Cited by 290Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignAdvanced Memory and Neural Computing

Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip.

Open access
Zeck, Günther, Fromherz, Peter·2001·Proceedings of the National Academy of Sciences

Abstract

A hybrid circuit of a semiconductor chip and synaptically connected neurons was implemented and characterized. Individual nerve cells from the snail Lymnaea stagnalis were immobilized on a silicon chip by microscopic picket fences of polyimide. The cells formed a network with electrical synapses after outgrowth in brain conditioned medium. Pairs of neurons were electronically interfaced for noninvasive stimulation and recording. Voltage pulses were applied to a capacitive stimulator on the chip to excite the attached neuron. Signals were transmitted in the neuronal net and elicited an action potential in a second neuron. The postsynaptic excitation modulated the current of a transistor on the chip. The implementation of the silicon-neuron-neuron-silicon circuit constitutes a proof-of-principle experiment for the development of neuroelectronic systems to be used in studies on neuronal signal processing, neurocomputation, and neuroprosthetics.

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Crossref · 10.1073/pnas.181348698

Cites

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  • An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites.

    “An array of nanowire transistors can detect, stimulate, or inhibit nerve impulses and their propagation along individual neurites (Freitas, 1999b; Zeck and Fromherz, 2001; Patolsky et al., 2006).”

    From Human Brain/Cloud Interface (2019) · cites this paper as Zeck and Fromherz, 2001

    The Abstract and Results and Discussion describe capacitive stimulation of snail neurons and transistor recording of their action potentials. But the Abstract says the study does not pursue array recording; its contacts are beneath neuron cell bodies, not individual neurites. The cited passages do not establish nanowire transistors or inhibition of nerve impulses. (LLM, conf=0.89)

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Cites

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Research works printed but not linked: 7

  1. [9]Stett A, Müller B, Fromherz P. Phys Rev E. 1997;55:1779–1782. [Google Scholar]
  2. [10]Ulbrich M, Fromherz P. Adv Mater. 2001;13:344–347. [Google Scholar]
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Authors
Zeck, G., & Fromherz, P.
Affiliations
Max Planck Institute of Biochemistry (DE)
Corresponding author
Fromherz, Peter
Venue
Proceedings of the National Academy of Sciences
Published
2001-08-28
Volume
98
Issue
18
Pages
10457-10462
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2125305661
Cited by
290
References
34
Citations by year
2024: 3 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 13 · 2015: 10 · 2014: 12 · 2013: 13 · 2012: 8
FWCI
7.88
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
Keywords
electrical synapses, neuronal networks, action potential propagation, neuroprosthetics, neural computation
MeSH terms
Animals, Cell Division, Cells, Cultured, Electrophysiology, Lymnaea, Microscopy, Electron, Scanning, Neurobiology, Neurons, Semiconductors, Synapses, Signal Transduction, Cells, Immobilized, In Vitro Techniques

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