Net Clinical Benefit of Warfarin in Patients With Atrial Fibrillation: A Report From the Swedish Atrial Fibrillation Cohort Study

Friberg, Leif; Rosenqvist, Mårten; Lip, Gregory Y.H.

doi:10.1161/circulationaha.111.055079

Cited by 455Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementVenous Thromboembolism Diagnosis and Management

Net Clinical Benefit of Warfarin in Patients With Atrial Fibrillation: A Report From the Swedish Atrial Fibrillation Cohort Study

Open access

Friberg, Leif, Rosenqvist, Mårten, Lip, Gregory Y.H.·2012·Circulation

DOI 10.1161/circulationaha.111.055079

Open this paper in CoChat — free account

Abstract

Background—: Known risk factors for bleeding during anticoagulant treatment are largely the same as those predicting thromboembolic events in patients with atrial fibrillation (AF). Our objective was to investigate how to maximize the likelihood of avoiding both stroke and bleeding. Methods and Results—: All 182 678 subjects with atrial fibrillation in the Swedish Hospital Discharge Register were studied for an average of 1.5 years (260 000 patient-years at risk). Patients were stratified according to risk scores with the use of historic International Classification of Disease diagnostic codes in the register. Information about medication was obtained from the Swedish Drug Registry. Our primary end point was net benefit defined as number of avoided ischemic strokes with anticoagulation minus the number of excess intracranial bleedings with a weight of 1.5 to compensate for the generally more severe outcome with intracranial bleedings. The adjusted net clinical benefit favored anticoagulation for almost all atrial fibrillation patients. The exceptions were patients at very low risk of ischemic stroke with a CHA 2 DS 2 -VASc score of 0 and moderately elevated bleeding risk (−1.7%/y). The results were broadly similar with CHADS 2 , except for patients with very low embolic risk; the CHA 2 DS 2 -VASc was able to identify those patients (n=6205, 3.9% of all patients) who had no net clinical benefit or even some disadvantage from anticoagulant treatment. Conclusions—: In almost all patients with atrial fibrillation, the risk of ischemic stroke without anticoagulant treatment is higher than the risk of intracranial bleeding with anticoagulant treatment. Analysis of the net benefit indicates that more patients may benefit from anticoagulant treatment.

Integrity signals

Registry

Crossref · 10.1161/circulationaha.111.055079

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Initial uptake of the ACF intervention was 99.4%.
“initial uptake of the intervention was 99.4%”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [30]
The annual health care cost of the ACF intervention is $96.
“These factors resulted in a total health care cost of $96”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [30]
This issue was addressed by performing a thorough cost accounting from 2 specific exemplar interventions.
“this issue was addressed by instead performing a thorough cost accounting from 2 specific exemplar interventions.30,31”
From Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US (2021) · cites this paper as [30]

Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215 · see citing works
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
Patel, M. R., Mahaffey, K. W., Garg, J., Pan, G., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Piccini, J. P., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009638 · Cited by 9,430 · see citing works
Apixaban versus warfarin in patients with atrial fibrillation
Granger, C. B., Alexander, J. H., McMurray, J. J. V., Lopes, R. D., Hylek, E. M., Hanna, M., Al-Khalidi, H. R., Ansell, J., Atar, D., Avezum, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1107039 · Cited by 8,943 · see citing works
Refining Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Using a Novel Risk Factor-Based Approach
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879 · see citing works
Self-citation
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,875 · see citing works
Self-citation
External review and validation of the Swedish national inpatient register
Ludvigsson, J. F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.-L., Reuterwall, C., Heurgren, M., & Olausson, P. O. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-450 · Cited by 5,055 · see citing works
Validation of Clinical Classification Schemes for Predicting Stroke: Results From the National Registry of Atrial Fibrillation
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832 · see citing works
Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793 · see citing works
A Novel User-Friendly Score (HAS-BLED) To Assess 1-Year Risk of Major Bleeding in Patients With Atrial Fibrillation
Pisters, R., Lane, D. A., Nieuwlaat, R., de Vos, C. B., Crijns, H. J. G. M., & Lip, G. Y. H. (2010) · CHEST Journal · doi:10.1378/chest.10-0134 · Cited by 4,517 · see citing works
Self-citation
Apixaban in patients with atrial fibrillation
Connolly, S. J., Eikelboom, J., Joyner, C., Diener, H.-C., Hart, R., Golitsyn, S., Flaker, G., Avezum, A., Hohnloser, S. H., Diaz, R., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1007432 · Cited by 2,483 · cited 3× · see citing works
“Frequent falls, n (%) 9294 (10) 2647 (4) 0.”
Self-citation
Stroke Prevention in Atrial Fibrillation Study. Final results.
Prevention, S., & Atrial Fibrillation Investigators (1991) · Circulation · doi:10.1161/01.cir.84.2.527 · Cited by 1,696 · see citing works
Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
Mant, J., Hobbs, F. R., Fletcher, K., Roalfe, A., Fitzmaurice, D., Lip, G. Y., & Murray, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61233-1 · Cited by 1,556 · cited 1× · see citing works
“COPD/emphysema, n (%) 7555 (8) 4619 (7) 0.”
Self-citation
Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study
Olesen, J. B., Lip, G. Y. H., Hansen, M. L., Hansen, P. R., Tolstrup, J. S., Lindhardsen, J., Selmer, C., Ahlehoff, O., Olsen, A.-M. S., Gislason, G. H., et al. (2011) · BMJ · doi:10.1136/bmj.d124 · Cited by 1,428 · see citing works
Self-citation
Canadian atrial fibrillation anticoaguiation (CAFA) study
Connolly, S. J., Laupacis, A., Gent, M., Roberts, R. S., Cairns, J. A., & Joyner, C. D. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90585-w · Cited by 1,109 · see citing works
Comparative Validation of a Novel Risk Score for Predicting Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation
Lip, G. Y. H., Frison, L., Halperin, J. L., & Lane, D. A. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.024 · Cited by 1,077 · see citing works
Self-citation
Major Hemorrhage and Tolerability of Warfarin in the First Year of Therapy Among Elderly Patients With Atrial Fibrillation
Hylek, E. M., Evans‐Molina, C., Shea, C., Henault, L. E., & Regan, S. (2007) · Circulation · doi:10.1161/circulationaha.106.653048 · Cited by 1,062 · see citing works
Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial
Olsson, S. B. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14841-6 · Cited by 807 · see citing works
The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation
Singer, D. E., Chang, Y., Fang, M. C., Borowsky, L. H., Pomernacki, N. K., Udaltsova, N., & Go, A. S. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-5-200909010-00003 · Cited by 655 · see citing works
Independent predictors of stroke in patients with atrial fibrillation
The Stroke Risk in Atrial Fibrillation Working Group (2007) · Neurology · doi:10.1212/01.wnl.0000267275.68538.8d · Cited by 545 · see citing works
Anticoagulation Control and Prediction of Adverse Events in Patients With Atrial Fibrillation: A Systematic Review
Wan, Y., Heneghan, C., Perera, R., Roberts, N., Hollowell, J., Glasziou, P., Bankhead, C., & Xu, Y. (2008) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.108.796185 · Cited by 514 · see citing works
Bleeding During Antithrombotic Therapy in Patients With Atrial Fibrillation
(1996) · Archives of Internal Medicine · doi:10.1001/archinte.156.4.409 · Cited by 435 · see citing works
Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: A net clinical benefit analysis using a ‘real world’ nationwide cohort study
Lip, G., Lindhardsen, J., Lane, D., Ahlehoff, O., Hansen, M., Raunsø, J., Tolstrup, J., Hansen, P., Gislason, G., Torp-Pedersen, C., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0364 · Cited by 428 · see citing works
Self-citation
The Validity of a Diagnosis of Heart Failure in a Hospital Discharge Register
Ingelsson, E., Ärnlöv, J., Sundström, J., & Lind, L. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.12.007 · Cited by 412 · see citing works
Canadian Cardiovascular Society Atrial Fibrillation Guidelines 2010: Prevention of Stroke and Systemic Thromboembolism in Atrial Fibrillation and Flutter
Cairns, J. A., Connolly, S. J., McMurtry, S., Stephenson, M., & Talajic, M. R. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.007 · Cited by 285 · see citing works
Bleeding During Antithrombotic Therapy in Patients With Atrial Fibrillation
(1996) · Archives of Internal Medicine · doi:10.1001/archinte.1996.00440040081009 · Cited by 283 · see citing works
Atrial fibrillation in the Malmö diet and cancer study: a study of occurrence, risk factors and diagnostic validity
Smith, J. G., Platonov, P. G., Hedblad, B., Engström, G., & Melander, O. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-009-9404-1 · Cited by 275 · see citing works
A comparison of risk stratification schemes for stroke in 79 884 atrial fibrillation patients in general practice
van Staa, T. P., Setakis, E., Tanna, G. L. D., Lane, D. A., & Lip, G. Y. H. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04085.x · Cited by 273 · see citing works
Self-citation
Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non-inferiority trial
‡ (2008) · The Lancet · doi:10.1016/s0140-6736(08)60168-3 · Cited by 273 · see citing works
Anticoagulation control in Sweden: reports of time in therapeutic range, major bleeding, and thrombo-embolic complications from the national quality registry AuriculA
Wieloch, M., Själander, A., Frykman, V., Rosenqvist, M., Eriksson, N., & Svensson, P. J. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr134 · Cited by 261 · see citing works
Self-citation
Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation
Stroke Risk in Atrial Fibrillation Working Group (2008) · Stroke · doi:10.1161/strokeaha.107.501825 · Cited by 241 · see citing works
Management and Prognostic Features of Intracerebral Hemorrhage During Anticoagulant Therapy: A Swedish Multicenter Study
Sjöblom, L., Hårdemark, H., Lindgren, A., Norrving, B. G., Fahlén, M., Samuelsson, M., Stigendal, L., Stockelberg, D., Taghavi, A., Wallrup, L., et al. (2001) · Stroke · doi:10.1161/hs1101.098523 · Cited by 228 · see citing works
Bleeding with anticoagulation therapy – Who is at risk, and how best to identify such patients
Cosmi, B., & Palareti, G. (2009) · Thrombosis and Haemostasis · doi:10.1160/th08-11-0730 · Cited by 226 · see citing works
Stroke prophylaxis in atrial fibrillation: who gets it and who does not?
Friberg, L., Hammar, N., Ringh, M., Pettersson, H., & Rosenqvist, M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl146 · Cited by 175 · see citing works
Self-citation
Untitled work
(1994) · PubMed · Cited by 167 · see citing works
Recent time trends in acute myocardial infarction in Stockholm, Sweden
Linnersjö, A., Hammar, N., Gustavsson, A., & Reuterwall, C. (2000) · International Journal of Cardiology · doi:10.1016/s0167-5273(00)00366-1 · Cited by 77 · see citing works
Warfarin and intracranial haemorrhage
Appelboam, R., & Thomas, E. (2008) · Blood Reviews · doi:10.1016/j.blre.2008.05.001 · Cited by 55 · see citing works
The inpatient care of patients with diabetes mellitus and foot ulcers. A validation study of the correspondence between medical records and the Swedish Inpatient Registry with the consequences for cost estimations
Tennvall, G. R., Apelqvist, J., & Eneroth, M. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00748.x · Cited by 39 · see citing works
Trends in Risk of Stroke in Patients with a Hospital Diagnosis of Nonvalvular Atrial Fibrillation: National Cohort Study in Denmark, 1980–2002
Frost, L., Andersen, L. V., Vestergaard, P., Husted, S., & Mortensen, L. S. (2006) · Neuroepidemiology · doi:10.1159/000092795 · Cited by 37 · see citing works

Flagged first, then by citations

Sorted by citations

2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · EP Europace · doi:10.1093/europace/eus305 · Cited by 3,814 · see citing works
Self-citation
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A. M., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001193 · Cited by 2,989 · see citing works
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs253 · Cited by 2,898 · see citing works
Self-citation
Epidemiology of atrial fibrillation: European perspective
Zoni-Berisso, M., Lercari, F., Carazza, T., & Domenicucci, S. (2014) · Clinical Epidemiology · doi:10.2147/clep.s47385 · Cited by 1,275 · see citing works
Stroke
Campbell, B. C. V., & Khatri, P. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31179-x · Cited by 1,147 · see citing works
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.017 · Cited by 933 · see citing works
The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation
O'Brien, E. C., Simon, D. N., Thomas, L. E., Hylek, E. M., Gersh, B. J., Ansell, J., Kowey, P. R., Mahaffey, K. W., Chang, P., Fonarow, G. C., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv476 · Cited by 440 · see citing works
Vitamin K antagonists in heart disease: Current status and perspectives (Section III)
Husted, S., Wallentin, L. C., Andreotti, F., Arnesen, H., Bachmann, F., Baigent, C., Huber, K., Jespersen, J., Kristensen, S. D., Lip, G. Y. H., et al. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-06-0443 · Cited by 367 · see citing works
Self-citation
Parenteral anticoagulants in heart disease: Current status and perspectives (Section II)
Husted, S., Wallentin, L. C., Andreotti, F., Arnesen, H., Bachmann, F., Baigent, C., Huber, K., Jespersen, J., Kristensen, S. D., Lip, G. Y. H., et al. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-06-0403 · Cited by 366 · see citing works
Self-citation
Stroke Prevention in Atrial Fibrillation
Lip, G. Y. H., & Lane, D. A. (2015) · JAMA · doi:10.1001/jama.2015.4369 · Cited by 327 · see citing works
Self-citation
Oral Anticoagulant Therapy Prescription in Patients With Atrial Fibrillation Across the Spectrum of Stroke Risk
Hsu, J. C., Maddox, T. M., Kennedy, K. F., Katz, D. F., Marzec, L., Lubitz, S. A., Gehi, A. K., Turakhia, M. P., & Marcus, G. M. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2015.0374 · Cited by 302 · see citing works
Atrial fibrillation prevalence revisited
Friberg, L., & Bergfeldt, L. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12114 · Cited by 256 · see citing works
Self-citation
2020 Clinical guidelines for Atrial fibrillation and atrial flutter
Arakelyan, M. S., Bockeria, L. A., Vasilieva, E., Sp, G., Golukhova, E. Z., Gorev, M. V., Davtyan, K. V., Drapkina, O. M., Станиславовна, К. Е., Kuchinskaya, Е. А., et al. (2021) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2021-4594 · Cited by 255 · see citing works
The Epidemiology of Atrial Fibrillation and Stroke
Pistoia, F., Sacco, S., Tiseo, C., Degan, D., Ornello, R., & Carolei, A. (2016) · Cardiology Clinics · doi:10.1016/j.ccl.2015.12.002 · Cited by 244 · see citing works
Antithrombotic therapy in the elderly: expert position paper of the European Society of Cardiology Working Group on Thrombosis
Andreotti, F., Rocca, B., Husted, S., Ajjan, R., ten Berg, J. M., Cattaneo, M., Collet, J., Caterina, R. D., Fox, K. A. A., Halvorsen, S., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv304 · Cited by 237 · see citing works
Self-citation
Hypertension and cardiac arrhythmias: a consensus document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE)
Lip, G. Y. H., Coca, A., Kahan, T., Boriani, G., Manolis, A. S., Olsen, M. H., Oto, A., Potpara, T., Steffel, J., Marín, F. R., et al. (2017) · EP Europace · doi:10.1093/europace/eux091 · Cited by 225 · see citing works
Self-citation
Intracranial Hemorrhage Among Patients With Atrial Fibrillation Anticoagulated With Warfarin or Rivaroxaban
Hankey, G. J., Stevens, S. R., Piccini, J. P., Lokhnygina, Y. V., Mahaffey, K. W., Halperin, J. L., Patel, M. R., BREITHARDT, G. E., Singer, D. E., Becker, R. C., et al. (2014) · Stroke · doi:10.1161/strokeaha.113.004506 · Cited by 211 · see citing works
Benefit of anticoagulation unlikely in patients with atrial fibrillation and a CHA2DS2-VASc score of 1
Friberg, L., Skeppholm, M., & Terént, A. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.10.052 · Cited by 207 · see citing works
Self-citation
Cessation of oral anticoagulation in relation to mortality and the risk of thrombotic events in patients with atrial fibrillation
Gallego, P., Roldan, V., Marín, F., Romera, M., Valdés, M., Vicente, V., & Lip, G. Y. H. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-07-0556 · Cited by 187 · see citing works
Self-citation
An Update on the Prognosis of Patients With Atrial Fibrillation
McManus, D. D., Rienstra, M., & Benjamin, E. J. (2012) · Circulation · doi:10.1161/circulationaha.112.129759 · Cited by 178 · see citing works
Oral anticoagulation, aspirin, or no therapy in patients with nonvalvular AF with 0 or 1 stroke risk factor based on the CHA2DS2-VASc score
Lip, G. Y. H., Skjøth, F., Rasmussen, L. H., & Larsen, T. B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.044 · Cited by 171 · see citing works
Self-citation
Non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in Asian patients with atrial fibrillation: Time for a reappraisal
Lip, G. Y. H., Wang, K.-L., & Chiang, C. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.182 · Cited by 162 · see citing works
Self-citation
Stroke and bleeding risk assessment in atrial fibrillation: when, how, and why?
Lip, G. Y. H. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs435 · Cited by 159 · see citing works
Self-citation
Safety and efficacy of well managed warfarin
Sjögren, V., Grzymala-Lubanski, B., Renlund, H., Friberg, L., Lip, G. Y. H., Svensson, P. J., & Själander, A. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-10-0859 · Cited by 143 · see citing works
Self-citation
Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference
Kirchhof, P., Breithardt, G., Aliot, E., Al Khatib, S., Apostolakis, S., Auricchio, A., Bailleul, C., Bax, J., Benninger, G., Blomstrom-Lundqvist, C., et al. (2013) · Europace · doi:10.1093/europace/eut232 · Cited by 141 · see citing works
Self-citation
Novel genetic markers improve measures of atrial fibrillation risk prediction
Everett, B. M., Cook, N. R., Conen, D., Chasman, D. I., Ridker, P. M., & Albert, C. M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht033 · Cited by 141 · see citing works
2016 Guidelines of the Taiwan Heart Rhythm Society and the Taiwan Society of Cardiology for the management of atrial fibrillation
Chiang, C., Wu, T.-J., Ueng, K.-C., Chao, T., Chang, K., Wang, C.-C., Lin, Y., Yin, W., Kuo, J., Lin, W., et al. (2016) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2016.10.005 · Cited by 138 · see citing works
Evaluation of the HAS-BLED, ATRIA, and ORBIT Bleeding Risk Scores in Patients with Atrial Fibrillation Taking Warfarin
Senoo, K., Proietti, M., Lane, D. A., & Lip, G. Y. H. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.10.001 · Cited by 123 · see citing works
Self-citation
Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper
Kalarus, Z. F., Mairesse, G. H., Sokal, A., Boriani, G., Średniawa, B., Casado-Arroyo, R., Wachter, R., Frommeyer, G., TRAYKOV, V. B., Dagres, N., et al. (2022) · EP Europace · doi:10.1093/europace/euac144 · Cited by 122 · see citing works
Self-citation
Reasons for warfarin discontinuation in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)
O'Brien, E. C., Simon, D. N., Allen, L. A., Singer, D. E., Fonarow, G. C., Kowey, P. R., Thomas, L. E., Ezekowitz, M. D., Mahaffey, K. W., Chang, P., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.07.002 · Cited by 121 · see citing works
Regular Bleeding Risk Assessment Associated with Reduction in Bleeding Outcomes: The mAFA-II Randomized Trial
Guo, Y., Lane, D. A., Chen, Y., & Lip, G. Y. H. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2020.03.019 · Cited by 119 · see citing works
Self-citation
Bleeding risk assessment in atrial fibrillation: observations on the use and misuse of bleeding risk scores
Lip, G. Y. H., & Lane, D. A. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13386 · Cited by 117 · see citing works
Self-citation
Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy
Calenda, B. W., Fuster, V., Halperin, J. L., & Granger, C. B. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.106 · Cited by 116 · see citing works
Risk of stroke and intracranial hemorrhage in 9727 Chinese with atrial fibrillation in Hong Kong
Siu, C., Lip, G. Y. H., Lam, K., & Tse, H. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.04.021 · Cited by 114 · see citing works
Self-citation
Dynamic Changes of CHA2DS2-VASc Score and the Risk of Ischaemic Stroke in Asian Patients with Atrial Fibrillation: A Nationwide Cohort Study
Yoon, M., Yang, P., Jang, E., Yu, H. J., Kim, T., Uhm, J., Kim, J., Pak, H., Lee, M., Lip, G. Y. H., et al. (2018) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651482 · Cited by 113 · see citing works
Self-citation
Non-valvular atrial fibrillation patients with none or one additional risk factor of the CHA2DS2-VASc score: A comprehensive net clinical benefit analysis for warfarin, aspirin, or no therapy
Skjøth, F., Nielsen, P., Larsen, T. B., & Lip, G. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-07-0565 · Cited by 106 · see citing works
Self-citation
Comparison of the CHADS2, CHA2DS2 -VASc and HAS-BLED scores for the prediction of clinically relevant bleeding in anticoagulated patients with atrial fibrillation: The AMADEUS trial
Apostolakis, S. Z., Lane, D. A., Buller, H. R., & Lip, G. Y. H. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-07-0552 · Cited by 106 · see citing works
Self-citation
Ischemic Stroke Risk in Patients With Atrial Fibrillation and CHA 2 DS 2 -VASc Score of 1
Joundi, R. A., Cipriano, L. E., Sposato, L. A., & Saposnik, G. (2016) · Stroke · doi:10.1161/strokeaha.115.012609 · Cited by 106 · see citing works
Validation of a Modified CHA 2 DS 2 -VASc Score for Stroke Risk Stratification in Asian Patients With Atrial Fibrillation
Chao, T., Lip, G. Y. H., Liu, C., Tuan, T., Chen, S., Wang, K.-L., Lin, Y., Chang, S., Lo, L., Hu, Y., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.013880 · Cited by 106 · see citing works
Self-citation
D‐dimer and risk of thromboembolic and bleeding events in patients with atrial fibrillation – observations from the ARISTOTLE trial
Christersson, C., Wallentin, L. C., Andersson, U., Alexander, J. H., Ansell, J., Caterina, R. D., Gersh, B. J., Granger, C. B., Hanna, M., Horowitz, J. D., et al. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12638 · Cited by 103 · see citing works
Anticoagulation in atrial fibrillation
Steinberg, B. A., & Piccini, J. P. (2014) · BMJ · doi:10.1136/bmj.g2116 · Cited by 103 · see citing works
Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation
Korompoki, E., Filippidis, F. T., Nielsen, P. B., Giudice, A. D., Lip, G. Y. H., Kuramatsu, J. B., Huttner, H. B., Fang, J., Schulman, S., Martí‐Fábregas, J., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004235 · Cited by 102 · see citing works
Self-citation
Population screening of 75- and 76-year-old men and women for silent atrial fibrillation (STROKESTOP)
Friberg, L., Engdahl, J., Frykman, V., Svennberg, E., Levin, L.-Å., & Rosenqvist, M. (2013) · EP Europace · doi:10.1093/europace/eus217 · Cited by 100 · see citing works
Self-citation
Ischemic Stroke and Intracranial Hemorrhage With Aspirin, Dabigatran, and Warfarin
Ho, C. W., Ho, M.-H., Chan, P., Hai, J. J., Cheung, E. H.-L., Yeung, C., Lau, K. K., Chan, K., Lau, C., Lip, G. Y. H., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.006476 · Cited by 95 · see citing works
Self-citation
Outcomes of Direct Oral Anticoagulants in Patients With Mitral Stenosis
Kim, J. Y., Kim, S., Myong, J., Kim, Y. R., Kim, T., Kim, J., Jang, S.-W., Oh, Y., Lee, M. Y., & Rho, T. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.047 · Cited by 92 · see citing works
Anemia is associated with bleeding and mortality, but not stroke, in patients with atrial fibrillation: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial
Westenbrink, B. D., Alings, M., Granger, C. B., Alexander, J. H., Lópes, R. D., Hylek, E. M., Thomas, L. E., WOJDYLA, D. M., Hanna, M., Keltai, M., et al. (2016) · American Heart Journal · doi:10.1016/j.ahj.2016.12.008 · Cited by 91 · see citing works
Atrial Fibrillation in Older People: Concepts and Controversies
Zathar, Z., Karunatilleke, A., Fawzy, A. M., & Lip, G. Y. H. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00175 · Cited by 91 · see citing works
Self-citation
Contraindications to Anticoagulation Therapy and Eligibility for Novel Anticoagulants in Older Patients with Atrial Fibrillation
Steinberg, B. A., Greiner, M. A., Hammill, B. G., Curtis, L. H., Benjamin, E. J., Heckbert, S. R., & Piccini, J. P. (2015) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12129 · Cited by 89 · see citing works
Risk factors for thromboembolic and bleeding events in anticoagulated patients with atrial fibrillation: the prospective, multicentre observational PREvention oF thromboembolic events - European Registry in Atrial Fibrillation (PREFER in AF)
Rohla, M., Weiss, T. W., Pecen, L., Patti, G., Siller-Matula, J. M., Schnabel, R. B., SCHILLING, R. J., Kotecha, D., Lucerna, M., Huber, K., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-022478 · Cited by 84 · see citing works
The APHRS's 2013 statement on antithrombotic therapy of patients with nonvalvular atrial fibrillation
Ogawa, S., Aonuma, K., Tse, H., Huang, D., Huang, J., Kalman, J. M., Kamakura, S., Nair, M., Shin, D., Stiles, M. K., et al. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2013.03.002 · Cited by 83 · see citing works
Risks and Benefits of Anticoagulation in Atrial Fibrillation
Cullen, M. W., Kim, S., Piccini, J. P., Ansell, J., Fonarow, G. C., Hylek, E. M., Singer, D. E., Mahaffey, K. W., Kowey, P. R., Thomas, L. E., et al. (2013) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.113.000127 · Cited by 83 · see citing works
Risk scoring and thromboprophylactic treatment of patients with atrial fibrillation with and without access to primary healthcare data: Experience from the Stockholm health care system
Forslund, T., Wettermark, B., Wändell, P. E., von Euler, M., Hasselström, J., & Hjemdahl, P. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.10.063 · Cited by 82 · see citing works
Antithrombotic therapy for stroke prevention in non-valvular atrial fibrillation
Alberts, M. J., Eikelboom, J. W., & Hankey, G. J. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70258-2 · Cited by 79 · see citing works
Major bleeding and intracranial hemorrhage risk prediction in patients with atrial fibrillation: Attention to modifiable bleeding risk factors or use of a bleeding risk stratification score? A nationwide cohort study
Chao, T., Lip, G. Y. H., Lin, Y., Chang, S., Lo, L., Hu, Y., Tuan, T., Liao, J., Chung, F., Chen, T., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.11.025 · Cited by 78 · see citing works
Self-citation
Anemia predicts thromboembolic events, bleeding complications and mortality in patients with atrial fibrillation: insights from the RE‐LY trial
Westenbrink, B. D., Alings, M., Connolly, S. J., Eikelboom, J. W., Ezekowitz, M. D., Oldgren, J., Yang, S., Pongue, J., Yusuf, S., Wallentin, L. C., et al. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12874 · Cited by 78 · see citing works
Left atrial appendage occlusion: rationale, evidence, devices, and patient selection
Piccini, J. P., Sievert, H., & Patel, M. R. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw330 · Cited by 73 · see citing works
Clinical evaluation of laboratory methods to monitor apixaban treatment in patients with atrial fibrillation
Skeppholm, M., Al-Aieshy, F., Berndtsson, M., Al‐Khalili, F., Rönquist-Nii, Y., Söderblom, L., Östlund, A., Pohanka, A., Antović, J. P., & Malmström, R. E. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2015.04.030 · Cited by 73 · see citing works
How to choose appropriate direct oral anticoagulant for patient with nonvalvular atrial fibrillation
Schaefer, J. K., McBane, R. D., & Wysokiński, W. E. (2015) · Annals of Hematology · doi:10.1007/s00277-015-2566-x · Cited by 70 · see citing works
Effect of Genetic Variants, Especially CYP2C9 and VKORC1, on the Pharmacology of Warfarin
Patsopoulos, N. A., Belknap, S. M., O’Rourke, D. J., Robb, J. F., Anderson, J. L., Shworak, N. W., Moore, J. H., & Fung, E. (2012) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0032-1328891 · Cited by 69 · see citing works
Gender-related differences in risk of cardiovascular morbidity and all-cause mortality in patients hospitalized with incident atrial fibrillation without concomitant diseases: A nationwide cohort study of 9519 patients
Andersson, T., Magnuson, A., Bryngelsson, I.-L., Frøbert, O., Henriksson, K. M., Edvardsson, N., & Poçi, D. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.09.092 · Cited by 68 · see citing works
Major bleeding with vitamin K antagonist anticoagulants in pulmonary hypertension
Henkens, I. R., Hazenoot, T., Boonstra, A., Huisman, M. V., & Noordegraaf, A. V. (2012) · European Respiratory Journal · doi:10.1183/09031936.00039212 · Cited by 67 · see citing works
CHADS 2 , CHA 2 DS 2 -VASc and HAS-BLED as predictors of outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention
Puurunen, M. K., Kiviniemi, T., Schlitt, A., Rubboli, A., Dietrich, B., Karjalainen, P. P., Nyman, K., Niemelä, M. J., Lip, G. Y. H., & Airaksinen, J. K. E. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.01.007 · Cited by 67 · see citing works
Self-citation
An update on atrial fibrillation in 2014: From pathophysiology to treatment
Ferrari, R., Bertini, M., Blomström‐Lundqvist, C., Dobrev, D., Kirchhof, P. F., Pappone, C., Ravens, U., Tamargo, J. L., Tavazzi, L., & Vicedomini, G. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.089 · Cited by 67 · see citing works
Accuracy requirements for cost-effective suicide risk prediction among primary care patients in the US
Ross, E. L., Zuromski, K. L., Reis, B. Y., Nock, M. K., Kessler, R. C., & Smoller, J. W. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.0089 · Cited by 65 · see citing works
Anticoagulant Use and Risk of Ischemic Stroke and Bleeding in Patients With Secondary Atrial Fibrillation Associated With Acute Coronary Syndromes, Acute Pulmonary Disease, or Sepsis
Quon, M. J., Behlouli, H., & Pilote, L. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.08.003 · Cited by 65 · see citing works
Risks and benefits of clopidogrel–aspirin in minor stroke or TIA
Pan, Y., Jing, J., Chen, W., Meng, X., Li, H., Zhao, X., Liu, L., Wang, D., Johnston, S. C., Wang, Y., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000003941 · Cited by 63 · see citing works
Acute, periprocedural and longterm antithrombotic therapy in older adults
Andreotti, F., Geisler, T., Collet, J., Gigante, B., Gorog, D. A., Halvorsen, S., Lip, G. Y. H., Morais, J., Navarese, E. P., Patrono, C., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac515 · Cited by 62 · see citing works
Self-citation
Apixaban in patients with atrial fibrillation and prior coronary artery disease: Insights from the ARISTOTLE trial
Bahit, M. C., Lópes, R. D., WOJDYLA, D. M., Hohnloser, S. H., Alexander, J. H., Lewis, B. S., Aylward, P. E., Verheugt, F. W. A., Keltai, M., Díaz, R., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.10.062 · Cited by 62 · see citing works
Effects on bleeding complications of pharmacogenetic testing for initial dosing of vitamin K antagonists: a systematic review and meta‐analysis
Franchini, M., Mengoli, C., Cruciani, M., Bonfanti, C., & Mannucci, P. M. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12647 · Cited by 60 · see citing works
Net Clinical Benefit of Oral Anticoagulation Among Older Adults With Atrial Fibrillation
Shah, S. J., Singer, D. E., Fang, M. C., Reynolds, K., Go, A. S., & Eckman, M. H. (2019) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.119.006212 · Cited by 60 · see citing works
Stroke risk in atrial fibrillation: Do we anticoagulate CHADS2 or CHA2DS2-VASc ≥1, or higher?
Olesen, J. B., & Torp-Pedersen, C. T. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-02-0154 · Cited by 59 · see citing works
Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies
Lauer, A., Pfeilschifter, W., Schaffer, C. B., Lo, E. H., & Foerch, C. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70049-8 · Cited by 58 · see citing works
Oral anticoagulation in patients with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 1: a current opinion of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and European Society of Cardiology Council on Stroke
Sulzgruber, P., Waßmann, S., Semb, A. G., Doehner, W., Widimský, P., Gremmel, T., Kaski, J. C., Savarese, G., Rosano, G. M. C., Borghi, C., et al. (2019) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvz016 · Cited by 58 · see citing works
Patterns of multimorbidity and pharmacotherapy: a total population cross-sectional study
Forslund, T., Carlsson, A. C., Ljunggren, G., Ärnlöv, J., & Wachtler, C. (2020) · Family Practice · doi:10.1093/fampra/cmaa056 · Cited by 58 · see citing works
Stroke and Bleeding Risk in Atrial Fibrillation: Navigating the Alphabet Soup of Risk‐Score Acronyms (CHADS 2 , CHA 2 DS 2 ‐VASc, R 2 CHADS 2 , HAS‐BLED, ATRIA, and More)
Dzeshka, M. S., Lane, D. A., & Lip, G. Y. H. (2014) · Clinical Cardiology · doi:10.1002/clc.22294 · Cited by 57 · see citing works
Self-citation
Stroke prevention in atrial fibrillation and ‘real world’ adherence to guidelines in the Balkan Region: The BALKAN-AF Survey
Potpara, T., Dan, G., Trendafilova, E., Goda, A., Kušljugić, Z., Manola, Š., Musić, L., Musetescu, R., Bădilă, E., Mitic, G. P., et al. (2016) · Scientific Reports · doi:10.1038/srep20432 · Cited by 57 · see citing works
Self-citation
A cost-effectiveness analysis of screening for silent atrial fibrillation after ischaemic stroke
Levin, L.-A., Husberg, M., Sobocinski, P. D., Kull, V. F., Friberg, L., Rosenqvist, M., & Davidson, T. (2015) · Europace · doi:10.1093/europace/euu213 · Cited by 56 · see citing works
Self-citation
Net Clinical Benefit of Warfarin Therapy in Elderly Chinese Patients With Atrial Fibrillation
Siu, C., & Tse, H. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.113.000858 · Cited by 56 · see citing works
Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis
Chan, P., Huang, D., Yip, P.-S., Hai, J. J., Tse, H., Chan, T. M., Lip, G. Y. H., Lo, W.-K., & Siu, C. (2015) · EP Europace · doi:10.1093/europace/euv289 · Cited by 55 · see citing works
Self-citation
Atrial fibrillation in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib: risk prediction, management, and clinical outcomes
Archibald, W. J., Rabe, K. G., Kabat, B., Herrmann, J., Ding, W., Kay, N. E., Kenderian, S. S., Muchtar, E., Leis, J. F., Wang, Y., et al. (2020) · Annals of Hematology · doi:10.1007/s00277-020-04094-3 · Cited by 55 · see citing works
Recent time trends in incidence, outcome and premorbid treatment of atrial fibrillation-related stroke and other embolic vascular events: a population-based study
Yiin, G. S. C., Howard, D. P. J., Paul, N. L. M., Li, L., Mehta, Z., & Rothwell, P. M. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311947 · Cited by 53 · see citing works
Clinical Benefit of Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients with Atrial Fibrillation and Bioprosthetic Heart Valves
Russo, V., Carbone, A., Attena, E., Rago, A., Mazzone, C., Proietti, R., Parisi, V., Scotti, A., Nigro, G., Golino, P., et al. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.10.008 · Cited by 53 · see citing works
Impact of Non-Vitamin K Antagonist Oral Anticoagulants on Intracranial Bleeding in Asian Patients With Non-Valvular Atrial Fibrillation
Yasaka, M., & Lip, G. Y. H. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0720 · Cited by 52 · see citing works
Self-citation
Oral Anticoagulant Therapy in Atrial Fibrillation Patients at High Stroke and Bleeding Risk
Potpara, T., & Lip, G. Y. H. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2015.07.003 · Cited by 51 · see citing works
Self-citation
The risks of risk scores for stroke risk assessment in atrial fibrillation
Chao, T., & Nielsen, P. B. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-03-0210 · Cited by 50 · see citing works
Oral anticoagulants in patients with atrial fibrillation at low stroke risk: a multicentre observational study
Komen, J. J., Pottegård, A., Mantel-Teeuwisse, A. K., Forslund, T., Hjemdahl, P., Wettermark, B., Hallas, J., Olesen, M. S., Bennie, M., Mueller, T., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac111 · Cited by 50 · see citing works
Perioperative challenges of atrial fibrillation
Philip, I., Berroëta, C., & Leblanc, I. (2014) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000070 · Cited by 50 · see citing works
Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines
Drapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. N., Викторович, А. М., Алексеева, Л. И., Almazova, I. I., Andreenko, Е. Y., Antipushina, D. N., Balanova, Y. А., et al. (2024) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2024-3996 · Cited by 49 · see citing works
II Diretrizes Brasileiras de Fibrilação Atrial
Magalhães, L., Figueiredo, M., Cintra, F., Eb, S., Kuniyoshi, R. R., Teixeira, R., Filho, A. L., d’Ávila, A., de Paola, A., Kalil, C., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160055 · Cited by 49 · see citing works
Early Detection and Treatment of Atrial Arrhythmias Alleviates the Arrhythmic Burden in Paced Patients: The SETAM Study
Amara, W., Montagnier, C., Cheggour, S., Boursier, M., Gully, C., BARNAY, C., Georger, F., Deplagne, A., Fromentin, S., Młotek, M., et al. (2017) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.13062 · Cited by 49 · see citing works
Refinement of Ischemic Stroke Risk in Patients with Atrial Fibrillation and CHA2DS2‐VASc Score of 1
Huang, D., ANGUO, L., Yue, W., Yin, L., Tse, H., & Siu, C. (2014) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12445 · Cited by 48 · see citing works
Detection of Atrial Fibrillation in Cryptogenic Stroke
Hæusler, K. G., Tütüncü, S., & Schnabel, R. B. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0871-1 · Cited by 48 · see citing works
Contemporary Management of Atrial Fibrillation: What Can Clinical Registries Tell Us About Stroke Prevention and Current Therapeutic Approaches?
Lip, G. Y. H., Al‐Khatib, S. M., Cosío, F. G., Banerjee, A., Savelieva, I., Ruskin, J. N., Blendea, D. C., Nattel, S., Bono, J. D., Conroy, J., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001179 · Cited by 47 · see citing works
Self-citation
Stroke and Bleeding Risk in Atrial Fibrillation
Senoo, K., Lane, D. A., & Lip, G. Y. H. (2014) · Korean Circulation Journal · doi:10.4070/kcj.2014.44.5.281 · Cited by 46 · see citing works
Self-citation
Risks for stroke and bleeding with warfarin or aspirin treatment in patients with atrial fibrillation at different CHA2DS2VASc scores: experience from the Stockholm region
Forslund, T., Wettermark, B., Wändell, P. E., von Euler, M., Hasselström, J., & Hjemdahl, P. (2014) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-014-1739-1 · Cited by 46 · see citing works
Net clinical benefit of warfarin in individuals with atrial fibrillation across stroke risk and across primary and secondary care
Allan, V., Banerjee, A., Shah, A. D., Patel, R. S., Denaxas, S., Casas, J. P., & Hemingway, H. (2016) · Heart · doi:10.1136/heartjnl-2016-309910 · Cited by 45 · see citing works
2025 Clinical practice guidelines for Atrial fibrillation and flutter
Golukhova, E. Z., Sp, G., Михайлов, Е. Н., Revishvili, A. S. H., Arakelyan, M. G., Vasilyeva, E. Y., Davtyan, K. V., Drapkina, O. M., Drozdova, L. Y., Станиславовна, К. Е., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6668 · Cited by 44 · see citing works
The safety and efficacy of vitamin K antagonist in patients with atrial fibrillation and liver cirrhosis
Lee, S., Uhm, J., Kim, J., Pak, H., Lee, M., & Joung, B. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.183 · Cited by 43 · see citing works
Comparative assessment of the HAS-BLED score with other published bleeding risk scoring schemes, for intracranial haemorrhage risk in a non-atrial fibrillation population: The Chin-Shan Community Cohort Study
Lip, G. Y. H., Lin, H., Hsu, H., Su, T., Chen, M.-F., Lee, Y., & Chien, K. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.12.076 · Cited by 43 · see citing works
Self-citation
Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial
Zeitouni, M., Giczewska, A., Lópes, R. D., WOJDYLA, D. M., Christersson, C., Siegbahn, A., Caterina, R. D., Steg, P. G., Granger, C. B., Wallentin, L. C., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.060 · Cited by 43 · see citing works

The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation
Singer, D. E., Chang, Y., Fang, M. C., Borowsky, L. H., Pomernacki, N. K., Udaltsova, N., & Go, A. S. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-5-200909010-00003 · Cited by 655 · see citing works
A net clinical benefit analysis of warfarin and aspirin on stroke in patients with atrial fibrillation: a nested case–control study
Azoulay, L., Dell’Aniello, S., Simon, T. A., Langleben, D., Renoux, C., & Suissa, S. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-49 · Cited by 17 · see citing works
Effect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation
Shah, S. J., Eckman, M. H., Aspberg, S., Go, A. S., & Singer, D. E. (2018) · Annals of Internal Medicine · doi:10.7326/m17-2762 · Cited by 25 · see citing works
Balancing individual benefits and risks of warfarin in patients with atrial fibrillation
van den Ham, R., Klungel, O. H., Leufkens, H. G. M., van Staa, T. P., Sub Pharmacotherapy, T., Pharmacoepidemiology, S., & Pharmacology, P. A. C. (2013) · Utrecht University Repository (Utrecht University)
Risks for stroke and bleeding with warfarin or aspirin treatment in patients with atrial fibrillation at different CHA2DS2VASc scores: experience from the Stockholm region
Forslund, T., Wettermark, B., Wändell, P. E., von Euler, M., Hasselström, J., & Hjemdahl, P. (2014) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-014-1739-1 · Cited by 46 · see citing works

Authors: Friberg, L., Rosenqvist, M., & Lip, G. Y. H.
Affiliations: Birmingham City Hospital (GB)
Danderyds sjukhus (SE)
ORCID: Friberg, Leif
Rosenqvist, Mårten
Lip, Gregory Y.H.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-05-15
Volume: 125
Issue: 19
Pages: 2298-2307
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.111.055079
OpenAlex: W2165762371
Cited by: 454
References: 38
Citations by year: 2026: 9 · 2025: 15 · 2024: 9 · 2023: 14 · 2022: 16 · 2021: 28 · 2020: 31 · 2019: 33 · 2018: 26 · 2017: 30 · 2016: 57 · 2015: 50 · 2014: 54 · 2013: 57 · 2012: 24
FWCI: 38.08
Type: journal article
Language: en
Open access: green
research.birmingham.ac.uk
Licence: other-oa
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords: atrial fibrillation, warfarin, anticoagulation, net clinical benefit, ischemic stroke, intracranial hemorrhage, CHA2DS2-VASc score, CHADS2 score, stroke risk stratification, bleeding risk, hospital discharge registry
MeSH terms: Aged, Anticoagulants, Atrial Fibrillation, Cerebral Hemorrhage, Female, Follow-Up Studies, Humans, Male, Middle Aged, Registries, Risk Factors, Sweden, Warfarin, Cohort Studies, Incidence, Stroke, Intracranial Embolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Net Clinical Benefit of Warfarin in Patients With Atrial Fibrillation: A Report From the Swedish Atrial Fibrillation Cohort Study

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks