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Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation
Open accessAbstract
Background The long-term outcome of atrial fibrillation (AF) ablation demonstrates attrition. This outcome may be due to failure to attenuate the progressive substrate promoted by cardiovascular risk factors.Objectives The goal of this study was to evaluate the impact of risk factor and weight management on AF ablation outcomes.Methods Of 281 consecutive patients undergoing AF ablation, 149 with a body mass index ≥27 kg/m(2) and ≥1 cardiac risk factor were offered risk factor management (RFM) according to American Heart Association/American College of Cardiology guidelines. After AF ablation, all 61 patients who opted for RFM and 88 control subjects were assessed every 3 to 6 months by clinic review and 7-day Holter monitoring. Changes in the Atrial Fibrillation Severity Scale scores were determined.Results There were no differences in baseline characteristics, number of procedures, or follow-up duration between the groups (p = NS). RFM resulted in greater reductions in weight (p = 0.002) and blood pressure (p = 0.006), and better glycemic control (p = 0.001) and lipid profiles (p = 0.01). At follow-up, AF frequency, duration, symptoms, and symptom severity decreased more in the RFM group compared with the control group (all p < 0.001). Single-procedure drug-unassisted arrhythmia-free survival was greater in RFM patients compared with control subjects (p < 0.001). Multiple-procedure arrhythmia-free survival was markedly better in RFM patients compared with control subjects (p < 0.001), with 16% and 42.4%, respectively, using antiarrhythmic drugs (p = 0.004). On multivariate analysis, type of AF (p < 0.001) and RFM (hazard ratio 4.8 [95% confidence interval: 2.04 to 11.4]; p < 0.001) were independent predictors of arrhythmia-free survival.Conclusions Aggressive RFM improved the long-term success of AF ablation. This study underscores the importance of therapy directed at the primary promoters of the AF substrate to facilitate rhythm control strategies.
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“Moderate or severe OSA (AHI ≥ 15) is reported in 20%–62%.330,704,706,710–715”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [330]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In studies, such as the ARREST-AF cohort study or the ACTIVE-AF trial, regular exercise programs exhibited a reduction in AF-related symptoms, AF incidence, and AF recurrence rates [76,77].”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [76]
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“Other groups have studied the relationship between subjective (grade) or objective (volume/weight) tonsil evaluation and AHI and reported a trend toward significance328 or a significant association.318,329–334”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [330]
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“Given the high incidence of AF after CTI ablation for typical AFL”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [166]
In the citing paper
“Intensive weight-reduction management in addition to management of other cardiovascular risk factors (in the range of 10-15 kg weight loss achieved) led to fewer AF recurrences and symptoms compared with an approach based on general advice in obese patients with AF.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [203]
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Items 201–300 of 949
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“Data from the ARREST-AF (Aggressive Risk Factor Reduction Study for AF) cohort show that aggressive management of risk factors, modifiable by exercise, alters AF burden in patients.(206) Those who attended a specific risk factor management clinic had decreased frequency, duration, symptoms, and symptom severity compar…”
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“The recent ARREST-AF trial provides spectacular new insights in this field, demonstrating that using a strategy of aggressive risk factor modification including weight loss and improved glycemic control, the odds of arrhythmiafree survival after ablation increased almost 5-fold (46) (Figure 2).”
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“Accordingly, aggressive risk factor and weight management improved the long-term success of AF ablation in patients with AF with a body mass index ≥27 kg/ m(2) and ≥1 cardiac risk factor (ARREST-AF [Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation] study).(43)…”
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“001).(93) Single-procedure drugunassisted arrhythmia-free survival was also greater in the intervention group compared with control subjects (32.”
BackgroundResultKhan, N., Bano, A., Shahid, M. A., Nasim, W., & Babar, M. A. (2018) · Biologia · doi:10.2478/s11756-018-0127-1 · Cited by 52
Molecular mechanisms of atrial fibrosis: implications for the clinic
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“free survival following catheter ablation for AF [135].”
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Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
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“On multivariate analysis, RFM was an independent predictor of arrhythmia free survival (Pathak et al., 2014).”
MethodAtrial fibrillation in adults with congenital heart disease
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Self-citationGlycemic control and atrial fibrillation: an intricate relationship, yet under investigation
Papazoglou, Α. S., Κάρτας, Α., Moysidis, D. V., Tsagkaris, C., Papadakos, S. P., Bekiaridou, Α., Samaras, A., Karagiannidis, E., Papadakis, M., & Giannakoulas, G. A. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01473-0 · Cited by 51
Therapeutic Approaches to Atrial Fibrillation Ablation Targeting Atrial Fibrosis
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“In the other direction, intensive risk factor management may substantially reduce the burden of AF by weakening the influence of these modulators, and this has been shown to significantly improve catheter ablation outcome (12).”
BackgroundInflammation and adiposity: new frontiers in atrial fibrillation
Vyas, V. S., Hunter, R. J., Longhi, M. P., & Finlay, M. (2020) · EP Europace · doi:10.1093/europace/euaa214 · Cited by 50
Cardio-Lipotoxicity of Epicardial Adipose Tissue
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“EAT also has a role in contributing to CAD, as it can contribute to this inflammation and immune response among various other mechanisms.”
The Impact of First Procedure Success Rate on the Economics of Atrial Fibrillation Ablation
MANSOUR, M. C., Karst, E., Heist, E. K., Dalal, N., Wasfy, J. H., Packer, D. L., Calkins, H. G., Ruskin, J. N., & Mahapatra, S. (2016) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2016.06.002 · Cited by 47
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“2014 [58] ARREST-AF”
BackgroundPrevalence of Undiagnosed Sleep Apnea in Patients With Atrial Fibrillation and its Impact on Therapy
Shapira‐Daniels, A., Mohanty, S., Contreras‐Valdes, F. M., Tieu, H. T., THOMAS, R. J., Natale, A., & Anter, E. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.05.030 · Cited by 44
Chinese guidelines for the diagnosis and management of atrial fibrillation
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“Obesity or overweight has been related to a worse ablation outcome in patients with AF [5,6].”
BackgroundAtrial Fibrillation and Heart Failure
Ariyaratnam, J., Lau, D. H., Sanders, P., & Kalman, J. M. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.11.004 · Cited by 44
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The burden of proof: The current state of atrial fibrillation prevention and treatment trials
Zakeri, R., Wagoner, D. R. V., Calkins, H. G., Wong, T., Ross, H., Heist, E. K., Meyer, T. E., Kowey, P. R., Mentz, R. J., Cleland, J. G. F., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.01.032 · Cited by 42
Sleep Apnea and Atrial Fibrillation
Linz, D., Nattel, S., Kalman, J. M., & Sanders, P. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.10.003 · Cited by 45
Self-citationDonnellan, E., Cotter, T. G., Wazni, O. M., Elshazly, M. B., Kochar, A., Wilner, B. R., Patel, D. R., Kanj, M. H., Hussein, A. A., Baranowski, B. J., et al. (2020) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2020.05.023 · Cited by 42
The counterintuitive role of exercise in the prevention and cause of atrial fibrillation
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Effect of metformin on outcomes of catheter ablation for atrial fibrillation
Deshmukh, A., Ghannam, M., Liang, J. J., Saeed, M., Cunnane, R. T., Ghanbari, H., Latchamsetty, R., Crawford, T. C., Batul, S. A., Chung, E. H., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14954 · Cited by 44
“As weight loss reduces the risk of incident AF, AF burden, and recurrence of AF after CA, it may be that metformin exerts a beneficial effect on the outcomes of CA through this mechanism.(4,5,32) Because the duration of metformin treatment before ablation was variable, the net effect of metformin on weight loss could…”
BackgroundAtrial Cardiomyopathy: An Emerging Cause of the Embolic Stroke of Undetermined Source
Ning, Y., Tse, G., Luo, G., & Li, G. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.674612 · Cited by 46
Epicardial fat and atrial fibrillation: the perils of atrial failure
Poggi, A. L., Gaborit, B., Schindler, T. H., Liberale, L., Montecucco, F., & Carbone, F. (2022) · EP Europace · doi:10.1093/europace/euac015 · Cited by 41
Tønnesen, J., Pallisgaard, J. L., Ruwald, M. H., Rasmussen, P. V., Johannessen, A. C., Hansen, J., Worck, R. H., Zörner, C. R., Riis‐Vestergaard, L. D., Middelfart, C., et al. (2022) · EP Europace · doi:10.1093/europace/euac225 · Cited by 41
“At 6 months of follow up, the intervention group displayed lesser AF frequency, duration, and symptoms than the control group, emphasizing the importance of weight loss.(20) The recently published SORT-AF trial included 133 patients having undergone AF ablation with BMI between 30 and 40.”
MethodAtrial fibrillation prevention: an appraisal of current evidence
Boriani, G., & Proietti, M. (2017) · Heart · doi:10.1136/heartjnl-2017-311546 · Cited by 41
Gulizia, M. M., Cemin, R., Colivicchi, F., Luca, L. D., Lenarda, A. D., Boriani, G., Pasquale, G. D., Nardi, F., Scherillo, M., Lucci, D., et al. (2018) · EP Europace · doi:10.1093/europace/euy166 · Cited by 42
“Obesity is an often-neglected risk factor for AF,(14) and weight loss was shown to be associated with a significant reduction of AF burden and maintenance of sinus rhythm,(15) improving also long-term success of AF ablation procedures.(16) Hypertension (77.”
Catheter ablation of atrial fibrillation in patients with diabetes mellitus
Wang, A., Truong, T., Black‐Maier, E., Green, C. L., Campbell, K. B., Barnett, A. S., Febre, J., Loring, Z., Al‐Khatib, S. M., Atwater, B. D., et al. (2020) · Heart Rhythm O2 · doi:10.1016/j.hroo.2020.04.006 · Cited by 41
“In the ARREST-AF (Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation) trial, intensive risk factor management, including improved glycemic control (HbA1c ,7%), was associated with a nearly 5-fold higher odds of arrhythmia-free survival after ablation.(18) In the…”
Background2023 update: The importance of cardiorespiratory fitness in the United States
Kaminsky, L. A., MYERS, J. N., Brubaker, P. H., Franklin, B. A., Bonikowske, A. R., German, C. A., & Arena, R. A. (2024) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2024.01.020 · Cited by 46
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Maat, G. E. D., Mulder, B. A., Berretty, W. L., Al-Jazairi, M. I. H., Tan, Y. E. S., Wiesfeld, A. C. P., Mariani, M. A., Gelder, I. C. V., Rienstra, M., & Blaauw, Y. (2018) · Open Heart · doi:10.1136/openhrt-2017-000771 · Cited by 40
“The recent ARREST-AF trial showed that aggressive risk factor management improves long-term outcomes of AF ablation.(12) Also, if weight loss is sustained at long-term follow-up, reduction of AF burden and maintenance of sinus rhythm are significantly higher compared with patients with weight fluctuation.”
BackgroundResultInfluentialYu, H. T., Kim, I., Kim, T., Uhm, J., Kim, J., Joung, B., Lee, M., & Pak, H. (2020) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14345 · Cited by 40
Alcohol Consumption Reduction and Clinical Outcomes of Catheter Ablation for Atrial Fibrillation
Takahashi, Y., Nitta, J., Kobori, A., Sakamoto, Y., Nagata, Y., Tanimoto, K., Matsuo, S., Yamane, T., Morita, N., Satomi, K., et al. (2021) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.009770 · Cited by 39
Obesity as a risk factor for cardiac arrhythmias
Patel, K. H. K., Reddy, R. K., Sau, A., Sivanandarajah, P., Ardissino, M., & Ng, F. S. (2022) · BMJ Medicine · doi:10.1136/bmjmed-2022-000308 · Cited by 43
Should We Perform Catheter Ablation for Asymptomatic Atrial Fibrillation?
Kalman, J. M., Sanders, P., Rosso, R., & Calkins, H. G. (2017) · Circulation · doi:10.1161/circulationaha.116.024926 · Cited by 42
Self-citationImpaired fasting glucose: a risk factor for atrial fibrillation and heart failure
Lind, V., Hammar, N., Lundman, P., Friberg, L., Talbäck, M., Walldius, G., & Norhammar, A. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01422-3 · Cited by 43
“The ARREST-AF study showed that multifactorial life-style changes in patients with atrial fibrillation resulted in reduced recurrence of atrial fibrillation [29].”
MethodBenjamin, E. J., Al‐Khatib, S. M., Desvigne-Nickens, P. M., Alonso, Á., Djoussé, L., Forman, D. E., Gillis, A. M., Hendriks, J., Hills, M. T., Kirchhof, P. F., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021566 · Cited by 38
“14,15 There also is evidence for a reversal of AF progression with a transition from persistent to paroxysmal or no AF.”
Self-citationAriyaratnam, J., Elliott, A. D., Mishima, R. S., Kadhim, K., McNamee, O., Kuklik, P., Emami, M., Malik, V., Fitzgerald, J. L., Gallagher, C., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.07.019 · Cited by 39
Self-citationVoskoboinik, A., Costello, B. T., Kalman, E., Prabhu, S., Sugumar, H., Wong, G. R., Nalliah, C. J., Ling, L., McLellan, A. J. A., Hettige, T., et al. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.07.010 · Cited by 39
“Nevertheless, in patients with AF, a reduction in alcohol intake to <3 standard drinks/week, among other cardiometabolic risk factor reduction measures, has been shown to reduce AF recurrence rates (31).”
BackgroundSelf-citationDesteghe, L., Hendriks, J., Heidbüchel, H., Potpara, T., Lee, G., & Linz, D. (2021) · EP Europace · doi:10.1093/europace/euab109 · Cited by 38
Kadhim, K., Middeldorp, M. E., Elliott, A. D., Agbaedeng, T. A., Gallagher, C., Malik, V., Wong, C. X. J., McEvoy, R. D., Kalman, J. M., Lau, D. H., et al. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.09.026 · Cited by 40
Self-citation2025 Clinical practice guidelines for Atrial fibrillation and flutter
Golukhova, E. Z., Sp, G., Михайлов, Е. Н., Revishvili, A. S. H., Arakelyan, M. G., Vasilyeva, E. Y., Davtyan, K. V., Drapkina, O. M., Drozdova, L. Y., Станиславовна, К. Е., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6668 · Cited by 44
Catheter ablation of atrial fibrillation in very young adults: a 5-year follow-up study
Saguner, A. M., Maurer, T., Wißner, E., Santoro, F., Lemeš, C., Mathew, S., Sohns, C., Heeger, C.-H. H., Reißmann, B., Riedl, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw378 · Cited by 36
“Recently, risk factor control including weight management targeting a BMI of <_ 25 kg/m(2) was demonstrated to improve long-term success of AF ablation, which is in line with our findings.(18) The majority of very young adults with AF was overweight in our study, and 26% were obese.”
ResultKato, M., Akira, K. U. B. O., Nihei, F., Ogano, M., & Takagi, H. (2017) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000232 · Cited by 38
“Pathak et al. (2014) reported that risk factor modifications including weight management in patients who had undergone AF ablation resulted in favorable changes in cardiac remodeling and significantly reduced AF burden and severity.”
Addressing Comorbidities in Heart Failure
Bavishi, A. A., & Patel, R. B. (2020) · Heart Failure Clinics · doi:10.1016/j.hfc.2020.06.005 · Cited by 40
Long-term influence of body mass index on cardiovascular events after atrial fibrillation ablation
Bunch, T. J., May, H. T., Bair, T. L., Crandall, B. G., Cutler, M. J., Jacobs, V., Mallender, C. D., Muhlestein, J. B., Osborn, J. S., Weiss, J. P., et al. (2016) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-016-0142-5 · Cited by 36
Atrial fibrillation: A review of modifiable risk factors and preventive strategies
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Cardiac mechanics and incident ischemic stroke: the Cardiovascular Health Study
Kamel, H., Bartz, T. M., Longstreth, W. T., Elkind, M. S. V., Gottdiener, J. S., Kizer, J. R., Gardin, J. M., Kim, J. J., & Shah, S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-96702-z · Cited by 35
Effects of Supervised Exercise Training on Atrial Fibrillation
Oesterle, A., Giancaterino, S., Noord, M. V., Pellegrini, C. N., Fan, D., Srivatsa, U. N., & Amsterdam, E. A. (2022) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000665 · Cited by 38
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Exercise Training: The Holistic Approach in Cardiovascular Prevention
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“Lastly, exercise training may prevent the onset of AF by reducing BP, promoting weight loss, reducing glycaemic levels; indeed EH, OB and T2D represent risk factors for the onset of AF as they contribute to atrial electrical and mechanical remodelling, that represents the substrate for reentries [196, 197].”
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Impact of Lifestyle Modification on Atrial Fibrillation
Wingerter, R., Steiger, N. A., Burrows, A., & Estes, N. A. M. (2019) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2019.10.018 · Cited by 35
Research Needs and Priorities for Catheter Ablation of Atrial Fibrillation
Al‐Khatib, S. M., Benjamin, E. J., Buxton, A. E., Calkins, H. G., Chung, M. K., Curtis, A. B., Desvigne-Nickens, P. M., Jaı̈s, P., Packer, D. L., Piccini, J. P., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.042706 · Cited by 35
Self-citationDigital Health and the Care of the Patient With Arrhythmia
Tarakji, K. G., Silva, J. N. A., Chen, L. Y., Turakhia, M. P., Perez, M. V., Attia, Z. I., PASSMAN, R. S., Boissy, A. R., Cho, D. J., Majmudar, M. D., et al. (2020) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.120.007953 · Cited by 35
Update on management of atrial fibrillation in heart failure: a focus on ablation
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Karayiannides, S., Lundman, P., Friberg, L., & Norhammar, A. (2017) · Diabetes and Vascular Disease Research · doi:10.1177/1479164117735013 · Cited by 36
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Obesity and atrial fibrillation: Prevalence, pathogenesis, and prognosis
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Self-citationThe impact of lifestyle intervention on atrial fibrillation
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Echocardiographic Risk Assessment to Guide Screening for Atrial Fibrillation
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Smoking Cessation after Diagnosis of New-Onset Atrial Fibrillation and the Risk of Stroke and Death
Lee, S., Choi, E., Jung, J., Han, K., Oh, S., & Lip, G. Y. H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112238 · Cited by 34
“The effect of aggressive risk factor reduction, including smoking cessation after AF ablation, has been reported [46].”
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Goudis, C. A., Vasileiadis, I. E., & Liu, T. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1462786 · Cited by 33
The Effects of Cardiac Rehabilitation in Patients With Atrial Fibrillation: A Systematic Review
Reed, J. L., Terada, T., Chirico, D., Prince, S. A., & Pipe, A. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.07.014 · Cited by 33
Arrhythmogenic Substrates for Atrial Fibrillation in Obesity
Lubbers, E. R., Price, M. V., & Mohler, P. J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01482 · Cited by 36
Atrial fibrillation: villain or bystander in vascular brain injury
Freedman, B., Kamel, H., Gelder, I. C. V., & Schnabel, R. B. (2020) · European Heart Journal Supplements · doi:10.1093/eurheartj/suaa166 · Cited by 33
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Impact of pre‐ablation weight loss on the success of catheter ablation for atrial fibrillation
Peigh, G., Wasserlauf, J., Vogel, K. A., Kaplan, R. M., Pfenniger, A., Marks, D., Mehta, A., Chicos, A. B., Arora, R., Kim, H., et al. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.15141 · Cited by 33
“The ARREST AF Cohort study recently assessed the impact of physician‐directed cardiometabolic risk factor modification on AF frequency, duration, and symptoms after radiofrequency catheter ablation.(7) Among 149 patients with a BMI > 27 kg/m(2), 61 self‐ selected patients participated in comprehensive physician‐direct…”
BackgroundMethodSelf-citationBariatric surgery reduces incidence of atrial fibrillation: a propensity score–matched analysis
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Incidence and Implications of Atrial Fibrillation/Flutter in Hypertension
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Cardiac arrhythmias in arterial hypertension
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Cardiac arrhythmias and conduction abnormalities in patients with type 2 diabetes
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Self-citationPersistent Asthma Is Associated With Increased Risk for Incident Atrial Fibrillation in the MESA
Tattersall, M. C., Dasiewicz, A. S. B., McClelland, R. L., Gepner, A. D., Kalscheur, M. M., Field, M. E., Heckbert, S. R., Hamdan, M. H., & Stein, J. H. (2020) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007685 · Cited by 32
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Lifestyle management to prevent and treat atrial fibrillation
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“in the context of an overall cardiovascular risk factor management strategy (Figure 1) [16].”
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Atrial fibrillation in the cardiometabolic patient
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Impact of Diabetes Mellitus on Stroke and Survival in Patients With Atrial Fibrillation
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Metadata
- Authors
- Pathak, R. K., Middeldorp, M. E., Lau, D. H., Mehta, A. B., Mahajan, R., Twomey, D., Alasady, M., Hanley, L., Antic, N. A., McEvoy, R. D., Kalman, J. M., Abhayaratna, W. P., & Sanders, P.
- Affiliations
- Royal Adelaide Hospital (AU)
- Australian National University (AU)
- Flinders University (AU)
- The Royal Melbourne Hospital (AU)
- Corresponding author
- Sanders, Prashanthan
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 64
- Issue
- 21
- Pages
- 2222-2231
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W140098974
- Semantic Scholar
- f4c9c27c3ab3730d2c2ca09e8648704e91ba7fde
- Cited by
- 949
- References
- 44
- Citations by year
- 2026: 57 · 2025: 85 · 2024: 72 · 2023: 73 · 2022: 81 · 2021: 107 · 2020: 97 · 2019: 80 · 2018: 70 · 2017: 92 · 2016: 79 · 2015: 52 · 2014: 4
- FWCI
- 52.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Flinders Academic Commons (Flinders University) (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Funders
- ResMed
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- atrial fibrillation, catheter ablation, cardiovascular risk management, obesity, weight loss, blood pressure reduction, glycemic control, lipid profile, arrhythmia-free survival, atrial fibrillation substrate, antiarrhythmic drugs, atrial fibrillation recurrence
- MeSH terms
- Alcohol Drinking, Atrial Fibrillation, Blood Glucose, Blood Pressure, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Life Style, Lipids, Male, Middle Aged, Recurrence, Risk Factors, Severity of Illness Index, Cohort Studies, Body Mass Index, Case-Control Studies, Smoking Cessation, Catheter Ablation, Sleep Apnea, Obstructive, Dyslipidemias, Weight Reduction Programs
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