Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
Open accessAbstract
Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furthermore, the evidence of the contribution of systemic delivered molecules to the disease pathogenesis, such as the gut microbiota composition, has been increasing during the last years. Under physiological conditions, microglia and astrocytes support the well-being and well-function of the brain through diverse functions, including neurotrophic factor secretion in both intact and injured brain. On the other hand, genes that cause PD are expressed in astrocytes and microglia, shifting their neuroprotective role to a pathogenic one, contributing to disease onset and progression. In addition, growth factors are a subset of molecules that promote cellular survival, differentiation and maturation, which are critical signaling factors promoting the communication between cells, including neurons and blood-derived immune cells. We summarize the potential targeting of astrocytes and microglia and the systemic contribution of the gut microbiota in neuroinflammation process archived in PD.
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Neuroinflammation is closely related to neurodegenerative diseases, such as Huntington's, Alzheimer's and Parkinson's disease, and neuropsychiatric disorders, such as major depressive disorder, bipolar disorder and anxiety.
“In fact, neuroinflammation is closely related to neurodegenerative diseases, as Huntington’s [133], Alzheimer’s [134] and Parkinson’s disease [135] and neuropsychiatric disorders, such as major depressive disorder, bipolar disorder and anxiety [136].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [135]
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Kim, J. S., Kim, J. H., Eo, H., Ju, I. G., Son, S.-R., Kim, J., Jang, D. S., & Oh, M. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04094-8 · Cited by 17 · see citing works
Mitophagy: A Bridge Linking HMGB1 and Parkinson’s Disease Using Adult Zebrafish as a Model Organism
Razali, K., Nasir, M. H. M., Kumar, J., & Mohamed, W. M. Y. (2023) · Brain Sciences · doi:10.3390/brainsci13071076 · Cited by 15 · see citing works
Assessment of CRISPRa-mediated gdnf overexpression in an In vitro Parkinson’s disease model
Guzmán-Sastoque, P., Sotelo, S., Esmeral, N. P., Albarracín, S. L., Sutachan, J. J., Reyes, L. H., Muñoz-Camargo, C., Cruz, J. C., & Bloch, N. I. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1420183 · Cited by 15 · see citing works
Strafella, C., Caputo, V., Termine, A., Assogna, F., Pellicano, C., Pontieri, F. E., Macchiusi, L., Minozzi, G., Gambardella, S., Centonze, D., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.651971 · Cited by 14 · see citing works
Koppula, S., Alluri, R., & Kopalli, S. R. (2021) · EXCLI journal · doi:10.17179/excli2021-3668 · Cited by 15 · see citing works
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The c-Abl/p73 pathway induces neurodegeneration in a Parkinson's disease model
Marín, T., Valls, C., Jerez, C., Huerta, T., Elgueta, D., Vidal, R. L., Alvarez, A. R., & Cancino, G. I. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.10.006 · Cited by 14 · see citing works
Self-citationDo Bacterial Outer Membrane Vesicles Contribute to Chronic Inflammation in Parkinson’s Disease?
Koukoulis, T. F., Beauchamp, L. C., Kaparakis‐Liaskos, M., McQuade, R. M., Purnianto, A., Finkelstein, D. I., Barnham, K. J., & Vella, L. J. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230315 · Cited by 14 · see citing works
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Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models
Muksuris, K., Scarisbrick, D. M., Mahoney, J. J., & Cherkasova, M. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175448 · Cited by 13 · see citing works
- Authors
- Troncoso-Escudero, P., Parra, A., Nassif, M., & Vidal, R. L.
- Affiliations
- Universidad Mayor (CL)
- Venue
- Frontiers in Neurology
- Publisher
- Frontiers Media SA
- Published
- 2018-10-15
- Volume
- 9
- Pages
- 860-860
- ISSN
- 1664-2295 (ISSN-L)
- PMC
- PMC6232883
- OpenAlex
- W2895971387
- Cited by
- 191
- References
- 193
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 22 · 2023: 38 · 2022: 35 · 2021: 19 · 2020: 32 · 2019: 6
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Frontiers in Neurology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Funders
- Fondo Nacional de Desarrollo Científico y Tecnológico (1150608, 11160288)
- Comisión Nacional de Investigación Científica y Tecnológica (21160843, 21181114)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Parkinson's disease, neuroinflammation, microglia, astrocytes, gut microbiota, systemic inflammation, disease progression, neuroprotective factors, growth factors, neurotrophic factors, immune cells, therapeutic targeting
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