The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis
Open accessAbstract
Background Fibrosis is a hallmark of many myocardial pathologies and contributes to distorted organ architecture and function. Recent studies have identified premature senescence as a regulatory mechanism of tissue fibrosis, but its relevance in the heart remains to be established.Objectives This study investigated the role of premature senescence in myocardial fibrosis.Methods Murine models of cardiac diseases and human heart biopsies were analyzed for characteristics of premature senescence and fibrosis. Loss-of-function and gain-of-function models of premature senescence were used to determine its pathophysiological role in myocardial fibrosis.Results Senescence markers p21(CIP1/WAF1), senescence-associated ß-galactosidase (SA-ß-gal), and p16(INK4a) were increased 2-, 8-, and 20-fold (n = 5 to 7; p < 0.01), respectively, in perivascular fibrotic areas after transverse aortic constriction compared with sham-treated control subjects. Similar results were observed with cardiomyocyte-specific β1-adrenoceptor transgenic mice and human heart biopsies. Senescent cells were positive for platelet-derived growth factor receptor-α, vimentin, and α-smooth muscle actin, specifying myofibroblasts as the predominant cell population undergoing premature senescence in the heart. Inactivation of the premature senescence program by genetic ablation of p53 and p16(INK4a) (Trp53(-/-)Cdkn2a(-/-) mice) resulted in aggravated fibrosis after transverse aortic constriction, when compared with wild-type control subjects (49 ± 4.9% vs. 33 ± 2.7%; p < 0.01), and was associated with impaired cardiac function. Conversely, cardiac-specific expression of CCN1 (CYR61), a potent inducer of premature senescence, by adeno-associated virus serotype 9 gene transfer, resulted in ∼50% reduction of perivascular fibrosis after transverse aortic constriction, when compared with mock- or dominant-negative CCN1-infected control subjects, and improved cardiac function.Conclusions Our data establish premature senescence of myofibroblasts as an essential antifibrotic mechanism and potential therapeutic target in myocardial fibrosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Experimental evidence shows that cellular senescence has roles in limiting myocardial206 and liver207 fibrosis, promoting skin healing,82 as well as in embryonal development,208 which have to be considered.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [206]
In the citing paper
“However, these studies focused on the function of senescence in acute organ injury, not in chronic processes such as atherosclerosis.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [206]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Rockman, H. A., Ross, R. S., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., Ross, J., & Chien, K. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.18.8277 · Cited by 807
RetractedThe serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441
Aging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 2×
“In contrast to replicative senescence, originally characterized in human fibroblasts undergoing telomere erosion in culture (5), premature senescence is an irreversible form of cell-cycle arrest that can be triggered by various cellular stresses, including deoxyribonucleic acid damage, oncogene activation, and oxidati…”
BackgroundCellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045
Cited by
Sorted by citations
Cellular Senescence: Aging, Cancer, and Injury
Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00020.2018 · Cited by 1,270
Frangogiannis, N. G. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa324 · Cited by 1,229
Unmasking Transcriptional Heterogeneity in Senescent Cells
Hernandez-Segura, A., de Jong, T. V., Melov, S., Guryev, V., Campisi, J., & Demaria, M. (2017) · Current Biology · doi:10.1016/j.cub.2017.07.033 · Cited by 972
Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
Frangogiannis, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.07.001 · Cited by 880
Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
Kanchanawong, P., & Calderwood, D. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00531-5 · Cited by 630
Strategies for targeting senescent cells in human disease
Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging · doi:10.1038/s43587-021-00121-8 · Cited by 501
Mechanisms and consequences of endothelial cell senescence
Bloom, S. I., Islam, M. T., Lesniewski, L. A., & Donato, A. J. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00739-0 · Cited by 521
Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives
Poller, W. C., Dimmeler, S., Heymans, S. R. B., Zeller, T., Haas, J., Karakas, M., Leistner, D. M., Jakob, P., Nakagawa, S., Blankenberg, S., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx165 · Cited by 417
Self-citationRole of immune cells in the removal of deleterious senescent cells
Kale, A., Sharma, A., Stolzing, A., Desprez, P.-Y., & Campisi, J. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00187-9 · Cited by 351
Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 358
Senescence mechanisms and targets in the heart
Chen, M. S., Lee, R. T., & Garbern, J. C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab161 · Cited by 353
The role of cellular senescence in cardiac disease: basic biology and clinical relevance
Mehdizadeh, M., Aguilar, M., Thorin, E., Ferbeyre, G., & Nattel, S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00624-2 · Cited by 304
de Boer, R. A., Keulenaer, G. W. D., Bauersachs, J. K., Brutsaert, D. L., Cleland, J. G. F., Dı́ez, J., Du, X., Ford, P., Heinzel, F. R., Lipson, K. E., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1406 · Cited by 305
Hallmarks of cardiovascular ageing
Abdellatif, M., Rainer, P. P., Sedej, S., & Kroemer, G. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00881-3 · Cited by 305
Tallquist, M. D. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034527 · Cited by 276
Targeting Age-Related Pathways in Heart Failure
Li, H., Hastings, M. H., Rhee, J., Trager, L. E., Roh, J. D., & Rosenzweig, A. (2020) · Circulation Research · doi:10.1161/circresaha.119.315889 · Cited by 276
Sawaki, D., Czibik, G., Pini, M., Ternacle, J., Suffee, N., Mercedes, R., Marcelin, G., Surénaud, M., Marcos, É., Gual, P., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.031358 · Cited by 217
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Maus, M., López-Polo, V., Mateo, L., Lafarga, M., Aguilera, M., De Lama, E., Meyer, K., Sola, A., Lopez-Martinez, C., López-Alonso, I., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00928-2 · Cited by 215
Self-citationSenescent cells: a therapeutic target for cardiovascular disease
Childs, B. G., Li, H., & van Deursen, J. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95146 · Cited by 192
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Song, P., An, J., & Zou, M.-H. (2020) · Cells · doi:10.3390/cells9030671 · Cited by 198
“Myofibroblasts Myocardial fibrosis reduction [86]”
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
Stojanović, S. D., Fiedler, J., Bauersachs, J., Thum, T., & Sedding, D. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz919 · Cited by 188
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Wilkinson, H. N., & Hardman, M. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00773 · Cited by 173
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
Dookun, E., Walaszczyk, A., Redgrave, R., Palmowski, P., Tual‐Chalot, S., Suwana, A., Chapman, J., Jirkovsky, E., Donastorg Sosa, L., Gill, E., et al. (2020) · Aging Cell · doi:10.1111/acel.13249 · Cited by 173
Cellular Senescence in Cardiovascular Diseases: A Systematic Review
Hu, C., Zhang, X., Teng, T., Ma, Z., & Tang, Q. (2022) · Aging and Disease · doi:10.14336/ad.2021.0927 · Cited by 184
Liu, T., Yang, Q., Zhang, X., Qin, R., Shan, W., Zhang, H., & Chen, X. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118116 · Cited by 161
The regulatory roles of p53 in cardiovascular health and disease
Men, H., Cai, H., Cheng, Q., Zhou, W., Wang, X., Huang, S., Zheng, Y., & Cai, L. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03694-6 · Cited by 137
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
Blokland, K. E. C., Pouwels, S. D., Schuliga, M. J., Knight, D. A., & Burgess, J. K. (2020) · Clinical Science · doi:10.1042/cs20190893 · Cited by 132
Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis
Parimon, T., Hohmann, M. S., & Yao, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126214 · Cited by 123
Li, C., Xie, N., Li, Y., Liu, C., Hou, F. F., & Wang, J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.006 · Cited by 121
Epigenetics in Cardiac Fibrosis
Felisbino, M. B., & McKinsey, T. A. (2018) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.05.003 · Cited by 124
Paramos-de-Carvalho, D., Jacinto, A., & Saúde, L. (2021) · eLife · doi:10.7554/elife.72449 · Cited by 111
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Suda, M., Paul, K. H., Minamino, T., Miller, J. D., Lerman, A., Ellison, G. M., Tchkonia, T., & Kirkland, J. L. (2023) · Cells · doi:10.3390/cells12091296 · Cited by 119
Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls
Owens, W. A., Walaszczyk, A., Spyridopoulos, I., Dookun, E., & Richardson, G. D. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111540 · Cited by 114
From traditional pharmacological towards nucleic acid-based therapies for cardiovascular diseases
Landmesser, U., Poller, W. C., Tsimikas, S., Most, P., Paneni, F., & Lüscher, T. F. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa229 · Cited by 102
Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging
Kato, K., Logsdon, N. J., Shin, Y.-J., Palumbo, S., Knox, A., Irish, J. D., Rounseville, S. P., Rummel, S. R., Mohamed, M., Ahmad, K., et al. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0092oc · Cited by 103
The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis
Murtha, L. A., Morten, M., Schuliga, M. J., Mabotuwana, N. S., Hardy, S. A., Waters, D. W., Burgess, J. K., Ngo, D. T. M., Sverdlov, A. L., Knight, D. A., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0601 · Cited by 98
Tocchetti, C. G., Ameri, P., de Boer, R. A., D’Alessandra, Y., Russo, M., Sorriento, D., Ciccarelli, M., Kiss, B., Bertrand, L., Dawson, D. K., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa222 · Cited by 94
Li, W., Tan, S., Li, X., Sun, T., Li, D., Du, J., Wei, S., Li, Y., & Zhang, B. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.10.023 · Cited by 97
Dissecting primary and secondary senescence to enable new senotherapeutic strategies
Admasu, T. D., Rae, M. J., & Stolzing, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101412 · Cited by 98
Cellular senescence: Implications for metabolic disease
Schafer, M. J., Miller, J. D., & LeBrasseur, N. K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.047 · Cited by 87
Gao, L., Wang, L., Liu, Z.-Q., Jiang, D., Wu, S., Guo, Y., Tao, H., Sun, M., You, L., Qin, S., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2243-4 · Cited by 83
Targeting senescent cells to attenuate cardiovascular disease progression
Song, P., Zhao, Q., & Zou, M. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101072 · Cited by 81
Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction
Redgrave, R. E., Dookun, E., Booth, L. K., Camacho-Encina, M., Folaranmi, O., Tual‐Chalot, S., Gill, J. H., Owens, W. A., Spyridopoulos, I., Passos, J. F., et al. (2023) · npj Aging · doi:10.1038/s41514-023-00113-5 · Cited by 79
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, D., Martins, I., Cristóvão, A. M., Dias, A. F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A., & Saúde, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109334 · Cited by 74
Cui, S., Li, X., Yang, F., Dai, S., Han, Z., Liu, K., Liu, B., Yuan, Q., Cui, Z., Zhang, Y., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009111 · Cited by 74
Therapeutic Potential of Senolytics in Cardiovascular Disease
Dookun, E., Passos, J. F., Arthur, H. M., & Richardson, G. D. (2022) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07075-w · Cited by 69
Neuregulin-1 attenuates stress-induced vascular senescence
Shakeri, H., Gevaert, A. B., Schrijvers, D. M., Meyer, G. R. Y. D., Keulenaer, G. W. D., Guns, P., Lemmens, K., & Segers, V. F. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy059 · Cited by 70
A coalition to heal—the impact of the cardiac microenvironment
Tzahor, E., & Dimmeler, S. (2022) · Science · doi:10.1126/science.abm4443 · Cited by 72
Obesity accelerates cardiovascular ageing
Ruperez, C., Madeo, F., de Cabo, R., Kroemer, G., & Abdellatif, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf216 · Cited by 73
CCN2 induces cellular senescence in fibroblasts
Jun, J.-I., & Lau, L. F. (2016) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-016-0359-1 · Cited by 66
NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis
Kato, K., & Hecker, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101541 · Cited by 67
Targeting aging and age-related diseases with vaccines
Wu, R., Sun, F., Zhang, W., Ren, J., & Liu, G.-H. (2024) · Nature Aging · doi:10.1038/s43587-024-00597-0 · Cited by 66
Stress-induced β cell early senescence confers protection against type 1 diabetes
Lee, H., Sahin, G. S., Chen, C.-W., Sonthalia, S., Cañas, S. M., Oktay, H. Z., Duckworth, A. T., Brawerman, G. M., Thompson, P. J., Hatzoglou, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.014 · Cited by 66
Liu, X., Burke, R. M., Lighthouse, J. K., Baker, C. D., Dirkx, R. A., Kang, B., Chakraborty, Y., Mickelsen, D. M., Twardowski, J. J., Mello, S. S., et al. (2023) · Circulation Research · doi:10.1161/circresaha.121.320324 · Cited by 65
Fibroblast‐mediated intercellular crosstalk in the healthy and diseased heart
Nicin, L., Wagner, J. U. G., Luxán, G., & Dimmeler, S. (2021) · FEBS Letters · doi:10.1002/1873-3468.14234 · Cited by 67
Ring, N., Valdivieso, K., Grillari, J., Redl, H. R., & Ogrodnik, M. B. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.04.005 · Cited by 59
Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
Guo, S. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12221 · Cited by 58
Induction of Fibroblast Senescence During Mouse Corneal Wound Healing
Wang, X., Qu, M., Li, J., Danielson, P., Yang, L., & Zhou, Q. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-26983 · Cited by 64
Sun, A. R., Ramli, M. F. H., Shen, X., Ramakanth, K. K., Chen, D., Hu, Y., Vidyasekar, P., Foo, R., Long, Y., Zhu, J., et al. (2025) · Nature Materials · doi:10.1038/s41563-025-02234-6 · Cited by 64
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59
Klingenberg, R., Aghlmandi, S., Liebetrau, C., Räber, L., Gencer, B., Nanchen, D., Carballo, D., Akhmedov, A. T., Montecucco, F., Zoller, S., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx640 · Cited by 56
Cellular senescence promotes progenitor cell expansion during axolotl limb regeneration
Yu, Q., Walters, H. E., Pasquini, G., Pal Singh, S., Lachnit, M., Oliveira, C. R., León-Periñán, D., Petzold, A., Kesavan, P., Subiran Adrados, C., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.09.009 · Cited by 52
Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation
Xie, J., Chen, Y., Hu, C., Pan, Q., Wang, B., Li, X., Geng, J., & Xu, B. (2017) · Oncotarget · doi:10.18632/oncotarget.19853 · Cited by 54
Liu, L., Jin, X., Hu, C., Zhang, Y., Zhou, Z., Li, R., & Shen, C. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0669-y · Cited by 52
RetractedChen, F., Li, X., Zhao, J., Geng, J., Xie, J., & Xu, B. (2020) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00481-2 · Cited by 54
Liu, Y., Xu, J., Wu, M., Kang, L., & Xu, B. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29732 · Cited by 50
Therapeutic opportunities for senolysis in cardiovascular disease
Sweeney, M. D., Cook, S. A., & Gil, J. (2022) · FEBS Journal · doi:10.1111/febs.16351 · Cited by 54
Senescent cardiac fibroblasts: A key role in cardiac fibrosis
Osorio, J. M., Espinoza-Pérez, C., Rimassa-Taré, C., Machuca, V., Bustos, J. O., Vallejos, M., Vargas, H., & Dı́az-Araya, G. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166642 · Cited by 50
Fibroblasts and immune cells: at the crossroad of organ inflammation and fibrosis
Smolgovsky, S. A., Theall, B. P., Wagner, N., & Alcaide, P. (2023) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00545.2023 · Cited by 49
Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence
Abdelgawad, I. Y., Sadak, K. T., Lone, D. W., Dabour, M. S., Niedernhofer, L. J., & Zordoky, B. N. M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107751 · Cited by 47
Cell senescence in cardiometabolic diseases
Grootaert, M. O. J. (2024) · npj Aging · doi:10.1038/s41514-024-00170-4 · Cited by 56
Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease
Nieto, M., Königsberg, M., & Silva‐Palacios, A. (2023) · Biogerontology · doi:10.1007/s10522-023-10068-5 · Cited by 48
HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy
Yamamoto, M., Hanatani, S., Araki, S., Izumiya, Y., Yamada, T., Nakanishi, N., Ishida, T., Yamamura, S., Kimura, Y., Arima, Y., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.021069 · Cited by 48
Understanding the health effects of caregiving stress: New directions in molecular aging
Christian, L. M., Wilson, S. J., Madison, A. A., Prakash, R. S., Burd, C. E., Rosko, A. E., & Kiecolt‐Glaser, J. K. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102096 · Cited by 50
Jesel, L., Abbas, M., Park, S., Matsushita, K., Kindo, M. J., Hasan, H., Auger, C., Sato, C., Ohlmann, P., Mazzucotelli, J., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010036 · Cited by 45
Liu, D., Richardson, G. D., Benli, F. M., Park, C., de Souza, J. V. B., Bronowska, A. K., & Spyridopoulos, I. (2020) · Clinical Science · doi:10.1042/cs20191213 · Cited by 47
Benítez, S., Cordero, A., Santamaría, P. G., Redondo-Pedraza, J., Rocha, A. S., Collado-Solé, A., Jimenez, M., Sanz-Moreno, A., Yoldi, G., Santos, J. C., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.022 · Cited by 41
Gao, X., Lai, Y., Luo, X., Peng, D., Li, Q., Zhou, H., Xue, Y., Guo, H., Zhao, J., Yang, H., et al. (2022) · Aging Cell · doi:10.1111/acel.13743 · Cited by 46
The role of senolytics in osteoporosis and other skeletal pathologies
Doolittle, M. L., Monroe, D. G., Farr, J. N., & Khosla, S. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111565 · Cited by 45
Hou, J., Yun, Y. J., Cui, C., & Kim, S. (2022) · Cell Proliferation · doi:10.1111/cpr.13246 · Cited by 43
Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart
Zhai, P., & Sadoshima, J. (2024) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2024.06 · Cited by 46
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells
Morsli, S., Doherty, G. J., & Muñoz‐Espín, D. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111618 · Cited by 41
Cellular senescence in tissue repair: every cloud has a silver lining
Yun, M. H. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180081my · Cited by 44
Emerging role of CCN family proteins in fibrosis
Sun, C., Zhang, H., & Liu, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30171 · Cited by 45
Cardiovascular aging: from cellular and molecular changes to therapeutic interventions
Vakka, A., Warren, J. S., & Drosatos, K. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.09 · Cited by 44
Senescent cells enhance newt limb regeneration by promoting muscle dedifferentiation
Walters, H. E., Troyanovskiy, K. E., Graf, A. M., & Yun, M. H. (2023) · Aging Cell · doi:10.1111/acel.13826 · Cited by 39
Dynamic regulation of myofibroblast phenotype in cellular senescence
López‐Antona, I., Contreras‐Jurado, C., Luque‐Martín, L., Carpintero‐Leyva, A., González‐Méndez, P., & Palmero, I. (2022) · Aging Cell · doi:10.1111/acel.13580 · Cited by 38
Effects of senescence on the tumour microenvironment and response to therapy
Reynolds, L. E., Maallin, S., Haston, S., Martínez-Barberá, J. P., Hodivala‐Dilke, K., & Pedrosa, A. (2023) · FEBS Journal · doi:10.1111/febs.16984 · Cited by 42
Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure—Recent insights and perspectives
Pang, J., Wang, J., Zhang, Y., Xu, F., & Chen, Y. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.004 · Cited by 39
Resolvin E1 attenuates doxorubicin-induced cardiac fibroblast senescence: A key role for IL-1β
Espitia-Corredor, J., Shamoon, L., Olivares-Silva, F., Rimassa-Taré, C., Muñoz-Rodríguez, C., Espinoza-Pérez, C., Sánchez‐Ferrer, C. F., Peiró, C., & Dı́az-Araya, G. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166525 · Cited by 41
Cellular senescence in ischemia/reperfusion injury
Chen, C., Zheng, M., Hou, H., Fang, S., Chen, L., Yang, J., Yao, W., Zhang, Q., & Hei, Z. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01205-z · Cited by 41
Torimoto, K., Elliott, K., Nakayama, Y., Yanagisawa, H., & Eguchi, S. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae044 · Cited by 38
Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats
Cheng, T.-C., Philip, J. L., Tabima, D. M., Kumari, S., Yakubov, B., Frump, A. L., Hacker, T. A., Bellofiore, A., Li, R., Sun, X., et al. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00247.2020 · Cited by 36
p53 and Myofibroblast Apoptosis in Organ Fibrosis
McElhinney, K., Irnaten, M., & O'Brien, C. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076737 · Cited by 37
Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation
Cannata, A. N., Camparini, L., Sinagra, G., Giacca, M., & Loffredo, F. S. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw106 · Cited by 34
Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation
Rapp, F., Simoniello, P., Wiedemann, J., Bahrami, K., Grünebaum, V., Ktitareva, S., Durante, M., Lugenbiel, P., Thomas, D., Lehmann, H. I., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41314-x · Cited by 34
Shibamoto, M., Higo, T., Naito, A. T., Nakagawa, A., Sumida, T. S., Okada, K., Sakai, T., Kuramoto, Y., Yamaguchi, T., Ito, M., et al. (2019) · International Heart Journal · doi:10.1536/ihj.18-701 · Cited by 36
Context‐dependent roles of cellular senescence in normal, aged, and disease states
Moiseeva, V., Cisneros, A., Cobos, A. C., Tarrega, A. B., Oñate, C. S., Perdiguero, E., Serrano, A. L., & Muñoz‐Cánoves, P. (2023) · The FEBS Journal · doi:10.1111/febs.16573 · Cited by 34
Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management
Subramanian, V., Tucker, W. J., Peters, A. E., Upadhya, B., Kitzman, D. W., & Pandey, A. (2025) · Circulation Research · doi:10.1161/circresaha.125.325531 · Cited by 34
Preeclampsia-Associated Alteration of DNA Methylation in Fetal Endothelial Progenitor Cells
Brodowski, L., Zindler, T., Hardenberg, S. V., Schröder‐Heurich, B., von Kaisenberg, C. S., Frieling, H., Hubel, C. A., Dörk, T., & von Versen‐Höynck, F. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00032 · Cited by 33
Metadata
- Authors
- Meyer, K., Hodwin, B., Ramanujam, D., Engelhardt, S., & Sarikas, A.
- Affiliations
- German Centre for Cardiovascular Research (DE)
- Technical University of Munich (DE)
- Corresponding author
- Sarikas, Antonio
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 67
- Issue
- 17
- Pages
- 2018-2028
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2343545062
- Cited by
- 247
- References
- 41
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 23 · 2023: 36 · 2022: 28 · 2021: 29 · 2020: 38 · 2019: 18 · 2018: 20 · 2017: 8 · 2016: 6
- FWCI
- 14.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- University of Illinois at Urbana-Champaign
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- premature senescence, myocardial fibrosis, myofibroblasts, p16INK4a, p53, CYR61, transverse aortic constriction, beta1-adrenergic receptor, senescence-associated β-galactosidase, antifibrotic mechanism, gene therapy, cardiac function
- MeSH terms
- Actins, Dependovirus, Animals, beta-Galactosidase, Fibrosis, Humans, Myocardium, Vimentin, Tumor Suppressor Protein p53, Cellular Senescence, Gene Transfer Techniques, Mice, Knockout, Cyclin-Dependent Kinase Inhibitor p16, Receptor, Platelet-Derived Growth Factor alpha, Cyclin-Dependent Kinase Inhibitor p21, Cysteine-Rich Protein 61, Myofibroblasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
