Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip.
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A hybrid circuit of a semiconductor chip and synaptically connected neurons was implemented and characterized. Individual nerve cells from the snail Lymnaea stagnalis were immobilized on a silicon chip by microscopic picket fences of polyimide. The cells formed a network with electrical synapses after outgrowth in brain conditioned medium. Pairs of neurons were electronically interfaced for noninvasive stimulation and recording. Voltage pulses were applied to a capacitive stimulator on the chip to excite the attached neuron. Signals were transmitted in the neuronal net and elicited an action potential in a second neuron. The postsynaptic excitation modulated the current of a transistor on the chip. The implementation of the silicon-neuron-neuron-silicon circuit constitutes a proof-of-principle experiment for the development of neuroelectronic systems to be used in studies on neuronal signal processing, neurocomputation, and neuroprosthetics.
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An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites.
“An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites (Freitas, 1999b; Zeck and Fromherz, 2001; Patolsky et al., 2006).”
From Human Brain/Cloud Interface (2019) · cites this paper as Zeck and Fromherz, 2001
The Abstract and Results and Discussion describe capacitive stimulation of snail neurons and transistor recording of their action potentials. But the Abstract says the study does not pursue array recording; its contacts are beneath neuron cell bodies, not individual neurites. The cited passages do not establish nanowire transistors or inhibition of nerve impulses. (LLM, conf=0.89)
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Self-citationBierman, R. D., Safarians, G., Huang, J., Rajput, B., Chen, J. Y., Wang, Z. Z., & Seidlits, S. K. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101577 · Cited by 57 · see citing works
Localized Neurotransmitter Release for Use in a Prototype Retinal Interface
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Noninvasive Monitoring of Transporter−Substrate Interaction at Cell Membrane
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Extracellular potentials in low-density dissociated neuronal cultures
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Chemical Defect Decoration of Carbon Nanotubes
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Ti O 2 and HfO2 in electrolyte-oxide-silicon configuration for applications in bioelectronics
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Layer‐by‐layer assembly of polyelectrolyte films improving cytocompatibility to neural cells
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Light-Directed Electrical Stimulation of Neurons Cultured on Silicon Wafers
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Transistor analogs of emergent iono‐neuronal dynamics
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Silicon‐on‐Insulator Based Thin‐Film Resistor for Chemical and Biological Sensor Applications
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Self-citationAstrocytic Ca2+ Waves Guide CNS Growth Cones to Remote Regions of Neuronal Activity
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Control of neural network patterning using collagen gel photothermal etching
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- Authors
- Zeck, G., & Fromherz, P.
- Affiliations
- Max Planck Institute of Biochemistry (DE)
- Corresponding author
- Fromherz, Peter
- ORCID
- Zeck, Günther
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-08-28
- Volume
- 98
- Issue
- 18
- Pages
- 10457-10462
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC56982
- OpenAlex
- W2125305661
- Cited by
- 290
- References
- 34
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 13 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 8
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- electrical synapses, neuronal networks, action potential propagation, neuroprosthetics, neural computation
- MeSH terms
- Animals, Cell Division, Cells, Cultured, Electrophysiology, Lymnaea, Microscopy, Electron, Scanning, Neurobiology, Neurons, Semiconductors, Synapses, Signal Transduction, Cells, Immobilized, In Vitro Techniques
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