Cited by 2,606Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Adipose tissue, adipokines, and inflammation

Fantuzzi, Giamila·2005·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2005.02.023

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Abstract

White adipose tissue is no longer considered an inert tissue mainly devoted to energy storage but is emerging as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation. Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte chemoattractant protein 1, and others. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified.

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Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,158
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756

Flagged first, then by citations

Show all 89 references

Research works printed but not linked: 2

White, 1992, Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue, J Biol Chem, 267, 9210, 10.1016/S0021-9258(19)50409-4 · DOI
Schaffler, 2003, Adipocytokines in synovial fluid, JAMA, 290, 1709

Sorted by citations

Items 201–300 of 1,002

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Ordway, D. J., Henao-Tamayo, M. I., Smith, E. E., Shanley, C. A., Harton, M. R., Troudt, J. M., Bai, X., Basaraba, R. J., Orme, I. M., & Chan, E. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1007696 · Cited by 132
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Tu, Q., Zhang, J., Dong, L., Saunders, E., Luo, E., Tang, J., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152405 · Cited by 122
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Klein‐Wieringa, I. R., van der Linden, M. P. M., Knevel, R., Kwekkeboom, J. C., van Beelen, E., Huizinga, T. W. J., Mil, A. H. M. V. D. H., Kloppenburg, M., Toes, R. E. M., & Ioan‐Facsinay, A. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30449 · Cited by 117
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Diet-induced obesity increases NF-κB signaling in reporter mice
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Vitamin C in the Treatment and/or Prevention of Obesity
García‐Díaz, D. F., Lopez‐Legarrea, P., QUINTERO, P., & Martínez, J. A. (2014) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.60.367 · Cited by 111
High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation.
Rayssiguier, Y., Gueux, E., Nowacki, W., Rock, E., & Mazur, A. (2006) · PubMed · Cited by 111
Inflammatory factors in age-related muscle wasting
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Luoto, R., Kalliomäki, M. A., Laitinen, K., Delzenne, N. M., Cani, P. D., Salminen, S., & Isolauri, E. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181f3457f · Cited by 110
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Intra-individual Variation of Plasma Adipokine Levels and Utility of Single Measurement of These Biomarkers in Population-Based Studies
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Ramanjaneya, M., Bettahi, I., Jerobin, J., Chandra, P., Khalil, C. A., Skarulis, M. C., Atkin, S. L., & Abou‐Samra, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00331 · Cited by 113
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Wenzl, F. A., Ambrosini, S., Mohammed, S. A., Kraler, S. C., Lüscher, T. F., Costantino, S., & Paneni, F. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.742178 · Cited by 115
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Konter, J., Duffen, J., Baez, E., Li, S. Z., Ranscht, B., Denzel, M. S., Little, F. F., Nakamura, K., Ouchi, N., Fine, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100426 · Cited by 107
Regulation of human airway smooth muscle cell migration and relevance to asthma
Salter, B., Pray, C., Radford, K., Martin, J. G., & Nair, P. K. (2017) · Respiratory Research · doi:10.1186/s12931-017-0640-8 · Cited by 107
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Cross‐susceptibility between periodontal disease and type 2 diabetes mellitus: an immunobiological perspective
Preshaw, P. M., Foster, N. M., & Taylor, J. J. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2007.00221.x · Cited by 111
[Inflammatory biomarkers: the link between obesity and associated pathologies].
Zulet, M. Á., Puchau, B., Navarro, C., Martí, A., & Martínez, J. A. (2007) · PubMed · Cited by 106
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Authors: Fantuzzi, G.
Affiliations: University of Illinois Chicago (US)
Corresponding author: Fantuzzi, Giamila
ORCID: Fantuzzi, Giamila
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2005-05
Volume: 115
Issue: 5
Pages: 911-919
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2005.02.023
OpenAlex: W2158079900
Cited by: 2,606
References: 89
Citations by year: 2026: 45 · 2025: 67 · 2024: 96 · 2023: 117 · 2022: 119 · 2021: 127 · 2020: 112 · 2019: 121 · 2018: 123 · 2017: 145 · 2016: 112 · 2015: 132 · 2014: 139 · 2013: 184 · 2012: 148
FWCI: 16.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061483, DK-061483)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: white adipose tissue, adipokines, inflammation, adipose tissue macrophages, leptin, adiponectin, resistin, visfatin, TNF-α, interleukin-6, MCP-1, insulin resistance, obesity, cardiovascular disease, infection susceptibility, T cell response, malnutrition
MeSH terms: Adipose Tissue, Animals, Autoimmune Diseases, Hormones, Ectopic, Humans, Inflammation, Insulin Resistance, Macrophages, Obesity, Complement Factor D, Serine Endopeptidases, Cytokines, Adipocytes, Leptin, Intercellular Signaling Peptides and Proteins, Adiponectin, Resistin, Nicotinamide Phosphoribosyltransferase

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