Sleep duration and circulating adipokine levels
Open accessAbstract
INTRODUCTION: Short sleep duration is associated with systemic inflammation and diabetes; however the mechanisms by which reduced sleep leads to these complications are unclear. One possibility is sleep may impact secretion of adipocyte derived hormones that regulate inflammation and insulin resistance. In this study we assessed the association between sleep duration and 3 adipokine levels. METHODS: A total of 561 adults from the Cleveland Family Study underwent standardized laboratory polysomnography followed by a morning fasting blood draw assayed for leptin, visfatin, and retinol binding protein-4 (RBP4) levels. RESULTS: The cohort had an age of 44.5 (16.1) years and total sleep time (TST) of 6.2 (1.3) hours (mean [SD]). Each hour reduction in TST was associated with a 10% increase in leptin (P = 0.01) and a 14% increase in visfatin levels (P = 0.03) in analyses adjusted for age, gender, and race. After additional adjustment for obesity, sleep apnea severity, hypertension, and diabetes, each hour reduction in TST was associated with a 6% increase in leptin (P = 0.01) and a 14% increase in visfatin levels (P = 0.02). Leptin increased by 15% (P = 0.01) and visfatin increased by 31% (P = 0.05) for every 1-h decrease in REM sleep. In contrast, no association between sleep duration and RBP4 was found. CONCLUSIONS: Reduced sleep and reduced REM sleep are associated with elevations in leptin and visfatin, 2 adipokines associated with inflammation and insulin resistance. Further investigation of the effect of sleep on adipose tissue function should be pursued.
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Physiologic studies show that sleep loss can influence metabolism through changes in metabolic hormones, adipocyte function, and beta-cell function.
“Physiologic studies also show that sleep loss can influence metabolism through changes in metabolic hormones,60,61 adipocyte function,62 and beta-cell function.63”
From Sleep, Health, and Society (2017) · cites this paper as [62]
In the Cleveland Family Study of adults (average age 45), shorter total sleep time and less REM sleep were associated with higher leptin levels, while slow-wave sleep was not associated with leptin.
“They found that shorter TST and less REM sleep was associated with higher leptin levels, while SWS was not associated with leptin [154].”
From Association between sleep deficiency and cardiometabolic disease: implications for health disparities (2016) · cites this paper as [154]
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- Authors
- Hayes, A. L., Xu, F., Babineau, D., & Patel, S. R.
- Affiliations
- University Hospitals Cleveland Medical Center (US)
- Case Western Reserve University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Patel, Sanjay R.
- Venue
- Sleep
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-02
- Volume
- 34
- Issue
- 2
- Pages
- 147-152
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC3022933
- OpenAlex
- W22092925
- Cited by
- 114
- References
- 53
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 12 · 2013: 11 · 2012: 14
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5kl2rr024990-05)
- National Heart, Lung, and Blood Institute (HL 081385, R01HL046380, HL046380, K08HL081385)
- National Center for Research Resources (M01RR000080, KL2-RR-024990, RR024990, RR 000080)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep duration, adipokines, leptin, visfatin, retinol-binding protein 4, REM sleep, total sleep time, insulin resistance, systemic inflammation, adipose tissue function, sleep apnea, obesity
- MeSH terms
- Adult, Female, Humans, Longitudinal Studies, Male, Middle Aged, Sleep, Sleep Stages, Time Factors, Cohort Studies, Polysomnography, Leptin, Adipokines, Nicotinamide Phosphoribosyltransferase, Retinol-Binding Proteins, Plasma
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