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Cited by 60Effects of Radiation ExposureCoenzyme Q10 studies and effectsRadiation Therapy and Dosimetry

Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways

Mohamed, Heba A., Said, Riham S.·2021·International Immunopharmacology
DOI 10.1016/j.intimp.2020.107347
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Abstract

Radiation enteropathy is one the most common clinical issue for patients receiving radiotherapy for abdominal/pelvic tumors which severely affect the quality of life of cancer patients due to dysplastic lesions (ischemia, ulcer, or fibrosis) that aggravate the radiation damage. Herein, this study demonstrated the prophylactic role of coenzyme Q10 (CoQ10), a powerful antioxidant, against radiotherapy-induced gastrointestinal injury. Male Sprague Dawley rats were divided into four groups: group 1 was defined as control, and group 2 was the irradiated group. Group 3 and 4 were CoQ10 control and radiation plus CoQ10 groups, respectively. CoQ10 (10 mg/kg) was orally administered for 10 days before 10 Gy whole-body radiation and was continued for 4 days post-irradiation. CoQ10 administration protected rats delivered a lethal dose of ϒ-radiation from changes in crypt-villus structures and promoted regeneration of the intestinal epithelium. CoQ10 attenuated radiation-induced oxidative stress by decreasing lipid peroxidation and increasing the antioxidant enzyme catalase activity and reduced glutathione level. CoQ10 also counteracts inflammatory response mediated after radiation exposure through downregulating intestinal NF-ĸB expression which subsequently decreased the level of inflammatory cytokine IL-6 and the expression of COX-2. Radiation-induced intestinal fibrosis confirmed via Masson's trichrome staining occurred through upregulating transforming growth factor (TGF)-β1 and matrix metalloproteinase (MMP)-9 expression, while CoQ10 administration significantly diminishes these effects which further confirmed the anti-fibrotic property of CoQ10. Therefore, CoQ10 is a promising radioprotector that could prevent intestinal complications and enhance the therapeutic ratio of radiotherapy in patients with pelvic tumors through suppressing the NF-kB/TGF-β1/MMP-9 signaling pathway.

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  • CoQ10 possesses anti-inflammatory and antioxidant properties, lowering inflammatory mediators such as TNFα, IL-6, and CRP through inhibition of NFκB.

    “Ekeuku et al. (2020) and Mohamed and Said (2021) found that CoQ10 possesses antiinflammatory and antioxidant properties: it lowers the level of inflammatory mediators such as TNFα, interleukin-6 (IL-6), and C-reactive protein (CRP). This occurs through inhibition of NFκB, the key regulator of inflammation.”

    From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Mohamed and Said 2021

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Authors
Mohamed, H. A., & Said, R. S.
Affiliations
Egyptian Atomic Energy Authority (EG)
Corresponding author
Said, Riham S.
ORCID
Mohamed, Heba A.
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2021-03
Volume
92
Pages
107347
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2020.107347
OpenAlex
W3118441478
Cited by
60
References
82
Citations by year
2026: 6 · 2025: 10 · 2024: 10 · 2023: 16 · 2022: 13 · 2021: 5
FWCI
5.84
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
coenzyme Q10, radiation enteritis, radiation protection, intestinal fibrosis, NF-κB signaling, TGF-β1, MMP-9, oxidative stress, intestinal inflammation, interleukin-6, cyclooxygenase-2, intestinal epithelial regeneration, antioxidant enzymes, whole-body irradiation, pelvic tumors
MeSH terms
Animals, Disease Models, Animal, Fibrosis, Gene Expression Regulation, Inflammation, Intestinal Diseases, Male, Radiation Injuries, Ubiquinone, Vitamins, Transforming Growth Factor beta, NF-kappa B, Rats, Sprague-Dawley, Matrix Metalloproteinase 9, Rats

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