Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes
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The GLA-MPS device's four-layered planar microfluidic structure allows integration of electrical read-out sensors in cell-culture chambers and circulation channel, enabling real-time and non-invasive monitoring of cell conditions and behaviors during culture and treatments.
“Owing to this feature, its another advantage is the capability to integrate electrical read-out sensors in cell-culture chambers and circulation channel, which allows monitoring cell conditions and behaviors during cell culture and treatments in a real-time and non-invasive fashion.38”
From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [38]
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The blood-brain barrier/neurovascular unit in health and disease
Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078 · see citing works
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
Muz, B., de la Puente, P., Azab, F., & Azab, A. K. (2015) · Hypoxia · doi:10.2147/hp.s93413 · Cited by 2,066 · see citing works
Kim, H. J., Huh, D., Hamilton, G., & Ingber, D. E. (2012) · Lab on a Chip · doi:10.1039/c2lc40074j · Cited by 1,734 · see citing works
Can Animal Models of Disease Reliably Inform Human Studies?
van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V., & Macleod, M. R. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000245 · Cited by 1,354 · see citing works
Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522193112 · Cited by 926 · see citing works
Muscular Thin Films for Building Actuators and Powering Devices
Feinberg, A. W., Feigel, A., Shevkoplyas, S. S., Sheehy, S., Whitesides, G. M., & Parker, K. K. (2007) · Science · doi:10.1126/science.1146885 · Cited by 765 · see citing works
Novel electrode technologies for neural recordings
Hong, G., & Lieber, C. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0140-6 · Cited by 695 · see citing works
Microfluidic Organ-on-a-Chip Models of Human Intestine
Bein, A., Shin, W., Jalili-Firoozinezhad, S., Park, M. H., Sontheimer-Phelps, A., Tovaglieri, A., Chalkiadaki, A., Kim, H. J., & Ingber, D. E. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.12.010 · Cited by 601 · see citing works
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
Monzel, A. S., Smits, L. M., Hemmer, K., Hachi, S., Moreno, E. L., van Wuellen, T., Jarazo, J., Walter, J., Brüggemann, I., Boussaad, I., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.03.010 · Cited by 435 · see citing works
Denning, C., Borgdorff, V., Crutchley, J., Firth, K. S. A., George, V., Kalra, S., Kondrashov, A., Hoang, M. D., Mosqueira, D., Patel, A., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.10.014 · Cited by 293 · see citing works
Zeck, G., & Fromherz, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181348698 · Cited by 290 · see citing works
Nguyen, T. A., Yin, T.-I., Reyes, D., & Urban, G. A. (2013) · Analytical Chemistry · doi:10.1021/ac402761s · Cited by 189 · see citing works
Flagged first, then by citations
Research works printed but not linked: 169
- Abassi Y.A. Xi B. Li N. Ouyang W. Seiler A. Watzele M. Kettenhofen R. Bohlen H. Ehlich A. Kolossov E. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment Br. J. Pharmacol. 165 2012 1424 1441 21838757 PMC3372727
- Agarwal A. Goss J. Cho A. McCain M. Parker K. Microfluidic heart on a chip for higher throughput pharmacological studies Lab Chip 13 2013 3599 3608 23807141 PMC3786400
- Alexander F.A. Eggert S. Wiest J. Skin-on-a-Chip: transepithelial electrical resistance and extracellular acidification measurements through an automated air-liquid interface Genes (Basel) 9 2018 PMC5852610 29466319
- Anava S. Greenbaum A. Ben Jacob E. Hanein Y. Ayali A. The regulative role of neurite mechanical tension in network development Biophys. J. 96 2009 1661 1670 19217881 PMC2717249
- Aung A. Bhullar I. Theprungsirikul J. Davey S. Lim H. Chiu Y.-J. Ma X. Dewan S. Lo Y.-H. McCulloch A. 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout Lab Chip 16 2015 153 162 26588203 PMC4681661
- Bank I.E.M. Timmers L. Gijsberts C.M. Zhang Y.-N. Mosterd A. Wang J.-W. Chan M.Y. Hoog V. Lim S. Sze S. The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease Expert Rev. Mol. Diagn. 15 2015 1577 1588 26535492
- Barizuddin S. Liu X. Mathai J.C. Hossain M. Kevin G.D. Gangopadhyay S. Automated targeting of cells to electrochemical electrodes using a surface chemistry approach for the measurement of quantal exocytosis ACS Chem. Neurosci. 1 2010 590 597 21113333 PMC2991071
- Bavli D. Prill S. Ezra E. Levy G. Cohen M. Vinken M. Vanfleteren J. Jaeger M. Nahmias Y. Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction Proc. Natl. Acad. Sci. U S A 113 2016 E2231 E2240 27044092 PMC4843487
- Bhatia S.N. Ingber D.E. Microfluidic organs-on-chips Nat. Biotechnol. 32 2014 760 772 25093883
- Booth R. Kim H. Characterization of a microfluidic in vitro model of the blood-brain barrier (muBBB) Lab Chip 12 2012 1784 1792 22422217
- Booth R. Kim H. Permeability analysis of neuroactive drugs through a dynamic microfluidic in vitro blood–brain barrier model Ann. Biomed. Eng. 42 2014 2379 2391 25118670
- Boudou T. Legant W.R. Mu A. Borochin M.A. Thavandiran N. Radisic M. Zandstra P.W. Epstein J.A. Margulies K.B. Chen C.S. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues Tissue Eng.Part A 18 2012 910 919 22092279 PMC3338105
- Bowen A.L. Martin S.R. Integration of on-chip peristaltic pumps and injection valves with microchip electrophoresis and electrochemical detection Electrophoresis 31 2010 2534 2540 20665914 PMC2921973
- Braam S.R. Tertoolen L. van de Stolpe A. Meyer T. Passier R. Mummery C.L. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes Stem Cell Res. 4 2010 107 116 20034863
- Brakeman P. Miao S. Cheng J. Lee C.-Z. Roy S. Fissell W.H. Ferrell N. A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells Biomicrofluidics 10 2016 64106 PMC5116024 27917253
- Bresadola M. Medicine and science in the life of Luigi Galvani (1737-1798) Brain Res.Bull. 46 1998 367 380 9739000
- Brown J.A. Codreanu S.G. Shi M. Sherrod S.D. Markov D.A. Neely M.D. Britt C.M. Hoilett O.S. Reiserer R.S. Samson P.C. Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit J. Neuroinflammation 13 2016 306 27955696 PMC5153753
- Brown J.A. Pensabene V. Markov D.A. Allwardt V. Neely M.D. Shi M. Britt C.M. Hoilett O.S. Yang Q. Brewer B.M. Recreating blood-brain barrier physiology and structure on chip: a novel neurovascular microfluidic bioreactor Biomicrofluidics 9 2015 PMC4627929 26576206
- Buehler S.M. Stubbe M. Gimsa U. Baumann W. Gimsa J. A decrease of intracellular ATP is compensated by increased respiration and acidification at sub-lethal parathion concentrations in murine embryonic neuronal cells: measurements in metabolic cell-culture chips Toxicol. Lett. 207 2011 182 190 21939746
- Butler M.I. Cryan J.F. Dinan T.G. Man and the microbiome: a new theory of everything? Annu. Rev. Clin. Psychol. 15 2019 371 398 30786244
- Byku M. Mann D.L. Neuromodulation of the failing heart: lost in translation? JACC Basic Transl. Sci. 1 2016 95 106 27525317 PMC4978351
- Caspi O. Itzhaki I. Kehat I. Gepstein A. Arbel G. Huber I. Satin J. Gepstein L. In Vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes Stem Cells Dev. 18 2009 161 172 18510453
- Chaffer C.L. Weinberg R.A. A perspective on cancer cell metastasis Science 331 2011 1559 1564 21436443
- Charwat V. Joksch M. Sticker D. Purtscher M. Rothbauer M. Ertl P. Monitoring cellular stress responses using integrated high-frequency impedance spectroscopy and time-resolved ELISA Analyst 139 2014 5271 5282 25137192
- Chaw K.C. Manimaran M. Tay F.E.H. Swaminathan S. Matrigel coated polydimethylsiloxane based microfluidic devices for studying metastatic and non-metastatic cancer cell invasion and migration Biomed. Microdevices 9 2007 597 602 17505887
- Chen H.-C.C. Boyden chamber assay Methods Mol. Biol. 294 2005 15 22 15576901
- Chen L. Ilham S.J. Guo T. Emadi S. Feng B. In vitro multichannel single-unit recordings of action potentials from mouse sciatic nerve Biomed. Phys. Eng. Express 3 2017 PMC5858727 29568573
- Cheng W. Klauke N. Smith G. Cooper J.M. Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes Electrophoresis 31 2010 1405 1413 20333720
- Cho S. Islas-Robles A. Nicolini A.M. Monks T.J. Yoon J.-Y. In situ, dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope Biosens. Bioelectron. 86 2016 697 705 27474967 PMC5028279
- Cimetta E. Godier-Furnémont A. Vunjak-Novakovic G. Bioengineering heart tissue for in vitro testing Curr. Opin. Biotechnol. 24 2013 926 932 23932513 PMC3783612
- Currie K.P.M. Inhibition of Ca2+ channels and adrenal catecholamine release by G protein coupled receptors Cell. Mol. Neurobiol. 30 2010 1201 1208 21061161 PMC3028936
- Curto V.F. Marchiori B. Hama A. Pappa A.M. Ferro M.P. Braendlein M. Rivnay J. Fiocchi M. Malliaras G.G. Ramuz M. Organic transistor platform with integrated microfluidics for in-line multi-parametric in vitro cell monitoring Microsyst. Nanoeng. 3 2017 17028 31057869 PMC6445009
- de Diego A.M. Electrophysiological and morphological features underlying neurotransmission efficacy at the splanchnic nerve-chromaffin cell synapse of bovine adrenal medulla Am. J. Physiol.Cell Physiol. 298 2010 C397 C405 19940070
- de Diego A.M.G. Gandia L. Garcia A.G. A physiological view of the central and peripheral mechanisms that regulate the release of catecholamines at the adrenal medulla Acta Physiol. 192 2008 287 301 18005392
- Deosarkar S.P. Prabhakarpandian B. Wang B. Sheffield J.B. Krynska B. Kiani M.F. A novel dynamic neonatal blood-brain barrier on a chip PLoS One 10 2015 e0142725 26555149 PMC4640840
- Dittami G.M. Rabbitt R.D. Electrically evoking and electrochemically resolving quantal release on a microchip Lab Chip 10 2009 30 35 20024047 PMC3000936
- Douville N.J. Tung Y.-C. Li R. Wang J.D. El-Sayed M. Takayama S. Fabrication of two-layered channel system with embedded electrodes to measure resistance across epithelial and endothelial barriers Anal. Chem. 82 2010 2505 2511 20178370 PMC2839931
- Douville N.J. Zamankhan P. Tung Y.C. Li R. Vaughan B.L. Tai C.F. White J. Christensen P.J. Grotberg J.B. Takayama S. Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model Lab Chip 11 2011 609 619 21152526
- Edington C.D. Chen W.L.K. Geishecker E. Kassis T. Soenksen L.R. Bhushan B.M. Freake D. Kirschner J. Maass C. Tsamandouras N. Interconnected microphysiological systems for quantitative biology and pharmacology studies Sci. Rep. 8 2018 4530 29540740 PMC5852083
- Essig M. Terzi F. Burtin M. Friedlander G. Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells Am. J. Physiol. Renal Physiol. 281 2001 F751 F762 11553522
- Even-Ram S. Yamada K.M. Cell migration in 3D matrix Curr. Opin. Cell Biol. 17 2005 524 532 16112853
- Falanga A.P. Pitingolo G. Celentano M. Cosentino A. Melone P. Vecchione R. Guarnieri D. Netti P.A. Shuttle-mediated nanoparticle transport across an in vitro brain endothelium under flow conditions Biotechnol. Bioeng. 114 2017 1087 1095 27861732
- Ferrell N. Desai R.R. Fleischman A.J. Roy S. Humes D.H. Fissell W.H. A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells Biotechnol. Bioeng. 107 2010 707 716 20552673 PMC3903011
- Gao C. Sun X. Gillis K.D. Fabrication of two-layer poly(dimethyl siloxane) devices for hydrodynamic cell trapping and exocytosis measurement with integrated indium tin oxide microelectrodes arrays Biomed. Microdevices 15 2013 445 451 23329291 PMC5002351
- Ges I.A. Brindley R.L. Currie K.P.M. Baudenbacher F.J. A microfluidic platform for chemical stimulation and real time analysis of catecholamine secretion from neuroendocrine cells Lab Chip 13 2013 4663 4673 24126415 PMC3892771
- Ges I.A. Currie K. Baudenbacher F. Electrochemical detection of catecholamine release using planar iridium oxide electrodes in nanoliter microfluidic cell culture volumes Biosens. Bioelectron. 34 2012 30 36 22398270 PMC3793634
- Gladkov A. Pigareva Y. Kutyina D. Kolpakov V. Bukatin A. Mukhina I. Kazantsev V. Pimashkin A. Design of cultured neuron networks in vitro with predefined connectivity using asymmetric microfluidic channels Sci. Rep. 7 2017 15625 29142321 PMC5688062
- Gribi S. du Bois de Dunilac S. Ghezzi D. Lacour S.P. A microfabricated nerve-on-a-chip platform for rapid assessment of neural conduction in explanted peripheral nerve fibers Nat. Commun. 9 2018 4403 30353009 PMC6199302
- Griep L.M. Wolbers F. de Wagenaar B. ter Braak P.M. Weksler B.B. Romero I.A. Couraud P.O. Vermes I. van der Meer A.D. van den Berg A. BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function Biomed. Microdevices 15 2013 145 150 22955726
- Grosberg A. Alford P.W. McCain M.L. Parker K. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip Lab Chip 11 2011 4165 4173 22072288 PMC4038963
- Heileman K. Daoud J. Tabrizian M. Dielectric spectroscopy as a viable biosensing tool for cell and tissue characterization and analysis Biosens. Bioelectron. 49 2013 348 359 23796534
- Henry O.Y.F. Villenave R. Cronce M.J. Leineweber W.D. Benz M.A. Ingber D.E. Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function Lab Chip 17 2017 2264 2271 28598479 PMC5526048
- Hittinger M. Schneider-Daum N. Lehr C.M. Cell and tissue-based in vitro models for improving the development of oral inhalation drug products Eur. J. Pharm. Biopharm. 118 2017 73 78 28254378
- Huang J.X. Blaskovich M.A. Cooper M.A. Cell- and biomarker-based assays for predicting nephrotoxicity Expert Opin. Drug Metab. Toxicol. 10 2014 1621 1635 25382677
- Huebsch N. Loskill P. Mandegar M.A. Marks N.C. Sheehan A.S. Ma Z. Mathur A. Nguyen T.N. Yoo J.C. Judge L.M. Automated video-based analysis of contractility and calcium flux in human-induced pluripotent stem cell-derived cardiomyocytes cultured over different spatial scales Tissue Eng. Part C Methods 21 2015 467 479 25333967 PMC4410286
- Hughes D.J. Kostrzewski T. Sceats E.L. Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems Exp. Biol. Med. 242 2017 1593 1604 PMC5661768 28504617
- Huh D. Leslie D.C. Matthews B.D. Fraser J.P. Jurek S. Hamilton G.A. Thorneloe K.S. McAlexander M.A. Ingber D.E. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice Sci. Transl. Med. 4 2012 159ra147 PMC8265389 23136042
- Huh D. Matthews B.D. Mammoto A. Montoya-Zavala M. Hsin H.Y. Ingber D.E. Reconstituting organ-level lung functions on a chip Science 328 2010 1662 1668 20576885 PMC8335790
- Huval R.M. Miller O.H. Curley J.L. Fan Y. Hall B.J. Moore M.J. Microengineered peripheral nerve-on-a-chip for preclinical physiological testing Lab Chip 15 2015 2221 2232 25850799
- Ingber D.E. Reverse engineering human pathophysiology with organs-on-chips Cell 164 2016 1105 1109 26967278
- Ionescu A. Zahavi E.E. Gradus T. Ben-Yaakov K. Perlson E. Compartmental microfluidic system for studying muscle-neuron communication and neuromuscular junction maintenance Eur. J.Cell Biol. 95 2016 69 88 26689471
- Jang K.J. Cho H.S. Kang D.H. Bae W.G. Kwon T.H. Suh K.Y. Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells Integr. Biol. (Camb.) 3 2011 134 141 21079870
- Jang K.J. Mehr A.P. Hamilton G.A. McPartlin L.A. Chung S. Suh K.Y. Ingber D.E. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment Integr. Biol. (Camb.) 5 2013 1119 1129 23644926
- Jang M.J. Kim W.R. Joo S. Ryu J.R. Lee E. Nam Y. Sun W. Cell-type dependent effect of surface-patterned microdot arrays on neuronal growth Front. Neurosci. 10 2016 217 27242421 PMC4870857
- Jeong S. Kim S. Buonocore J. Park J. Welsh C.J. Li J. Han A. A three-dimensional arrayed microfluidic blood-brain barrier model with integrated electrical sensor array IEEE Trans. Biomed. Eng. 65 2018 431 439 29346110 PMC11233983
- Jiang B. Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment Genes Dis. 4 2017 25 27 30258905 PMC6136593
- Johnson C. Han Y. Hughart N. McCarra J. Alpini G. Meng F. Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer Transl. Gastrointest. Cancer 1 2012 58 70 22724089 PMC3378312
- Joy J.E. Johnston R.B. Institute of Medicine Committee on Multiple Sclerosis: Current Status and Strategies for the Future Multiple Sclerosis: Current Status and Strategies for the Future 2001 National Academy Press 25057543
- Jungblut M. Knoll W. Thielemann C. Pottek M. Triangular neuronal networks on microelectrode arrays: an approach to improve the properties of low-density networks for extracellular recording Biomed. Microdevices 11 2009 1269 1278 19757074 PMC2776171
- Kanagasabapathi T.T. Ciliberti D. Martinoia S. Wadman W.J. Decre M.M. Dual-compartment neurofluidic system for electrophysiological measurements in physically segregated and functionally connected neuronal cell culture Front. Neuroeng. 4 2011 13 22025913 PMC3198030
- Kanagasabapathi T.T. Franco M. Barone R.A. Martinoia S. Wadman W.J. Decre M.M. Selective pharmacological manipulation of cortical-thalamic co-cultures in a dual-compartment device J. Neurosci. Methods 214 2013 1 8 23305774
- Kanagasabapathi T.T. Massobrio P. Barone R.A. Tedesco M. Martinoia S. Wadman W.J. Decre M.M. Functional connectivity and dynamics of cortical-thalamic networks co-cultured in a dual compartment device J. Neural Eng. 9 2012 22614532
- Kato Y. Ozawa S. Miyamoto C. Maehata Y. Suzuki A. Maeda T. Baba Y. Acidic extracellular microenvironment and cancer Cancer Cell Int. 13 2013 89 24004445 PMC3849184
- Khoshakhlagh P. Sivakumar A. Pace L.A. Sazer D.W. Moore M.J. Methods for fabrication and evaluation of a 3D microengineered model of myelinated peripheral nerve J. Neural Eng. 15 2018 064001 30211687 PMC6239950
- Kim B.N. Herbst A.D. Kim S.J. Minch B.A. Lindau M. Parallel recording of neurotransmitters release from chromaffin cells using a 10×10 CMOS IC potentiostat array with on-chip working electrodes Biosens. Bioelectron. 41 2013 736 744 23084756 PMC3525730
- Kim H.J. Lee J. Choi J.-H. Bahinski A. Ingber D.E. Co-culture of living microbiome with microengineered human intestinal villi in a gut-on-a-chip microfluidic device J. Vis. Exp. 2016 e54344 PMC5091968 27684630
- Kim S.H. Kang J.H. Chung I.Y. Chung B.G. Mucin (MUC5AC) expression by lung epithelial cells cultured in a microfluidic gradient device Electrophoresis 32 2011 254 260 21254123
- Kirby R. Cho E.J. Gehrke B. Bayer T. Park Y.S. Neikirk D.P. McDevitt J.T. Ellington A.D. Aptamer-based sensor arrays for the detection and quantitation of proteins Anal. Chem. 76 2004 4066 4075 15253644
- Kleinfeld D. Kahler K.H. Hockberger P.E. Controlled outgrowth of dissociated neurons on patterned substrates J. Neurosci. 8 1988 4098 4120 3054009 PMC6569488
- Koester P. Buehler S. Stubbe M. Tautorat C. Niendorf M. Baumann W. Gimsa J. Modular glass chip system measuring the electric activity and adhesion of neuronal cells —application and drug testing with sodium valproic acid Lab Chip 10 2010 1579 1586 20358045
- Koester P.J. Buehler S.M. Stubbe M. Tautorat C. Niendorf M. Baumann W. Gimsa J. Modular glass chip system measuring the electric activity and adhesion of neuronal cells–application and drug testing with sodium valproic acid Lab Chip 10 2010 1579 1586 20358045
- Koziolek M. Grimm M. Schneider F. Jedamzik P. Sager M. Kuhn J.P. Siegmund W. Weitschies W. Navigating the human gastrointestinal tract for oral drug delivery: uncharted waters and new frontiers Adv. Drug Deliv. Rev. 101 2016 75 88 27037063
- Kujala V.J. Pasqualini F. Goss J.A. Nawroth J.C. Parker K. Laminar ventricular myocardium on a microelectrode array-based chip J. Mater. Chem. B 4 2016 3534 3543 32263387
- Lee S. Ko J. Park D. Lee S.R. Chung M. Lee Y. Jeon N.L. Microfluidic-based vascularized microphysiological systems Lab Chip 18 2018 2686 2709 30110034
- Lei K. Tseng H.-P. Lee C.-Y. Tsang N.-M. Quantitative study of cell invasion process under extracellular stimulation of cytokine in a microfluidic device Sci. Rep. 6 2016 25557 27150137 PMC4858876
- Levsky J.M. Singer R.H. Gene expression and the myth of the average cell Trends Cell Biol. 13 2003 4 6 12480334
- Lewandowska M.K. Bakkum D.J. Rompani S.B. Hierlemann A. Recording large extracellular spikes in microchannels along many axonal sites from individual neurons PLoS One 10 2015 e0118514 25734567 PMC4348166
- Li M.W. Martin S.R. Microchip-based integration of cell immobilization, electrophoresis, post-column derivatization, and fluorescence detection for monitoring the release of dopamine from PC 12 cells Analyst 133 2008 1358 1366 18810283 PMC2613758
- Lind J.U. Busbee T.A. Valentine A.D. Pasqualini F.S. Yuan H. Yadid M. Park S.-J. Kotikian A. Nesmith A.P. Campbell P.H. Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing Nat. Mater. 16 2016 PMC5321777 27775708
- Lind J.U. Yadid M. Perkins I. O'Connor B.B. Eweje F. Chantre C.O. Hemphill M.A. Yuan H. Campbell P.H. Vlassak J.J. Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening Lab Chip 17 2017 3692 3703 28976521 PMC5810940
- Liu X. Barizuddin S. Shin W. Mathai C.J. Gangopadhyay S. Gillis K.D. Microwell device for targeting single cells to electrochemical microelectrodes for high-throughput amperometric detection of quantal exocytosis Anal. Chem. 83 2011 2445 2451 21355543 PMC3069130
- Lonardoni D. Amin H. Zordan S. Boi F. Lecomte A. Angotzi G.N. Berdondini L. Active high-density electrode arrays: technology and applications in neuronal cell cultures Adv. Neurobiol. 22 2019 253 273 31073940
- Ma Z. Liu Q. Liu H. Yang H. Yun J.X. Eisenberg C. Borg T.K. Xu M. Gao B.Z. Laser-patterned stem-cell bridges in a cardiac muscle model for on-chip electrical conductivity analyses Lab Chip 12 2011 566 573 22170399 PMC3342821
- Maoz B.M. Herland A. Henry O.Y.F. Leineweber W.D. Yadid M. Doyle J. Mannix R. Kujala V.J. FitzGerald E.A. Parker K. Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities Lab Chip 17 2017 2294 2302 28608907
- Marconi E. Nieus T. Maccione A. Valente P. Simi A. Messa M. Dante S. Baldelli P. Berdondini L. Benfenati F. Emergent functional properties of neuronal networks with controlled topology PLoS One 7 2012 e34648 22493706 PMC3321036
- Massry S.G. Glassock R.J. Massry & glassock's textbook of nephrology 4th edition 2001 Lippincott Williams & Wilkins
- Megha R. Leslie S.W. Anatomy, abdomen and pelvis, adrenal glands (suprarenal glands) StatPearls 2019 StatPearls Publishing Treasure Island (FL) https://www.ncbi.nlm.nih.gov/books/NBK482264/ 29489211
- Michael D.J. Wightman R.M. Electrochemical monitoring of biogenic amine neurotransmission in real time J. Pharm. Biomed. Anal. 19 1999 33 46 10698566
- Miller P.G. Shuler M.L. Design and demonstration of a pumpless 14 compartment microphysiological system Biotechnol. Bioeng. 113 2016 2213 2227 27070809
- Mori N. Morimoto Y. Takeuchi S. Skin integrated with perfusable vascular channels on a chip Biomaterials 116 2017 48 56 27914266
- Morimoto Y. Kato-Negishi M. Onoe H. Takeuchi S. Three-dimensional neuron-muscle constructs with neuromuscular junctions Biomaterials 34 2013 9413 9419 24041425
- Moutaux E. Charlot B. Genoux A. Saudou F. Cazorla M. An integrated microfluidic/microelectrode array for the study of activity-dependent intracellular dynamics in neuronal networks Lab Chip 18 2018 3425 3435 30289147
- Moya A. Ortega-Ribera M. Guimerà X. Sowade E. Zea M. Illa X. Ramon E. Villa R. Gracia-Sancho J. Gabriel G. Online oxygen monitoring using integrated inkjet-printed sensors in a liver-on-a-chip system Lab Chip 18 2018 2023 2035 29892739
- Musick K. Khatami D. Wheeler B.C. Three-dimensional micro-electrode array for recording dissociated neuronal cultures Lab Chip 9 2009 2036 2042 19568672 PMC2818679
- Neher E. Sakmann B. Single-channel currents recorded from membrane of denervated frog muscle fibres Nature 260 1976 799 802 1083489
- Nguemo F. Šaric T. Pfannkuche K. Watzele M. Reppel M. Hescheler J. In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements Cell Physiol. Biochem. 29 2012 819 832 22613982
- Oiwa K. Shimba K. Numata T. Takeuchi A. Kotani K. Jimbo Y. A device for co-culturing autonomic neurons and cardiomyocytes using micro-fabrication techniques Integr. Biol. (Camb.) 8 2016 341 348 26863082
- Oleaga C. Lavado A. Riu A. Rothemund S. Carmona-Moran C.A. Persaud K. Yurko A. Lear J. Narasimhan N. Long C.J. Long-term electrical and mechanical function monitoring of a human-on-a-chip system Adv. Funct. Mater. 29 2019 1805792 PMC9113405 35586798
- Oleaga C. Riu A. Rothemund S. Lavado A. McAleer C.W. Long C.J. Persaud K. Narasimhan N. Tran M. Roles J. Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system Biomaterials 182 2018 176 190 30130706 PMC6126670
- Ortega M.A. Fernandez-Garibay X. Castano A.G. De Chiara F. Hernandez-Albors A. Balaguer-Trias J. Ramon-Azcon J. Muscle-on-a-chip with an on-site multiplexed biosensing system for in situ monitoring of secreted IL-6 and TNF-alpha Lab Chip 19 2019 2568 2580 31243422
- Osaki T. Sivathanu V. Kamm R.D. Engineered 3D vascular and neuronal networks in a microfluidic platform Sci. Rep. 8 2018 5168 29581463 PMC5979969
- Pan L. Alagapan S. Franca E. Leondopulos S.S. DeMarse T.B. Brewer G.J. Wheeler B.C. An in vitro method to manipulate the direction and functional strength between neural populations Front. Neural Circuits 9 2015 32 26236198 PMC4500931
- Parrish J. Lim K. Zhang B. Radisic M. Woodfield T.B.F. New frontiers for biofabrication and bioreactor design in microphysiological system development Trends Biotechnol. 2019 PMC6874730 31202544
- Pedersen B.K. Febbraio M.A. Muscle as an endocrine organ: focus on muscle-derived interleukin-6 Physiol. Rev. 88 2008 1379 1406 18923185
- Peloso A. Katari R. Murphy S.V. Zambon J.P. DeFrancesco A. Farney A.C. Rogers J. Stratta R.J. Manzia T.M. Orlando G. Prospect for kidney bioengineering: shortcomings of the status quo Expert Opin. Biol. Ther. 15 2015 547 558 25640286
- Pine J. Recording action potentials from cultured neurons with extracellular microcircuit electrodes J. Neurosci. Methods 2 1980 19 31 7329089
- Portillo-Lara R. Annabi N. Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment Lab Chip 16 2016 4063 4081 27605305
- Qian F. Huang C. Lin Y.-D. Ivanovskaya A.N. O'Hara T.J. Booth R.H. Creek C.J. Enright H.A. Soscia D.A. Belle A.M. Simultaneous electrical recording of cardiac electrophysiology and contraction on chip Lab Chip 17 2017 1732 1739 28448074
- Ramadan Q. Ting F.C. In vitro micro-physiological immune-competent model of the human skin Lab Chip 16 2016 1899 1908 27098052
- Riahi R. Shaegh S.A.M. Ghaderi M. Zhang Y.S. Shin S.R. Aleman J. Massa S. Kim D. Dokmeci M.R. Khademhosseini A. Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers Sci. Rep. 6 2016 24598 27098564 PMC4838915
- Ripplinger C.M. Noujaim S.F. Linz D. The nervous heart Prog. Biophys. Mol. Biol. 120 2016 199 209 26780507 PMC4808395
- Robelek R. Wegener J. Label-free and time-resolved measurements of cell volume changes by surface plasmon resonance (SPR) spectroscopy Biosens. Bioelectron. 25 2010 1221 1224 19818594
- Rothbauer M. Charwat V. Bachmann B. Sticker D. Novak R. Wanzenbock H. Mathies R.A. Ertl P. Monitoring transient cell-to-cell interactions in a multi-layered and multi-functional allergy-on-a-chip system Lab Chip 19 2019 1916 1921 31070645
- Rowe L. Almasri M. Lee K. Fogleman N. Brewer G.J. Nam Y. Wheeler B.C. Vukasinovic J. Glezer A. Frazier A.B. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks Lab Chip 7 2007 475 482 17389964
- Sakai K. Shimba K. Kotani K. Jimbo Y. A co-culture microtunnel technique demonstrating a significant contribution of unmyelinated Schwann cells to the acceleration of axonal conduction in Schwann cell-regulated peripheral nerve development Integr. Biol. (Camb.) 9 2017 678 686 28581556
- Sato T. Clevers H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications Science 340 2013 1190 1194 23744940
- Selimovic A. Erkal J.L. Spence D.M. Martin R.S. Microfluidic device with tunable post arrays and integrated electrodes for studying cellular release Analyst 139 2014 5686 5694 25105251 PMC4313528
- Sellgren K.L. Butala E.J. Gilmour B.P. Randell S.H. Grego S. A biomimetic multicellular model of the airways using primary human cells Lab Chip 14 2014 3349 3358 25000964
- Shah P. Fritz J.V. Glaab E. Desai M.S. Greenhalgh K. Frachet A. Niegowska M. Estes M. Jäger C. Seguin-Devaux C. A microfluidics-based in vitro model of the gastrointestinal human–microbe interface Nat. Commun. 7 2016 11535 27168102 PMC4865890
- Sharma A.D. McCoy L. Jacobs E. Willey H. Behn J.Q. Nguyen H. Bolon B. Curley J.L. Moore M.J. Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform Sci. Rep. 9 2019 8921 31222141 PMC6586937
- Shin S. Zhang Y. Kim D.-J. Manbohi A. Avci H. Silvestri A. Aleman J. Hu N. Kilic T. Keung W. Aptamer-based microfluidic electrochemical biosensor for monitoring cell-secreted trace cardiac biomarkers Anal. Chem. 2016 PMC5844853 27617489
- Shin S.R. Kilic T. Zhang Y.S. Avci H. Hu N. Kim D. Branco C. Aleman J. Massa S. Silvestri A. Label-free and regenerative electrochemical microfluidic biosensors for continual monitoring of cell secretomes Adv. Sci. 4 2017 1600522 PMC5441508 28546915
- Skardal A. Murphy S.V. Devarasetty M. Mead I. Kang H.W. Seol Y.J. Shrike Zhang Y. Shin S.R. Zhao L. Aleman J. Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform Sci. Rep. 7 2017 8837 28821762 PMC5562747
- Smith A.S. Long C.J. Pirozzi K. Hickman J.J. A functional system for high-content screening of neuromuscular junctions in vitro Technology (Singap. World Sci.) 1 2013 37 48 25019094 PMC4092002
- Son K.J. Gheibi P. Stybayeva G. Rahimian A. Revzin A. Detecting cell-secreted growth factors in microfluidic devices using bead-based biosensors Microsyst. Nanoeng. 3 2017 17025 29963323 PMC6023413
- Spira M.E. Hai A. Multi-electrode array technologies for neuroscience and cardiology Nat. Nanotechnol. 8 2013 83 23380931
- Stancescu M. Molnar P. McAleer C.W. McLamb W. Long C.J. Oleaga C. Prot J.-M. Hickman J.J. A phenotypic in vitro model for the main determinants of human whole heart function Biomaterials 60 2015 20 30 25978005 PMC4458149
- Strakosas X. Sessolo M. Hama A. Rivnay J. Stavrinidou E. Malliaras G.G. Owens R.M. A facile biofunctionalisation route for solution processable conducting polymer devices J. Mater. Chem. B 2 2014 2537 2545 32261421
- Strakosas X. Wei B. Martin D.C. Owens R.M. Biofunctionalization of polydioxythiophene derivatives for biomedical applications J. Mater. Chem. B 4 2016 4952 4968 32264022
- Stucki J.D. Hobi N. Galimov A. Stucki A.O. Schneider-Daum N. Lehr C.M. Huwer H. Frick M. Funke-Chambour M. Geiser T. Medium throughput breathing human primary cell alveolus-on-chip model Sci. Rep. 8 2018 14359 30254327 PMC6156575
- Sun X. Gillis K.D. On-chip amperometric measurement of quantal catecholamine release using transparent indium tin oxide electrodes Anal. Chem. 78 2006 2521 2525 16615759
- Sung J.H. Wang Y.I. Narasimhan Sriram N. Jackson M. Long C. Hickman J.J. Shuler M.L. Recent advances in body-on-a-chip systems Anal. Chem. 91 2019 330 351 30472828 PMC6687466
- Takeuchi A. Nakafutami S. Tani H. Mori M. Takayama Y. Moriguchi H. Kotani K. Miwa K. Lee J.K. Noshiro M. Device for co-culture of sympathetic neurons and cardiomyocytes using microfabrication Lab Chip 11 2011 2268 2275 21566854
- Tandon N. Cannizzaro C. Chao P.-H.G.H. Maidhof R. Marsano A. Au H.T. Radisic M. Vunjak-Novakovic G. Electrical stimulation systems for cardiac tissue engineering Nat. Protoc. 4 2009 155 173 19180087 PMC2775058
- Tandon N. Marsano A. Maidhof R. Numata K. Montouri-Sorrentino C. Cannizzaro C. Voldman J. Vunjak-Novakovic G. Surface-patterned electrode bioreactor for electrical stimulation Lab Chip 10 2010 692 700 20221556 PMC3618471
- Taveggia C. Zanazzi G. Petrylak A. Yano H. Rosenbluth J. Einheber S. Xu X. Esper R.M. Loeb J.A. Shrager P. Neuregulin-1 type III determines the ensheathment fate of axons Neuron 47 2005 681 694 16129398 PMC2387056
- Thomas C.A. Jr. Springer P.A. Loeb G.E. Berwald-Netter Y. Okun L.M. A miniature microelectrode array to monitor the bioelectric activity of cultured cells Exp. Cell Res. 74 1972 61 66 4672477
- Toepke M.W. Beebe D.J. PDMS absorption of small molecules and consequences in microfluidic applications Lab Chip 6 2006 1484 1486 17203151
- Trapecar M. Communal C. Velazquez J. Maass C.A. Huang Y.-J. Schneider K. Wright C.W. Eng G. Yilmaz O. Trumper D. Gut-Liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids bioRxiv 2019 PMC8143761 32191873
- Uzel S.G. Platt R.J. Subramanian V. Pearl T.M. Rowlands C.J. Chan V. Boyer L.A. So P.T. Kamm R.D. Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units Sci. Adv. 2 2016 e1501429 27493991 PMC4972469
- Vala M. Robelek R. Bocková M. Wegener J. Homola J. Real-time label-free monitoring of the cellular response to osmotic stress using conventional and long-range surface plasmons Biosens. Bioelectron. 40 2013 417 421 22863117
- van der Helm M.W. Henry O.Y.F. Bein A. Hamkins-Indik T. Cronce M.J. Leineweber W.D. Odijk M. van der Meer A.D. Eijkel J.C.T. Ingber D.E. Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy Lab Chip 19 2019 452 463 30632575
- van der Helm M.W. van der Meer A.D. Eijkel J.C. van den Berg A. Segerink L.I. Microfluidic organ-on-chip technology for blood-brain barrier research Tissue Barriers 4 2016 e1142493 27141422 PMC4836466
- Van Gele M. Geusens B. Brochez L. Speeckaert R. Lambert J. Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations Expert Opin. Drug Deliv. 8 2011 705 720 21446890
- van Meer B.J. de Vries H. Firth K.S.A. van Weerd J. Tertoolen L.G.J. Karperien H.B.J. Jonkheijm P. Denning C. IJzerman A.P. Mummery C.L. Small molecule absorption by PDMS in the context of drug response bioassays Biochem. Biophys. Res. Commun. 482 2017 323 328 27856254 PMC5240851
- Vogel P.A. Halpin S.T. Martin R.S. Spence D.M. Microfluidic transendothelial electrical resistance measurement device that enables blood flow and postgrowth experiments Anal. Chem. 83 2011 4296 4301 21513343
- Wang Y.I. Abaci H.E. Shuler M.L. Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening Biotechnol. Bioeng. 114 2017 184 194 27399645 PMC6650146
- Weltin A. Slotwinski K. Kieninger J. Moser I. Jobst G. Wego M. Ehret R. Urban G.A. Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem Lab Chip 14 2013 138 146 24217869
- Wheeler B.C. Brewer G.J. Designing Neural Networks in Culture: experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes Proc. IEEE Inst. Electr.Electron. Eng. 98 2010 398 406 21625406 PMC3101502
- Wilmer M.J. Ng C. Lanz H.L. Vulto P. Suter-Dick L. Masereeuw R. Kidney-on-a-Chip technology for drug-induced nephrotoxicity screening Trends Biotechnol. 34 2016 156 170 26708346
- Winer J.B. An update in guillain-barre syndrome Autoimmune Dis. 2014 2014 793024 24511391 PMC3910670
- Wolf K. Zarkua G. Chan S.A. Sridhar A. Smith C. Spatial and activity-dependent catecholamine release in rat adrenal medulla under native neuronal stimulation Physiol. Rep. 4 2016 PMC5027341 27597763
- Xu H. Li Z. Yu Y. Sizdahkhani S. Ho W.S. Yin F. Wang L. Zhu G. Zhang M. Jiang L. A dynamic in vivo-like organotypic blood-brain barrier model to probe metastatic brain tumors Sci. Rep. 6 2016 36670 27830712 PMC5103210
- Yin S.H. Zhang X.Q. Zhan C. Wu J.T. Xu J.C. Cheung J. Measuring single cardiac myocyte contractile force via moving a magnetic bead Biophys. J. 88 2005 1489 1495 15533919 PMC1305150
- Zahavi E.E. Ionescu A. Gluska S. Gradus T. Ben-Yaakov K. Perlson E. A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions J.Cell Sci. 128 2015 1241 1252 25632161 PMC4359927
- Zhang B. Radisic M. Organ-on-a-chip devices advance to market Lab Chip 17 2017 2395 2420 28617487
- Zhang X. Wang T. Wang P. Hu N. High-throughput assessment of drug cardiac safety using a high-speed impedance detection technology-based heart-on-a-chip Micromachines (Basel) 7 2016 122 PMC6189730 30404295
- Zhang Y.S. Aleman J. Shin S.R. Kilic T. Kim D. Mousavi Shaegh S.A. Massa S. Riahi R. Chae S. Hu N. Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors Proc. Natl. Acad. Sci. U S A 114 2017 E2293 E2302 28265064 PMC5373350
- Zhou Q. Patel D. Kwa T. Haque A. Matharu Z. Stybayeva G. Gao Y. Diehl A.M. Revzin A. Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury Lab A Chip 15 2015 4467 4478 26480303
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A guide to the organ-on-a-chip
Leung, C. M., de Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H. S., Chen, Z., Habibovic, P., Jeon, N. L., Takayama, S., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00118-6 · Cited by 1,116 · see citing works
Yang, J., Hirai, Y., Imamura, S., Tsuchiya, T., Tabata, O., & Kamei, K.-I. (2022) · doi:10.1101/2022.01.31.478467 · Cited by 21 · see citing works
- Authors
- Soucy, J. R., Bindas, A. J., Koppes, A. N., & Koppes, R. A.
- ORCID
- Koppes, Ryan A.
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 21
- Pages
- 521-548
- ISSN
- 2589-0042
- PMC
- PMC6849363
- Cited by
- 61
- References
- 13
- Language
- en
- Licence
- Funders
- National Institutes of Health (R21EB025395-01)
- American Heart Association (19PRE34430181)
- Department of Mechanical Engineering, College of Engineering, Michigan State University
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