Intersection of mTOR and STAT signaling in immunity

Saleiro, Diana; Platanias, Leonidas C.

doi:10.1016/j.it.2014.10.006

Cited by 142Cytokine Signaling Pathways and InteractionsPI3K/AKT/mTOR signaling in cancerT-cell and B-cell Immunology

Intersection of mTOR and STAT signaling in immunity

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Saleiro, Diana, Platanias, Leonidas C.·2015·Trends in Immunology

DOI 10.1016/j.it.2014.10.006PMC PMC4297313

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Abstract

Optimal regulation of immune networks is essential for the generation of effective immune responses, and defects in such networks can lead to immunodeficiency while uncontrolled responses can result in autoimmune disorders. mTOR and STAT signaling cascades are key regulators of the differentiation and function of cells of the immune system. Both pathways act as sensors and transducers of environmental stimuli, and recent evidence has revealed points of crosstalk between these pathways, highlighting synergistic regulation of immune cell differentiation and function. We review here the current understanding of mTOR and STAT interactions in T cells and innate immune cells, and discuss potential mechanisms underlying these events. We further outline models for the intersection of these pathways in the regulation of immunity and highlight important areas for future research.

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mTOR regulates STAT signaling.
“mTOR has also been shown to regulate STAT signaling175, and studies in older humans show that the elevation in baseline phosphorylation of STAT proteins in T cells distinguishes healthy ageing from unhealthy ageing subjects based on cardiovascular ageing phenotypes17.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [175]

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Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4 + CD25 + Foxp3 + regulatory T‐cell development in mice
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An overview of the mTOR pathway as a target in cancer therapy
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Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
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Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses
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Next generation of mammalian target of rapamycin inhibitors for the treatment of cancer
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Tuning mTOR activity for immune balance
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Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180 · see citing works
Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells
Zegeye, M. M., Lindkvist, M., Fälker, K., Kumawat, A., Paramel, G., Grenegård, M., Sirsjö, A., & Ljungberg, L. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0268-4 · Cited by 343 · see citing works
SARS-CoV-2, COVID-19 and the aging immune system
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Commentary: IL-4 and IL-13 receptors and signaling
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Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review
Chen, K., Liu, J., & Cao, X. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.03.008 · Cited by 313 · see citing works
Metformin and Autoimmunity: A “New Deal” of an Old Drug
Ursini, F., Russo, E., Pellino, G., D’Angelo, S., Chiaravalloti, A., Sarro, G. D., Manfredini, R., & GIORGIO, R. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01236 · Cited by 195 · see citing works
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-Immunotherapy in Multiple Solid Tumors
Mei, K.-C., Liao, Y.-P., Jiang, J., Chiang, M., Khazaieli, M., Liu, X.-S., Wang, X., Liu, Q., Chang, C., Zhang, X., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05194 · Cited by 139 · see citing works
IL-21 and T Cell Differentiation: Consider the Context
Tian, Y., & Zajac, A. J. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.06.001 · Cited by 148 · see citing works
mTOR Cross-Talk in Cancer and Potential for Combination Therapy
Conciatori, F., Ciuffreda, L., Bazzichetto, C., Falcone, I., Pilotto, S., Bria, E., Cognetti, F., & Milella, M. (2018) · Cancers · doi:10.3390/cancers10010023 · Cited by 140 · see citing works
T cells and autoimmune kidney disease
Suárez‐Fueyo, A., Bradley, S. J., Klatzmann, D., & Tsokos, G. C. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.34 · Cited by 136 · see citing works
RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex
Yang, J., Zhao, Y., Zhang, L., Fan, H., Qi, C., Zhang, K., Liu, X., Fei, L., Chen, S., Wang, M., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy089 · Cited by 129 · see citing works
Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism
Patel, A., Tsilioni, I., Leeman, S. E., & Theoharides, T. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604992113 · Cited by 121 · see citing works
mTOR, cardiomyocytes and inflammation in cardiac hypertrophy
Xu, L., & Brink, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.003 · Cited by 112 · see citing works
The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus
Goropevšek, A., Holcar, M., & Avčin, T. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-016-8550-y · Cited by 110 · see citing works
Astragaloside IV Alleviates the Experimental DSS-Induced Colitis by Remodeling Macrophage Polarization Through STAT Signaling
Tian, L., Zhao, J., Kang, J., Guo, S., Zhang, N., Shang, L., Zhang, Y., Zhang, J., Jiang, X., & Yan, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.740565 · Cited by 108 · see citing works
mTORC1 signaling and IL‐17 expression: Defining pathways and possible therapeutic targets
Ren, W., Yin, J., Duan, J., Liu, G., Tan, B., Yang, G., Wu, G., Bazer, F. W., Peng, Y., & Yin, Y. (2015) · European Journal of Immunology · doi:10.1002/eji.201545886 · Cited by 101 · see citing works
The crucial regulatory role of type I interferon in inflammatory diseases
Ji, L., Li, T., Chen, H., Yang, Y., Liu, J., Liu, J., Qiao, W., & Chen, H. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01188-z · Cited by 101 · see citing works
Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation
Jitschin, R., Böttcher, M., Saul, D., Lukassen, S., Bruns, H., Loschinski, R., Ekici, A. B., Reis, A., Mackensen, A., & Mougiakakos, D. (2019) · Leukemia · doi:10.1038/s41375-018-0376-6 · Cited by 97 · see citing works
Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
Jones, N., Vincent, E. E., Cronin, J., Panetti, S., Chambers, M., Holm, S. R., Owens, S. E., Francis, N., Finlay, D. K., & Thornton, C. A. (2019) · Nature Communications · doi:10.1038/s41467-019-10023-4 · Cited by 86 · see citing works
The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products
Wang, R., Zhou, M., Ma, H., Qiao, Y., & Li, Q. (2021) · ChemMedChem · doi:10.1002/cmdc.202000996 · Cited by 86 · see citing works
Interferon signaling in cancer. Non-canonical pathways and control of intracellular immune checkpoints
Saleiro, D., & Platanias, L. C. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101299 · Cited by 72 · see citing works
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IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation
Venet, F., Demaret, J., Blaise, B. J., Rouget, C., Girardot, T., Idealisoa, E., Rimmele, T. R., Mallet, F., Lepape, A., Textoris, J., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700127 · Cited by 68 · see citing works
Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts
Calender, A., Weichhart, T., Valeyre, D., & Pachéco, Y. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082633 · Cited by 66 · see citing works
TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice
Cui, Y., Chen, C., Tang, Z., Yuan, W., Yue, K., Cui, P., Qiu, X., Zhang, H., Li, T., Zhu, X., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06756-w · Cited by 68 · see citing works
Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment
Mills, J. D., Iyer, A. M., van Scheppingen, J., Bongaarts, A., Anink, J. J., Janssen, B. J., Zimmer, T. S., Spliet, W. G. M., van Rijen, P. C., Jansen, F. E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06145-8 · Cited by 62 · see citing works
Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice
Liu, H., Huang, R., Shen, B., Huang, C., Zhou, Q., Xu, J., Chen, S., Lin, X., Wang, J., Zhao, X., et al. (2024) · Microbiome · doi:10.1186/s40168-024-01995-7 · Cited by 61 · see citing works
Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential
Kamyshnyi, O., Matskevych, V. M., Lenchuk, T., Strilbytska, O. M., Storey, K. B., & Lushchak, O. V. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112230 · Cited by 62 · see citing works
Metabolic Mechanism for l -Leucine-Induced Metabolome To Eliminate Streptococcus iniae
Du, C., Yang, M., Li, M., Yang, J., Peng, B., Li, H., & Peng, X. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00944 · Cited by 57 · see citing works
Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome
Duffy, F. J., Weiner, J. M., Hansen, S. G., Tabb, D. L., Suliman, S., Thompson, E. G., Maertzdorf, J., Shankar, S., Tromp, G. C., Parida, S. K., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00527 · Cited by 55 · see citing works
Innate Immune Recognition: An Issue More Complex Than Expected
Kubelková, K., & Macela, A. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00241 · Cited by 53 · see citing works
Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cells
Patel, A., & Theoharides, T. C. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.240564 · Cited by 54 · see citing works
PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury
Li, S., Hua, X., Zheng, M., Wu, J., Ma, Z., Xing, X., Ma, J., Zhang, J., Shan, C., & Xu, J. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113854 · Cited by 53 · see citing works
Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo
Kościuczuk, E. M., Saleiro, D., Kroczyńska, B., Beauchamp, E. M., Eckerdt, F., Blyth, G. T., Abedin, S. M., Giles, F. J., Altman, J. K., & Platanias, L. C. (2016) · Blood · doi:10.1182/blood-2016-02-698704 · Cited by 51 · see citing works
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MEF2C regulates NK cell effector functions through control of lipid metabolism
Li, J. H., Zhou, A., Lee, C. D., Shah, S. N., Ji, J. H., Senthilkumar, V., Padilla, E. T., Ball, A. B., Feng, Q., Bustillos, C. G., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01811-2 · Cited by 48 · see citing works
Immune metabolism regulation of the germinal center response
Choi, S., & Morel, L. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0392-2 · Cited by 48 · see citing works
Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
Reich, N., & Hölscher, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614828 · Cited by 48 · see citing works
Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression
Bak, S., Tischer, S., Dragon, A. C., Ravens, S., Pape, L., Koenecke, C., Oelke, M., Blasczyk, R., Maecker‐Kolhoff, B., & Eiz‐Vesper, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02953 · Cited by 44 · see citing works
Targeting STATs in neuroinflammation: The road less traveled!
Nabavi, S. M., Ahmed, T., Nawaz, M., Devi, K. P., Balan, D. J., Pittalà, V., Argüelles, S., Testai, L., Khan, H. Z., Sureda, A., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.004 · Cited by 41 · see citing works
Transcriptome analysis of immune response in fat greenling (Hexagrammos otakii) against Vibrio harveyi infection
Diao, J., Liu, H., Hu, F., Li, L., Wang, X., Gai, C., Yu, X., Fan, Y., Xu, L., & Ye, H. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.10.067 · Cited by 40 · see citing works
Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia
Kościuczuk, E. M., Saleiro, D., & Platanias, L. C. (2016) · Cytokine · doi:10.1016/j.cyto.2016.01.024 · Cited by 40 · see citing works
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Mesenchymal Stem Cell Protects Injured Renal Tubular Epithelial Cells by Regulating mTOR-Mediated Th17/Treg Axis
Luo, Y., Guo, J., Zhang, P., Cheuk, Y. C., Jiang, Y., Wang, J., Xu, S., & Rong, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.684197 · Cited by 39 · see citing works
Therapeutic mTOR blockade in systemic autoimmunity: Implications for antiviral immunity and extension of lifespan
Geier, C., & Perl, A. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102984 · Cited by 39 · see citing works
Metabolic Regulation of Immune Responses to Mycobacterium tuberculosis: A Spotlight on L-Arginine and L-Tryptophan Metabolism
Crowther, R. R., & Qualls, J. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.628432 · Cited by 37 · see citing works
Immune system-mediated cellular and molecular mechanisms in idiopathic membranous nephropathy pathogenesis and possible therapeutic targets
Motavalli, R., Etemadi, J., Kahroba, H., Mehdizadeh, A., & Yousefi, M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116923 · Cited by 33 · see citing works
Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats
El-Ghannam, M. S., Saad, M. A., Nassar, N. N., El-Yamany, M. F., & El-Bahy, A. A. Z. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.115906 · Cited by 33 · see citing works
STAT1 maintains naïve CD8 + T cell quiescence by suppressing the type I IFN-STAT4-mTORC1 signaling axis
Kye, Y.-C., Lee, G.-W., Lee, S.-W., Ju, Y.-J., Kim, H.-O., Yun, C., & Cho, J.-H. (2021) · Science Advances · doi:10.1126/sciadv.abg8764 · Cited by 31 · see citing works
Rapamycin attenuates Tc1 and Tc17 cell responses in cigarette smoke-induced emphysema in mice
Zhang, H., Zhou, X., Chen, X., Lin, Y., Qiu, S., Zhao, Y. F., Tang, Q., Liang, Y., & Zhong, X. (2019) · Inflammation Research · doi:10.1007/s00011-019-01278-0 · Cited by 31 · see citing works
Modulating mTOR Signaling as a Promising Therapeutic Strategy for Atherosclerosis
Poznyak, A. V., Sukhorukov, V. N., Zhuravlev, A. D., Orekhov, N. A., Kalmykov, V. A., & Orekhov, A. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031153 · Cited by 30 · see citing works
Human macrophage differentiation induces OCTN2–mediated L-carnitine transport through stimulation of mTOR–STAT3 axis
Ingoglia, F., Visigalli, R., Rotoli, B. M., Barilli, A., Riccardi, B., Puccini, P., Milioli, M., Lascia, M. D., Bernuzzi, G., & Dall’Asta, V. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0616-254r · Cited by 30 · see citing works
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
Iqbal, A., Eckerdt, F., Bell, J. B., Nakano, I., Giles, F. J., Cheng, S., Lulla, R. R., Goldman, S., & Platanias, L. C. (2016) · Oncotarget · doi:10.18632/oncotarget.8899 · Cited by 29 · see citing works
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NAD/NAMPT and mTOR Pathways in Melanoma: Drivers of Drug Resistance and Prospective Therapeutic Targets
Indini, A., Fiorilla, I., Ponzone, L., Calautti, E., & Audrito, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179985 · Cited by 30 · see citing works
JAK2 inhibitor ameliorates the progression of experimental autoimmune myasthenia gravis and balances Th17/Treg cells via regulating the JAK2/STAT3-AKT/mTOR signaling pathway
Lu, Y., Ma, Q., Yu, L., Huang, H., Liu, X., Chen, P., Ran, H., & Liu, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109693 · Cited by 28 · see citing works
Sin1-mediated mTOR signaling in cell growth, metabolism and immune response
Ruan, C.-H., Ouyang, X.-X., Liu, H.-Z., Li, S., Jin, J.-S., Tang, W.-T., Xia, Y.-J., & Su, B. (2019) · National Science Review · doi:10.1093/nsr/nwz171 · Cited by 20 · see citing works
NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors
Antón, O. M., Vielkind, S., Peterson, M., Tagaya, Y., & Long, E. O. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500414 · Cited by 26 · see citing works
Reduction of infection by inhibiting mTOR pathway is associated with reversed repression of type I interferon by porcine reproductive and respiratory syndrome virus
Liu, Q., Miller, L. C., Blecha, F., & Sang, Y. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000802 · Cited by 26 · see citing works
A case series of acne following Janus kinase inhibitors in patients with atopic dermatitis
Lee, S.-D., Ahn, H., & Shin, M. K. (2022) · JAAD Case Reports · doi:10.1016/j.jdcr.2022.09.029 · Cited by 25 · see citing works
Upregulation of miR-196b-5p attenuates BCG uptake via targeting SOCS3 and activating STAT3 in macrophages from patients with long-term cigarette smoking-related active pulmonary tuberculosis
Yuan, Y., Lin, D., Feng, L., Huang, M., Yan, H., Li, Y., Chen, Y., Lin, B., Ma, Y., Ye, Z., et al. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1654-9 · Cited by 23 · see citing works
AMPK suppresses Th2 cell responses by repressing mTORC2
Pandit, M., Timilshina, M., Gu, Y., Acharya, S., Chung, Y., Seo, S., & Chang, J. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00832-x · Cited by 24 · see citing works
Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses
Saleiro, D., Kościuczuk, E. M., & Platanias, L. C. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.03.008 · Cited by 22 · see citing works
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Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production
Gillespie, Z. E., MacKay, K., Sander, M., Trost, B., Dawicki, W., Wickramarathna, A. D., Gordon, J., Eramian, M., Kill, I. R., Bridger, J. M., et al. (2015) · Nucleus · doi:10.1080/19491034.2015.1128610 · Cited by 22 · see citing works
Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery
Aghaeepour, N., Kin, C., Ganio, E. A., Jensen, K. P., Gaudilliere, D. K., Tingle, M. S., Tsai, A. S., Lancero, H. L., Choisy, B., McNeil, L. S., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700421 · Cited by 22 · see citing works
Mining therapeutic and prognostic significance of STATs in renal cell carcinoma with bioinformatics analysis
Zhou, L., Li, Y., Li, Z., & Huang, Q. (2020) · Genomics · doi:10.1016/j.ygeno.2020.06.032 · Cited by 21 · see citing works
Scalable, compressed phenotypic screening using pooled perturbations
Liu, N., Kattan, W. E., Mead, B. E., Kummerlowe, C., Cheng, T., Ingabire, S., Cheah, J. H., Soule, C. K., Vrcic, A., McIninch, J. K., et al. (2024) · Nature Biotechnology · doi:10.1038/s41587-024-02403-z · Cited by 25 · see citing works
Upcoming therapeutic targets in cutaneous lupus erythematous
Klaeschen, A. S., & Wenzel, J. (2016) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1145543 · Cited by 21 · see citing works
Integrative Multi-PTM Proteomics Reveals Dynamic Global, Redox, Phosphorylation, and Acetylation Regulation in Cytokine-Treated Pancreatic Beta Cells
Gluth, A., Li, X., Gritsenko, M. A., Gaffrey, M. J., Kim, D. N., Lalli, P. M., Chu, R., Day, N. J., Sagendorf, T. J., Monroe, M. E., et al. (2024) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2024.100881 · Cited by 21 · see citing works
Janus kinase inhibitors in atopic dermatitis: an umbrella review of meta-analyses
He, Q., Xie, X., Chen, Q., Li, W., Song, Z., Wang, X., Ma, X., Zeng, J., & Guo, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1342810 · Cited by 20 · see citing works
Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons
Demiröz, D., Platanitis, E., Bryant, M., Fischer, P., Prchal‐Murphy, M., Lercher, A., Lassnig, C., Baccarini, M., Müller, M. M., Bergthaler, A., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009697 · Cited by 17 · see citing works
Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder
Park, S. W., Seo, M. K., Webster, M. J., Lee, J. G., & Kim, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01944-8 · Cited by 19 · see citing works
Transcriptional programing of T cell metabolism by STAT family transcription factors
Villarino, A. V. (2023) · European Journal of Immunology · doi:10.1002/eji.202048825 · Cited by 19 · see citing works
Latitudinal and longitudinal regulation of tissue macrophages in inflammatory diseases
He, X.-Y., Tan, S., Shao, Z., & Wang, X. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.06.007 · Cited by 19 · see citing works
Exploring the mechanism of berberine-mediated Tfh cell immunosuppression
Vita, A. A., & Pullen, N. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154343 · Cited by 18 · see citing works
Association of risk of incident acne and treatment with systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis
Sun, C., Su, Z., & Zeng, Y. (2023) · Inflammation Research · doi:10.1007/s00011-023-01789-x · Cited by 18 · see citing works
Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma
Wolf, B., Krieg, K., Falk, C. S., Breuhahn, K., Keppeler, H., Biedermann, T., Schmid, E., Warmann, S. W., Fuchs, J., Vetter, S., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3453 · Cited by 18 · see citing works
mTOR regulates PRMT1 expression and mitochondrial mass through STAT1 phosphorylation in hepatic cell.
Zhang, X., Li, L., Li, Y., Li, Z., Zhai, W., Sun, Q.-Z., Yang, X.-J., Roth, M., & Lu, S.-M. (2021) · Biochimica et biophysica acta. Molecular cell research · doi:10.1016/j.bbamcr.2021.119017 · Cited by 18 · see citing works
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Authors: Saleiro, D., & Platanias, L. C.
Affiliations: Northwestern University (US)
Corresponding author: Platanias, Leonidas C.
ORCID: Saleiro, Diana
Platanias, Leonidas C.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2015-01
Volume: 36
Issue: 1
Pages: 21-29
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2014.10.006
PMC: PMC4297313
OpenAlex: W2028684481
Cited by: 142
References: 84
Citations by year: 2026: 9 · 2025: 10 · 2024: 10 · 2023: 9 · 2022: 12 · 2021: 17 · 2020: 14 · 2019: 13 · 2018: 12 · 2017: 12 · 2016: 16 · 2015: 7
FWCI: 1.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA161796, CA-77816, CA121192, R01CA121192, R01CA155566, CA161196, R01CA077816, CA155566, P30CA060553)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: mTOR signaling, STAT signaling, pathway crosstalk, immune cell differentiation, T cells, innate immune cells, immune regulation, immunodeficiency, autoimmunity, signal transduction
MeSH terms: Mechanistic Target of Rapamycin Complex 2, Animals, Dendritic Cells, Humans, Immune System, Immunity, Macrophages, Protein Binding, T-Lymphocytes, Signal Transduction, Multiprotein Complexes, STAT Transcription Factors, Receptor, Interferon alpha-beta, TOR Serine-Threonine Kinases

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