Cited by 191Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease

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Troncoso-Escudero, Paulina, Parra, Alejandra, Nassif, Melissa, Vidal, Rene L.·2018·Frontiers in Neurology

Abstract

Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furthermore, the evidence of the contribution of systemic delivered molecules to the disease pathogenesis, such as the gut microbiota composition, has been increasing during the last years. Under physiological conditions, microglia and astrocytes support the well-being and well-function of the brain through diverse functions, including neurotrophic factor secretion in both intact and injured brain. On the other hand, genes that cause PD are expressed in astrocytes and microglia, shifting their neuroprotective role to a pathogenic one, contributing to disease onset and progression. In addition, growth factors are a subset of molecules that promote cellular survival, differentiation and maturation, which are critical signaling factors promoting the communication between cells, including neurons and blood-derived immune cells. We summarize the potential targeting of astrocytes and microglia and the systemic contribution of the gut microbiota in neuroinflammation process archived in PD.

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Crossref · 10.3389/fneur.2018.00860

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  • Neuroinflammation is closely related to neurodegenerative diseases, such as Huntington's, Alzheimer's and Parkinson's disease, and neuropsychiatric disorders, such as major depressive disorder, bipolar disorder and anxiety.

    “In fact, neuroinflammation is closely related to neurodegenerative diseases, as Huntington’s [133], Alzheimer’s [134] and Parkinson’s disease [135] and neuropsychiatric disorders, such as major depressive disorder, bipolar disorder and anxiety [136].”

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Authors
Troncoso-Escudero, P., Parra, A., Nassif, M., & Vidal, R. L.
Affiliations
Universidad Mayor (CL)
Venue
Frontiers in Neurology
Published
2018-10-15
Volume
9
Pages
860-860
ISSN
1664-2295 (ISSN-L)
OpenAlex
W2895971387
Cited by
191
References
193
Citations by year
2026: 12 · 2025: 27 · 2024: 22 · 2023: 38 · 2022: 35 · 2021: 19 · 2020: 32 · 2019: 6
FWCI
1.35
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Neurology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
Funders
  • Fondo Nacional de Desarrollo Científico y Tecnológico (1150608, 11160288)
  • Comisión Nacional de Investigación Científica y Tecnológica (21160843, 21181114)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, neuroinflammation, microglia, astrocytes, gut microbiota, systemic inflammation, disease progression, neuroprotective factors, growth factors, neurotrophic factors, immune cells, therapeutic targeting

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