The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients
Open accessAbstract
Background As an ongoing worldwide health issue, Coronavirus disease 2019 (COVID–19) has been causing serious complications, including pneumonia, acute respiratory distress syndrome (ARDS), and multi-organ failure. However, there is no decisive treatment approach available for this disorder, which is primarily attributed to the large amount of inflammatory cytokine production. We aimed to identify the effects of Nano-curcumin on the modulation of inflammatory cytokines in COVID-19 patients. Method Forty COVID-19 patients and 40 healthy controls were recruited and evaluated for inflammatory cytokine expression and secretion. Subsequently, COVID-19 patients were divided into two groups: 20 patients receiving Nano-curcumin and 20 patients as the placebo group. The mRNA expression and cytokine secretion levels of IL-1β, IL-6, TNF-α and IL‐18 were assessed by Real‐time PCR and ELISA, respectively. Result Our primary results indicated that the mRNA expression and cytokine secretion of IL-1β, IL-6, TNF-α, and IL-18 were increased significantly in COVID-19 patients compared with healthy control group. After treatment with Nano-curcumin, a significant decrease in IL-6 expression and secretion in serum and in supernatant (P = 0.0003, 0.0038, and 0.0001, respectively) and IL-1β gene expression and secretion level in serum and supernatant (P = 0.0017, 0.0082, and 0.0041, respectively) was observed. However, IL-18 mRNA expression and TNF-α concentration were not influenced by Nano-curcumin. Conclusion Nano-curcumin, as an anti-inflammatory herbal based agent, may be able to modulate the increased rate of inflammatory cytokines especially IL-1β and IL-6 mRNA expression and cytokine secretion in COVID-19 patients, which may cause an improvement in clinical manifestation and overall recovery.
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COVID-19: Virology, biology and novel laboratory diagnosis
Mohamadian, M., Chiti, H., Shoghli, A., Biglari, S., Parsamanesh, N., & Esmaeilzadeh, A. (2021) · The Journal of Gene Medicine · doi:10.1002/jgm.3303 · Cited by 371
Self-citationAntiinflammatory Activities of Curcumin and Spirulina: Focus on Their Role against COVID-19
Perna, A., Hay, E., Sellitto, C., Del Genio, E., De Falco, M., Guerra, G., De Luca, A., De Blasiis, P., & Lucariello, A. (2023) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2173354 · Cited by 12
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Metadata
- Authors
- Valizadeh, H., Abdolmohammadi-vahid, S., Danshina, S., Ziya Gencer, M., Ammari, A., Sadeghi, A., Roshangar, L., Aslani, S., Esmaeilzadeh, A., Ghaebi, M., Valizadeh, S., & Ahmadi, M.
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 89
- Issue
- Pt B
- Pages
- 107088
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W3093587072
- Cited by
- 267
- References
- 33
- FWCI
- 14.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Valizadeh, H., Abdolmohammadi-vahid, S., Danshina, S., Ziya Gencer, M., Ammari, A., Sadeghi, A., Roshangar, L., Aslani, S., Esmaeilzadeh, A., Ghaebi, M., Valizadeh, S., & Ahmadi, M. (2020). Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients. International Immunopharmacology. https://doi.org/10.1016/j.intimp.2020.107088
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