The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Mechanical Factors in Arterial Aging
Open accessAbstract
The human arterial system in youth is beautifully designed for its role of receiving spurts of blood from the left ventricle and distributing this as steady flow through peripheral capillaries. Central to such design is "tuning" of the heart to arterial tree; this minimizes aortic pressure fluctuations and confines flow pulsations to the larger arteries. With aging, repetitive pulsations (some 30 million/year) cause fatigue and fracture of elastin lamellae of central arteries, causing them to stiffen (and dilate), so that reflections return earlier to the heart; in consequence, aortic systolic pressure rises, diastolic pressure falls, and pulsations of flow extend further into smaller vessels of vasodilated organs (notably the brain and kidney). Stiffening leads to increased left ventricular (LV) load with hypertrophy, decreased capacity for myocardial perfusion, and increased stresses on small arterial vessels, particularly of brain and kidney. Clinical manifestations are a result of diastolic LV dysfunction with dyspnea, predisposition to angina, and heart failure, and small vessel degeneration in brain and kidney with intellectual deterioration and renal failure. While aortic stiffening is the principal cause of cardiovascular disease with age in persons who escape atherosclerotic complications, it is not a specific target for therapy. The principal target is the smooth muscle in distributing arteries, whose relaxation has little effect on peripheral resistance but causes substantial reduction in the magnitude of wave reflection. Such relaxation is achieved through regular exercise and with the vasodilating drugs that are used in modern treatment of hypertension and cardiac failure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077
Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P., & Benetos, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1236 · Cited by 3,856
Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study
Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997) · Circulation · doi:10.1161/01.cir.96.1.308 · Cited by 2,321
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244
The progression from hypertension to congestive heart failure
Levy, D. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03530440037034 · Cited by 2,155 · cited 1×
“Hypertension is a condition arbitrarily efined by blood pressure limits that are achieved by the vast ajority of the population who reach 90 years of age (8), nd is better described by underlying structural change.”
BackgroundImpact of Aortic Stiffness on Survival in End-Stage Renal Disease
Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (1999) · Circulation · doi:10.1161/01.cir.99.18.2434 · Cited by 2,138
Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914
Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients
Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493
O’Rourke, M. F., & Safar, M. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000168052.00426.65 · Cited by 1,279 · cited 1×
“A full iscussion is not possible here, but links between large artery tiffening and microvascular disease in brain and kidney, and amage to and dysfunction of these organs (42,51–53), are onsistent with the strong and causative association that had een described (41,42) on the basis of pathophysiological echanisms.”
BackgroundSelf-citation
Cited by
Mechanotransduction and extracellular matrix homeostasis
Humphrey, J. D., Dufresne, E. R., & Schwartz, M. A. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3896 · Cited by 2,124
Wang (2012) · doi:10.1161/circresaha.111.261388 · Cited by 957
Toward ubiquitous blood pressure monitoring via pulse transit time: Theory and practice
Mukkamala, R., Hahn, J.-O., Inan, O. T., Mestha, L. K., Kim, C.-S., Toreyin, H., & Kyal, S. (2015) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2015.2441951 · Cited by 935
“Further, it is well known that aging alters the composition in the central arteries but not the peripheral arteries [24]–[26].”
BackgroundCuffless Blood Pressure Estimation Algorithms for Continuous Health-Care Monitoring
Kachuee, M., Kiani, M. M., Mohammadzade, H., & Shabany, M. (2017) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2016.2580904 · Cited by 621
Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall
Werner, C., Fürster, T., Widmann, T., Pöss, J., Roggia, C., Hanhoun, M., Scharhag, J., Büchner, N., Meyer, T., Kindermann, W., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.861005 · Cited by 380
Metadata
- Authors
- O’Rourke, M. F., & Hashimoto, J.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 50
- Issue
- 1
- Pages
- 1-13
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W58419149
- Cited by
- 1,250
- References
- 16
- FWCI
- 44.71
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanical Factors in Arterial Aging. https://app.cochat.ai/papers/10.1016/j.jacc.2006.12.050
- The paper
- O’Rourke, M. F., & Hashimoto, J. (2007). Mechanical Factors in Arterial Aging. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2006.12.050
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
