A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s Disease

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Neurogenesis in the adult human hippocampus

Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works

Revised Estimates for the Number of Human and Bacteria Cells in the Body

Sender, R., Fuchs, S., & Milo, R. (2016) · PLOS Biology · doi:10.1371/journal.pbio.1002533 · Cited by 5,425 · see citing works

Role of the microbiota in immunity and inflammation.

Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385 · see citing works

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Gut microbiota functions: metabolism of nutrients and other food components

Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878 · see citing works

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

Desai, M. S., Seekatz, A. M., Koropatkin, N. M., Kamada, N., Hickey, C. A., Wolter, M., Pudlo, N. A., Kitamoto, S., Terrapon, N., Muller, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.043 · Cited by 2,805 · see citing works

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.

(2015) · PubMed Central · Cited by 2,540 · see citing works

Amyloid deposition as the central event in the aetiology of Alzheimer’s disease

Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538 · see citing works

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works

2019 Alzheimer’s disease facts and figures.

Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461 · see citing works

Bifidobacteria can protect from enteropathogenic infection through production of acetate

Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387 · see citing works

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works

Alzheimer's disease

Masters, C. L., Bateman, R., Blennow, K., Rowe, C. C., Sperling, R. A., & Cummings, J. L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.56 · Cited by 1,853 · see citing works

Intestinal barrier function: molecular regulation and disease pathogenesis

Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775 · see citing works

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577 · see citing works

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine · doi:10.1038/nm890 · Cited by 1,426 · see citing works

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422 · see citing works

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works

Human Hippocampal Neurogenesis Persists throughout Aging

Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345 · see citing works

The composition of the gut microbiota throughout life, with an emphasis on early life

Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works

Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease

Simard, A. R., Soulet, D., Gowing, G., Julien, J.-P., & Rivest, S. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.022 · Cited by 1,265 · see citing works

Gut microbiota and aging

O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202 · see citing works

Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works

The blood-brain barrier in systemic inflammation

Varatharaj, A., & Galea, I. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.03.010 · Cited by 1,172 · see citing works

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144 · see citing works

Role of oxidative stress in Alzheimer’s disease

HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works

Adult hippocampal neurogenesis and its role in Alzheimer’s disease

Mu, Y., & Gage, F. H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-85 · Cited by 1,021 · see citing works

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004 · see citing works

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works

A gut-brain neural circuit for nutrient sensory transduction

Kaelberer, M. M., Buchanan, K. L., Klein, M. E., Barth, B. B., Montoya, M. M., Shen, X., & Bohórquez, D. V. (2018) · Science · doi:10.1126/science.aat5236 · Cited by 932 · see citing works

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

Holmqvist, S., Chutna, O., Bousset, L., Aldrin-Kirk, P., Li, W., Björklund, T., Wang, Z.-Y., Roybon, L., Melki, R., & Li, J.-Y. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1343-6 · Cited by 925 · see citing works

The role of microbial amino acid metabolism in host metabolism

Neis, E., Dejong, C., & Rensen, S. (2015) · Nutrients · doi:10.3390/nu7042930 · Cited by 920 · see citing works

Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis

Jenkins, T., Nguyen, J., Polglaze, K., & Bertrand, P. (2016) · Nutrients · doi:10.3390/nu8010056 · Cited by 904 · see citing works

The enteric nervous system and gastrointestinal innervation: integrated local and central control

Furness, J. B., Callaghan, B. P., Rivera, L. R., & Cho, H.-J. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_3 · Cited by 827 · see citing works

Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases

Lee, S. H. (2015) · Intestinal Research · doi:10.5217/ir.2015.13.1.11 · Cited by 810 · see citing works

Bacteroides thetaiotaomicron and Faecalibacterium prausnitziiinfluence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent

Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., Blecher, R., Ulas, T., Squarzoni, P., Hoeffel, G., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.042 · Cited by 779 · see citing works

Neurodegenerative disease: models, mechanisms, and a new hope

Gitler, A. D., Dhillon, P., & Shorter, J. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030205 · Cited by 746 · see citing works

Hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes: sex differences in regulation of stress responsivity

Oyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710 · see citing works

Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health

Chambers, E. S., Preston, T., Frost, G., & Morrison, D. J. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0248-8 · Cited by 691 · see citing works

Revisiting the Mechanisms of CNS Immune Privilege

Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works

Gut microbiome and aging: physiological and mechanistic insights

Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670 · see citing works

Alzheimer’s disease hypothesis and related therapies

Du, X., Wang, X., & Geng, M. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0107-y · Cited by 609 · see citing works

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603 · see citing works

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

van de Haar, H. J., Burgmans, S., Jansen, J. F. A., van Osch, M. J. P., van Buchem, M. A., Muller, M., Hofman, P. A. M., Verhey, F. R. J., & Backes, W. H. (2016) · Radiology · doi:10.1148/radiol.2016152244 · Cited by 601 · see citing works

Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation

Berkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 594 · see citing works

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

Hoyles, L., Snelling, T., Umlai, U.-K., Nicholson, J. K., Carding, S. R., Glen, R. C., & McArthur, S. (2018) · Microbiome · doi:10.1186/s40168-018-0439-y · Cited by 591 · see citing works

Microbial Ecology along the Gastrointestinal Tract

Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 586 · see citing works

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Cai, Z., Hussain, M. D., & Yan, L.-J. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2013.833510 · Cited by 583 · see citing works

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

De Vadder, F., Grasset, E., Mannerås Holm, L., Karsenty, G., Macpherson, A. J., Olofsson, L. E., & Bäckhed, F. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720017115 · Cited by 566 · see citing works

Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis

Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 548 · see citing works

Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential, and Factor Responsiveness

Crane, G. M., Mosher, J. T., Bixby, S., Joseph, N. M., Iwashita, T., & Morrison, S. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00827-9 · Cited by 543 · see citing works

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

Liu, P. Z., & Nusslock, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00052 · Cited by 533 · see citing works

The microbiome: a key regulator of stress and neuroinflammation

Rea, K., Dinan, T. G., & Cryan, J. F. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.001 · Cited by 508 · see citing works

New insights into the role of TREM2 in Alzheimer’s disease

Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works

Gut microbiota and the neuroendocrine system

Farzi, A., Fröhlich, E. E., & Holzer, P. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0600-5 · Cited by 478 · see citing works

Microbiome–microglia connections via the gut–brain axis

Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471 · see citing works

Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

Möhle, L., Mattei, D., Heimesaat, M. M., Bereswill, S., Fischer, A., Alutis, M., French, T., Hambardzumyan, D., Matzinger, P., Dunay, I. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.074 · Cited by 470 · see citing works

Exposure to the functional bacterial amyloid protein curli enhances alpha-synuclein aggregation in aged Fischer 344 rats and Caenorhabditis elegans

Chen, S. G., Stribinskis, V., Rane, M. J., Demuth, D. R., Gozal, E., Roberts, A. M., Jagadapillai, R., Liu, R., Choe, K., Shivakumar, B., et al. (2016) · Scientific Reports · doi:10.1038/srep34477 · Cited by 463 · see citing works

Meconium Microbiome Analysis Identifies Bacteria Correlated with Premature Birth

Ardissone, A. N., de la Cruz, D., Davis‐Richardson, A. G., Rechcigl, K. T., Li, N., Drew, J. C., Torrazza, R. J. M., Sharma, R. R., Hudak, M. L., Triplett, E. W., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090784 · Cited by 460 · see citing works

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

Cabezas, R., Ávila, M. F., González, J., El-Bachá, R. D. S., Báez-Jurado, E., García‐Segura, L. M., Jurado-Coronel, J. C., Capani, F., Cardona‐Gómez, G. P., & Barreto, G. E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00211 · Cited by 453 · see citing works

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili, L., Cecarini, V., Berardi, S., Scarpona, S., Suchodolski, J. S., Nasuti, C., Fiorini, D., Boarelli, M. C., Rossi, G., & Eleuteri, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-02587-2 · Cited by 453 · see citing works

TLR2 Is a Primary Receptor for Alzheimer’s Amyloid β Peptide To Trigger Neuroinflammatory Activation

Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., Rübe, C. E., Walter, J., Heneka, M. T., Hartmann, T., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101121 · Cited by 439 · see citing works

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-151 · Cited by 400 · see citing works

Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response

Gao, X., Cao, Q., Cheng, Y., Zhao, D., Wang, Z., Yang, H., Wu, Q., You, L., Wang, Y., Lin, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720696115 · Cited by 400 · see citing works

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling

Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397 · see citing works

Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants

Gosalbes, M. J., Llop, S., Vallès, Y., Moyá, A., Ballester, F., & Francino, M. P. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12063 · Cited by 382 · see citing works

Layered defense: how mucus and tight junctions seal the intestinal barrier

Capaldo, C., Powell, D. N., & Kalman, D. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1557-x · Cited by 375 · see citing works

Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

Wu, H.-Y., Hudry, E., Hashimoto, T., Kuchibhotla, K., Rozkalne, A., Fan, Z., Spires-Jones, T., Xie, H., Arbel-Ornath, M., Grosskreutz, C. L., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4456-09.2010 · Cited by 367 · see citing works

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Fachi, J. L., Felipe, J. D. S., Pral, L. P., da Silva, B. K., Corrêa, R. O., de Andrade, M. C. P., da Fonseca, D. M., Basso, P. J., Câmara, N. O. S., de Sales e Souza, É. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.054 · Cited by 364 · see citing works

Microbiota controls the homeostasis of glial cells in the gut lamina propria

Kabouridis, P. S., Lasrado, R., McCallum, S., Chng, S. H., Snippert, H. J., Clevers, H., Pettersson, S., & Pachnis, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.037 · Cited by 358 · see citing works

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

Mandrekar-Colucci, S., Karlo, J. C., & Landreth, G. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5268-11.2012 · Cited by 355 · see citing works

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

Wattananit, S., Tornero, D., Graubardt, N., Memanishvili, T., Monni, E., Tatarishvili, J., Miskinyte, G., Ge, R., Ahlenius, H., Lindvall, O., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-15.2016 · Cited by 354 · see citing works

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

Baranello, R., Bharani, K., Padmaraju, V., Chopra, N., Lahiri, D., Greig, N., Pappolla, M., & Sambamurti, K. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666141218140953 · Cited by 331 · see citing works

Impaired neurogenesis is an early event in the etiology of familial Alzheimer’s disease in transgenic mice

Demars, M., Hu, Y., Gadadhar, A., & Lazarov, O. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22387 · Cited by 326 · see citing works

Stage-dependent BDNF serum concentrations in Alzheimer’s disease

Laske, C., Stransky, E., Leyhe, T., Eschweiler, G. W., Wittorf, A., Richartz, E., Bartels, M., Buchkremer, G., & Schott, K. J. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0397-y · Cited by 325 · see citing works

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

Emery, D. C., Shoemark, D. K., Batstone, T. E., Waterfall, C. M., Coghill, J. A., Cerajewska, T. L., Davies, M., West, N. X., & Allen, S. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00195 · Cited by 317 · see citing works

Modulation of immune development and function by intestinal microbiota

Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 312 · see citing works

A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers

Coureuil, M., Lécuyer, H., Bourdoulous, S., & Nassif, X. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.178 · Cited by 296 · see citing works

Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia

Barajon, I., Serrao, G., Arnaboldi, F., Opizzi, E., Ripamonti, G., Balsari, A., & Rumio, C. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.953539 · Cited by 287 · see citing works

The Infant Microbiome

Yang, I. H., Corwin, E. J., Brennan, P. A., Jordan, S., Murphy, J. R., & Dunlop, A. L. (2015) · Nursing Research · doi:10.1097/nnr.0000000000000133 · Cited by 283 · see citing works

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

Jaeger, L. B., Dohgu, S., Sultana, R., Lynch, J. L., Owen, J. B., Erickson, M. A., Shah, G. N., Price, T. O., Fleegal-Demotta, M. A., Butterfiled, D. A., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.017 · Cited by 281 · see citing works

Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: a randomised, double-blind, placebo-controlled study

Lew, L.-C., Hor, Y.-Y., Yusoff, N. A. A., Choi, S.-B., Yusoff, M. S. B., Roslan, N. S., Ahmad, A., Mohammad, J. A. M., Abdullah, M. F. I. L., Zakaria, N., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.010 · Cited by 272 · see citing works

Probiotic Supplementation in Patients with Alzheimer’s Dementia - An Explorative Intervention Study

Leblhuber, F., Steiner, K., Schuetz, B., Fuchs, D., & Gostner, J. M. (2018) · Current Alzheimer Research · doi:10.2174/1389200219666180813144834 · Cited by 269 · see citing works

Diversified Microbiota of Meconium Is Affected by Maternal Diabetes Status

Hu, J., Nomura, Y., Bashir, A., Fernandez-Hernandez, H., Itzkowitz, S. H., Pei, Z., Stone, J. L., Loudon, H., & Peter, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078257 · Cited by 257 · see citing works

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

Meaney, M. J., Aitken, D. H., Bhatnagar, S., & Sapolsky, R. M. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90036-j · Cited by 250 · see citing works

Effect of LPS on the permeability of the blood–brain barrier to insulin

Xaio, H., Banks, W. A., Niehoff, M. L., & Morley, J. E. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03247-9 · Cited by 231 · see citing works

Powerful beneficial effects of macrophage colony-stimulating factor on -amyloid deposition and cognitive impairment in Alzheimer's disease

Boissonneault, V., Filali, M., Lessard, M., Relton, J., Wong, G., & Rivest, S. (2008) · Brain · doi:10.1093/brain/awn331 · Cited by 221 · see citing works

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

Bien-Ly, N., Boswell, C. A., Jeet, S., Beach, T. G., Hoyte, K., Luk, W., Shihadeh, V., Ulufatu, S., Foreman, O., Lu, Y., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.036 · Cited by 198 · see citing works

Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

Morales, R., Estrada, L. D., Díaz‐Espinoza, R., Morales‐Scheihing, D., Jara, M. C., Castilla, J., & Soto, C. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5924-09.2010 · Cited by 196 · see citing works

Probiotics: their role in the treatment and prevention of disease

Doron, S., & Gorbach, S. L. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.2.261 · Cited by 192 · see citing works

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Aβ42 peptide

Kim, W., & Hecht, M. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605629103 · Cited by 191 · see citing works

Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors

Blennow, K., Wallin, A., Fredman, P., Karlsson, I., Gottfries, C. G., & Svennerholm, L. T. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1990.tb01563.x · Cited by 185 · see citing works

Oligomeric Amyloid Decreases Basal Levels of Brain-Derived Neurotrophic factor (BDNF) mRNA via Specific Downregulation of BDNF Transcripts IV and V in Differentiated Human Neuroblastoma Cells

Garzon, D. J., & Fahnestock, M. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5053-06.2007 · Cited by 182 · see citing works

Correlating familial Alzheimer’s disease gene mutations with clinical phenotype

Ryan, N. S., & Rossor, M. N. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.92 · Cited by 176 · see citing works

Amyloid β-peptide1–42 alters tight junction protein distribution and expression in brain microvessel endothelial cells

Marco, S., & Skaper, S. D. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.03.047 · Cited by 172 · see citing works

Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain

Zhao, Y., Cong, L., Jaber, V. R., & Lukiw, W. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01064 · Cited by 170 · see citing works

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

Erickson, M. A., Hartvigson, P. E., Morofuji, Y., Owen, J. B., Butterfield, D. A., & Banks, W. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-150 · Cited by 145 · see citing works

Circulating amyloid-β peptide crosses the blood–brain barrier in aged monkeys and contributes to Alzheimer's disease lesions

Mačkić, J. B., Bading, J. R., Ghiso, J. A., Walker, L. C., Wısnıewskı, T., Frangione, B., & Zloković, B. V. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(02)00198-2 · Cited by 141 · see citing works

Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

Clayton, K. A., Enoo, A. A. V., & Ikezu, T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00680 · Cited by 132 · see citing works

GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice

Boyd, T. D., Bennett, S. P., Mori, T., Governatori, N., Runfeldt, M., Norden, M., Padmanabhan, J., Neame, P., Wefes, I., Sanchez-Ramos, J., et al. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091471 · Cited by 128 · see citing works

Disruption of Corticocortical Connections Ameliorates Amyloid Burden in Terminal Fields in a Transgenic Model of Aβ Amyloidosis

Sheng, J. G., Price, D. L., & Koliatsos, V. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09794.2002 · Cited by 124 · see citing works

Stress matters: randomized controlled trial on the effect of probiotics on neurocognition

Papalini, S., Michels, F., Kohn, N., Wegman, J., van Hemert, S., Roelofs, K., Arias-Vasquez, A., & Aarts, E. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.100141 · Cited by 123 · see citing works

Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment

Wei, S., Peng, W., Mai, Y., Li, K., Wei, W., Hu, L., Zhu, S., Zhou, H., Jie, W., Wei, Z., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29362 · Cited by 122 · see citing works

Neuroinflammation‐induced acceleration of amyloid deposition in the APP^V717F transgenic mouse

Qiao, X., Cummins, D. J., & Paul, S. M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01666.x · Cited by 119 · see citing works

Robust amyloid clearance in a mouse model of Alzheimer’s disease provides novel insights into the mechanism of amyloid-β immunotherapy

Wang, A., Das, P., Switzer, R. C., Golde, T. E., & Jankowsky, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5077-10.2011 · Cited by 118 · see citing works

Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease

Gao, Q., Wang, Y., Wang, X., Fu, S., Zhang, X., Wang, R., & Zhang, X. (2019) · Aging · doi:10.18632/aging.102352 · Cited by 118 · see citing works

The role of SOX10 during enteric nervous system development

Bondurand, N., & Sham, M. H. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.024 · Cited by 115 · see citing works

A Microbial Signature of Psychological Distress in Irritable Bowel Syndrome

Peter, J., Fournier, C., Durdević, M., Knoblich, L., Keip, B., Dejaco, C., Trauner, M. A., & Moser, G. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000630 · Cited by 98 · see citing works

Astrocytes contribute to Aβ‐induced blood–brain barrier damage through activation of endothelial <scp>MMP</scp> 9

Spampinato, S. F., Merlo, S., Sano, Y., Kanda, T., & Sortino, M. A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14068 · Cited by 90 · see citing works

Phase II clinical trials of anti–amyloid β antibodies: When is enough, enough?

Gold, M. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.04.005 · Cited by 75 · see citing works

Seed-induced acceleration of amyloid-β mediated neurotoxicity in vivo

Sowade, R. F., & Jahn, T. R. (2017) · Nature Communications · doi:10.1038/s41467-017-00579-4 · Cited by 75 · see citing works

Reference genes for gene expression studies in the mouse heart

Ruiz‐Villalba, A., Mattiotti, A., Gunst, Q. D., Ballesteros, S. C., van den Hoff, M. J. B., & Ruijter, J. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00043-9 · Cited by 73 · see citing works

Chronic lipopolysaccharide exposure induces cognitive dysfunction without affecting BDNF expression in the rat hippocampus

Zhu, B., WANG, Z.-G., Ding, J., Liu, N., WANG, D.-M., Ding, L., & Yang, C. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1479 · Cited by 68 · see citing works

Geographical Distribution and Diversity of Gut Microbial NADH:Ubiquinone Oxidoreductase Sequence Associated with Alzheimer’s Disease

Paley, E. L., Merkulova‐Rainon, T., Faynboym, A. M., Shestopalov, V. I., & Aksenoff, I. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170764 · Cited by 67 · see citing works

Maternal influence on the fetal microbiome in a population-based study of the first-pass meconium

Tapiainen, T., Paalanne, N., Tejesvi, M. V., Koivusaari, P., Korpela, K., Pokka, T. M.-L., Salo, J., Kaukola, T., Pirttilä, A. M., Uhari, M. K., et al. (2018) · Pediatric Research · doi:10.1038/pr.2018.29 · Cited by 66 · see citing works

Fold modulating function: bacterial toxins to functional amyloids

Syed, A. K., & Boles, B. R. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00401 · Cited by 65 · see citing works

Diet-Related Metabolic Perturbations of Gut Microbial Shikimate Pathway-Tryptamine-tRNA Aminoacylation-Protein Synthesis in Human Health and Disease

Paley, E. L. (2019) · International Journal of Tryptophan Research · doi:10.1177/1178646919834550 · Cited by 48 · see citing works

Diet-Induced Alterations in Gut Microflora Contribute to Lethal Pulmonary Damage in TLR2/TLR4-Deficient Mice

Ji, Y., Sun, S., Goodrich, J. K., Kim, H., Poole, A. C., Duhamel, G. E., Ley, R. E., & Qi, L. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.040 · Cited by 45 · see citing works

Meconium microbiome associates with the development of neonatal jaundice

Dong, T., Chen, T., White, R. A., III, Wang, X., Hu, W., Liang, Y., Zhang, Y., Lu, C., Chen, M., Aase, H., et al. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0048-x · Cited by 45 · see citing works

Maintenance of the enteric stem cell niche by bacterial lipopolysaccharides? Evidence and perspectives

Schuster, A. M., Klotz, M., Schwab, T., Liddo, R. D., Bertalot, T., Schrenk, S., Martin, M., Nguyen, T. D., Nguyen, T. N. Q., Gries, M., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12292 · Cited by 39 · see citing works

Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease

Baglietto‐Vargas, D., Sánchez‐Mejías, E., Navarro, V., Jiménez, S., Trujillo‐Estrada, L., Gómez-Arboledas, Á., Sanchez-Mico, M. V., Sanchez-Varo, R. M., Vizuete, M., Dávila, J. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10353-7 · Cited by 38 · see citing works

Dysregulated Metabolism of the Amyloid‐β Protein and Therapeutic Approaches in Alzheimer Disease

Kikuchi, K., Kidana, K., Tatebe, T., & Tomita, T. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26129 · Cited by 34 · see citing works

Variations of brain histamine levels in germ-free and nephrectomized rats.

Lr, H., & Rj, H. (1986) · Neurochemical Research · doi:10.1007/bf00967967 · Cited by 19 · see citing works

‘Neurasthenia gastrica’ revisited: perceptions of nerve-gut interactions in nervous exhaustion, 1880–1920

Lillestøl, K. (2018) · Microbial Ecology in Health and Disease · doi:10.1080/16512235.2018.1553438 · Cited by 4 · see citing works

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347 · see citing works

The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?

Misiak, B., Łoniewski, I., Marlicz, W., Frydecka, D., Szulc, A., Rudzki, L., & Samochowiec, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109951 · Cited by 343 · see citing works

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217 · see citing works

SAMP8 Mice as a Model of Age-Related Cognition Decline with Underlying Mechanisms in Alzheimer’s Disease

Liu, B., Liu, J., & Shi, J.-S. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200063 · Cited by 156 · see citing works

Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis

Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158 · see citing works

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works

Outdoor green space exposure and brain health measures related to Alzheimer’s disease: a rapid review

Besser, L. M. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043456 · Cited by 99 · see citing works

Roles of Gut Microbiota in the Regulation of Hippocampal Plasticity, Inflammation, and Hippocampus-Dependent Behaviors

Tang, W., Meng, Z., Li, N., Liu, Y., Li, L., Chen, D., & Yang, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.611014 · Cited by 89 · see citing works

Gut Microbiota: Implications in Alzheimer’s Disease

He, Y., Li, B., Sun, D., & Chen, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072042 · Cited by 81 · see citing works

Gut microbiota-derived short chain fatty acids act as mediators of the gut–brain axis targeting age-related neurodegenerative disorders: a narrative review

Guo, B., Zhang, J., Zhang, W., Chen, F., & Liu, B. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2272769 · Cited by 84 · see citing works

Gut–Brain Axis as a Pathological and Therapeutic Target for Neurodegenerative Disorders

Toledo, A. R. L., Monroy, G. R., Salazar, F. E., Lee, J.-Y., Jain, S., Yadav, H., & Borlongan, C. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031184 · Cited by 79 · see citing works

Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease

Tang, B. L. (2020) · Toxics · doi:10.3390/toxics8020021 · Cited by 81 · see citing works

Association between dietary diversity and cognitive impairment among the oldest-old: Findings from a nationwide cohort study

Zheng, J., Zhou, R., Li, F., Chen, L., Wu, K., Huang, J., Liu, H., Huang, Z., Xu, L., Yuan, Z., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.02.041 · Cited by 77 · see citing works

The Potential Role of Polyphenols in Oxidative Stress and Inflammation Induced by Gut Microbiota in Alzheimer’s Disease

Shabbir, U., Tyagi, A., Elahi, F., Aloo, S. O., & Oh, D. (2021) · Antioxidants · doi:10.3390/antiox10091370 · Cited by 70 · see citing works

Contribution of Gut Microbiota to Immunological Changes in Alzheimer’s Disease

van Olst, L., Roks, S. J. M., Kamermans, A., Verhaar, B. J. H., van der Geest, A. M., Muller, M., van der Flier, W. M., & de Vries, H. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.683068 · Cited by 67 · see citing works

The Microbiota–Gut–Brain Axis and Alzheimer Disease. From Dysbiosis to Neurodegeneration: Focus on the Central Nervous System Glial Cells

Giovannini, M. G., Lana, D., Traini, C., & Vannucchi, M. G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112358 · Cited by 63 · see citing works

Microbiota-gut-brain axis and Alzheimer’s disease: Implications of the blood-brain barrier as an intervention target

Liu, S., Gao, J., Liu, K., & Zhang, H. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111560 · Cited by 58 · see citing works

An emerging role of astrocytes in aging/neuroinflammation and gut-brain axis with consequences on sleep and sleep disorders

Gudkov, S. V., Burmistrov, D. E., Kondakova, E. V., Sarimov, R. M., Yarkov, R. S., Franceschi, C., & Vedunova, M. V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101775 · Cited by 56 · see citing works

Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer’s Disease

Borsom, E. M., Lee, K., & Cope, E. K. (2020) · Brain Sciences · doi:10.3390/brainsci10110814 · Cited by 54 · see citing works

Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization

Clemente‐Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025) · Bioengineering · doi:10.3390/bioengineering12020208 · Cited by 47 · see citing works

Nutritional Modulation of the Gut–Brain Axis: A Comprehensive Review of Dietary Interventions in Depression and Anxiety Management

Merino, M., Clemente‐Suárez, V. J., Ruisoto, P., Jiménez, M., Ramos‐Campo, D. J., Beltrán-Velasco, A. I., Martínez‐Guardado, I., Rubio-Zarapuz, A., Navarro-Jiménez, E., & Tornero-Aguilera, J. F. (2024) · Metabolites · doi:10.3390/metabo14100549 · Cited by 51 · see citing works

The Role of the Microbiota-Gut-Brain Axis in the Health and Illness Condition: A Focus on Alzheimer’s Disease

la Fuente, M. D. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201587 · Cited by 43 · see citing works

The Emerging Scenario of the Gut–Brain Axis: The Therapeutic Actions of the New Actor Kefir against Neurodegenerative Diseases

Pereira, T. D. M. C., Côco, L. Z., Ton, A. M. M., Meyrelles, S. S., Campos‐Toimil, M., Campagnaro, B. P., & Vasquez, E. C. (2021) · Antioxidants · doi:10.3390/antiox10111845 · Cited by 42 · see citing works

The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer’s Disease

Prajapati, S. K., Shah, R., Alford, N., Mishra, S. P., Jain, S., HANSEN, B. C., Sanberg, P. R., Molina, A. J. A., & Yadav, H. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad226 · Cited by 42 · see citing works

Prevotella copri transplantation promotes neurorehabilitation in a mouse model of traumatic brain injury

Gu, N., Yan, J., Tang, W., Zhang, Z., Wang, L., Zhao, L., Wang, Y., Zhu, Y., Tang, S., Zhong, J., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03116-5 · Cited by 40 · see citing works

Kefir metabolites in a fly model for Alzheimer’s disease

Batista, L. L., Malta, S. M., Silva, H. C. G., Borges, L. D. F., Rocha, L. O., da Silva, J. R., Rodrigues, T. S., Venturini, G., Padilha, K., Pereira, A. C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90749-8 · Cited by 41 · see citing works

Gut microbiota dysbiosis in Alzheimer's disease (AD): Insights from human clinical studies and the mouse AD models

Manfredi, J. N., Gupta, S. K., Vyavahare, S. S., Deák, F., Lu, X., Buddha, L., Wankhade, U. D., Lohakare, J., Isales, C. M., & Fulzele, S. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114778 · Cited by 38 · see citing works

A Randomized, Double-Blind, and Sham-Controlled Trial of an Innovative Brain-Gut Photobiomodulation Therapy: Safety and Patient Compliance

Blivet, G., Relaño-Ginés, A., Bodnar‐Wachtel, M., & Touchon, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220467 · Cited by 37 · see citing works

Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?

Ross, F. C., Mayer, D. E., Horn, J. V., Cryan, J. F., Rio, D. D., Randolph, E., Gill, C. I. R., Gupta, A., Ross, R. P., Stanton, C., et al. (2024) · Nutritional Neuroscience · doi:10.1080/1028415x.2023.2298098 · Cited by 37 · see citing works

Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles

Liu, X., Shen, L., Wan, M., Xie, H., & Wang, Z. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02428-1 · Cited by 33 · see citing works

The Gut Microbiome as a Component of the Gut–Brain Axis in Cognitive Health

Gao, W., Baumgartel, K. L., & Alexander, S. A. (2020) · Biological Research For Nursing · doi:10.1177/1099800420941923 · Cited by 34 · see citing works

Intestinal Flora Affect Alzheimer's Disease by Regulating Endogenous Hormones

Wu, Y., Hang, Z., Tong, L., & Du, H. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03784-w · Cited by 34 · see citing works

Interplay between engineered nanomaterials and microbiota

Zhang, Y., Mortimer, M., & Guo, L. (2020) · Environmental Science Nano · doi:10.1039/d0en00557f · Cited by 31 · see citing works

Dietary Interventions to Prevent or Delay Alzheimer’s Disease: What the Evidence Shows

Bartochowski, Z., Conway, J., Wallach, Y., Chakkamparambil, B., Alakkassery, S., & Grossberg, G. T. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00333-1 · Cited by 30 · see citing works

Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats

Li, M., Wang, S., Zhang, C., Chi, C., Liu, R., Wang, T., & Fu, F.-H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109659 · Cited by 29 · see citing works

Gut microbiota, pathogenic proteins and neurodegenerative diseases

Wei, W., Wang, S., Xu, C., Zhou, X., Lian, X., He, L., & Li, K. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.959856 · Cited by 29 · see citing works

Can nicotinamide riboside protect against cognitive impairment?

Braidy, N., & Liu, Y. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000691 · Cited by 29 · see citing works

Gut Microbiota, Peroxisome Proliferator-Activated Receptors, and Hepatocellular Carcinoma

Yu, Q., Wu, L., Ji, J., Feng, J., Dai, W., Li, J., Wu, J., & Guo, C. (2020) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s277870 · Cited by 27 · see citing works

Chronic administration of prebiotics and probiotics ameliorates pathophysiological hallmarks of Alzheimer’s disease in a APP/PS1 transgenic mouse model

Lana, D., Traini, C., Bulli, I., Sarti, G., Magni, G., Attorre, S., Giovannini, M. G., & Vannucchi, M. G. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1451114 · Cited by 25 · see citing works

Gut microbiota depletion delays somatic peripheral nerve development and impairs neuromuscular junction maturation

Cescon, M., Gambarotta, G., Calabrò, S., Cicconetti, C., Anselmi, F., Kankowski, S., Lang, L., Basic, M., Bleich, A., Bolsega, S., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2363015 · Cited by 23 · see citing works

Multi-omic Analysis of the Gut Microbiome in Rats with Lithium-Pilocarpine-Induced Temporal Lobe Epilepsy

Oliveira, M. E. T., Paulino, G. V. B., Júnior, E. D. D. S., Oliveira, F. A. D. S., Melo, V. M. M., Ursulino, J. S., de Aquino, T. M., Shetty, A. K., Landell, M. F., & Gitaí, D. L. G. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02984-3 · Cited by 23 · see citing works

Periodontal disease is associated with cognitive dysfunction in aging dogs: a blinded prospective comparison of visual periodontal and cognitive questionnaire scores

Dewey, C. W., & Rishniw, M. (2021) · Open Veterinary Journal · doi:10.5455/ovj.2021.v11.i2.4 · Cited by 22 · see citing works

Rebalancing immune homeostasis in combating disease: The impact of medicine food homology plants and gut microbiome

Xia, L., Li, C., Zhao, J., Sun, Q., & Mao, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156150 · Cited by 22 · see citing works

Gut Microbiota Alteration Is Associated With Cognitive Deficits in Genetically Diabetic (Db/db) Mice During Aging

Zhang, J., Zhang, Y., Yuan, Y., Liu, L., Zhao, Y., & Wang, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.815562 · Cited by 21 · see citing works

Bacteria-driven bio-therapy: From fundamental studies to clinical trials

Yu, Y., Lin, S., Chen, Z., Qin, B. Y., He, Z., Cheng, M., Sun, M., & Sun, J. Y. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101731 · Cited by 21 · see citing works

Integrated Analyses of Microbiomics and Metabolomics Explore the Effect of Gut Microbiota Transplantation on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats

Bi, T., Zhang, L., Zhan, L., Feng, R., Zhao, T., Ren, W., Hang, T., Zhou, W., & Lu, X. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.913002 · Cited by 19 · see citing works

The altered TBI fecal microbiome is stable and functionally distinct

Pyles, R. B., Miller, A. L., Urban, R. J., Sheffield‐Moore, M., Wright, T. J., Maxwell, C. A., Randolph, K. M., Danesi, C. P., McGovern, K. A., Vargas, J., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1341808 · Cited by 20 · see citing works

Adherence to High Dietary Diversity and Incident Cognitive Impairment for the Oldest-Old: A Community-Based, Nationwide Cohort Study

Song, Y., Zeng, L., Gao, J., Chen, L., Sun, C., Yan, M., Li, M., & Jiang, H. (2022) · Nutrients · doi:10.3390/nu14214530 · Cited by 19 · see citing works

Dietary diversity and overweight are associated with high intrinsic capacity among Chinese urban older adults (2020−2021)

Lin, S., Huang, M., Yang, L., Chen, S., Huang, X., Zheng, J., Yuan, Y., Li, N., Huang, F., & Zhu, P. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112194 · Cited by 18 · see citing works

Gut microbiota and Alzheimer's disease: Exploring natural product intervention and the Gut–Brain axis for therapeutic strategies

Pasupalak, J. K., Rajput, P., & Gupta, G. L. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177022 · Cited by 18 · see citing works

Gut Microbiome and Serum Metabolome Alterations Associated with Isolated Dystonia

Ma, L., Keng, J., Cheng, M., Pan, H., Feng, B., Hu, Y., Feng, T., & Yang, F. (2021) · mSphere · doi:10.1128/msphere.00283-21 · Cited by 17 · see citing works

Cerebrospinal fluid biomarkers in SARS-CoV-2 patients with acute neurological syndromes

Chaumont, H., Kaczorowski, F., San‐Galli, A., Michel, P. P., Tressières, B., Roze, E. F., Quadrio, I., & Lannuzel, A. (2022) · Revue Neurologique · doi:10.1016/j.neurol.2022.11.002 · Cited by 16 · see citing works

Oral Health and Cognitive Decline: A Systematic Review of the Periodontitis–Alzheimer’s Connection

Inchingolo, A. M., Inchingolo, A. D., Piras, F., Avantario, P., Ferrante, L., Paduanelli, G., Inchingolo, F., Palermo, A., Dipalma, G., & Corsalini, M. (2025) · Applied Sciences · doi:10.3390/app15126728 · Cited by 15 · see citing works

Microbiome-targeted Alzheimer’s interventions via gut-brain axis

Qin, R., Li, C., Yuan, X., & Chen, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1729708 · Cited by 15 · see citing works

Regulation by Different Types of Chaperones of Amyloid Transformation of Proteins Involved in the Development of Neurodegenerative Diseases

Muronetz, V. I., Kudryavtseva, S. S., Leisi, E. V., Kurochkina, L. P., Barinova, K. V., & Schmalhausen, E. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052747 · Cited by 15 · see citing works

Microbial SCFAs as epigenetic mediators: fine-tuning the gut-brain axis in neurodegenerative disorders

Xu, X., Cheng, Y., Liu, X., Ding, W., Zhu, Z., Wu, L., Ling, Z., Gao, Y., & Jing, Y. (2026) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2026.100574 · Cited by 16 · see citing works

An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review

Singh, S., Mahajan, M., Kumar, D., Singh, K., Chowdhary, M., & Amit (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102369 · Cited by 14 · see citing works

The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders

Wang, H., Chen, Y., Zhao, A., Shen, Z., & Zhang, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1709060 · Cited by 17 · see citing works

Managing the Microbiome: How the Gut Influences Development and Disease

Weinstein, N., Garten, B., Vainer, J., Minaya, D. M., & Czaja, K. (2020) · Nutrients · doi:10.3390/nu13010074 · Cited by 13 · see citing works

NMDA Receptors in Drosophila

Xia, S., & Chiang, A. (2009) · Europe PMC (PubMed Central) · Cited by 13 · see citing works

Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study

Pils, M., Dybala, A., Schaffrath, A., Rehn, F., Kutzsche, J., Blömeke, L., Tusche, M., Özdüzenciler, P., Bujnicki, T., Kraemer‐Schulien, V., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01597-3 · Cited by 12 · see citing works

Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice

Gao, J., Zhou, N., Lu, M., Wang, Q., Zhao, C., Wang, J., Zhou, M., & Xu, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1047121 · Cited by 12 · see citing works

Marked Response of Rat Ileal and Colonic Microbiota After the Establishment of Alzheimer’s Disease Model With Bilateral Intraventricular Injection of Aβ (1-42)

Xu, Q., Wen, L., Wei, G., Zhao, X., Liu, Y., Xiong, W., Zhang, T., Fan, Y., Chen, C., Xiang, C., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.819523 · Cited by 11 · see citing works

Cognitive Function, Healthy Lifestyle, and All-Cause Mortality among Chinese Older Adults: A Longitudinal Prospective Study

Li, H., Zheng, Y., Li, Q., & Wang, M. (2024) · Nutrients · doi:10.3390/nu16091297 · Cited by 10 · see citing works

Examining the Effects of an Anti-Salmonella Bacteriophage Preparation, BAFASAL®, on Ex-Vivo Human Gut Microbiome Composition and Function Using a Multi-Omics Approach

Mayne, J., Zhang, X., Butcher, J., Walker, K., Ning, Z., Wójcik, E. A., Dastych, J., Stintzi, A. P., & Figeys, D. (2021) · Viruses · doi:10.3390/v13091734 · Cited by 11 · see citing works

Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer’s disease in the cortex of APP/PS1 mice

Sarti, G., Traini, C., Magni, G., Attorre, S., Tognozzi, G., Calussi, E., Giovannini, M. G., Vannucchi, M. G., & Lana, D. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1596469 · Cited by 11 · see citing works

Dietary Diversity and Mild Cognitive Impairment in Middle-Aged and Older Chinese People: A Cross-Sectional Study

Xiao, Q., Li, Y., Li, B., Li, T., Li, F., Li, Y., Chen, L., Zhao, Z., Wáng, Q., & Rong, S. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230060 · Cited by 10 · see citing works

Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Wu, J., Cao, M., Hu, M., Gong, Y., Xue, J., Yang, Y., & Zhou, H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9855411 · Cited by 9 · see citing works

An integral view of gut microbiome diversity and functional metabolic changes of a gut-brain axis associated with dementia based on metagenomic analysis

Hsu, B., Chen, J., Wang, W., Chen, C., Fan, C.-W., Wu, C.-C., Hussain, B., & Tsai, H.-C. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115112 · Cited by 9 · see citing works

Protective effects of crocin against endogenous Aβ-induced neurotoxicity in N2a/APP695swe cells

Du, J., Li, Y., Song, D., Liu, J., Huang, Q., Li, J., Li, B., & Li, L. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05899-4 · Cited by 9 · see citing works

A Reappraisal of the Pathophysiology of Cushing Ulcer: A Narrative Review

Kumaria, A., Kirkman, M. A., Scott, R. A., Dow, G. R., Leggate, A. J., Macarthur, D., Ingale, H. A., Smith, S. J., & Basu, S. (2023) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000918 · Cited by 9 · see citing works

The Role of Extracellular Vesicles in Brain‐Peripheral Communication Following Ischemic Stroke: Implications for Neural Repair and Regeneration

de Rezende, V. L., Mathias, K., da Costa, M. D. A., Gonçalves, C. L., Barichello, T., & Petronilho, F. C. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70155 · Cited by 8 · see citing works

Update on new trends and progress of natural active ingredients in the intervention of Alzheimer's disease, based on understanding of traditional Chinese and Western relevant theories: A review

Li, W., Rang, Y., Liu, H., & Liu, C. (2023) · Phytotherapy Research · doi:10.1002/ptr.7908 · Cited by 8 · see citing works

Exploring the gut-brain-microbiome axis in Alzheimer's disease: Integrating metagenomics, metabolomics, and artificial intelligence for next-generation biomarker discovery

Oso, T. A., Ahmed, M. M., Okesanya, O. J., Adebayo, U. O., Obadeyi, K. B., Othman, Z. K., & Lucero‐Prisno, D. E. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251407700 · Cited by 7 · see citing works

Gastrointestinal dysfunction in Parkinson's disease

Timpka, J., & Odin, P. (2021) · International review of movement disorders · doi:10.1016/bs.irmvd.2021.07.004 · Cited by 7 · see citing works

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu, M., Li, T., Liang, H., & Zhong, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1416502 · Cited by 6 · see citing works

Influence of the Gut Microbiota, Metabolism and Environment on Neuropsychiatric Disorders

Wang, M., Ma, Y., Zeng, B., Yang, W., Huang, C., & Tang, B.-Q. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328335219241202142003 · Cited by 7 · see citing works

Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study

Zhao, B., Cheng, B., Li, X., Xia, J., Gou, Y., Kang, M., Hui, J., Liu, Y., Zhou, R., Liu, C., et al. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100078 · Cited by 6 · see citing works

Gut microbiota: a new player in the pathogenesis of perioperative neurocognitive disorder?

Dong, L., Li, J., Zhang, C., & Liu, D. (2021) · Ibrain · doi:10.1002/j.2769-2795.2021.tb00063.x · Cited by 6 · see citing works

Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting

Alwood, J. S., Mulavara, A. P., Iyer, J. S., Mhatre, S. D., Rosi, S., Shelhamer, M., Davis, C. M., Jones, C. W., Mao, X. W., Desai, R. I., et al. (2023) · Life · doi:10.3390/life13091852 · Cited by 7 · see citing works

Futoquinol improves Aβ25–35‐induced memory impairment in mice by inhibiting the activation of p38MAPK through the glycolysis pathway and regulating the composition of the gut microbiota

Zhang, Y., Chen, H., Zeng, M., Guo, P., Liu, M., Cao, B., Wang, R., Hao, F.-X., Zheng, X., & Feng, W. (2024) · Phytotherapy Research · doi:10.1002/ptr.8136 · Cited by 6 · see citing works

Association of dietary diversity and weight change with cognitive impairment among Chinese elderly: A prospective national cohort study

Lou, Y., Jiang, Q., Huang, S., Xie, Y., Wang, H., Wang, L., Wang, S., Xu, M., Lu, Z., Wang, F., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.057 · Cited by 5 · see citing works

Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression

Lana, D., Ugolini, F., Iovino, L., Attorre, S., & Giovannini, M. G. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1512985 · Cited by 5 · see citing works

Salvianolic acids modulate lifespan and gut microbiota composition in amyloid-β-expressing Drosophila melanogaster

Go, W., Ishak, I. H., Zarkasi, K. Z., & Azzam, G. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-04163-z · Cited by 4 · see citing works

Piper Kadsura Extract and its Bioactive Components Attenuates Aβ25−35-Induced Neurotoxicity by Modulating Glycolysis and Activating the SIRT1/PPARγ/GLUT1 Axis

Ye, K., Zeng, M., Zhang, B., Hao, F., Guo, P., Zhang, Y., Liu, T., Chen, H., Feng, W., & Zheng, X. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04433-8 · Cited by 4 · see citing works

A novel gentiopicroside derivative clears phosphorylation tau to improve memory of AD mice by targeting AMPK and increase of gut neuroprotective metabolites

Wang, Y., Cheng, C., Li, L., Chen, D., Wang, G., Ohno, H., Xiang, L., & Qi, J. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157781 · Cited by 4 · see citing works

Neonatal gut Bifidobacterium associates with indole-3-lactic acid levels in blood and risk of ADHD at age 10

Widdowson, M., Shah, S. A., Thorsen, J., Poulsen, C. S., Rosenberg, J. B., Mohammadzadeh, P., Jepsen, J. R. M., Vinding, R., Poulsen, C. E., Rodríguez, C. L., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03480-z · Cited by 4 · see citing works

Changes of Dopamine and Tyrosine Hydroxylase Levels in the Brain of Germ-free Mice.

Wang, Y., Qiao, H., & Zhang, Y. (2023) · PubMed Central · doi:10.30498/ijb.2022.236732.2798 · Cited by 4 · see citing works

Exploratory Study of Gastrointestinal Redox Biomarkers in the Presymptomatic and Symptomatic Tg2576 Mouse Model of Familial Alzheimer’s Disease: Phenotypic Correlates and Effects of Chronic Oral d -Galactose

Homolak, J., Perhoč, A. B., Knezović, A., Barilar, J. O., Virag, D., & Šalković‐Petrišić, M. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00495 · Cited by 4 · see citing works

Microbiome-Based Therapies in Parkinson’s Disease: Can Tuning the Microbiota Become a Viable Therapeutic Strategy?

Onaolapo, A. Y., Ojo, F. O., Olofinnade, A. T., Falade, J., Lawal, I. A., & Onaolapo, O. J. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220903114559 · Cited by 3 · see citing works

The influence of gut brain axis in neurodegenerative diseases: short review

Pérez, R. M., Alcantar-Garibay, O., Ben-Zión, E. W., Blancarte-Hernández, E., Marion, E. T., Loza-López, E. C., Galindo-Ruiz, M., & Monroy, G. R. (2022) · Revista de Fomento Social · doi:10.24875/rmn.210000821 · Cited by 3 · see citing works

Investigation for the involvement of microbial FliC and DING proteins in Alzheimer's Disease and Mild Cognitive Impairment and correlation with neurodegeneration and inflammation markers

Andreadou, E. G., Katsipis, G., Tsolaki, M., & Pantazaki, Α. A. (2023) · Brain Disorders · doi:10.1016/j.dscb.2023.100091 · Cited by 3 · see citing works

Mediating effects of physical activities and cognitive function on the relationship between dietary diversity and all-cause mortality in community-dwelling older adults

Zhang, C., Bai, A., Fan, G., Shen, J., Kang, Y., & Zhang, P. (2024) · Journal of Global Health · doi:10.7189/jogh.14.04169 · Cited by 2 · see citing works

Amelioration of cognitive and behavioral damage by Bifidobacterium breve 05 via regulation of BDNF/NeuN and LPS/Iba1/aβ expression

Zhou, S., Ma, X., Nie, H., Mu, G., & Wu, X. (2025) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2025.2584325 · Cited by 2 · see citing works

A Narrative Review of Dietary, Lifestyle, and Other Complementary and Alternative Approaches in Alzheimer’s Disease and Related Dementias

Musich, M. L., Shenker, J. I., & Beversdorf, D. Q. (2026) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad3010004 · Cited by 2 · see citing works

Epigenetic regulons in Alzheimer's disease

Raval, M., Mishra, S., & Tiwari, A. K. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.01.012 · Cited by 2 · see citing works

Central nervous system diseases associated with blood brain barrier breakdown - A Comprehensive update of existing literature

Dutta, R. (2020) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001035 · Cited by 2 · see citing works

Neuroendocrine signaling as a pathological seed for the female bias of Alzheimer’s disease and the concept of estrobolome

Rapaka, D., Saniotis, A., Monkgogi, T., & Bitra, V. R. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.118999 · Cited by 2 · see citing works

Marine-Derived bioactive compounds from Aquaculture: Receptor-Mediated neuroprotection in neurodegenerative disorders

Patwekar, F. I., Patwekar, M. F., Wei, L. S., Rather, G. A., Mohammed, A., Hussain, M. S., Gupta, G., Fuloria, S., & Fuloria, N. K. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150208 · Cited by 1 · see citing works

Unhealthy dietary patterns and Alzheimer’s disease: associations and underlying mechanistic pathways

Ramasinghe, C., & Xu, B. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2691237 · Cited by 1 · see citing works

The Microbiota-Gut-Brain Axis: Role in Alzheimer’s Disease

Churi, K. P., & Gandre, V. (2024) · Journal of Asian Medical Students Association

The role of Gut-Microbiome-Brain-axis in Alzheirmer's disease

Rocha, V. M. N., Rocha, V. M. N., Gomes, G. F., Galvão, S. L., de Paula, L. Z. M., Oliveira, M. E., Oliveira, I. D., da Silva, L. A., Freitas, V. H. M., Sales, C. R., et al. (2024) · Brazilian Journal of Clinical Medicine and Review · doi:10.52600/2965-0968.bjcmr.2023.2.3.22-28 · Cited by 3 · see citing works

The Roles of the Microbiome in Alzheimer’s Disease

Hafiz, Z., Malek, M., & Ju, W. (2021) · UTSC s Journal of Natural Sciences · doi:10.33137/jns.v2i1.35867

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347 · see citing works

Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease

Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works