Cited by 380Cardiovascular and exercise physiologyCardiac Health and Mental HealthPhysical Activity and Health

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Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation

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Kavanagh, Terence, Mertens, Donald J, Hamm, Larry F, Beyene, Joseph, Kennedy, Johanna, Corey, Paul, Shephard, Roy J·2003·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2003.07.028

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Abstract

Objectives This study investigated the prognostic importance of measured peak oxygen intake (VO(2peak)) in women with known coronary heart disease referred for outpatient cardiac rehabilitation.Background Exercise capacity is a powerful predictor of prognosis in men with known or suspected coronary disease. Similar findings are described in women, but fewer studies have utilized measured VO(2peak), the most accurate measure of exercise capacity.Methods A single-center design took data from 2,380 women, age 59.7 +/- 9.5 years (1,052 myocardial infarctions, 620 coronary bypass procedures, and 708 with proven ischemic heart disease), who underwent cardiorespiratory exercise testing. They were followed for an average of 6.1 +/- 5 years (median 4.5 years, range 0.4 to 25 years) until cardiac and all-cause death.Results We recorded 95 cardiac deaths and 209 all-cause deaths. Measured VO(2peak) was an independent predictor of risk, values > or =13 ml/kg/min (3.7 multiples of resting metabolic rate) conferring a 50% reduction in cardiac mortality (hazard ratio [HR] 0.5, p = 0.001). Considered as a continuous variable, a 1 ml/kg/min advantage in initial VO(2peak) was associated with a 10% lower cardiac mortality. Adverse predictors were diabetes (HR 2.73, p = 0.0005) and antiarrhythmic therapy (HR 3.93, p = 0.0001).Conclusions As in men, measured VO(2peak) is a strong independent predictor of cardiac mortality in women referred for cardiac rehabilitation.

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Authors: Kavanagh, T., Mertens, D. J., Hamm, L. F., Beyene, J., Kennedy, J., Corey, P., & Shephard, R. J.
Affiliations: University of Toronto (CA)
Toronto Rehabilitation Institute (CA)
George Washington University (US)
Corresponding author: Kavanagh, Terence
ORCID: Beyene, Joseph
Shephard, Roy J
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2003-12
Volume: 42
Issue: 12
Pages: 2139-2143
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2003.07.028
OpenAlex: W2119705713
Cited by: 380
References: 22
Citations by year: 2026: 7 · 2025: 14 · 2024: 12 · 2023: 15 · 2022: 19 · 2021: 18 · 2020: 22 · 2019: 26 · 2018: 14 · 2017: 17 · 2016: 21 · 2015: 17 · 2014: 19 · 2013: 21 · 2012: 28
FWCI: 22.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3515 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: exercise capacity, cardiac mortality, women, coronary artery disease, cardiac rehabilitation, prognosis, all-cause mortality, diabetes mellitus, antiarrhythmic therapy, myocardial infarction, coronary artery bypass grafting
MeSH terms: Coronary Artery Bypass, Coronary Disease, Exercise Test, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction, Oxygen Consumption, Prognosis

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Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation

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