Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
Open accessAbstract
Type 2 immune responses are critical in tissue homeostasis, anti-helminth immunity, and allergy. T helper 2 (Th2) cells produce interleukin-4 (IL-4), IL-5, and IL-13 from the type 2 gene cluster under regulation by transcription factors (TFs) including GATA3. To better understand transcriptional regulation of Th2 cell differentiation, we performed CRISPR-Cas9 screens targeting 1,131 TFs. We discovered that activity-dependent neuroprotector homeobox protein (ADNP) was indispensable for immune reactions to allergen. Mechanistically, ADNP performed a previously unappreciated role in gene activation, forming a critical bridge in the transition from pioneer TFs to chromatin remodeling by recruiting the helicase CHD4 and ATPase BRG1. Although GATA3 and AP-1 bound the type 2 cytokine locus in the absence of ADNP, they were unable to initiate histone acetylation or DNA accessibility, resulting in highly impaired type 2 cytokine expression. Our results demonstrate an important role for ADNP in promoting immune cell specialization.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neuroprotective agents such as NAP, the activity-dependent neuroprotective protein generated from ADNP, have been shown to be useful in preventing the death of neurons, in order to preserve microtubules and maintain neuronal function.
“In order to preserve microtubules and maintain neuronal function, neuroprotective agents—substances such as NAP, the activity-dependent neuroprotective protein generated from ADNP—have been shown to be useful in preventing the death of neurons [211,212].”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [212]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422 · see citing works
Keller, A., Nesvizhskii, A., Kolker, E., & Aebersold, R. (2002) · Analytical Chemistry · doi:10.1021/ac025747h · Cited by 4,970 · see citing works
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
Doench, J. G., Fusi, N., Sullender, M., Hegde, M., Vaimberg, E. W., Donovan, K. F., Smith, I., Tothova, Z., Wilen, C., Orchard, R., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3437 · Cited by 4,637 · see citing works
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302 · see citing works
ATAC-seq: a method for assaying chromatin accessibility genome-wide
Buenrostro, J. D., Wu, B., Chang, H. Y., & Greenleaf, W. J. (2015) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb2129s109 · Cited by 3,289 · see citing works
Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384 · see citing works
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
Platt, R. J., Chen, S., Zhou, Y., Yim, M. J., Swiech, L., Kempton, H. R., Dahlman, J. E., Parnas, O., Eisenhaure, T. M., Jovanovic, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.014 · Cited by 2,001 · see citing works
The basic immunology of asthma
Hammad, H., & Lambrecht, B. N. (2021) · Cell · doi:10.1016/j.cell.2021.02.016 · Cited by 1,131 · see citing works
Moon, J. J., Chu, H., Pepper, M., McSorley, S. J., Jameson, S. C., Kedl, R. M., & Jenkins, M. K. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.007 · Cited by 977 · see citing works
How are TH2-type immune responses initiated and amplified?
Paul, W. E., & Zhu, J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2735 · Cited by 957 · see citing works
Halim, T. Y. F., Steer, C. A., Mathä, L., Gold, M. J., Martínez-González, I., McNagny, K. M., McKenzie, A. N. J., & Takei, F. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.011 · Cited by 950 · see citing works
The 3 major types of innate and adaptive cell-mediated effector immunity
Annunziato, F., Romagnani, C., & Romagnani, S. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.001 · Cited by 818 · see citing works
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
Junttila, I. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00888 · Cited by 687 · see citing works
TH2 cell development and function
Walker, J. A., & McKenzie, A. N. J. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.118 · Cited by 634 · see citing works
The AP-1 transcription factor Batf controls TH17 differentiation
Schraml, B. U., Hildner, K., Ise, W., Lee, W.-L., Smith, W. A.-E., Solomon, B. D., Sahota, G., Sim, J. E., Mukasa, R., Čemerski, S., et al. (2009) · Nature · doi:10.1038/nature08114 · Cited by 622 · see citing works
Peripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors
Zhu, J., & Paul, W. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00951.x · Cited by 596 · see citing works
Cai, S., Lee, C. C., & Kohwi-shigematsu, T. (2006) · Nature Genetics · doi:10.1038/ng1913 · Cited by 547 · see citing works
ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors
Schmidl, C., Rendeiro, A. F., Sheffield, N. C., & Bock, C. (2015) · Nature Methods · doi:10.1038/nmeth.3542 · Cited by 509 · see citing works
Zhu, J., Yamane, H., Cote-Sierra, J., Guo, L.-Y., & Paul, W. (2006) · Cell Research · doi:10.1038/sj.cr.7310002 · Cited by 497 · see citing works
Barlow, J. L., Bellosi, A., Hardman, C. S., Drynan, L. F., Wong, S. H., Cruickshank, J., & McKenzie, A. N. J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.041 · Cited by 474 · see citing works
Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
Liang, H.-E., Reinhardt, R. L., Bando, J. K., Sullivan, B. M., Ho, I., & Locksley, R. M. (2011) · Nature Immunology · doi:10.1038/ni.2182 · Cited by 434 · see citing works
Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
Spilianakis, C. G., & Flavell, R. A. (2004) · Nature Immunology · doi:10.1038/ni1115 · Cited by 425 · see citing works
An epigenetic view of helper T cell differentiation
Ansel, K. M., Lee, D. U., & Rao, A. (2003) · Nature Immunology · doi:10.1038/ni0703-616 · Cited by 419 · see citing works
Regulation of IL‐4 expression by the transcription factor JunB during T helper cell differentiation
Li, B., Tournier, C., Davis, R. J., & Flavell, R. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.2.420 · Cited by 362 · see citing works
A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP
Helsmoortel, C., Vulto-van Silfhout, A. T., Coe, B. P., Vandeweyer, G., Rooms, L., van den Ende, J., Schuurs-Hoeijmakers, J. H. M., Marcelis, C. L., Willemsen, M. H., Vissers, L. E. L. M., et al. (2014) · Nature Genetics · doi:10.1038/ng.2899 · Cited by 354 · see citing works
McKenzie, G. J., Fallon, P. G., Emson, C. L., Grencis, R. K., & McKenzie, A. N. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.10.1565 · Cited by 354 · see citing works
IL-4 Induces Characteristic Th2 Responses Even in the Combined Absence of IL-5, IL-9, and IL-13
Fallon, P. G., Jolin, H. E., Smith, P., Emson, C. L., Townsend, M. J., Fallon, R. E., Smith, P., & McKenzie, A. N. J. (2002) · Immunity · doi:10.1016/s1074-7613(02)00332-1 · Cited by 349 · see citing works
Kanhere, A., Hertweck, A., Bhatia, U., Gökmen, M. R., Perucha, E., Jackson, I., Lord, G. M., & Jenner, R. G. (2012) · Nature Communications · doi:10.1038/ncomms2260 · Cited by 345 · see citing works
Fields, P. E., Kim, S. T., & Flavell, R. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.647 · Cited by 328 · see citing works
Fate Mapping Reveals Separate Origins of T Cells and Myeloid Lineages in the Thymus
Schlenner, S., Madan, V., Busch, K., Tietz, A., Läufle, C., Costa, C., Blum, C., Fehling, H. J., & Rodewald, H.-R. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.005 · Cited by 322 · see citing works
Ho, I., Lo, D. D., & Glimcher, L. H. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1859 · Cited by 303 · see citing works
Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo
Agarwal, S., Avni, O., & Rao, A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80215-0 · Cited by 274 · see citing works
The Chromatin Remodeler Mi-2β Is Required for CD4 Expression and T Cell Development
Williams, C. J., Naito, T., Arco, P. G., Seavitt, J. R., Cashman, S. M., Souza, B. D., Qi, X., Keables, P., von Andrian, U. H., & Georgopoulos, K. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.005 · Cited by 266 · see citing works
Activity-dependent neuroprotective protein: a novel gene essential for brain formation
Pinhasov, A., Mandel, S., Torchinsky, A., Giladi, E., Pittel, Z., Goldsweig, A. M., Servoss, S. J., Brenneman, D. E., & Gozes, I. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00162-7 · Cited by 239 · see citing works
Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes
Ostapcuk, V., Mohn, F., Carl, S. H., Basters, A., Heß, D., Iešmantavičius, V., Lampersberger, L., Flemr, M., Pandey, A., Thomä, N. H., et al. (2018) · Nature · doi:10.1038/s41586-018-0153-8 · Cited by 221 · see citing works
Yamashita, M., Ukai‐Tadenuma, M., Kimura, M. Y., Omori, M., Inami, M., Taniguchi, M., & Nakayama, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205876200 · Cited by 196 · see citing works
Th2-Specific Chromatin Remodeling and Enhancer Activity in the Th2 Cytokine Locus Control Region
Fields, P. E., Lee, G. R., Kim, S. T., Bartsevich, V. V., & Flavell, R. A. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.015 · Cited by 189 · see citing works
Development and function of group 2 innate lymphoid cells
Walker, J. A., & McKenzie, A. N. J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.02.010 · Cited by 187 · see citing works
Paul, W. E. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.038 · Cited by 178 · see citing works
Chromatin Structure and Gene Regulation in the Immune System
Smale, S. T., & Fisher, A. G. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064739 · Cited by 176 · see citing works
Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP
Dijck, A. V., Silfhout, A. T. V., Cappuyns, E., van der Werf, I. M., Mancini, G. M. S., Tzschach, A., Bernier, R., Gozes, I., Eichler, E. E., Romano, C., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.1173 · Cited by 168 · see citing works
Mandel, S., Rechavi, G., & Gozes, I. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.11.039 · Cited by 167 · see citing works
Gozes, I., Morimoto, B. H., Tiong, J., Fox, A. W., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P. E., Aisen, P. S. S., et al. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2005.tb00053.x · Cited by 144 · see citing works
Type-2 Innate Lymphoid Cells in Asthma and Allergy
McKenzie, A. N. J. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201403-097aw · Cited by 136 · see citing works
Kaaij, L. J. T., Mohn, F., van der Weide, R. H., de Wit, E., & Bühler, M. (2019) · Cell · doi:10.1016/j.cell.2019.08.007 · Cited by 133 · see citing works
Chu, V. T., Graf, R., Wirtz, T., Weber, T., Favret, J., Li, X., Petsch, K., Tran, N. T., Sieweke, M. H., Berek, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613884113 · Cited by 129 · see citing works
Batf is important for IL-4 expression in T follicular helper cells
Sahoo, A., Alekseev, A., Tanaka, K., Obertas, L., Lerman, B., Haymaker, C., Clise-Dwyer, K., McMurray, J. S., & Nurieva, R. (2015) · Nature Communications · doi:10.1038/ncomms8997 · Cited by 122 · see citing works
ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling
Sun, X., Peng, X., Cao, Y., Zhou, Y., & Sun, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-16799-0 · Cited by 107 · see citing works
Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity
Hosokawa, H., Tanaka, T., Suzuki, Y., Iwamura, C., Ohkubo, S., Endoh, K., Kato, M., Endo, Y., Onodera, A., Tumes, D. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220865110 · Cited by 98 · see citing works
Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations
Farnung, L., Ochmann, M., & Cramer, P. (2020) · eLife · doi:10.7554/elife.56178 · Cited by 95 · see citing works
Kang, Y., Kim, Y. W., Kang, J., & Kim, A. (2021) · The FASEB Journal · doi:10.1096/fj.202100488r · Cited by 93 · see citing works
Hwang, S. S., Kim, Y. U., Lee, S., Jang, S. W., Kim, M. K., Koh, B. H., Lee, W., Kim, J., Souabni, A., Busslinger, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214682110 · Cited by 82 · see citing works
Shimono, Y., Murakami, H., Kawai, K., Wade, P. A., Shimokata, K., & Takahashi, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309198200 · Cited by 82 · see citing works
BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and function
Miller, M. M., Patel, P. S., Bao, K., Danhorn, T., O’Connor, B. P., & Reinhardt, R. L. (2020) · Science Immunology · doi:10.1126/sciimmunol.aay3994 · Cited by 81 · see citing works
Papain-induced asthma—physiological and immunological features
Novey, H. S., Marchioli, L. E., Sokol, W. N., & Wells, I. D. (1979) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(79)90198-2 · Cited by 78 · see citing works
Scheler, C., Li, X., Salnikow, J., Dunn, M. J., & Jungblut, P. R. (1999) · Electrophoresis · doi:10.1002/(sici)1522-2683(19991201)20:18 · Cited by 72 · see citing works
BRG1-Mediated Chromatin Remodeling Regulates Differentiation and Gene Expression of T Helper Cells
Wurster, A. L., & Pazin, M. J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00835-08 · Cited by 72 · see citing works
de Almeida, C. R., Heath, H., Krpic, S., Dingjan, G. M., van Hamburg, J. P., Bergen, I. M., van de Nobelen, S., Sleutels, F., Grosveld, F. G., Galjart, N., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.999 · Cited by 65 · see citing works
De, S., Wurster, A. L., Precht, P., Wood, W. H., Becker, K. G., & Pazin, M. J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00920-10 · Cited by 58 · see citing works
Mechanism(s) of SWI/SNF‐Induced Nucleosome Mobilization
Liu, N., Balliano, A., & Hayes, J. J. (2010) · ChemBioChem · doi:10.1002/cbic.201000455 · Cited by 48 · see citing works
Bao, K., Carr, T. M., Wu, J., Barclay, W. E., Jin, J., Ciofani, M., & Reinhardt, R. L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601371 · Cited by 44 · see citing works
ADNP Controls Gene Expression Through Local Chromatin Architecture by Association With BRG1 and CHD4
Sun, X., Yu, W., Li, L., & Sun, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00553 · Cited by 43 · see citing works
Szeto, A. C. H., Ferreira, A. C. F., Mannion, J., Clark, P. A., Sivasubramaniam, M., Heycock, M. W. D., Crisp, A., Jolin, H. E., Kozik, P., Knolle, M. D., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01378-w · Cited by 38 · see citing works
Howrylak, J. A., Moll, M. R., Weiss, S. T., Raby, B. A., Wu, W., & Xing, E. P. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.09.058 · Cited by 29 · see citing works
Opejin, A., Surnov, A., Misulovin, Z., Pherson, M., Gross, C. J., Iberg, C. A., Fallahee, I., Bourque, J., Dorsett, D., & Hawiger, D. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108424 · Cited by 29 · see citing works
Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Michieletto, M. F., Tello-Cajiao, J. J., Mowel, W. K., Chandra, A., Yoon, S.-Y., Joannas, L., Clark, M., Jimenez, M. T., Wright, J. M., Lundgren, P., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01295-y · Cited by 29 · see citing works
Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice
Zhou, R., Flaswinkel, H., Schneider, M. R., Lahm, H., Hoeflich, A., Wanke, R., & Wolf, E. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0320349 · Cited by 27 · see citing works
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression
Nagashima, H., Shayne, J., Jiang, K., Petermann, F., Pękowska, A., Kanno, Y., & O’Shea, J. J. (2024) · Nature Immunology · doi:10.1038/s41590-024-02007-4 · Cited by 22 · see citing works
3D genome organization during lymphocyte development and activation
Schoonhoven, A. O.-V., Huylebroeck, D., Hendriks, R. W., & Stadhouders, R. (2019) · Briefings in Functional Genomics · doi:10.1093/bfgp/elz030 · Cited by 21 · see citing works
Roles of Hopx in the differentiation and functions of immune cells
Bourque, J., Kousnetsov, R., & Hawiger, D. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151242 · Cited by 19 · see citing works
Chromodomain helicase DNA‐binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*
Hagman, J. R., Arends, T., Laborda, C., Knapp, J. R., Harmacek, L. D., & O’Connor, B. P. (2021) · Immunological Reviews · doi:10.1111/imr.13054 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lambrecht, B., Ahmed, E., & Hammad, H. (2025) · Nature Immunology · doi:10.1038/s41590-025-02212-9 · Cited by 54 · see citing works
CRISPR–Cas9 applications in T cells and adoptive T cell therapies
Chen, X., Zhong, S., Zhan, Y., & Zhang, X. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00561-1 · Cited by 56 · see citing works
Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56 · see citing works
“In order to preserve microtubules and maintain neuronal function, neuroprotective agents—substances such as NAP, the activity-dependent neuroprotective protein generated from ADNP—have been shown to be useful in preventing the death of neurons [211,212].”
BackgroundAdvancements in CRISPR/Cas systems for disease treatment
Xu, Y., Le, H., Wu, Q., Wang, N., & Gong, C. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.007 · Cited by 35 · see citing works
Ganaiem, M., Gildor, N. D., Shazman, S., Karmon, G., Ivashko‐Pachima, Y., & Gozes, I. (2023) · Cells · doi:10.3390/cells12182251 · Cited by 30 · see citing works
Mef2d potentiates type-2 immune responses and allergic lung inflammation
Szeto, A. C. H., Clark, P. A., Ferreira, A. C. F., Heycock, M. W. D., Griffiths, E. L., Jou, E., Mannion, J., Luan, S., Storrar, S., Knolle, M. D., et al. (2024) · Science · doi:10.1126/science.adl0370 · Cited by 29 · see citing works
Recent Developments in the Role of Histone Acetylation in Asthma
Potaczek, D. P., Bazan‐Socha, S., Wypasek, E., Wygrecka, M., & Garn, H. (2024) · International Archives of Allergy and Immunology · doi:10.1159/000536460 · Cited by 27 · see citing works
Wu, T., Su, D., Zhang, L., Liu, T., Wang, Q., Yan, C., Liu, M., Ji, H., Lei, J., Zheng, M., et al. (2024) · Arthritis & Rheumatology · doi:10.1002/art.42954 · Cited by 21 · see citing works
D’Incal, C. P., Dijck, A. V., Ibrahim, J., Man, K. D., Bastini, L., Konings, A., Elinck, E., Theys, C., Gozes, I., Marušić, Z., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01743-w · Cited by 18 · see citing works
Gorska, M. M. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.11.003 · Cited by 13 · see citing works
Gozes, I. (2023) · Cytoskeleton · doi:10.1002/cm.21776 · Cited by 11 · see citing works
Tissue‐Resident Th2 Cells in Type 2 Immunity and Allergic Diseases
Mannion, J. M., & Rahimi, R. A. (2025) · Immunological Reviews · doi:10.1111/imr.70006 · Cited by 11 · see citing works
Tan, R., Bai, Q., Jia, L.-H., Wang, Y., Li, T., Lin, J.-Y., Liu, J., Su, H.-W., Kantawong, F., & Wang, L. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117842 · Cited by 10 · see citing works
High-throughput CRISPR technology: a novel horizon for solid organ transplantation
Li, X., Chen, Z., Ye, W., Yu, J., Zhang, X., Li, Y., Niu, Y., Ran, S., Wang, S., Luo, Z., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295523 · Cited by 9 · see citing works
Gozes, I., Shazman, S., Giladi, E., & Levine, J. (2024) · Genomic psychiatry : · doi:10.61373/gp024r.0079 · Cited by 8 · see citing works
Molecular mechanisms regulating T helper 2 cell differentiation and function
Szeto, A. C. H., Ferreira, A. C. F., & McKenzie, A. N. J. (2024) · Current Opinion in Immunology · doi:10.1016/j.coi.2024.102483 · Cited by 6 · see citing works
Molecular requirements of pathogenic Th2 cell differentiation in allergic airway disease
Khan, M., Fuhrmann, V., Cavanagh, L. L., & Boucheron, N. (2026) · Immunology Letters · doi:10.1016/j.imlet.2026.107143 · Cited by 5 · see citing works
Single-cell RNA sequencing indicates AP-1 as a potential therapeutic target for autoimmune uveitis.
Zhao, S., Wu, D.-T., Lu, Y., Zhu, L., Wang, S.-H. E., Li, Z.-H., Peng, X., Li, H., Xu, X.-F., & Su, W.-R. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116945 · Cited by 3 · see citing works
D’Incal, C. P., Rossem, K. E. V., Cappuyns, E., Dijck, A. V., Elinck, E., Man, K. D., Scott, A., Konings, A., Annear, D. J., & Kooy, R. F. (2025) · Autism Research · doi:10.1002/aur.70132 · Cited by 3 · see citing works
D’Incal, C. P., Cappuyns, E., Paldi, F., van der Lei, M. B., Annear, D. J., Alastruey, C. M., Sokolova, D., Elinck, E., Man, K. D., Konings, A., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106309 · Cited by 4 · see citing works
Cao, H., Tao, Y., Jin, R., Li, P., Zhou, H., & Cheng, J. (2025) · Renal Failure · doi:10.1080/0886022x.2024.2443032 · Cited by 1 · see citing works
Liu, P., Yang, D., & Ma, R. (2025) · Medicine · doi:10.1097/md.0000000000042561
Wei, D., Ge, G., Chiang, C.-Y., Cao, Y., Kline, Z. J., Jing, H., Golec, D. P., Shibata, H., Fang, D., Schwartzberg, P. L., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20260418
- Authors
- Ferreira, A. C. F., Szeto, A. C. H., Clark, P. A., Crisp, A., Kozik, P., Jolin, H. E., & McKenzie, A. N. J.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Ferreira, Ana C.F.
- McKenzie, Andrew N.J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2023-07
- Volume
- 56
- Issue
- 7
- Pages
- 1468-1484.e7
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4379537564
- Cited by
- 23
- References
- 73
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 10 · 2023: 2
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- Funders
- Wellcome Trust (100963/Z/13/Z, 220223/Z/20/Z)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- ADNP, Th2 immune response, CHD4, SMARCA4, GATA3, AP-1, histone acetylation, DNA accessibility, pioneer transcription factors, CRISPR-Cas9 screen, transcriptional regulation
- MeSH terms
- Cell Differentiation, Gene Expression Regulation, Histones, Transcription Factors, Cytokines, Th2 Cells, GATA3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review