Cited by 695Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignNeural dynamics and brain function

Novel electrode technologies for neural recordings

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Hong, Guosong, Lieber, Charles M.·2019·Nature Reviews Neuroscience

Abstract

Neural recording electrode technologies have contributed considerably to neuroscience by enabling the extracellular detection of low-frequency local field potential oscillations and high-frequency action potentials of single units. Nevertheless, several long-standing limitations exist, including low multiplexity, deleterious chronic immune responses and long-term recording instability. Driven by initiatives encouraging the generation of novel neurotechnologies and the maturation of technologies to fabricate high-density electronics, novel electrode technologies are emerging. Here, we provide an overview of recently developed neural recording electrode technologies with high spatial integration, long-term stability and multiple functionalities. We describe how these emergent neurotechnologies can approach the ultimate goal of illuminating chronic brain activity with minimal disruption of the neural environment, thereby providing unprecedented opportunities for neuroscience research in the future.

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  • Approaches are being developed to improve throughput, sampling, biocompatibility and stability of MEAs.

    “Similarly, both in academic and industry settings, approaches are being developed to improve throughput, sampling, biocompatibility and stability of MEAs183–186.”

    From The speech neuroprosthesis (2024) · cites this paper as [185]

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Research works printed but not linked: 3

  1. [14]Carter M & Shieh JC Guide to research techniques in neuroscience (Academic Press, 2015).
  2. [107]Kandel ER Principles of neural science (McGraw-Hill, 2013).
  3. [119]Johnson BC in 2018 IEEE Custom Integrated Circuits Conference (CICC). 1– 4 (IEEE).

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Authors
Hong, G., & Lieber, C. M.
Affiliations
Harvard University (US)
Corresponding author
Lieber, Charles M.
Venue
Nature Reviews Neuroscience
Published
2019-03-04
Volume
20
Issue
6
Pages
330-345
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2920339115
Cited by
695
References
157
Citations by year
2026: 58 · 2025: 104 · 2024: 101 · 2023: 117 · 2022: 108 · 2021: 110 · 2020: 77 · 2019: 19 · 2018: 1
FWCI
10.45
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (R00AG056636)
  • National Institute of Biomedical Imaging and Bioengineering (DP1EB025835)
  • Air Force Office of Scientific Research
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
neural recording electrodes, single-unit recording, chronic neural recording, multifunctional electrodes, extracellular recording, neurotechnology
MeSH terms
Action Potentials, Animals, Brain, Electrodes, Electrodes, Implanted, Humans, Neurons

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