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Cited by 558

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

The inflammatory response in sepsis

Open access
Bosmann, Markus, Ward, Peter A.·2013·Trends in Immunology
DOI 10.1016/j.it.2012.09.004
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Abstract

The pathophysiology of sepsis and its accompanying systemic inflammatory response syndrome (SIRS) and the events that lead to multiorgan failure and death are poorly understood. It is known that, in septic humans and rodents, the development of SIRS is associated with a loss of the redox balance, but SIRS can also develop in non-infectious states. In addition, a hyperinflammatory state develops, together with impaired innate immune functions of phagocytes, immunosuppression, and complement activation, collectively leading to septic shock and lethality. Here we discuss recent insights into the signaling pathways in immune and phagocytic cells that underlie sepsis and SIRS and consider how these might be targeted for therapeutic interventions to reverse or attenuate pathways that lead to lethality during sepsis.

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Metadata

Authors
Bosmann, M., & Ward, P. A.
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2013-03
Volume
34
Issue
3
Pages
129-136
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2012.09.004
OpenAlex
W2080196545
Cited by
558
References
65
FWCI
2.95
Type
journal article
Language
en
Open access
green

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.