The right time for senescence
Open accessAbstract
Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress, implicated in a wide spectrum of biological processes like tissue remodelling, injury and cancer. The development of new tools to study senescence in vivo paved the way to uncover its functional roles in various frameworks, which are sometimes hard to reconcile. Here, we review the functional impact of senescent cells on different organismal contexts. We provide updated insights on the role of senescent cells in tissue repair and regeneration, in which they essentially modulate the levels of fibrosis and inflammation, discussing how "time" seems to be the key maestro of their effects. Finally, we overview the current clinical research landscape to target senescent cells and contemplate its repercussions on this fast-evolving field.
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Progressive accumulation of senescent cells, facilitated by defective immunosurveillance, contributes to tissue fibrosis and low-grade inflammation that define aging and exacerbates the risk of neoplastic transformation.
“Conversely, the progressive accumulation of senescent cells (facilitated by defective immunosurveillance) contributes to the phenomena of tissue fibrosis and lowgrade inflammation that define the aging process and exacerbate the risk of neoplastic transformation.176”
From Meta-hallmarks of aging and cancer (2023) · cites this paper as [176]
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 2× · see citing works
“The first experimental evidence of OIS came from the overexpression of oncogenic Ras in human fibroblasts, resulting in upregulation of p53, p16, pRB, and permanent cell cycle arrest (Serrano et al., 1997).”
BackgroundChronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“Remarkably, the use of progeroid mouse models has provided evidence that ablation of p16 cells improves many of these disease symptoms, reinforcing a detrimental role of SCs in aged tissues (Baker et al., 2011; Rhinn et al., 2019).”
BackgroundCellular Senescence: Defining a Path Forward
Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · cited 2× · see citing works
“This multi- marker workflow includes: (1) screening for senescence with SA-β-gal and/or lipofuscin accumulation; (2) co- staining with markers frequently present (p16INK4a, p21CIP1) or absent (proliferation markers, Lamin B1) in SCs; and (3) identification of factors predicted to be altered in specific senescence cont…”
MethodAging, Cellular Senescence, and Cancer
Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954 · cited 2× · see citing works
“Aging entails a progressive loss of tissue functions that eventually leads to several chronic and agerelated diseases (Campisi, 2013).”
BackgroundNaturally occurring p16Ink4a-positive cells shorten healthy lifespan
Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,891 · see citing works
Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., et al. (2015) · Aging Cell · doi:10.1111/acel.12344 · Cited by 2,562 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · cited 4× · see citing works
“Therefore, paracrine senescence has been shown to mediate the deleterious effects of SCs on tissue homeostasis, namely in promoting tumourigenesis and agingrelated organ dysfunction, as well as in impairing regeneration (Campisi, 2005; FerreiraGonzalez et al., 2018; Gonzalez- Meljem et al., 2018).”
BackgroundInfluentialA complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 2× · see citing works
“Importantly, some SASP factors of tumour cells, such as TGF-β, VEGF, CCL2, and CCL20, also induce senescence in normal cells (Acosta et al., 2013).”
BackgroundOncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · cited 1× · see citing works
“On the other hand, inhibition of IL- 1α and IL- 6 promotes OIS evasion (Di Mitri and Alimonti, 2016; Kuilman et al., 2008).”
BackgroundAn Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045 · see citing works
Senescence of activated stellate cells limits liver fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.06.049 · Cited by 2,029 · see citing works
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
Four faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · cited 3× · see citing works
“Secretion of IL6 and IL- 8 has been shown to promote both tumourigenesis and tumour suppression in different contexts (Rodier and Campisi, 2011).”
BackgroundCrucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works
Krtolica, A., Parrinello, S., Lockett, S., Desprez, P.-Y., & Campisi, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211053698 · Cited by 1,730 · see citing works
Cellular senescence mediates fibrotic pulmonary disease
Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14532 · Cited by 1,613 · cited 1× · see citing works
“Similarly, in a mouse model of idiopathic pulmonary fibrosis (IPF), a chronic lung disease characterized by decreased lung function due to persistent scarring, senescent epithelial cells and fibroblasts accumulate continuously over time, inducing myofibroblast differentiation and exacerbating the fibrotic response (Sc…”
BackgroundSenescence-associated β-galactosidase is lysosomal β-galactosidase.
Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works
A proteomic atlas of senescence-associated secretomes for aging biomarker development
Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., Ferrucci, L., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000599 · Cited by 1,348 · see citing works
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K., & Yamanaka, S. (2009) · Nature · doi:10.1038/nature08235 · Cited by 1,301 · see citing works
Cellular Senescence: Aging, Cancer, and Injury
Calcinotto, A., Kohli, J., Zagato, E., Pellegrini, L., Demaria, M., & Alimonti, A. (2019) · Physiological Reviews · doi:10.1152/physrev.00020.2018 · Cited by 1,270 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1× · see citing works
“Recruited immune cells, namely macrophages and NK cells, can also execute proregenerative functions (Godwin et al., 2013; Lucas et al., 2010; Rajagopalan and Long, 2012).”
BackgroundSenescence is a developmental mechanism that contributes to embryonic growth and patterning
Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works
Senescence-associated reprogramming promotes cancer stemness
Milanovic, M., Fan, D. N. Y., Belenki, D., Däbritz, J. H. M., Zhao, Z., Yu, Y., Dörr, J. R., Dimitrova, L., Lenze, D., Monteiro Barbosa, I. A., et al. (2018) · Nature · doi:10.1038/nature25167 · Cited by 1,131 · see citing works
Senescence in tumours: evidence from mice and humans
Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124 · cited 1× · see citing works
“Cancer Cellular senescence is a powerful barrier to tumourigenesis (Collado and Serrano, 2010).”
BackgroundStem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works
Forging a signature of in vivo senescence
Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3960 · Cited by 1,104 · see citing works
Senolytic CAR T cells reverse senescence-associated pathologies
Amor, C., Feucht, J., Leibold, J., Ho, Y.-J., Zhu, C., Alonso-Curbelo, D., Mansilla-Soto, J., Boyer, J. A., Li, X., Giavridis, T., et al. (2020) · Nature · doi:10.1038/s41586-020-2403-9 · Cited by 1,098 · see citing works
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00734-1 · Cited by 1,050 · see citing works
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010 · see citing works
Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998 · see citing works
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science · doi:10.1126/science.aaa5612 · Cited by 982 · see citing works
Unmasking Transcriptional Heterogeneity in Senescent Cells
Hernandez-Segura, A., de Jong, T. V., Melov, S., Guryev, V., Campisi, J., & Demaria, M. (2017) · Current Biology · doi:10.1016/j.cub.2017.07.033 · Cited by 972 · see citing works
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature · doi:10.1038/nature08290 · Cited by 968 · see citing works
Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M., & Green, M. R. (2008) · Cell · doi:10.1016/j.cell.2007.12.032 · Cited by 903 · see citing works
Macrophages are required for adult salamander limb regeneration
Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300290110 · Cited by 829 · see citing works
Therapy-induced senescence in cancer.
Ewald, J. A., Desotelle, J. A., Wilding, G., & Jarrard, D. F. (2010) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djq364 · Cited by 824 · see citing works
A senescent cell bystander effect: senescence‐induced senescence
Nelson, G., Wordsworth, J., Wang, C., Jurk, D., Lawless, C., Martin‐Ruiz, C., & von Zglinicki, T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00795.x · Cited by 755 · see citing works
T-helper-1-cell cytokines drive cancer into senescence
Braumüller, H., Wieder, T., Brenner, E., Aßmann, S., Hahn, M., Alkhaled, M., Schilbach, K., Essmann, F., Kneilling, M., Griessinger, C., et al. (2013) · Nature · doi:10.1038/nature11824 · Cited by 720 · see citing works
Oxidative DNA damage and senescence of human diploid fibroblast cells.
Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720 · see citing works
DNA damage response and cellular senescence in tissues of aging mice
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L., & Blau, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3464 · Cited by 677 · see citing works
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654 · see citing works
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M. C., Morton, J. P., Sansom, O. J., Zender, L., & Keyes, W. M. (2017) · Genes & Development · doi:10.1101/gad.290635.116 · Cited by 650 · see citing works
Senescence impairs successful reprogramming to pluripotent stem cells
Banito, A., Rashid, S. T., Acosta, J. C., Li, S., Pereira, C. F., Geti, I., Pinho, S., Silva, J. C., Azuara, V., Walsh, M., et al. (2009) · Genes & Development · doi:10.1101/gad.1811609 · Cited by 642 · see citing works
Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Eisner, V., Picard, M., & Hajnóczky, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0133-0 · Cited by 622 · see citing works
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604 · see citing works
Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598 · see citing works
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo
Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589 · see citing works
Accumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition
Pereira, B. I., Devine, O. P., Vukmanovic-Stejic, M., Chambers, E. S., Subramanian, P., Patel, N., Virasami, A., Sebire, N. J., Kinsler, V., Valdovinos, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10335-5 · Cited by 556 · see citing works
Rodier, F., Muñoz, D. P., Teachenor, R., Chu, V., Le, O., Bhaumik, D., Coppé, J.-P., Campeau, E., Beauséjour, C. M., Kim, S.-H., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.071340 · Cited by 535 · see citing works
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan
Grosse, L., Wagner, N., Emelyanov, A., Molina, C., Lacas-Gervais, S., Wagner, K.-D., & Bulavin, D. V. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.002 · Cited by 460 · see citing works
Toso, A., Revandkar, A., Di Mitri, D., Guccini, I., Proietti, M., Sarti, M., Pinton, S., Zhang, J., Kalathur, M., Civenni, G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.044 · Cited by 418 · cited 1× · see citing works
“with antagonists of CXCR2, a receptor for several SASP cytokines) may be used to enhance the efficacy of pro- senescence therapies and promote senescence immune surveillance (Calcinotto et al., 2019; Toso et al., 2014).”
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works
Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer
Di Mitri, D., Toso, A., Chen, J. J., Sarti, M., Pinton, S., Jost, T. R., D’Antuono, R., Montani, E., Garcia-Escudero, R., Guccini, I., et al. (2014) · Nature · doi:10.1038/nature13638 · Cited by 388 · see citing works
Recurrent turnover of senescent cells during regeneration of a complex structure
Yun, M. H., Davaapil, H., & Brockes, J. P. (2015) · eLife · doi:10.7554/elife.05505 · Cited by 385 · see citing works
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
Di Micco, R., Sulli, G., Dobreva, M., Liontos, M., Botrugno, O. A., Gargiulo, G., dal Zuffo, R., Matti, V., d'Ario, G., Montani, E., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2170 · Cited by 382 · see citing works
Aged-senescent cells contribute to impaired heart regeneration
Lewis‐McDougall, F. C., Ruchaya, P. J., Domenjo‐Vila, E., Shin Teoh, T., Prata, L., Cottle, B. J., Clark, J. E., Punjabi, P. P., Awad, W., Torella, D., et al. (2019) · Aging Cell · doi:10.1111/acel.12931 · Cited by 317 · see citing works
Cellular senescence in development, regeneration and disease
Rhinn, M., Ritschka, B., & Keyes, W. M. (2019) · Development · doi:10.1242/dev.151837 · Cited by 296 · see citing works
Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle
Chiche, A., Le Roux, I., von Joest, M., Sakai, H., Aguín, S. B., Cazin, C., Salam, R., Fiette, L., Alegria, O., Flamant, P., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.11.020 · Cited by 295 · see citing works
Targeting senescent cells in translational medicine
Pàez‐Ribes, M., González‐Gualda, E., Doherty, G. J., & Muñoz‐Espín, D. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810234 · Cited by 289 · see citing works
Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy
Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., et al. (2020) · Science · doi:10.1126/science.aay5356 · Cited by 283 · see citing works
Cellular senescence and the aging brain
Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works
The promises and perils of p53
Krizhanovsky, V., & Lowe, S. W. (2009) · Nature · doi:10.1038/4601085a · Cited by 274 · see citing works
Identification of senescent cell surface targetable protein DPP4
Kim, K. M., Noh, J. H., Bodogai, M., Martindale, J. L., Yang, X., Indig, F. E., Basu, S. K., Ohnuma, K., Morimoto, C., Johnson, P. F., et al. (2017) · Genes & Development · doi:10.1101/gad.302570.117 · Cited by 270 · see citing works
Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
Chuprin, A., Gal, H., Biron-Shental, T., Biran, A., Amiel, A., Rozenblatt, S., & Krizhanovsky, V. (2013) · Genes & Development · doi:10.1101/gad.227512.113 · Cited by 262 · see citing works
Tumor cell escape from therapy-induced senescence as a model of disease recurrence after dormancy.
Saleh, T., Tyutyunyk-Massey, L., & Gewirtz, D. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3437 · Cited by 259 · see citing works
Essential role for premature senescence of myofibroblasts in myocardial fibrosis
Meyer, K., Hodwin, B., Ramanujam, D., Engelhardt, S., & Sarikas, A. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.02.047 · Cited by 247 · see citing works
AP-1 imprints a reversible transcriptional programme of senescent cells.
Martínez-Zamudio, R. I., Roux, P.-F., de Freitas, J. A. N. L. F., Robinson, L., Doré, G., Sun, B., Belenki, D., Milanovic, M., Herbig, U., Schmitt, C. A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0529-5 · Cited by 236 · see citing works
Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
Zhu, F., Li, Y., Zhang, J., Piao, C., Liu, T., Li, H.-H., & Du, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074535 · Cited by 201 · see citing works
Saito, Y., Chikenji, T. S., Matsumura, T., Nakano, M., & Fujimiya, M. (2020) · Nature Communications · doi:10.1038/s41467-020-14734-x · Cited by 196 · see citing works
Frailty in childhood cancer survivors
Ness, K. K., Armstrong, G. T., Kundu, M., Wilson, C. L., Tchkonia, T., & Kirkland, J. L. (2015) · Cancer · doi:10.1002/cncr.29211 · Cited by 188 · see citing works
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
Reimann, M., Lee, S., Loddenkemper, C., Dörr, J. R., Tabor, V., Aichele, P., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.043 · Cited by 184 · see citing works
Paracrine roles of cellular senescence in promoting tumourigenesis
Gonzalez-Meljem, J. M., Apps, J. R., Fraser, H. C., & Martinez-Barbera, J. P. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0066-1 · Cited by 183 · see citing works
Cellular Senescence Limits Regenerative Capacity and Allograft Survival
Braun, H., Schmidt, B. M. W., Raiss, M., Baisantry, A., Mircea-Constantin, D., Wang, S., Groß, M.-L., Serrano, M., Schmitt, R., & Melk, A. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011100967 · Cited by 179 · see citing works
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
Dookun, E., Walaszczyk, A., Redgrave, R., Palmowski, P., Tual‐Chalot, S., Suwana, A., Chapman, J., Jirkovsky, E., Donastorg Sosa, L., Gill, E., et al. (2020) · Aging Cell · doi:10.1111/acel.13249 · Cited by 173 · see citing works
Le, O. N. L., Rodier, F., Fontaine, F., Coppe, J., Campisi, J., DeGregori, J., Laverdière, C., Kokta, V., Haddad, E., & Beauséjour, C. M. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00567.x · Cited by 168 · see citing works
Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
Rajagopalan, S., & Long, E. O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208248109 · Cited by 168 · see citing works
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration
Ferreira-Gonzalez, S., Lu, W.-Y., Raven, A., Dwyer, B., Man, T. Y., O’Duibhir, E., Lewis, P. J. S., Campana, L., Kendall, T. J., Bird, T. G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03299-5 · Cited by 161 · see citing works
Cell Senescence in the Aging Kidney
Yang, H., & Fogo, A. B. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010020205 · Cited by 158 · see citing works
Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
Quijano, C., Cao, L., Fergusson, M. M., Romero, H., Liu, J., Gutkind, S., Rovira, I. I., Mohney, R. P., Karoly, E. D., & Finkel, T. (2012) · Cell Cycle · doi:10.4161/cc.19800 · Cited by 155 · see citing works
Cellular senescence impact on immune cell fate and function
Vicente, R., Mausset-Bonnefont, A.-L., Jorgensen, C., Louis-Plence, P., & Brondello, J.-M. (2016) · Aging Cell · doi:10.1111/acel.12455 · Cited by 151 · see citing works
Frescas, D., Roux, C. M., Aygun-Sunar, S., Gleiberman, A. S., Krasnov, P., Kurnasov, O. V., Strom, E., Virtuoso, L. P., Wrobel, M., Osterman, A. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614661114 · Cited by 140 · see citing works
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, C., Maciel-Barón, L. A., Konigsberg, M., Massieu, L., & Castro-Obregón, S. (2019) · Aging · doi:10.18632/aging.102181 · Cited by 128 · see citing works
Cell senescence contributes to tissue regeneration in zebrafish
Da Silva‐Álvarez, S., Guerra‐Varela, J., Sobrido‐Cameán, D., Quelle, A., Barreiro‐Iglesias, A., Sánchez, L., & Collado, M. (2020) · Aging Cell · doi:10.1111/acel.13052 · Cited by 126 · see citing works
Kang, C. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.0298 · Cited by 125 · see citing works
Conserved and novel functions of programmed cellular senescence during vertebrate development
Davaapil, H., Brockes, J. P., & Yun, M. H. (2016) · Development · doi:10.1242/dev.138222 · Cited by 124 · see citing works
Tanaka, H. V., Ng, N. C. Y., Yu, Z. Y., Casco‐Robles, M. M., Maruo, F., Tsonis, P. A., & Chiba, C. (2016) · Nature Communications · doi:10.1038/ncomms11069 · Cited by 105 · see citing works
Ritschka, B., Knauer-Meyer, T., Gonçalves, D. S., Mas, A., Plassat, J.-L., Durik, M., Jacobs, H., Pedone, E., Di Vicino, U., Cosma, M. P., et al. (2020) · Genes & Development · doi:10.1101/gad.332643.119 · Cited by 105 · see citing works
Functional Aging and Gradual Senescence in Zebrafish
Kishi, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.097 · Cited by 103 · see citing works
Zhao, Y., Tyshkovskiy, A., Muñoz‐Espín, D., Tian, X., Serrano, M., de Magalhães, J. P., Nevo, E., Gladyshev, V. N., Seluanov, A., & Gorbunova, V. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721160115 · Cited by 92 · see citing works
Kornicka, K., Szłapka‐Kosarzewska, J., Śmieszek, A., & Marycz, K. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13914 · Cited by 92 · see citing works
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer
Mitri, D. D., & Alimonti, A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.005 · Cited by 88 · see citing works
Transient p53-Mediated Regenerative Senescence in the Injured Heart
Sarig, R., Rimmer, R., Bassat, E., Zhang, L., Umansky, K. B., Lendengolts, D., Perlmoter, G., Yaniv, K., & Tzahor, E. (2019) · Circulation · doi:10.1161/circulationaha.119.040125 · Cited by 86 · see citing works
Telomerase Is Essential for Zebrafish Heart Regeneration
Bednarek, D., González‐Rosa, J. M., Guzmán, G., Gutiérrez‐Gutiérrez, Ó., Aguado, T., Sánchez-Ferrer, C., Marques, I. J., Galardi‐Castilla, M., de Diego, I., Gómez, M. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.064 · Cited by 79 · see citing works
Xu, S., Wu, W., Huang, H., Huang, R., Xie, L., Su, A., Liu, S., Zheng, R., Yuan, Y., Zheng, H., et al. (2019) · Aging Cell · doi:10.1111/acel.12918 · Cited by 79 · see citing works
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, D., Martins, I., Cristóvão, A. M., Dias, A. F., Neves-Silva, D., Pereira, T., Chapela, D., Farinho, A., Jacinto, A., & Saúde, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109334 · Cited by 74 · see citing works
Self-citationCD9 induces cellular senescence and aggravates atherosclerotic plaque formation
Cho, J. H., Kim, E.-C., Son, Y., Lee, D.-W., Park, Y. S., Choi, J. H., Cho, K., Kwon, K., & Kim, J.-R. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0537-9 · Cited by 73 · see citing works
Kennedy, A. L., McBryan, T., Enders, G. H., Johnson, F. B., Zhang, R., & Adams, P. D. (2010) · Cell Division · doi:10.1186/1747-1028-5-16 · Cited by 61 · see citing works
An, S., Cho, S., Kang, J., Lee, S., Kim, H.-S., Min, D., Son, E.-D., & Cho, K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920338117 · Cited by 61 · see citing works
Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish
Lex, K., Maia-Gil, M., Lopes-Bastos, B., Figueira, M., Marzullo, M., Giannetti, K., Carvalho, T., & Ferreira, M. G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920049117 · Cited by 60 · see citing works
TGFβ2-induced senescence during early inner ear development
Gibaja, A., Aburto, M. R., Pulido, S., Collado, M., Hurlé, J. M., Varela‐Nieto, I., & Magariños, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-42040-0 · Cited by 58 · see citing works
HMGB1 modulates the balance between senescence and apoptosis in response to genotoxic stress
Lee, J., Park, I. H., Rhee, W. J., Kim, H. S., & Shin, J. (2019) · The FASEB Journal · doi:10.1096/fj.201900288r · Cited by 57 · see citing works
Marcoux, S., Lê, O., Langlois-Pelletier, C., Laverdière, C., Hatami, A., Robaey, P., & Beausejour, C. M. (2013) · Radiation Oncology · doi:10.1186/1748-717x-8-252 · Cited by 49 · see citing works
The quail mesonephros: a new model for renal senescence?
Nacher, V., Carretero, A., Navarro, M., Armengol, C., Llombart, C., Rodríguez, A., Herrero-Fresneda, I., Ayuso, E., & Ruberte, J. (2006) · Journal of Vascular Research · doi:10.1159/000096076 · Cited by 47 · see citing works
Senescence gives insights into the morphogenetic evolution of anamniotes
Villiard, É., Denis, J.-F., Hashemi, F. S., Igelmann, S., Ferbeyre, G., & Roy, S. (2017) · Biology Open · doi:10.1242/bio.025809 · Cited by 46 · see citing works
Maï, M. E., Marzullo, M., de Castro, I. P., & Ferreira, M. G. (2020) · eLife · doi:10.7554/elife.54935 · Cited by 43 · see citing works
Cellular senescence in tissue repair: every cloud has a silver lining
Yun, M. H. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180081my · Cited by 42 · see citing works
Huang, T., & Rivera‐Pérez, J. A. (2014) · genesis · doi:10.1002/dvg.22761 · Cited by 38 · see citing works
Developmentally-programmed cellular senescence is conserved and widespread in zebrafish
Silva‐Álvarez, S. D., Guerra‐Varela, J., Sobrido‐Cameán, D., Quelle‐Regaldie, A., Barreiro‐Iglesias, A., Sanchez, L. E., & Collado, M. (2020) · Aging · doi:10.18632/aging.103968 · Cited by 32 · see citing works
Unknown fates of (brain) oxidation or UFO: Close encounters with neuronal senescence
Walton, C. C., & Andersen, J. K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.012 · Cited by 26 · see citing works
Wang, S., Liu, Y., Liu, Y., Li, C., Wan, Q., Liu, Y., Su, Y., Cheng, Y., Liu, C., Wang, X., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.588050 · Cited by 20 · see citing works
Graham, Z., Goldberger, A., Azulai, D., Conover, C. F., Ye, F., Bauman, W. A., Cardozo, C. P., & Yarrow, J. F. (2020) · Physiological Reports · doi:10.14814/phy2.14357 · Cited by 15 · see citing works
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Cellular senescence: a key therapeutic target in aging and diseases
Zhang, L., Pitcher, L. E., Yousefzadeh, M. J., Niedernhofer, L. J., Robbins, P. D., & Zhu, Y. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158450 · Cited by 631 · see citing works
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works
Local immune recognition of trophoblast in early human pregnancy: controversies and questions
Moffett, A., & Shreeve, N. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00777-2 · Cited by 151 · see citing works
Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
Rim, C., You, M., Nahm, M., & Kwon, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00402-3 · Cited by 147 · see citing works
Role of cellular senescence in inflammation and regeneration
Saito, Y., Yamamoto, S., & Chikenji, T. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00342-5 · Cited by 117 · see citing works
The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Mebratu, Y. A., Soni, S., Rosas, L., Rojas, M. M., Horowitz, J. C., & Nho, R. S. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00124.2023 · Cited by 89 · see citing works
TFEB‐dependent lysosome biogenesis is required for senescence
Curnock, R., Yalci, K., Palmfeldt, J., Jäättelä, M., Liu, B., & Carroll, B. (2023) · The EMBO Journal · doi:10.15252/embj.2022111241 · Cited by 87 · see citing works
Cellular senescence and the host immune system in aging and age-related disorders
Giannoula, Y., Kroemer, G., & Pietrocola, F. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.02.001 · Cited by 81 · see citing works
Jang, D. S., Shin, J., Shim, E., Ohtani, N., & Jeon, O. H. (2024) · Aging Cell · doi:10.1111/acel.14315 · Cited by 84 · see citing works
A coalition to heal—the impact of the cardiac microenvironment
Tzahor, E., & Dimmeler, S. (2022) · Science · doi:10.1126/science.abm4443 · Cited by 66 · see citing works
Stress-induced β cell early senescence confers protection against type 1 diabetes
Lee, H., Sahin, G. S., Chen, C.-W., Sonthalia, S., Cañas, S. M., Oktay, H. Z., Duckworth, A. T., Brawerman, G. M., Thompson, P. J., Hatzoglou, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.10.014 · Cited by 65 · see citing works
Roadmap for alleviating the manifestations of ageing in the cardiovascular system
Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works
Cognitive interventions for memory and psychological well-being in aging and dementias
Dinius, C. J., Pocknell, C. E., Caffrey, M. P., & Roche, R. A. P. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1070012 · Cited by 58 · see citing works
Kaur, G., Muthumalage, T., & Rahman, I. (2023) · Aging Cell · doi:10.1111/acel.13850 · Cited by 53 · see citing works
Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish
Maï, M. E., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J., Kang, D., Pourcher, T., Yue, J., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00401-5 · Cited by 57 · see citing works
Subcellular structure, heterogeneity, and plasticity of senescent cells
Bitencourt, T. C., Vargas, J. E., Silva, A. O., Fraga, L. R., & Filippi‐Chiela, E. C. (2024) · Aging Cell · doi:10.1111/acel.14154 · Cited by 46 · see citing works
Cell senescence in cardiometabolic diseases
Grootaert, M. O. J. (2024) · npj Aging · doi:10.1038/s41514-024-00170-4 · Cited by 54 · see citing works
Macrophage Involvement in Aging-Associated Skeletal Muscle Regeneration
Cui, C., Ferrucci, L., & Gorospe, M. (2023) · Cells · doi:10.3390/cells12091214 · Cited by 47 · see citing works
Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration
Salinas-Saavedra, M., Febrimarsa, Krasovec, G., Horkan, H. R., Baxevanis, A. D., & Frank, U. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112687 · Cited by 45 · see citing works
Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2
Rangel, P. X. M., Cross, E., Liu, C., Pedigo, C. E., Tian, X., Gutiérrez-Calabrés, E., Nagata, S., Priyadarshini, A., Lerner, G., Bunda, P., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022050598 · Cited by 46 · see citing works
Delenko, J., Xue, X., Chatterjee, P. K., Hyman, N., Shih, A., Adelson, R. P., Tepeš, P. Š., Gregersen, P. K., & Metz, C. N. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01265-z · Cited by 43 · see citing works
Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKD
Mae, S.-I., Hattanda, F., Morita, H., Nozaki, A., Katagiri, N., Ogawa, H., Teranaka, K., Nishimura, Y., Kudoh, A., Yamanaka, S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113431 · Cited by 41 · see citing works
Wong, G. C., & Chow, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220203 · Cited by 40 · see citing works
Senescent cells at the crossroads of aging, disease, and tissue homeostasis
Kuehnemann, C., & Wiley, C. D. (2023) · Aging Cell · doi:10.1111/acel.13988 · Cited by 41 · see citing works
Egr1 regulates regenerative senescence and cardiac repair
Zhang, L., Elkahal, J., Wang, T., Rimmer, R., Genzelinakh, A., Bassat, E., Wang, J., Perez, D. E., Kain, D., Lendengolts, D., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00493-1 · Cited by 37 · see citing works
Oda, T., Gotoh, N., Kasamatsu, T., Handa, H., Saitoh, T., & Sasaki, N. (2023) · Cell Proliferation · doi:10.1111/cpr.13398 · Cited by 33 · see citing works
Is “cellular senescence” a misnomer?
Gems, D., & Kern, C. C. (2022) · GeroScience · doi:10.1007/s11357-022-00652-x · Cited by 33 · see citing works
Senolytic treatment for low back pain
Mannarino, M., Cherif, H., Darband, S. G., Martinez, O. W., Sheng, K., Cousineau, E., Lee, S., Millecamps, M., Gao, C., Gilbert, A., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr1719 · Cited by 33 · see citing works
Tieing together loose ends: telomere instability in cancer and aging
Borges, G. D. O., Criqui, M., & Harrington, L. A. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13299 · Cited by 31 · see citing works
Endothelial Senescence and Its Impact on Angiogenesis in Alzheimer’s Disease
Georgieva, I., Tchekalarova, J. D., Iliev, D. B., & Tzoneva, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411344 · Cited by 29 · see citing works
Understanding and targeting senescence in kidney disease
Chanvillard, L., Mason, T., & Ferenbach, D. A. (2025) · Clinical Kidney Journal · doi:10.1093/ckj/sfaf190 · Cited by 26 · see citing works
Yang, F., Shu, R., Dai, W., Li, B., Liu, C., Yang, H., Johnson, H. M., Yu, S., Bai, D., Yang, W., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122659 · Cited by 24 · see citing works
Adenosine A2A receptor activation reduces chondrocyte senescence
Friedman, B., Larranaga‐Vera, A., Castro, C. M., Corciulo, C., Rabbani, P. S., & Cronstein, B. N. (2023) · The FASEB Journal · doi:10.1096/fj.202201212rr · Cited by 23 · see citing works
The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging
Lavarti, R., Alvarez‐Diaz, T., Marti, K., Kar, P., & Raju, R. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102760 · Cited by 22 · see citing works
Qamsari, E. S., & Stewart, D. J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1403669 · Cited by 21 · see citing works
Senescence: a double-edged sword in beta-cell health and failure?
Varghese, S. S., & Dhawan, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1196460 · Cited by 23 · see citing works
Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells
Garcia-Arias, J. M., Pinal, N., Cristobal-Vargas, S., Estella, C., & Morata, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01583-y · Cited by 19 · see citing works
Transposon control as a checkpoint for tissue regeneration
Angileri, K. M., Bagia, N. A., & Feschotte, C. (2022) · Development · doi:10.1242/dev.191957 · Cited by 15 · see citing works
Targeting senescent cells in atherosclerosis: Pathways to novel therapies
Tian, Y., Shao, S., Feng, H., Zeng, R., Li, S., & Zhang, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102502 · Cited by 15 · see citing works
The Potent and Paradoxical Biology of Cellular Senescence in Cancer
Romesser, P. B., & Lowe, S. W. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-061421-124434 · Cited by 14 · see citing works
Fujita, M., Sasada, M., Iyoda, T., & Fukai, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126591 · Cited by 14 · see citing works
Morelli, N. R., Préfontaine, C., Pipella, J., & Thompson, P. J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2024 · Cited by 12 · see citing works
Specific types of male infertility are correlated with T cell exhaustion or senescence signatures
Amodio, G., Giacomini, G., Boeri, L., Raffo, M., Cilio, S., Pozzi, E., Belladelli, F., Negri, F., Ferrara, A. M., d’Arma, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56193-2 · Cited by 12 · see citing works
Increased chromatin accessibility underpins senescence
Lopes‐Paciencia, S., & Ferbeyre, G. (2025) · FEBS Journal · doi:10.1111/febs.70136 · Cited by 14 · see citing works
Jiang, R., Fang, Z., Lai, Y., Li, L., Tan, J., Yu, C., Fan, M., Tao, L., Shen, W., Xu, C., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176318 · Cited by 11 · see citing works
Mapping the core senescence phenotype of primary human colon fibroblasts
Hattangady, N. G., Carter, K. T., Maroni-Rana, B., Wang, T., Ayers, J., Yu, M., & Grady, W. M. (2024) · Aging · doi:10.18632/aging.205577 · Cited by 11 · see citing works
Targeted delivery strategy: A beneficial partner for emerging senotherapy
Zhang, Q., Li, S., Chen, F., Zeng, R., & Tong, R. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113737 · Cited by 12 · see citing works
Venz, R., Goyala, A., Soto-Gamez, A., Yenice, T., Demaria, M., & Ewald, C. Y. (2023) · GeroScience · doi:10.1007/s11357-023-00909-z · Cited by 11 · see citing works
Kang, T., Moore, E. C., Kopania, E. E. K., King, C. D., Schilling, B., Campisi, J., Good, J. M., & Brem, R. B. (2023) · G3: Genes, Genomes, Genetics · doi:10.1093/g3journal/jkad091 · Cited by 10 · see citing works
Hultberg, J., Blixt, E., Göransson, R., Adolfsson, J., Govender, M., Larsson, M., Nilsdotter‐Augustinsson, Å., Ernerudh, J., & Nyström, S. N. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109816 · Cited by 10 · see citing works
Tejerina-Miranda, S., Pérez‐Ginés, V., Torrente-Rodríguez, R. M., Pedrero, M., Montero‐Calle, A., Pingarrón, J. M., Barderas, R., & Campuzano, S. (2024) · Sensors & Diagnostics · doi:10.1039/d3sd00311f · Cited by 10 · see citing works
Datta, I., & Bangi, E. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.01.009 · Cited by 10 · see citing works
Harada, M., Su-Harada, K., Kimura, T., Ono, K., & Ashida, N. (2024) · Cell Cycle · doi:10.1080/15384101.2024.2325802 · Cited by 10 · see citing works
Liu, C., Pan, J., & Bao, Q. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10338-0 · Cited by 11 · see citing works
Ahmed, S., Gozal, D., & Khalyfa, A. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102170 · Cited by 10 · see citing works
Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
Yang, Z., Potenza, D. M., & Ming, X. (2025) · Biomolecules · doi:10.3390/biom15040545 · Cited by 9 · see citing works
Polzer, O., Kinloch, E., & Fitzsimons, C. P. (2025) · Aging Brain · doi:10.1016/j.nbas.2025.100141 · Cited by 10 · see citing works
Cellular senescence contributes to spontaneous repair of the rat meniscus
Aimono, Y., Endo, K., & Sekiya, I. (2024) · Aging Cell · doi:10.1111/acel.14385 · Cited by 9 · see citing works
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation
Luo, Y., Zeng, Y., Liu, Y., Liu, S., Dai, Y., Pan, W., Zhang, L., Zhu, R., Feng, D., Du, K., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03474-1 · Cited by 10 · see citing works
Promise and Perspective of Nanomaterials in Antisenescence Tissue Engineering Applications
Lu, Z., Singh, G., Lesani, P., & Zreiqat, H. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01298 · Cited by 8 · see citing works
Cellular senescence in the cancer microenvironment
Meguro, S., & Nakanishi, M. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvaf001 · Cited by 7 · see citing works
The IGF-1 senescence switch: a biphasic model for SASP-driven aging and precision senomodulation
Manni, E., Al‐kuraishy, H. M., Hussain, N. R., Abdelaziz, A. M., & Batiha, G. E. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157143 · Cited by 7 · see citing works
Cell Senescence and the Genetics of Melanoma Development
Constantinou, S. M., & Bennett, D. C. (2024) · Genes Chromosomes and Cancer · doi:10.1002/gcc.23273 · Cited by 7 · see citing works
Juvenile zebrafish (Danio rerio) are able to recover from lordosis
Printzi, A., Mazurais, D., Witten, P. E., Madec, L., Gonzalez, A., Mialhe, X., Zambonino‐Infante, J., & Koumoundouros, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-26112-2 · Cited by 7 · see citing works
Overview of molecular signatures of senescence and associated resources: pros and cons
Ntintas, O. A., Vagena, S., Pantelis, P., Theocharous, G., Petty, R., Evangelou, K., & Gorgoulis, V. G. (2026) · FEBS Open Bio · doi:10.1002/2211-5463.70134 · Cited by 6 · see citing works
Chromatin architectural factor CTCF is essential for progesterone‐dependent uterine maturation
Hewitt, S. C., Gruzdev, A., Willson, C. J., Wu, S., Lydon, J. P., Galjart, N., & DeMayo, F. J. (2023) · The FASEB Journal · doi:10.1096/fj.202300862r · Cited by 6 · see citing works
Cellular Senescence in Craniofacial Tissue Regeneration: Inducers, Biomarkers, and Interventions
Tang, W., Huo, F., Long, J., Zhang, S., & Tian, W. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0136 · Cited by 6 · see citing works
Chandrasegaran, S., Sluka, J. P., & Shanley, D. P. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012298 · Cited by 8 · see citing works
Júnior, J. X. D. N., Gomes, J. D. C., Filho, R. I., Valença, H. D. M., Branco, J. R., Araújo, A. B., Moreira, A. D. O. E., Crepaldi, L. D., Paixão, L. P., Ochioni, A. C., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07451-y · Cited by 5 · see citing works
Akagi, K., Koizumi, K., Kadowaki, M., Kitajima, I., & Saito, S. (2023) · Cells · doi:10.3390/cells12182297 · Cited by 5 · see citing works
Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia
Suvakov, S. R., Kattah, A. G., Gojković, T., Enninga, E. A. L., Pruett, J. E., Jayachandran, M., Sousa, C., Santos, J., Hassan, C. A., Suarez, M. L. G., et al. (2023) · Comprehensive physiology · doi:10.1002/cphy.c230003 · Cited by 6 · see citing works
Cellular senescence in reproduction: a two-edged sword
Pretto, L., Nabinger, E., Filippi‐Chiela, E. C., & Fraga, L. R. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae025 · Cited by 5 · see citing works
de Mendonça, L. B., Lenz, G., & Filippi‐Chiela, E. C. (2025) · Biochemical Society Transactions · doi:10.1042/bst20253054 · Cited by 4 · see citing works
Immunological consequences of senescence in physiology and pathology
Zubova, A., Pietrocola, F., & Morsli, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08335-3 · Cited by 6 · see citing works
Damage-Induced Senescent Immune Cells Regulate Regeneration of the Zebrafish Retina
Patton, J. G., Konar, G. J., Flickinger, Z., Sharma, S., Vallone, K. T., Lyon, C. E., Doshier, C., Lingan, A. L., & Lyon, W. (2024) · doi:10.59368/agingbio.20240021 · Cited by 4 · see citing works
Natural Product-Derived Senotherapeutics: Extraction and Biological Evaluation Techniques
Pratsinis, H., Mavrogonatou, E., Zervou, S., Triantis, T. M., Hiskia, A. E., & Kletsas, D. (2025) · Methods in molecular biology · doi:10.1007/978-1-0716-4426-3_19 · Cited by 4 · see citing works
Zhang, F., Wang, Y., Zhang, L., Wang, C., Chen, D., Liu, H., Xu, R., Haynes, C. M., Shim, J., & Ge, X. (2025) · eLife · doi:10.7554/elife.101984.3 · Cited by 3 · see citing works
Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications
Yan, J., Zhang, Y., Mao, G., Yu, J., Zhou, T., & Hao, J. (2025) · MedComm – Oncology · doi:10.1002/mog2.70029 · Cited by 3 · see citing works
Martic, I., Guerrero‐Navarro, L., Cappuccio, E., Hassan, A., Jenewein, B., Arcalís, E., Hrapovic, N., Visdal‐Johnsen, L., Declercq, L., Jansen‐Dürr, P., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-28590-6 · Cited by 3 · see citing works
Chromatin Structure from Development to Ageing
Ayala-Guerrero, L., Claudio-Galeana, S., Furlan-Magaril, M., & Castro‐Obregón, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_2 · Cited by 2 · see citing works
Survey on large language model annotation of cellular senescence from figures in review articles
Yamagata, Y., & Yamada, R. (2024) · Genomics & Informatics · doi:10.1186/s44342-024-00011-6 · Cited by 2 · see citing works
A Potential Contribution of S100A11 to Skin Fibrosis and Pulmonary Involvement in Systemic Sclerosis
Takahashi, T., Takahashi, T., Segawa, Y., Ikawa, T., Terui, H., Takahashi, T., Sumida, H., Yoshizaki, A., Sato, S., & Asano, Y. (2024) · Experimental Dermatology · doi:10.1111/exd.70026 · Cited by 2 · see citing works
Two roads to fibrosis: Contrasting initiating mechanisms of Bleomycin and TGFβ-1 in lung fibroblasts
D’Alessandro, N., Möbus, L., del Giudice, G., Perho, N., Serra, A., & Greco, D. (2025) · Toxicology · doi:10.1016/j.tox.2025.154233 · Cited by 2 · see citing works
DRUGS WITH SENOLYTIC ACTIVITY: PROSPECTS AND POSSIBLE LIMITATIONS
Васильевна, М. Г., & Khokhlov, A. N. (2024) · Vestnik Moskovskogo universiteta Seria 16 Biologia · doi:10.55959/msu0137-0952-16-78-4-3 · Cited by 2 · see citing works
Drugs with Senolytic Activity: Prospects and Possible Limitations
Васильевна, М. Г., & Khokhlov, A. N. (2023) · Moscow University Biological Sciences Bulletin · doi:10.3103/s0096392524600455 · Cited by 2 · see citing works
Zhang, F., Wang, Y., Zhang, L., Wang, C., Chen, D., Liu, H., Xu, R., Haynes, C. M., Shim, J., & Ge, X. (2024) · eLife · doi:10.7554/elife.101984 · Cited by 2 · see citing works
Cellular senescence perspective of mTOR in the delay of aging process
Armadivin, F. H., Achadiyani, A., & Atik, N. (2024) · Journal Of Advanced Pharmacy Education And Research · doi:10.51847/ovga9z0wdb · Cited by 1 · see citing works
Cheng, H., Zhao, Z.-W., Liu, D., Wang, Y., & Zhang, M. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400013 · Cited by 1 · see citing works
Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation
Childress, L., Gatrell, L. B., Wu, H., Ferreira, E., Nookaew, I., & Porter, R. M. (2025) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2025.100620 · Cited by 1 · see citing works
Calma, M. L., Navasumrit, P., Parnlob, V., Rattanayut, P., & Ruchirawat, M. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.119670 · Cited by 1 · see citing works
Valieva, Y., Igrunkova, A., Fayzullin, A. L., Serejnikova, N. B., Kurkov, A. V., Fayzullina, N., Valishina, D., Bakulina, A., Timashev, P. S., & Shekhter, A. B. (2023) · Biology · doi:10.3390/biology12040565 · Cited by 1 · see citing works
Impact of Aging and Cellular Senescence in the Pathophysiology of Preeclampsia
Suvakov, S. R., Kattah, A. G., Gojković, T., Enninga, E. A. L., Pruett, J. E., Jayachandran, M., Sousa, C., Santos, J., Hassan, C. A., Suarez, M. L. G., et al. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00282.x · Cited by 1 · see citing works
Zhang, F., Wang, Y., Zhang, L., Wang, C., Chen, D., Liu, H., Xu, R., Haynes, C. M., Shim, J., & Ge, X. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.03.233874
An Overview of the Role of Senescence in Cancer
Al-Janabi, I. I. (2022) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v3i.77
Albagli, O., & Pelczar, H. (2023) · médecine/sciences · doi:10.1051/medsci/2022186
Kopsidas, C. A., Lowe, C. C., Zhang, J., Kang, W., Zhou, X., & Feng, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.26.525738
Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cellsPreprint
García-Arias, J. M., Pinal, N., Cristobal‐Vargas, S., Estella, C., & Morata, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.08.539867
Senescent Subtypes Transition ModelPreprint
Singh, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.10.544466
Cellular senescence is required for cardiac regeneration
(2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00494-0
Kaur, G., Wang, Q., Tjitropranoto, A., Unwalla, H. J., & Rahman, I. (2024) · Experimental Lung Research · doi:10.1080/01902148.2024.2414974 · Cited by 1 · see citing works
- Authors
- Paramos-de-Carvalho, D., Jacinto, A., & Saúde, L.
- Affiliations
- University of Lisbon (PT)
- CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade Nova de Lisboa
- Corresponding author
- Paramos-de-Carvalho, Diogo
- Saúde, Leonor
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-11-10
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC8580479
- OpenAlex
- W3211748729
- Cited by
- 111
- References
- 123
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 30 · 2023: 34 · 2022: 14 · 2020: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação para a Ciência e a Tecnologia (PD/BD/105770/2014, PTDC/MED-NEU/30428/2017, HR18-00187)
- "la Caixa" Banking Foundation (HR18-00187)
- Santa Casa da Misericórdia de Lisboa (MC36-2020 (Melo e Castro Award))
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senolytics, tissue repair, tissue regeneration, fibrosis, inflammation, aging, stress response, cancer
- MeSH terms
- Aging, Animals, Fibrosis, Humans, Inflammation, Regeneration, Cellular Senescence
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