The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells
Open accessAbstract
Immunity in the newborn is characterized by minimal Th1 function but an excess of Th2 activity. Since Th1 lymphocytes are important to counter microbes and Th2 cells favor allergies, the newborn faces susceptibility to microbial infections and allergic reactions. Delayed maturation of certain dendritic cells leads to limited IL-12 production during the neonatal period. The Th2 cytokine locus of neonatal CD4+ T cells is epigenetically poised for rapid and robust production of IL-4 and IL-13. Together, these circumstances lead to efficient differentiation of Th2 cells and the expression of an IL-4Rα/IL-13Rα1 heteroreceptor on Th1 cells. Upon rechallenge, Th2 cells rapidly produce IL-4 which utilizes the heteroreceptor to drive apoptosis of Th1 cells yielding the Th2 bias of neonatal immunity.
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Cites
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Self-citationDevelopment of allergen-specific T-cell memory in atopic and normal children
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Cited by
Basha, S., Surendran, N., & Pichichero, M. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.942288 · Cited by 513
Ontogeny of early life immunity
Dowling, D. J., & Levy, O. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.007 · Cited by 364
Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder
Krakowiak, P., Goines, P. E., Tancredi, D. J., Ashwood, P., Hansen, R. L., Hertz-Picciotto, I., & Van de Water, J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.007 · Cited by 249
“an inflammatory Th1 phenotype) compared with adults (60,61).”
Background
Metadata
- Authors
- Zaghouani, H., Hoeman, C. M., & Adkins, B.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 30
- Issue
- 12
- Pages
- 585-591
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2163592077
- Cited by
- 263
- References
- 46
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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