynn, E. A., Steinhart, B., Driscoll, J., Jacobson, S. R., Henson, P. M., Mould, K. J., Moore, C. M., & Janssen, W. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.30.657106 · Cited by 4

Spatial tumour-immune ecosystems shape the efficacy of anti-PD1 immunotherapy in primary cutaneous melanomaPreprint

Pham, F., Dufeu, M., Benboubker, V., Grimont, M., LHORISSON, A., Berthet, J., Donzel, M., Schneider, R., Tonon, L., Doffin, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.661465 · Cited by 2

Cancer-myeloid cell invasive program in pediatric-type diffuse high-grade gliomaPreprint

Ruiz-Moreno, C., Collot, R. V. U., van den Broek, T. J. M., Wehrens, E. J., Bessler, N., Dharmadhikari, G., Pas, B. M. T., Ibarra, I. L., Metselaar, D. S., Kranendonk, M. E. G., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.23.701142 · Cited by 3

Scalable multimodal mapping of macrophage regulatory architecture by integrating optical and transcriptomic pooled screensPreprint

Kudo, T., Lopez, R., Meireles, A. M., Rios, A., Coelho, P. P., Chandrasekar, V., Lam, D. C., Huetter, J.-C., Ota, M., Rozenblatt–Rosen, O., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.27.728345 · Cited by 2

Single-cell RNA sequencing and functional analysis reveal the role of altered glycosylation levels of hepatic macrophages in liver cirrhosis

Wen, C., Tao, H., Chen, H., Pu, W., Yan, Q., Zou, Y., Su, S. S., Zhou, L., Peng, Y., Wang, G., et al. (2025) · Journal of Gastroenterology · doi:10.1007/s00535-025-02218-y · Cited by 1

Myeloid cells: key players in tumor microenvironments

Hua, Q., Li, Z., Weng, Y., Wu, Y., & Zheng, L. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1124-8 · Cited by 1

Mechanisms of indoleamine 2,3-dioxygenase (IDO)-mediated immunosuppression

Wu, Y., Wang, M., & Yu, B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-14064-8.00042-4 · Cited by 1

Deciphering Intercellular Communication of the Immune Landscape within Autosomal Dominant Polycystic Kidney Disease Microenvironment at Single-Cell Resolution

Liu, F., Li, X., Li, Q., Gu, J., Shi, Q., Song, J., Jiao, N., & Mao, J. (2025) · Kidney Diseases · doi:10.1159/000545663 · Cited by 4

Molecular analysis highlights TREM2 as a discriminating biomarker for patients suffering from pancreatic ductal adenocarcinoma

Papakonstantinou, D., Wang, H., Bani, M. A., Mulder, K., Dunsmore, G., Boilève, A., Jules-Clément, G., Panunzi, L. G., de Sousa, L. R., de la Calle‐Fabregat, C., et al. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.100939 · Cited by 2

Unveiling the Role of Sdc4 + Monocytes in NASH: A Single-Cell RNA Sequencing Study

Li, J.-Z., Mao, T., Gao, Y.-X., Xu, M., & Li, H. (2025) · Immunological Investigations · doi:10.1080/08820139.2025.2544180 · Cited by 1

Single cell map of the adult female mouse urethra reveals epithelial and stromal macrophages with distinct functional identities

Jasmine, Samtiya, M., Rodrigues, R., Mandal, A., Kavya, T. T., Anushree, A., Lafin, J. T., Vezina, C. M., Strand, D. W., & Joseph, D. B. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.09.001 · Cited by 4

Macrophage Nogo-B Drives Liver Fibrosis

Zhang, L., Ni, M., Si, J., Cheng, F., Zhang, L., Liang, Y., Liu, M., Li, W., Li, J., Chi, Y., et al. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101622 · Cited by 1

FAM49B mediates tumor progression and poor prognosis of gastric cancer through activating PI3K/AKT pathway

Yang, H., Ji, Y., Ju, Y., Shen, Y., Sun, X., & Dai, K. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10589-y · Cited by 1

Tumour Single‐Cell Bioinformatics: From Immune Profiling to Molecular Dynamics

Li, J. S., Ji, Z. Z., Zhang, A. Q., Ng, C. S. H., Qiao, G., Zhang, D., Li, C., Zhang, Q., To, K., & Tang, P. M. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70783 · Cited by 1

Single-cell profiling of peripheral and local immune compartments reveal unique genotype-independent prognostic immune signatures across isocitrate dehydrogenase-stratified glioma

Sussman, J. H., Cillo, A. R., Kohli, S., Cardello, C., Patterson, J., Akca, E., Angione, A., Moon, D., Krueger, K., Ghamari, A., et al. (2025) · Neuro-Oncology · doi:10.1093/neuonc/noaf206 · Cited by 1

Metabolic heterogeneity in adipose resident immunocytes and its link to type 2 diabetes via response to catabolism defects

Huang, S., Chen, X., Yuan, Y., Yuan, Y., Shen, L., Wang, H., Tang, W., Bi, Y., & Wu, T. (2025) · Genomics · doi:10.1016/j.ygeno.2025.111152 · Cited by 1

Acetylcholine in the gingival epithelium drives the pathogenesis of periodontitis

Xu, S., Guo, J., Yang, S., Cheng, B., & Xia, J. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1701252 · Cited by 1

Ovine macrophage identity and plasticity: novel insights into CSF-driven polarization and species-specific responses

Hecker, Y. P., Coronado, M., Hurtado-Morillas, C., Arranz-Solís, D., Sánchez-Sánchez, R., Corbí, A. L., & Ortega‐Mora, L. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680086 · Cited by 1

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Cui, J., Wang, J., Li, X., Wang, L., Mao, X., Lyv, R., Yan, W., Xu, J., Zhou, J., Du, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202510816 · Cited by 2

When blood mutations turn beneficial

de la Calle‐Fabregat, C., Bernard, E., & Ginhoux, F. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.11.004 · Cited by 1

Folate receptor beta targeting of tumor-associated macrophages improves lymphoma cell responses to CD19 CAR T cells

Kalander, K., Oksa, K., Sorri, S., Monzó, H. J., Leivonen, S., Ojala, P. M., & Leppä, S. (2025) · HemaSphere · doi:10.1002/hem3.70390 · Cited by 1

IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis

Liu, H., Wu, C., Li, G., Peng, X., Zhang, Z., Su, Z., Lin, J., Wang, X., Shen, H., Wu, Y., et al. (2025) · Arthritis Research & Therapy · doi:10.1186/s13075-025-03708-3 · Cited by 2

Targeting Gut Immune Dysregulation: Therapeutic Potential of Huangqin Decoction in Inflammatory Bowel Disease

Dai, X.-L., Cao, H., & Zhou, J. (2025) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-025-3855-4 · Cited by 1

Novel pan-cancer T cell exhaustion signature forecasts immunotherapy response and unveils BCAP31 in macrophages as a therapeutic target in neuroblastoma

Li, S., Zhu, J., Huang, X., Ji, F., Li, J., Yao, Z., Tang, H., Liu, L., Yan, B., & Zhanghuang, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1709225 · Cited by 2

Tumor-associated macrophages in head and neck carcinoma: clinicopathological correlations and implications for immunotherapy

Evrard, D., Bèaufrere, A., Dumont, C., Louerat, S., Chaud, A., Guyard, A., Laouirem, S., Albuquerque, M., Tijeras‐Raballand, A., Couvelard, A., et al. (2026) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04282-y · Cited by 1

Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics

Loke, P., & Lin, J.-D. (2022) · Science Immunology · doi:10.1126/sciimmunol.abo4652 · Cited by 24

Abstract 7280: Pan-cancer single-cell RNA sequencing analysis refines multiorigin monocyte and macrophage lineages

Nguyen, T. D., Lee, A., Park, H. J., Shah, N., Mandzhieva, B., Lee, D., Jung, I., & Park, W.-Y. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-7280

A spatial map of human macrophage niches links tissue location with functionPreprint

Matusiak, M., Hickey, J., Luca, B., Lu, G., Kidzinski, L., Shu, S., Colburg, D., Phillips, D., Brubaker, S. W., Charville, G., et al. (2022) · bioRxiv · doi:10.1101/2022.08.18.504434 · Cited by 8

Antiproliferative effect of IL-1 and alpha interferon in melanoma cells

Alvino, E. (1992) · Pharmacological Research · doi:10.1016/1043-6618(92)91297-t

Integrative cross‐tissue and spatially resolved single‐cell profiling uncovers tumour‐educated inflammatory remodelling of tissue‐resident macrophage ecosystem with immunotherapeutic prognostic significance in pan‐cancer

Wang, W., Chen, Z., Huang, Y., Hu, Z., Zhu, P., Huang, Z., Lv, J., Liao, Z., Zheng, Y., Wei, C., et al. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70608 · Cited by 4