Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751 · see citing works

Hallmarks of Cellular Senescence

Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Veglia, F., Sanseviero, E., & Gabrilovich, D. I. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00490-y · Cited by 1,940 · see citing works

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Gong, T., Liu, L., Jiang, W., & Zhou, R. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0215-7 · Cited by 1,672 · see citing works

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335 · see citing works

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255 · see citing works

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

Glück, S., Guey, B., Gulen, M. F., Wolter, K., Kang, T.-W., Schmacke, N. A., Bridgeman, A., Rehwinkel, J., Zender, L., & Ablasser, A. (2017) · Nature Cell Biology · doi:10.1038/ncb3586 · Cited by 1,196 · see citing works

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Frezza, C., Cipolat, S., & Scorrano, L. (2007) · Nature Protocols · doi:10.1038/nprot.2006.478 · Cited by 1,188 · see citing works

Mitochondrial DNA in innate immune responses and inflammatory pathology

West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115 · see citing works

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., San Chin, H., et al. (2018) · Science · doi:10.1126/science.aao6047 · Cited by 1,072 · see citing works

Mitochondrial dysfunction in cell senescence and aging

Miwa, S., Kashyap, S., Chini, E., & von Zglinicki, T. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158447 · Cited by 1,061 · see citing works

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Yu, C.-H., Davidson, S., Harapas, C. R., Hilton, J. B., Mlodzianoski, M. J., Laohamonthonkul, P., Louis, C., Low, R. R. J., Moecking, J., De Nardo, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.020 · Cited by 1,019 · see citing works

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Passos, J. F., Saretzki, G., Ahmed, S., Nelson, G., Richter, T., Peters, H., Wappler, I., Birket, M. J., Harold, G., Schaeuble, K., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050110 · Cited by 796 · see citing works

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

Kim, J., Gupta, R., Blanco, L. P., Yang, S., Shteinfer-Kuzmine, A., Wang, K., Zhu, J., Yoon, H. E., Wang, X., Kerkhofs, M., et al. (2019) · Science · doi:10.1126/science.aav4011 · Cited by 793 · see citing works

Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression

Hu, P., Han, Z., Couvillon, A., Kaufman, R., & Exton, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3071-3084.2006 · Cited by 777 · see citing works

Apoptotic stress causes mtDNA release during senescence and drives the SASP

Victorelli, S. G., Salmonowicz, H., Chapman, J., Martini, H., Vizioli, M. G., Riley, J. S., Cloix, C., Hall-Younger, E., Espíndola‐Netto, J. M., Jurk, D., et al. (2023) · Nature · doi:10.1038/s41586-023-06621-4 · Cited by 696 · see citing works

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

Chung, K. W., Dhillon, P., Huang, S., Sheng, X., Shrestha, R., Qiu, C., Kaufman, B. A., Park, J., Pei, L., Baur, J. A., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.003 · Cited by 655 · see citing works

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

Kaplon, J., Zheng, L., Meissl, K., Chaneton, B., Selivanov, V. A., Mackay, G., van der Burg, S. H., Verdegaal, E. M. E., Cascante, M., Shlomi, T., et al. (2013) · Nature · doi:10.1038/nature12154 · Cited by 633 · see citing works

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

Wang, G., Lü, X., Dey, P., Deng, P., Wu, C.-C., Jiang, S., Fang, Z., Zhao, K., Konaparthi, R., Hua, S., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0224 · Cited by 556 · see citing works

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

Alshetaiwi, H. S., Pervolarakis, N., McIntyre, L. L., Ma, D., Nguyen, Q., Rath, J. A., Nee, K., Hernandez, G. A., Evans, K. T., Torosian, L., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aay6017 · Cited by 521 · see citing works

The role of retrotransposable elements in ageing and age-associated diseases

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature · doi:10.1038/s41586-021-03542-y · Cited by 457 · see citing works

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

Huang, L. S., Hong, Z., Wu, W., Xiong, S., Zhong, M., Gao, X., Rehman, J., & Malik, A. B. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.002 · Cited by 435 · see citing works

Mitochondrial endonuclease G is important for apoptosis in C. elegans

Parrish, J., Li, L., Klotz, K., Ledwich, D., Wang, X., & Xue, D. (2001) · Nature · doi:10.1038/35083608 · Cited by 427 · see citing works

Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

Toso, A., Revandkar, A., Di Mitri, D., Guccini, I., Proietti, M., Sarti, M., Pinton, S., Zhang, J., Kalathur, M., Civenni, G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.044 · Cited by 418 · see citing works

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

Korolchuk, V. I., Miwa, S., Carroll, B., & von Zglinicki, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.020 · Cited by 409 · see citing works

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

Moiseeva, O., Bourdeau, V., Roux, A., Deschênes-Simard, X., & Ferbeyre, G. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01868-08 · Cited by 408 · see citing works

NAD+ metabolism governs the proinflammatory senescence-associated secretome

Nacarelli, T., Lau, L., Fukumoto, T., Zundell, J., Fatkhutdinov, N., Wu, S., Aird, K. M., Iwasaki, O., Kossenkov, A. V., Schultz, D., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0287-4 · Cited by 402 · see citing works

Il-23 secreted by myeloid cells drives castration-resistant prostate cancer

Calcinotto, A., Spataro, C., Zagato, E., Di Mitri, D., Gil, V., Crespo, M., De Bernardis, G., Losa, M., Mirenda, M., Pasquini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0266-0 · Cited by 394 · see citing works

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in <i>Caenorhabditis elegans</i>

Wang, X., Yang, C., Chai, J., Shi, Y., & Xue, D. (2002) · Science · doi:10.1126/science.1076194 · Cited by 393 · see citing works

Resurrection of endogenous retroviruses during aging reinforces senescence

Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.017 · Cited by 390 · see citing works

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer

Di Mitri, D., Toso, A., Chen, J. J., Sarti, M., Pinton, S., Jost, T. R., D’Antuono, R., Montani, E., Garcia-Escudero, R., Guccini, I., et al. (2014) · Nature · doi:10.1038/nature13638 · Cited by 388 · see citing works

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation

Loo, G., Schotte, P., van Gurp, M., Demol, H., Hoorelbeke, B., Gevaert, K., Rodríguez, I., Ruiz-Carrillo, A., Vandekerckhove, J. S., Declercq, W., et al. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400944 · Cited by 350 · see citing works

Cellular senescence: all roads lead to mitochondria

Martini, H., & Passos, J. F. (2023) · The FEBS Journal · doi:10.1111/febs.16361 · Cited by 334 · see citing works

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

Borghesan, M., Fafián-Labora, J., Eleftheriadou, O., Carpintero-Fernández, P., Paez-Ribes, M., Vizcay-Barrena, G., Swisa, A., Kolodkin-Gal, D., Ximénez-Embún, P., Lowe, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.095 · Cited by 315 · see citing works

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

Xu, M. M., Yang, P., Han, D., Shi, Y., Cao, X., Liang, H. L., Chen, X., Li, X.-D., Deng, L., Chen, Z. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.016 · Cited by 315 · see citing works

Transcriptomic Analysis Comparing Tumor-Associated Neutrophils with Granulocytic Myeloid-Derived Suppressor Cells and Normal Neutrophils

Fridlender, Z. G., Sun, J., Mishalian, I., Singhal, S. K., Cheng, G., Kapoor, V., Horng, W.-H., Fridlender, G., Bayuh, R., Worthen, G. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031524 · Cited by 311 · see citing works

IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy

Weber, R., Groth, C., Lasser, S., Arkhypov, I., Petrova, V., Altevogt, P., Utikal, J. S., & Umansky, V. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104254 · Cited by 310 · see citing works

A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis

Zhang, D., Liu, Y., Zhu, Y., Zhang, Q. Y., Guan, H., Liu, S., Chen, S., Chen, M., Chen, C., Liao, Z., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00894-z · Cited by 295 · see citing works

DNA binding to TLR9 expressed by red blood cells promotes innate immune activation and anemia

Lam, L., Murphy, S., Kokkinaki, D., Venosa, A., Sherrill-Mix, S. A., Casu, C., Rivella, S., Weiner, A. I., Park, J., Shin, S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj1008 · Cited by 209 · see citing works

Unfolded protein response mediator PERK governs myeloid cell-driven immunosuppression in tumors through inhibition of STING signaling

Mohamed, E., Sierra, R. A., Trillo-Tinoco, J., Cao, Y., Innamarato, P., Payne, K., Pulido, Á. D. M., Mandula, J., Zhang, S., Thevenot, P., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.03.004 · Cited by 203 · see citing works

Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis

Hajizadeh, S., DeGroot, J., TeKoppele, J. M., Tarkowski, A., & Collins, L. V. (2003) · Arthritis Res Ther · doi:10.1186/ar787 · Cited by 196 · see citing works

Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

Trovato, R., Fiore, A., Sartori, S., Canè, S., Giugno, R., Cascione, L., Paiella, S., Salvia, R., Sanctis, F. D., Poffe, O., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0734-6 · Cited by 189 · see citing works

Mitochondria: Are they causal players in cellular senescence?

Correia-Melo, C., & Passos, J. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.017 · Cited by 160 · see citing works

Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer

Kim, J. H., Lee, C., & Baek, M. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00898-7 · Cited by 135 · see citing works

Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway

Alicea-Torres, K. M., Sanseviero, E., Gui, J., Chen, J., Veglia, F., Yu, Q., Donthireddy, L., Kossenkov, A. V., Lin, C., Fu, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22033-2 · Cited by 123 · see citing works

Pharmacological CDK4/6 inhibition reveals a p53‐dependent senescent state with restricted toxicity

Wang, B., Varela‐Eirin, M., Brandenburg, S. M., Hernandez‐Segura, A., van Vliet, T., Jongbloed, E. M., Wilting, S. M., Ohtani, N., Jager, A., & Demaria, M. (2022) · The EMBO Journal · doi:10.15252/embj.2021108946 · Cited by 113 · see citing works

Coagulome and the tumor microenvironment: an actionable interplay

Galmiche, A., Rak, J., Roumenina, L. T., & Saidak, Z. (2022) · Trends in cancer · doi:10.1016/j.trecan.2021.12.008 · Cited by 108 · see citing works

Phagosome maturation in polarized macrophages

Canton, J. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1mr0114-021r · Cited by 100 · see citing works

Involvement of Endonuclease G in Nucleosomal DNA Fragmentation under Sustained Endogenous Oxidative Stress

Ishihara, Y., & Shimamoto, N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510382200 · Cited by 70 · see citing works

Endonuclease G: A role for the enzyme in recombination and cellular proliferation

Huang, K.-J., Ku, C., & Lehman, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603445103 · Cited by 65 · see citing works

A Randomized Phase II Study of Androgen Deprivation Therapy with or without Palbociclib in RB-positive Metastatic Hormone-Sensitive Prostate Cancer

Palmbos, P. L., Daignault‐Newton, S., Tomlins, S. A., Agarwal, N., Twardowski, P. W., Morgans, A. K., Kelly, W. K., Arora, V. K., Antonarakis, E. S., Siddiqui, J., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-0024 · Cited by 57 · see citing works

Methods to Measure MDSC Immune Suppressive Activity In Vitro and In Vivo

Solito, S., Pinton, L., Sanctis, F. D., Ugel, S., Bronte, V., Mandruzzato, S., & Marigo, I. (2018) · Current Protocols in Immunology · doi:10.1002/cpim.61 · Cited by 47 · see citing works

Endonuclease G promotes mitochondrial genome cleavage and replication

Wiehe, R. S., Gole, B., Châtre, L., Walther, P., Calzia, E., Ricchetti, M., & Wiesmüller, L. (2018) · Oncotarget · doi:10.18632/oncotarget.24822 · Cited by 44 · see citing works

<i>PTEN</i> deletion in luminal cells of mature prostate induces replication stress and senescence in vivo

Parisotto, M., Grelet, E., El Bizri, R., Dai, Y., Terzic, J., Eckert, D., Gargowitsch, L., Bornert, J.-M., & Metzger, D. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171207 · Cited by 43 · see citing works

Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G

Lin, J. L. J., Nakagawa, A., Skeen-Gaar, R., Yang, W.-Z., Zhao, P., Zhang, Z., Ge, X., Mitani, S., Xue, D., & Yuan, H. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.090 · Cited by 40 · see citing works

Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4

Meng, Q., Chen, C., Yang, N., Gololobova, O. A., Shi, C., Dunn, C., Rossi, M. S., Martindale, J. L., Basisty, N., Ding, J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219801120 · Cited by 40 · see citing works

Methods for Efficient Elimination of Mitochondrial DNA from Cultured Cells

Spadafora, D., Kozhukhar, N., Chouljenko, V. N., Kousoulas, K. G., & ALEXEYEV, M. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154684 · Cited by 40 · see citing works

The complement system as a regulator of tumor-promoting activities mediated by myeloid-derived suppressor cells

Senent, Y., Tavira, B., Pı́o, R., & Ajona, D. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215900 · Cited by 37 · see citing works

The downregulation of type I IFN signaling in G-MDSCs under tumor conditions promotes their development towards an immunosuppressive phenotype

Sun, Y., Han, X., Shang, C., Wang, Y., Xu, B., Jiang, S., Mo, Y., Wang, D., Ke, Y., & Zeng, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-021-04487-w · Cited by 28 · see citing works

Clinical outcomes and markers of treatment response in a randomized phase II study of androgen deprivation therapy with or without palbociclib in RB-intact metastatic hormone-sensitive prostate cancer (mHSPC).

Palmbos, P. L., Tomlins, S. A., Daignault, S. D., Agarwal, N., Twardowski, P. W., Morgans, A. K., Kelly, W. K., Arora, V. K., Antonarakis, E. S., Siddiqui, J., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.2020.38.15_suppl.5573 · Cited by 7 · see citing works

Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies

Bai, X., Guo, Y.-R., Zhao, Z., Li, X., Dai, D.-Q., Zhang, J., Li, Y.-S., & Zhang, C. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217772 · Cited by 137 · see citing works

Senescence in cancer

Colucci, M., Sarill, M., Maddalena, M., Valdata, A., Troiani, M., Massarotti, M., Bolis, M., Bressan, S., Kohl, A., Robesti, D., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.05.015 · Cited by 130 · see citing works

cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives

Li, H., Cai, R., Zhou, Y., Jiang, Y., & Tan, S. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03563-8 · Cited by 70 · see citing works

Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics

Feng, T., Xie, F., Lee, L. M.-Y., Lin, Z., Tu, Y., Lyu, Y., Yu, P., Wu, J., Chen, B., Zhang, G., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02419-2 · Cited by 66 · see citing works

The cGAS-STING pathway: a dual regulator of immune response in cancer and therapeutic implications

Huang, Z., Zhu, J., Zhou, Y. L., & Shi, J. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06843-2 · Cited by 57 · see citing works

Mitochondrial RNA cytosolic leakage drives the SASP

Victorelli, S. G., Eppard, M., Martini, H., Woo, S., Everts, S. P. A., Lee, G., Pirius, N., Han, N., Liang, E. Y., Franco, A. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66159-z · Cited by 35 · see citing works

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Yan, Y., Tan, X., Song, B., Yi, M., Chu, Q., & Wu, K. (2025) · 癌症：英文版 · doi:10.1002/cac2.70067 · Cited by 35 · see citing works

Context-dependent impact of type I interferon signaling in cancer

Ruiz-Iglesias, A., Guilbaud, E., Galluzzi, L., & Mañes, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02495-4 · Cited by 25 · see citing works

Metabolic control of immunity and inflammation: Mitochondrial dynamics, pharmacological targets, and therapeutic opportunities

Wang, C., Zhang, W., Shu, Y., Song, L., Wan, Y., Zhang, H., Bo, L., & Guo, Y. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108194 · Cited by 22 · see citing works

DAMP signaling networks: from receptors to diverse pathophysiological functions

Chen, R., Zou, J., Zhong, X. Y., Liu, J., Kang, R., & Tang, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.047 · Cited by 20 · see citing works

Reprogramming the tumor microenvironment: synergistic mechanisms of antibody–drug conjugates and immune checkpoint inhibitors

Yin, L., Zhou, S.-B., Zhang, H., Yao, C.-B., Al-Qadhi, Z., Shang, Y., Wu, S., & Jin, T. (2025) · Antibody Therapeutics · doi:10.1093/abt/tbaf017 · Cited by 23 · see citing works

Cytosolic DNA crosstalk in senescence: a new axis of inflammatory signaling?

Dou, Z., Kreiling, J. A., Heynen‐Genel, S., Jurk, D., Neretti, N., Adams, P. D., Sedivy, J. M., & Passos, J. F. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00531-z · Cited by 17 · see citing works

A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration

Zhao, L., Liang, K., Cheng, W., Zhou, X., Yang, L., Mao, X., Qi, W., Jin, H., Zhang, W., Pan, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63194-8 · Cited by 16 · see citing works

The cGAS-STING pathway: Mechanism and medical implications

Hooftman, A., Keller, A., & Ablasser, A. (2026) · Cell · doi:10.1016/j.cell.2026.06.001 · Cited by 20 · see citing works

The dual role of VDAC in cancer: Molecular mechanisms and advances in targeted therapy

Huang, H., Chen, M., Feng, S., Lin, Z., & Liu, Y. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118530 · Cited by 15 · see citing works

The importance of mitochondria and mitochondrial calcium signaling in health and disease: an updated outlook on inflammation

Morciano, G., Pellielo, G., Agyapong, E. D., Pellegrino, C., Patergnani, S., Franceschini, D., Koutsikos, K., Rigon, L., Pinton, P., & Rimessi, A. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07783-1 · Cited by 17 · see citing works

Precision targeting of STING: Challenges, innovations, and clinical outlook for cancer therapy

Shi, J., Zhang, Y., Zhao, N., Seki, E., Ma, L., Kocic, G. M., Li, X., Terzić, J., & Zheng, T. (2025) · The Innovation · doi:10.1016/j.xinn.2025.101074 · Cited by 14 · see citing works

Neoepitopes at the crossroads of immunometabolism: metabolic remodeling of antigen presentation in type 1 diabetes

Mittal, R., Goldmann, R., Mittal, M., Chaudhary, N., Ravindra, V., & Hirani, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1744422 · Cited by 13 · see citing works

The Role of Senescence, its Therapeutic Relevance and Clinical Implications in the Tumor Microenvironment

Shi, H., Xiao, M., Li, Y., Liu, X., Na, J., Liang, C., Hua, J., Meng, Q., Wei, M., Wang, W., et al. (2025) · Theranostics · doi:10.7150/thno.112633 · Cited by 12 · see citing works

The roles of the mtDNA-cGAS-STING axis in tumor immunity: from immune activation to immune evasion

Huang, N., Liu, Z., Lei, H., & Liu, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1739559 · Cited by 11 · see citing works

mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression

Cañadas, I., Murayama, T., & Galluzzi, L. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.06.010 · Cited by 11 · see citing works

The interplay between DNA damage response and mitochondrial dysfunction in radiotherapy

Yang, S., Li, Y., Zhang, J., Shen, A., Hu, B., & Yan, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1642100 · Cited by 11 · see citing works

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

Gong, N., Pan, X., Deng, Y., Che, J., Bao, J., Wang, M., Xu, C., Liu, X., & Shi, Y. (2025) · MedComm · doi:10.1002/mco2.70515 · Cited by 11 · see citing works

The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities

Zhang, X.-R., Wei, B., Jiang, B.-H., & Ren, W. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02645-2 · Cited by 10 · see citing works

Mitochondrial DNA release via VDAC1 in keratinocytes: a key driver of innate immunity and vitiligo pathogenesis

Lv, J., Xu, W., Jiang, P., Yu, W., Xue, H., Hu, N., Cao, Y., Zhang, H., Yin, C., & Gao, R. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08585-5 · Cited by 10 · see citing works

Mitochondrial-targeted photodynamic therapy combined with TGF-β inhibition potentiates anti-PD-1 therapy in pancreatic ductal adenocarcinoma

Xu, S., Yang, N., Du, F., Zhang, Z., Zhang, Y., Zhang, Y., Liang, J., Zhao, Y., Zhang, J., Zhang, Z., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03795-z · Cited by 8 · see citing works

cGAS-STING pathway as a promising target for digestive diseases: insights from natural plant products

Long, D., Mao, C., Zhu, Y., & Xu, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1594120 · Cited by 7 · see citing works

Engineering Metal‐Organic‐Framework‐Based STING Nanoagonists for PROTAC‐Enhanced Cancer Chemo‐Metalloimmunotherapy

Chen, Z., Feng, Z., Wang, S., & Zhang, J. (2025) · Advanced Science · doi:10.1002/advs.202515006 · Cited by 7 · see citing works

Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation

Han, H., Yu, D., Liu, Y., Jia, H., & Liu, W. (2025) · Science Advances · doi:10.1126/sciadv.adz4126 · Cited by 7 · see citing works

Mitochondrial DNA as a driver of inflammation via the cGAS-STING pathway

Wen, X., Yang, F., Zhang, L., & Huang, D. (2026) · Inflammation Research · doi:10.1007/s00011-026-02231-8 · Cited by 6 · see citing works

Mitochondrial quality control in health and disease: mechanisms and therapeutic targets

Creus, A., Mohapatra, S., Ortega, L., & Sebastián, D. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02813-2 · Cited by 7 · see citing works

The role and mechanisms of the cGAS-STING signaling pathway in age-related pathophysiological processes: challenges and therapeutic strategies

Wei, Y., Cai, S., Ji, Y., Wang, J., Shang, T., Dai, B., & Sun, H. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118317 · Cited by 5 · see citing works

Research on the interactive mechanisms between mitochondrial variations and immune responses in gliomas based on integrated visualization analysis

Li, S., Lu, E., Mi, L., Li, C., Guan, H., Cao, T., & Zhang, Q. (2025) · Discover Oncology · doi:10.1007/s12672-025-03926-w · Cited by 4 · see citing works

SNHG18 deficiency reprograms arginine metabolism to foster an immunosuppressive microenvironment in prostate cancer bone metastasis

Xie, Z., Li, S., Yang, J., Zhang, Z., Li, S., Lang, C., Yang, M., Wang, B., Yu, X., Li, Z., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218326 · Cited by 5 · see citing works

Harnessing myeloid cell plasticity for cancer therapy

Sanseviero, E., Barry, S. T., & Gabrilovich, D. I. (2026) · Nature Cancer · doi:10.1038/s43018-026-01159-6 · Cited by 4 · see citing works

The cGAS–STING pathway in cancer immunotherapy: prognostic value and therapeutic potential

Alabi, F. A., Imodoye, S. O., Adedokun, K. A., Eltokhy, M. A., Curcic, M., Okoyeocha, E., Thapa, I., Tiwari, S., Ogundele, A. V., Ayo, T. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760947 · Cited by 4 · see citing works

The cGAS-STING pathway in age-related ocular diseases: Mechanisms and therapeutic opportunities

Shang, Z., Qin, D., Liu, X., Li, H., Liu, C., Zhang, R., Sun, T., Pan, Z., Feng, W., & You, X.-G. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112069 · Cited by 3 · see citing works

Targeting age-related cell-free DNA for prevention, early diagnosis and treatment of rheumatoid arthritis

Ma, N., Xu, Y., Zhang, D., Zhang, H., Luo, W., Cao, Y., & Wong, V. K. W. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103961 · Cited by 3 · see citing works

Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review

Hu, G., Li, Z., Chen, Y., Liao, H., & Zhou, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1664587 · Cited by 3 · see citing works

The cGAS-STING Pathway: Insights into Regulatory Mechanisms, Disease Dysregulation, and Therapeutic Development

Wang, Y., Lu, X., Tan, J. M., He, J., Yin, H., Chen, P., Wu, H., Luo, Y., & Li, M. (2025) · Life Conflux · doi:10.71321/dr57c347 · Cited by 3 · see citing works

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Li, J., Wang, Y., Fan, X., Xu, M., Li, J., Tan, W., Zhang, J., & Li, H. (2026) · Advanced Science · doi:10.1002/advs.202520383 · Cited by 4 · see citing works

AQP4-IgG-Induced Astrocyte-Derived Small Extracellular Vesicles Carrying Mitochondrial DNA Regulate the TLR9/MyD88/NF-κB Pathway to Drive Microglial Activation and Neuromyelitis Optica

Zhou, J., Li, H., Wen, Y., He, L., He, Y., & Meng, H. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04685-y · Cited by 3 · see citing works

Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury

Wu, C., Fu, Q., Liu, J., Fu, J., Zhang, B., Zhou, J., Xu, J., Zhang, Y., Zhu, T., Yang, L., et al. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101049 · Cited by 3 · see citing works

Pueraria flavones attenuate DSS-induced colitis by regulating the microbiota-bile acid-FXR/TGR5 axis and suppressing mtDNA-cGAS-STING signaling

Kang, L., Feng, C., Tang, Z., Gu, W., Wang, Y., Pei, A., & Piao, M. (2026) · iScience · doi:10.1016/j.isci.2026.115275 · Cited by 3 · see citing works

Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity

Arumugam, P., Heim, C. E., Fallet, R. W., Shinde, D., Thomas, V. C., Argüello, R. J., & Kielian, T. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117057 · Cited by 3 · see citing works

Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis

Yu, Q., Guo, K., Yang, Y., Liu, H., Han, Y., Yu, X., Wang, J., Zhao, Y., Su, X., Zhu, K., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04251-2 · Cited by 3 · see citing works

Therapy-induced senescent cancer cells as bidirectional regulators of antitumor immunity and resistance in the tumor microenvironment

Choi, M., Lee, D., Yang, W.-H., & Cha, J. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08688-z · Cited by 4 · see citing works

Danger or Salvation? The Role of DAMPs in Cancer Therapy

Vedunova, A. A., Guryev, E. L., Gudkov, S. V., Mishchenko, T. A., & Vedunova, M. V. (2026) · Cancers · doi:10.3390/cancers18091442 · Cited by 3 · see citing works

The Role of Mitochondrial Genome Stability and Metabolic Plasticity in Thyroid Cancer

Ren, L., Liu, W., Zheng, J., Wu, Q. Y., & Ai, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13112599 · Cited by 2 · see citing works

Mitochondrial involvement in PC: improving therapeutic strategies

Zhang, J., & Lou, C. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1710923 · Cited by 2 · see citing works

Beyond tumour suppression: cGAS‐STING pathway in urologic malignancies: Context‐dependent duality and therapeutic implications

Wei, Q., Zhao, K., Wu, Y., Wu, W., & Hao, N. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70531 · Cited by 2 · see citing works

Mechanosensitive Yes-Associated Protein/TAZ–cGAS–STING Axis Induces Periodontal Ligament Fibroblasts Senescence and Mediates Compression-Induced Root Resorption

Wu, Z., Bao, S., Chen, Q., Xiao, L., Guan, G., Song, R., Chen, Q., & Chen, X. (2025) · International Dental Journal · doi:10.1016/j.identj.2025.109303 · Cited by 2 · see citing works

Prokaryotic organelle mitochondria drive tumorigenesis: “the original sin”

Wang, C., Luo, M., Zhou, J., Zhang, Q., Xiawei, J., He, J., Wang, L., Huang, Y., Xu, X., & 王方岩 (2026) · Frontiers in Oncology · doi:10.3389/fonc.2025.1632702 · Cited by 2 · see citing works

Cytosolic Immunostimulatory DNA Ligands and DNA Damage Activate the Integrated Stress Response, Stress Granule Formation, and Cytokine Production

Devale, T., Katuri, L., Mishra, G., Acharya, A., Manivannan, P., Hibbard, B. R., & Malathi, K. (2026) · Cells · doi:10.3390/cells15020139 · Cited by 2 · see citing works

Electroacupuncture-Activated Mitochondria-Targeted Polymeric Radicals for cGAS-STING-Activated Immunotherapy

Li, Y., Zhang, Y., Nie, R., Yan, C., Tao, Y., Liu, X., Ning, H., Yuan, K., Liu, Z., Liu, Z., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c19551 · Cited by 2 · see citing works

cGAS–STING signaling pathway in urogenital oncology: Regulation, resistance, and routes to response

Gong, C., Li, S., Huang, Y., Luo, E., Tan, Z., Li, H., Kong, Y., & Ding, M. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105222 · Cited by 2 · see citing works

cGAS-STING signaling in pollution-induced toxicity: mechanism and relieving medication

Yan, M., Li, S., Wei, Y., Wu, J., Zhou, X., Yang, K., & Liang, Y. A. N. G. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02301-6 · Cited by 2 · see citing works

Challenges and advances in drug resistance and tolerance in cancer

Bivona, T. G., Yanai, I., Calabrò, F., Mechta‐Grigoriou, F., Corleone, G., Martile, M. D., Tocci, A., Tocci, P., Vaccarella, S., Ferriero, M., et al. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03665-y · Cited by 2 · see citing works

Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy

Hu, X., Lai, W., Liu, M., & Wang, B. (2026) · Chinese Medical Journal · doi:10.1097/cm9.0000000000004042 · Cited by 2 · see citing works

Inside Out: How Cellular Localisation Shapes cGAS Functions in Health and Disease

Wu, J., Zhou, Y., Zeng, B., Wang, Y., & Wang, C. (2026) · Immunology · doi:10.1111/imm.70133 · Cited by 2 · see citing works

Cuproptosis in spinal cord injury: emerging mechanisms and immunological relevance

Li, L.-H., Zhang, J.-Q., Ying, X.-H., Huang, Y., Xu, C.-C., Wang, X., He, K.-L., & Ma, R. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2641867 · Cited by 2 · see citing works

Endothelial NAD + depletion drives vascular senescence and neuroinflammation via mtDNA‐cGAS/STING‐CD38 signaling in Alzheimer's disease

Luo, Q., Li, F., Yang, L., Pan, H., Zhu, W., Hu, P., Tao, C., Yin, M., Zhang, S., Liao, Q., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71423 · Cited by 2 · see citing works

IFI204 drives gasdermin D–mediated mitochondrial permeabilization to amplify neuronal pyroptosis in ischemic stroke

Xu, P., Shen, N., 邱添, Zhou, M., Li, R., Tao, C., Zhu, Y., & Hu, W. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03847-7 · Cited by 2 · see citing works

Mitochondrial DNA release contributes to neuropathic pain via a cGAS-STING-IRF3-CMPK2-associated immunometabolic feedback mechanism

Wang, B., Zeng, H., Zhan, H., Xu, Y., Hu, Z., Pang, J., Zhang, Z., Ma, Y., & Wu, W. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08314-8 · Cited by 2 · see citing works

Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging

Huang, J., Sun, X., Liu, H., Li, K. E. X. I. N., Liu, X., Bai, Y., Dong, Z., Wu, X., Liu, X., Jia, L., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08882-z · Cited by 2 · see citing works

Mitochondrial dynamics and metabolic regulation in cellular inflammation: From mechanisms to precision therapeutics

Park, W. H. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109086 · Cited by 2 · see citing works

The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

Wang, Y., Angulo-Lozano, J. C., Wang, Y., & Deng, L. (2026) · Journal of Clinical Investigation · doi:10.1172/jci204552 · Cited by 2 · see citing works

Immune surveillance and immune evasion of senescent cells

Garcia-Baucells, P., Serrano, M., & Amor, C. (2026) · Nature reviews. Immunology · doi:10.1038/s41577-026-01335-w · Cited by 3 · see citing works

The mtDNA-ZBP1 axis in alzheimer's disease: Mechanisms, pathogenesis, and therapeutic implications

Chen, Y., Liu, Y., Hu, H., & Li, S. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115853 · Cited by 1 · see citing works

Dendritic cell-derived biomimetic vesicles as cancer vaccine platforms for melanoma immunotherapy

Liu, J., Lu, J., Miao, F., Wu, L., Ding, L., Ma, T., Wang, R., Han, Y., Cui, Z., Chen, Z., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114405 · Cited by 1 · see citing works

m 1 A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Li, T., Huang, M., Cai, J., Li, X., Xing, Y., He, R., Wan, Z., Gan, Y., Li, Z., Weng, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202518536 · Cited by 1 · see citing works

LINE-1 Retrotransposon Protein ORF1p Forms Condensates That Drive cGAS-Induced Immune Evasion in Lung Squamous Cell Carcinoma

Xing, B., Liu, J., Xie, Y., Liu, P., Zhang, L., Tian, W., Yu, W., Wang, H., Wang, J., Sun, Z., et al. (2026) · Cancer Research · doi:10.1158/0008-5472.can-25-2611 · Cited by 1 · see citing works

Targeting Myeloid-Derived Suppressor Cells: A Promising Strategy for Cancer Treatment

Wang, Z., Li, M., Hua, D., Hu, X., & Wang, Y. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-025-00485-y · Cited by 1 · see citing works

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

Wang, Q., Sun, X., Han, X., Zhang, X., Wang, W., Wang, H., Ren, H., & Gu, L. (2026) · MedComm – Oncology · doi:10.1002/mog2.70054 · Cited by 1 · see citing works

Myeloid-derived suppressor cells promote therapy-induced resistance in prostate cancer

Liu, A., Song, P., Liu, Z., Colucci, M., Lai, P., Yang, L., Yan, X., Qiu, H., & Dong, Q. (2026) · International Journal of Surgery · doi:10.1097/js9.0000000000004227 · Cited by 1 · see citing works

Targeting the cGAS-STING pathway in ophthalmology: from innate immunity to therapeutic innovation

Yan, D., Ouyang, W., Li, K., & Sun, X. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.110978 · Cited by 1 · see citing works

Enhanced photodynamic therapy induces dual nuclear/mitochondrial DNA damage and cGAS/STING-driven innate immunity for improved colorectal cancer immunotherapy

Zhu, D., Huang, W., Wang, Y., Yang, Y., Su, F., Lu, C., Lin, Z., Zhou, E., Chen, Z., Liu, R., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.175330 · Cited by 1 · see citing works

ATP-responsive metal–polyphenol networks deliver celastrol to cancer cell mitochondria to activate mtDNA–cGAS–STING axis and boost tumor immunotherapy

Zhang, Z., Tong, J., Cao, X., Xu, W., Qi, Z., Kuang, X., Huang, Y., He, Y., Zeng, C., Hu, M., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.175311 · Cited by 1 · see citing works

L-Arginine-Modified Chitosan Curcumin Nanocrystals Target M1 Macrophages via CAT-2/Clathrin-Mediated Endocytosis for Mitochondrial Protection and ALI/ARDS Therapy

Yang, X., Wu, S. Q., Dou, Z., Dong, Y., & Dai, J. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18040425 · Cited by 1 · see citing works

Neutrophil polarization landscapes in HCC: From immunosuppressive niches to antitumor immunity resuscitation

Sun, J., Yang, F., Li, Y., Li, S., & Song, J. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218527 · Cited by 2 · see citing works

VDAC2 deficiency: a new target for cancer immunotherapy and regulation of inflammatory responses

Fu, Y., Gao, F., & Yu, Y. (2026) · Medicine Plus · doi:10.1016/j.medp.2026.100139 · Cited by 1 · see citing works

Mitochondrial Stress Orchestrates Tumor Immune Evasion and Immunotherapy Resistance

Bılır, A., Yıldırım, B., & Karalök, M. H. (2026) · Cells · doi:10.3390/cells15100890 · Cited by 1 · see citing works

Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence

Zaongo, S. D., Yang, Q., Han, M., Xi, T., Luo, Z., Wang, X., Yang, J., & Ouyang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792954 · Cited by 1 · see citing works

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Zhong, S., Chen, W., Liu, F., Zhou, S., Yu, B., Wang, Y., Zhou, X., Wang, X., Liu, D., Zhang, Z., et al. (2026) · Advanced Science · doi:10.1002/advs.76321 · Cited by 1 · see citing works

Neurovascular unit senescence as a driver of blood–brain barrier dysfunction in Alzheimer’s disease：Mechanisms, consequences, and therapeutic implications

Yao, M., Liu, A., Xing, L., Song, J., Yang, Y., Yue, X., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103260 · Cited by 1 · see citing works

From binary senescence to state-resolved senotherapy in cancer: Therapeutic windows from heterogeneity

Xu, Z., Guo, J., Liu, Z., Yu, J., Yuan, R., Min, Y., Wei, Z., & Peng, X. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103270 · Cited by 1 · see citing works

Glycerol-3-Phosphate Attenuates Hypoxic-Ischemic Brain Injury via Modulation of Microglia-Mediated Neuroinflammation

Qin, D., Lei, Y., Le, M., Cheng, M., Zhao, Y., Xia, L., Li, X., & Dong, X. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04848-x · Cited by 1 · see citing works

Mitochondrial transfer in the tumor microenvironment: Mechanisms, immunometabolic consequences, and therapeutic implications

Feng, S., Hu, Y., Li, S., 常玉巧, Li, Z., Liu, Y., & Xu, K. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105530 · Cited by 1 · see citing works

Reprogramming Autoimmune Immunity via Mitochondrial Quality Control: Mechanisms, Biomarkers, and Windows for Intervention

Chen, X., Ding, J., Liu-qing, M. E. N. G., Li, S., Chen, Y., Wei, X., Hu, W., Wang, K., Yao, F., Zhao, Y.-J., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117316 · Cited by 1 · see citing works

STING’s suppressive turn in PMN-MDSCs

Liang, D., & Zheng, S. G. (2025) · Aging Research · doi:10.26599/agr.2025.9340052

Recharging cellular immunotherapy – targeting immunometabolic aging

Rallis, K. S., Pommier, A., Singh, A. K., & Cancelas, J. A. (2025) · Immunotherapy · doi:10.1080/1750743x.2025.2607468

Decoding mitochondrial signaling: neutrophil-tumor cell crosstalk in orchestrating cancer progression

Shen, Q., Pan, X., Li, J., Li, Y., Lin, J., Liu, F., Jiang, X., Zhang, C., & Pang, B. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07659-w

Ganciclovir for refractory allergic rhinitis: a case series and literature review

Hu, Q., Hao, Y., Gao, P., Long, Z., Huo, B., Cheng, X., Xie, T., Li, L., Zhou, T., Zhou, L., et al. (2026) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-025-09977-7

Multimodal psychological intervention improves psychological well-being and inflammatory profiles in patients with diabetic nephropathy

Tang, H., & Liu, S. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168171

The human and murine immune systems: regulated by dichotomous molecules

Silva, R. C. M. C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116329

A 2D/0D hybrid magnetothermal platform enables multimodal energy synergy for inducing irreversible tumor senescence and promoting immune remodeling

Liang, X., Li, Z., Zeng, G., Qin, J., Yuan, L., Zhou, Y., Tao, N., Deng, L., Wang, D., & Chen, J. (2026) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-026-01682-1

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

Mao, H., Liu, W., Su, Y., Ma, Y., Zhao, X., & Lu, Y. (2026) · MedComm – Oncology · doi:10.1002/mog2.70060

Integrative multi-omics and experimental validation identify histone acetylation-related genes BCL9L, STX10 and LSM7 as key mediators of PD-1-driven immune evasion and prognosis in non-small cell lung cancer

Zhou, J., Qiu, T., Hu, Z., Xiao, D., & Liu, Z. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116424

Mitochondria and tumor microenvironment

Taghizadeh‐Hesary, F., & Bitarafan, F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40535-8.00017-x

RNA Methylation and T Cells in Tumor Immunity: Functions, Therapeutic Strategies, and Prospections

Shang, S., & Ma, L. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015037

Mitochondrial DNA released by senescent cells triggers immunosuppression in cancerPreprint

Lai, P., Liu, L., Bancaro, N., Troiani, M., Calì, B., Chen, J., Singh, P. K., Arzola, R. A., Attanasio, G., Pernigoni, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.06.551763 · Cited by 2 · see citing works

The Role of mtDNA in Senescence and Prostate Cancer Immune Response Regulation

Lai, P. (2024) · SERVAL (Université de Lausanne)

mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression

Cañadas, I., Murayama, T., & Galluzzi, L. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.06.010 · Cited by 11 · see citing works

STING’s suppressive turn in PMN-MDSCs

Liang, D., & Zheng, S. G. (2025) · Aging Research · doi:10.26599/agr.2025.9340052

Mitochondrial DNA release and cGAS-STING activation: Emerging insights into anti-tumor immunity

Aloraini, G. S. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156158 · Cited by 38 · see citing works