The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Bench-to-bedside review: Sepsis - from the redox point of view
Open accessAbstract
The pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and septic shock have been the subject of investigations for nearly half a century. Controversies still exist with regard to understanding the molecular pathophysiology of sepsis in relation to the complex roles played by reactive oxygen species, nitric oxide, complements and cytokines. In the present review we categorise the key turning points in sepsis development and outline the most probable sequence of events leading to cellular dysfunction and organ failure under septic conditions. We have applied an integrative approach in order to fuse current state-of-the-art knowledge about redox processes involving hydrogen peroxide, nitric oxide, superoxide, peroxynitrite and hydroxyl radical, which lead to mitochondrial respiratory dysfunction. Finally, from this point of view, the potential of redox therapy targeting sepsis is discussed.
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Cites
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Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
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Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
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Ascorbic acid dynamics in the seriously ill and injured
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Cited by
The immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
The inflammatory response in sepsis
Bosmann, M., & Ward, P. A. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.09.004 · Cited by 558
The ‘cytokine storm’: molecular mechanisms and therapeutic prospects
Karki, R., & Kanneganti, T.-D. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.06.001 · Cited by 438
Ceria–Zirconia Nanoparticles as an Enhanced Multi‐Antioxidant for Sepsis Treatment
Soh, M., Kang, D., Jeong, H., Kim, D., Kim, D. Y., Yang, W., Song, C., Baik, S., Choi, I., Ki, S., et al. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201704904 · Cited by 367
Cao, F., Zhang, L., You, Y., Zheng, L., Ren, J., & Qu, X. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201912182 · Cited by 319
Metadata
- Authors
- Andrades, M., Morina, A., Spasić, S., & Spasojević, I.
- Venue
- Critical Care
- Published
- 2011
- Volume
- 15
- Issue
- 5
- Pages
- 230
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2141678261
- Cited by
- 158
- References
- 14
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Andrades, M., Morina, A., Spasić, S., & Spasojević, I. (2011). Bench-to-bedside review: Sepsis - from the redox point of view. Critical Care. https://doi.org/10.1186/cc10334
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
