The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
Open accessAbstract
Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted T cell activation, either spontaneous or due to immunotherapy. Here we review the current understanding of mechanisms by which IDO participates in the control of inflammation and in peripheral tolerance. Focusing on the tumor microenvironment, we examine the role of IDO in response to apoptotic cells and the impact of IDO on Treg cell function. We discuss how the counter-regulatory and tolerogenic functions of IDO can be targeted for cancer immunotherapy and present an overview of the current clinical progress in this area.
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Cites
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Cited by
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
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“Interestingly, CD276 (B7-H3), known to augment Tregs and inhibit T cell responses (Costa et al., 2018; Prasad et al., 2004; Suh et al., 2003), was expressed most prominently on CAFs and TSKs.”
BackgroundInfluentialTryptophan metabolism in health and disease
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cGAS-STING, an important pathway in cancer immunotherapy
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Metadata
- Authors
- Munn, D. H., & Mellor, A. L.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 37
- Issue
- 3
- Pages
- 193-207
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2273004055
- Cited by
- 1,041
- References
- 15
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
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