Cited by 176Natural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesMedicinal Plant Research

Vernonia cinerea leaves as the source of phenolic compounds, antioxidants, and anti-diabetic activity using microwave-assisted extraction technique

Alara, Oluwaseun Ruth, Abdurahman, Nour Hamid, Ukaegbu, Chinonso Ishmael, Azhari, Nour Hamid·2018·Industrial Crops and Products

Abstract

Diabetes mellitus is a metabolic disorder disease emanating from the inability of body’s response to high glucose levels in the blood. However, the side-effects from consuming synthetic drugs have reduced the effectiveness, thus, the potential of purple fleabane (Vernonia cinerea) leaf was investigated using microwave-assisted extraction (MAE) in this study. The influences of extraction factors such as irradiation time, microwave power level, feed/solvent, and ethanol concentration on the recovery yields of polyphenol and flavonoids were as well studied. Thirty experimental runs using a face-centered central composite design (FCCCD) with six centre points were employed and optimal yields were obtained by generating quadratic models based on response surface methodology. The obtained optimal MAE conditions were as follows: irradiation time, 2 min; microwave power level, 444 W; feed/solvent, 1:14 g/mL; and ethanol concentration, 47% v/v. There was an insignificant difference between the predicted and experimental data (p > 0.05), showing good predictive models for the extraction of phenolic compounds from V. cinerea leaves using MAE. Also, the results confirmed that MAE can recover higher phenolic compounds, antioxidant, and anti-diabetic activities from V. cinerea leaves in shorter extraction time. In addition, the phenolic compounds in V. cinerea leaf extract were identified using liquid chromatography-mass spectrometry quadrupole time of flight (LC–MS-Q-TOF) and Fourier tran…

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Crossref · 10.1016/j.indcrop.2018.06.034

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Authors
Alara, O. R., Abdurahman, N. H., Ukaegbu, C. I., & Azhari, N. H.
Affiliations
  • Universiti Malaysia Pahang Al-Sultan Abdullah (MY)
  • International University of Africa (SD)
Venue
Industrial Crops and Products
Publisher
Elsevier BV
Published
2018-10
Volume
122
Pages
533-544
ISSN
0926-6690 (ISSN-L)
OpenAlex
W2808345003
Cited by
176
References
52
Citations by year
2026: 9 · 2025: 20 · 2024: 23 · 2023: 29 · 2022: 17 · 2021: 29 · 2020: 21 · 2019: 21 · 2018: 7
FWCI
15.63
Type
journal article
Language
en
Open access
closed
Locations
  • Industrial Crops and Products (publishedVersion)
  • UMP Institutional Repository (Universiti Malaysia Pahang) (acceptedVersion)
Funders
Universiti Malaysia Pahang (RDU180329)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Vernonia cinerea, microwave-assisted extraction, phenolic compounds, flavonoids, antioxidant activity, antidiabetic activity, diabetes mellitus, α-amylase inhibition, α-glycosidase inhibition, extraction optimization, response surface methodology, functional foods

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