Cited by 133Protease and Inhibitor MechanismsCardiac Imaging and DiagnosticsCerebrovascular and Carotid Artery Diseases

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Molecular Imaging of Matrix Metalloproteinase in Atherosclerotic Lesions

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Fujimoto, Shinichiro, Hartung, Dagmar, Ohshima, Satoru, Edwards, D. Scott, Zhou, Jun, Yalamanchili, Padmaja, Azure, Michael, Fujimoto, Ai, Isobe, Satoshi, Matsumoto, Yuji, Boersma, Hendricus, Wong, Nathan, Yamazaki, Junichi, Narula, Navneet, Petrov, Artiom, Narula, Jagat·2008·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2008.08.048

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Abstract

Objectives This study sought to evaluate the feasibility of noninvasive detection of matrix metalloproteinase (MMP) activity in experimental atherosclerosis using technetium-99m-labeled broad matrix metalloproteinase inhibitor (MPI) and to determine the effect of dietary modification and statin treatment on MMP activity.Background The MMP activity in atherosclerotic lesions contributes to the vulnerability of atherosclerotic plaques to rupture.Methods Atherosclerosis was produced in 34 New Zealand White rabbits by balloon de-endotheliazation of the abdominal aorta and a high-cholesterol diet. In addition, 12 unmanipulated rabbits were used as controls and 3 for blood clearance characteristics. In vivo micro-single-photon emission computed tomography (SPECT) imaging was performed after radiolabeled MPI administration. Subsequently, aortas were explanted to quantitatively measure percent injected dose per gram (%ID/g) MPI uptake. Histological and immunohistochemical characterization was performed and the extent of MMP activity was determined by gel zymography or enzyme-linked immunosorbent assays.Results The MPI uptake in atherosclerotic lesions (n = 18) was clearly visualized by micro-SPECT imaging; MPI uptake was markedly reduced by administration of unlabeled MPI before the radiotracer (n = 4). The MPI uptake was also significantly reduced after diet withdrawal (n = 6) and fluvastatin treatment (n = 6); no uptake was observed in normal control rabbits (n = 12). The %ID/g MPI uptake (0.10 +/- 0.03%) in the atherosclerotic lesions was significantly higher than the uptake in control aorta (0.016 +/- 0.004%, p < 0.0001). Uptake in fluvastatin (0.056 +/- 0.011%, p < 0.0005) and diet withdrawal groups (0.043 +/- 0.011%, p < 0.0001) was lower than the untreated group. The MPI uptake correlated with immunohistochemically verified macrophage infiltration (r = 0.643, p < 0.0001), and MMP-2 (r = 0.542, p < 0.0001) or MMP-9 (r = 0.578, p < 0.0001) expression in plaques.Conclusions The present data show the feasibility of noninvasive detection of MMP activity in atherosclerotic plaques, and confirm that dietary modification and statin therapy reduce MMP activity.

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Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry
Visse, R., & Nagase, H. (2003) · Circulation Research · doi:10.1161/01.res.0000070112.80711.3d · Cited by 4,575
Lessons From Sudden Coronary Death: A Comprehensive Morphological Classification Scheme for Atherosclerotic Lesions
Virmani, R., Kolodgie, F. D., Burke, A. P., Farb, A., & Schwartz, S. M. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.5.1262 · Cited by 4,084
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.
Galis, Z. S., Sukhova, G. K., Lark, M. W., & Libby, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117619 · Cited by 2,537
Pathology of the Vulnerable Plaque
Virmani, R., BURKE, A. P., Farb, A. A., & Kolodgie, F. D. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.065 · Cited by 2,358
Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.
Davies, M. J., & Thomas, A. C. (1985) · Heart · doi:10.1136/hrt.53.4.363 · Cited by 1,985
Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis
Galis, Z. S., & Khatri, J. J. (2002) · Circulation Research · doi:10.1161/res.90.3.251 · Cited by 1,965
Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.
van der Wal, A. C., Becker, A. E., van der Loos, C. M., & Das, P. K. (1994) · Circulation · doi:10.1161/01.cir.89.1.36 · Cited by 1,921
Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.
Galis, Z. S., & Khatri, J. J. (2002) · PubMed · Cited by 1,787
Coronary Plaque Erosion Without Rupture Into a Lipid Core
Farb, A. A., BURKE, A. P., Tang, A. L., Liang, Y.-H., Mannan, P., Smialek, J. E., & Virmani, R. (1996) · Circulation · doi:10.1161/01.cir.93.7.1354 · Cited by 1,272
Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture.
Moreno, P., Falk, E., Palacios, I. F., Newell, J. B., Fuster, V., & Fallon, J. T. (1994) · Circulation · doi:10.1161/01.cir.90.2.775 · Cited by 1,105

Show all 42 references

Research works printed but not linked: 2

Shah, 1995, Human monocyte-derived macrophage induce collagen breakdown in fibrous caps of atherosclerotic plaques, Circulation, 92, 1565
Fujimoto, 2007, Molecular Imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy, Circulation, 116

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Authors: Fujimoto, S., Hartung, D., Ohshima, S., Edwards, D. S., Zhou, J., Yalamanchili, P., Azure, M., Fujimoto, A., Isobe, S., Matsumoto, Y., Boersma, H., Wong, N., Yamazaki, J., Narula, N., Petrov, A., & Narula, J.
Affiliations: University of California, Irvine (US)
Bristol-Myers Squibb (United States) (US)
Toho University (JP)
Corresponding author: Petrov, Artiom
ORCID: Edwards, D. Scott
Zhou, Jun
Fujimoto, Ai
Wong, Nathan
Narula, Navneet
Petrov, Artiom
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2008-12
Volume: 52
Issue: 23
Pages: 1847-1857
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2008.08.048
OpenAlex: W2141910805
Cited by: 133
References: 42
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 10 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 10 · 2016: 2 · 2015: 6 · 2014: 16 · 2013: 8 · 2012: 11
FWCI: 5.00
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1688 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
Funders: National Heart, Lung, and Blood Institute (R01HL078681)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords: matrix metalloproteinases, atherosclerosis, MMP-2, MMP-9, plaque vulnerability, macrophage infiltration, fluvastatin, statin therapy, high-cholesterol diet, rabbit model, atherosclerotic plaque imaging, radiotracer clearance
MeSH terms: Animals, Aorta, Abdominal, Combined Modality Therapy, Immunohistochemistry, Macrophages, Male, Models, Chemical, Rabbits, Technetium, Tomography, Emission-Computed, Single-Photon, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Atherosclerosis, Matrix Metalloproteinase Inhibitors

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Molecular Imaging of Matrix Metalloproteinase in Atherosclerotic Lesions

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