The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans
Open accessAbstract
Objectives We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF).Background Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has established the pattern of aging-associated DF impairment, whereas little change is observed in systolic function (SF).Methods Diastolic function was assessed in 25 subjects (age 53 +/- 12 years) practicing CR for 6.5 +/- 4.6 years and 25 age- and gender-matched control subjects consuming Western diets. Diastolic function was quantified by transmitral flow, Doppler tissue imaging, and model-based image processing (MBIP) of E waves. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta1 (TGF-beta1) were also measured.Results No difference in SF was observed between groups; however, standard transmitral Doppler flow DF indexes of the CR group were similar to those of younger individuals, and MBIP-based, flow-derived DF indexes, reflecting chamber viscoelasticity and stiffness, were significantly lower than in control subjects. Blood pressure, serum CRP, TNF-alpha, and TGF-beta(1) levels were significantly lower in the CR group (102 +/- 10/61 +/- 7 mm Hg, 0.3 +/- 0.3 mg/l, 0.8 +/- 0.5 pg/ml, 29.4 +/- 6.9 ng/ml, respectively) compared with the Western diet group (131 +/- 11/83 +/- 6 mm Hg, 1.9 +/- 2.8 mg/l, 1.5 +/- 1.0 pg/ml, 35.4 +/- 7.1 ng/ml, respectively).Conclusions Caloric restriction has cardiac-specific effects that ameliorate aging-associated changes in DF. These beneficial effects on cardiac function might be mediated by the effect of CR on blood pressure, systemic inflammation, and myocardial fibrosis.
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“This diet was associated with improvements in oxidative stress, inflammation, glucose, insulin sensitivity, blood pressure, lipids, and cardiac function (34,35).”
From Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health (2008) · cites this paper as [35]
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“A similar degree of calorie restriction in humans has been achieved by diets low in processed foods and high in vegetables, fruits, nuts, low-fat dairy, egg whites, soy protein, whole wheat, and lean meat that provides Ͼ100% of the daily value for all of the essential nutrients (34,35).”
From Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health (2008) · cites this paper as [35]
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“Those on the calorie-restricted diet demonstrated a number of metabolic improvements including body fat, lower blood pressure, and improved insulin sensitivity, and lipid profile (210–212).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [212]
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Metadata
- Authors
- Meyer, T. E., Kovács, S. J., Ehsani, A. A., Klein, S., Holloszy, J. O., & Fontana, L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Fontana, Luigi
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 47
- Issue
- 2
- Pages
- 398-402
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2083860193
- Cited by
- 383
- References
- 21
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 18 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 14 · 2016: 19 · 2015: 24 · 2014: 17 · 2013: 33 · 2012: 23
- FWCI
- 22.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Funders
- American Heart Association
- National Institutes of Health (DK56351, DK20579, RR‐00036)
- National Institute on Aging (AG 00078)
- National Heart, Lung, and Blood Institute (K24HL004023, HL-04023, HL 54179, R01HL054179)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 56351, DK20579, P30DK056341)
- National Center for Research Resources (RR.00036)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- caloric restriction, diastolic function, cardiac aging, systolic function, myocardial stiffness, transmitral flow, tissue Doppler imaging, model-based image processing, E-wave, C-reactive protein, TNF-α, TGF-β1, systemic inflammation, blood pressure, myocardial fibrosis, Western diet
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, C-Reactive Protein, Cross-Sectional Studies, Diastole, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Systole, Tumor Necrosis Factor-alpha, Echocardiography, Doppler, Transforming Growth Factor beta, Caloric Restriction, Transforming Growth Factor beta1
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