Cited by 350Dermatology and Skin DiseasesContact Dermatitis and AllergiesSkin and Cellular Biology Research

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Filaggrin in atopic dermatitis

O'Regan, Grainne M., Sandilands, Aileen, McLean, W.H. Irwin, Irvine, Alan D.·2008·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2008.08.002

Open this paper in CoChat — free account

Abstract

The recent identification of loss-of-function mutations in the structural protein filaggrin as a widely replicated major risk factor for eczema sheds new light on disease mechanisms in eczema, a disease that had heretofore largely been considered to have a primarily immunologic etiopathogenesis. The filaggrin gene (FLG) mutation findings are consistent with a recently proposed unifying hypothesis that offers a mechanistic understanding of eczema pathogenesis synthesizing a heritable epithelial barrier defect and resultant diminished epidermal defense mechanisms to allergens and microbes, followed by polarized T(H)2 lymphocyte responses with resultant chronic inflammation, including autoimmune mechanisms. Although compelling evidence from genetic studies on FLG implicates perturbed barrier function as a key player in the pathogenesis of eczema in many patients, much is still unknown about the sequence of biologic, physicochemical, and aberrant regulatory events that constitute the transition from an inherited barrier defect to clinical manifestations of inflammatory eczematous lesions and susceptibility to related atopic disorders. The exact contribution of FLG to the wider atopic story, factors modifying FLG expression, and the role of other barrier proteins remain to be delineated. In this review we highlight recent advances in our understanding of the FLG genetics in the cause of eczema and related complex diseases.

Integrity signals

Registry

Crossref · 10.1016/j.jaci.2008.08.002

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Self-citation
The cornified envelope: a model of cell death in the skin
Candi, E., Schmidt, R., & Melino, G. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1619 · Cited by 1,776
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026
Self-citation
Moisturization and skin barrier function
Rawlings, A. V., & Harding, C. R. (2004) · Dermatologic Therapy · doi:10.1111/j.1396-0296.2004.04s1005.x · Cited by 924
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Sandilands, A., Terron-Kwiatkowski, A., Hull, P. R., O’Regan, G. M., Clayton, T. H., Watson, R. M., Carrick, T., Evans, A. T., Liao, H., Zhao, Y., et al. (2007) · Nature Genetics · doi:10.1038/ng2020 · Cited by 665
Self-citation
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
Weidinger, S., Illig, T., Baurecht, H., Irvine, A. D., Rodríguez, E., Diaz-Lacava, A. N., Klopp, N., Wagenpfeil, S., Zhao, Y., Liao, H., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.05.004 · Cited by 619
Self-citation
Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex (“Epidermal Differentiation Complex”) on Human Chromosome 1q21
Mischke, D., Korge, B. P., Marenholz, I., Volz, A., & Ziegler, A. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12338501 · Cited by 505
Antimicrobial peptides and the skin immune defense system
Schauber, J., & Gallo, R. L. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.027 · Cited by 483
Basis for the barrier abnormality in atopic dermatitis: Outside-inside-outside pathogenic mechanisms
Elias, P. M., Hatano, Y., & Williams, M. L. K. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.01.022 · Cited by 466

Flagged first, then by citations

Show all 25 references

Sorted by citations

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation
Boguniewicz, M., & Leung, D. Y. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01027.x · Cited by 1,100
Epidermal Barrier Dysfunction in Atopic Dermatitis
Cork, M. J., Danby, S. G., Vasilopoulos, Y., Hadgraft, J., Lane, M. E., Moustafa, M., Guy, R. H., MacGowan, A., Ahnini, R. T., & Ward, S. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.133 · Cited by 800
Atopic dermatitis endotypes and implications for targeted therapeutics
Czarnowicki, T., He, H., Krueger, J. G., & Guttman‐Yassky, E. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.10.032 · Cited by 659
Structure and function of the human skin microbiome
Schommer, N. N., & Gallo, R. L. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.10.001 · Cited by 561
Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship
Geoghegan, J. A., Irvine, A. D., & Foster, T. J. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.11.008 · Cited by 533
Self-citation
Pathophysiology of Eosinophilic Esophagitis
O’Shea, K. M., Aceves, S. S., Dellon, E. S., Gupta, S. K., Spergel, J. M., Furuta, G. T., & Rothenberg, M. E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.065 · Cited by 521
γδ T Cells and the Lymphoid Stress-Surveillance Response
Hayday, A. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.006 · Cited by 517
Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis
Tsoi, L. C., Rodriguez, E., Degenhardt, F., Baurecht, H., Wehkamp, U., Volks, N., Szymczak, S., Swindell, W. R., Sarkar, M. K., Raja, K., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.12.018 · Cited by 469
IgE, Mast Cells, and Eosinophils in Atopic Dermatitis
Liu, F., Goodarzi, H., & Chen, H. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-011-8252-4 · Cited by 474
Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis
van den Oord, R. A. H. M., & Sheikh, A. (2009) · BMJ · doi:10.1136/bmj.b2433 · Cited by 471
Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease
Rodríguez, E., Baurecht, H., Herberich, E., Wagenpfeil, S., Brown, S., Cordell, H. J., Irvine, A. D., & Weidinger, S. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.03.036 · Cited by 434
Self-citation
Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease
Sözener, Z. Ç., Öztürk, B. Ö., Çerçi, P., Türk, M., Akın, B. G., Akdiş, M., Altıner, S., Yücel, Ü. Ö., Öğülür, İ., Mitamura, Y., et al. (2022) · Allergy · doi:10.1111/all.15240 · Cited by 455
The multifunctional role of filaggrin in allergic skin disease
McAleer, M. A., & Irvine, A. D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.668 · Cited by 426
Self-citation
Significance of Skin Barrier Dysfunction in Atopic Dermatitis
Kim, B. E., & Leung, D. Y. M. (2018) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2018.10.3.207 · Cited by 393
Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases
Kubo, A., Nagao, K., & Amagai, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57416 · Cited by 378
House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation
Serhan, N., Basso, L., Sibilano, R., Petitfils, C., Meixiong, J., Bonnart, C., Reber, L. L., Marichal, T., Starkl, P. M., Cénac, N., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0493-z · Cited by 353
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2008
Sicherer, S. H., & Leung, D. Y. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.025 · Cited by 340
Recent insights into atopic dermatitis and implications for management of infectious complications
Boguniewicz, M., & Leung, D. Y. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.11.027 · Cited by 334
An update on the genetics of atopic dermatitis: Scratching the surface in 2009
Barnes, K. C. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.11.008 · Cited by 316
Biology and Treatment of Eosinophilic Esophagitis
Rothenberg, M. E. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.07.007 · Cited by 286
Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
Jungersted, J. M., Scheer, H., Mempel, M., Baurecht, H., Cifuentes, L., Høgh, J. K., Hellgren, L. I., Jemec, G. B. E., Agner, T., & Weidinger, S. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02326.x · Cited by 344
Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
Kežić, S., O’Regan, G. M., Lutter, R., Jakaša, I., Koster, E. S., Saunders, S. P., Caspers, P. J., Kemperman, P. M. J. H., Puppels, G. J., Sandilands, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.989 · Cited by 276
Self-citation
Research Progress in Atopic March
Yang, L., Fu, J., & Zhou, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01907 · Cited by 285
Psychoneuroimmunology of Psychological Stress and Atopic Dermatitis: Pathophysiologic and Therapeutic Updates
Steinhoff, M. S., Suárez, A., Feramisco, J. D., & Koo, J. Y. M. (2012) · Acta Dermato Venereologica · doi:10.2340/00015555-1188 · Cited by 266
Phenotype of atopic dermatitis subjects with a history of eczema herpeticum
Beck, L. A., Boguniewicz, M., Hata, T. R., Schneider, L. C., Hanifin, J. M., Gallo, R. L., Paller, A. S., Lieff, S., Reese, J., Zaccaro, D. J., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.020 · Cited by 262
Moisture-Associated Skin Damage
GRAY, M. L., Black, J. M., Baharestani, M. M., Bliss, D. Z., Colwell, J. C., Goldberg, M., Kennedy-Evans, K. L., Logan, S., & Ratliff, C. R. (2011) · Journal of Wound Ostomy and Continence Nursing · doi:10.1097/won.0b013e318215f798 · Cited by 261
Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
Elias, P. M., & Schmuth, M. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32832e7d36 · Cited by 248
Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis
Elias, P. M., & Wakefield, J. S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.048 · Cited by 238
Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum
Gao, P.-S., Rafaels, N. M., Hand, T. A., Murray, T., Boguniewicz, M., Hata, T. R., Schneider, L. C., Hanifin, J. M., Gallo, R. L., Gao, L., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.034 · Cited by 242
Chapter 3 Cellular and Molecular Mechanisms in Atopic Dermatitis
Oyoshi, M. K., He, R., Kumar, L., Yoon, J., & Geha, R. S. (2009) · Advances in immunology · doi:10.1016/s0065-2776(09)01203-6 · Cited by 247
Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus
Miajlović, H., Fallon, P. G., Irvine, A. D., & Foster, T. J. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.09.015 · Cited by 242
Self-citation
Genetic and epigenetic studies of atopic dermatitis
Bin, L., & Leung, D. Y. M. (2016) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-016-0158-5 · Cited by 242
Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis
Guttman-Yassky, E., Suárez-Fariñas, M., Chiricozzi, A., Nograles, K. E., Shemer, A., Fuentes-Duculan, J., Cardinale, I., Lin, P., Bergman, R., Bowcock, A. M., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.09.031 · Cited by 268
Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides
Kihara, A. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.04.001 · Cited by 244
The emerging roles of serine protease cascades in the epidermis
Ovaere, P., Lippens, S., Vandenabeele, P., & Declercq, W. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.08.001 · Cited by 238
Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity
Sampson, H. A., Shreffler, W. G., Yang, W. H.-C., Sussman, G. L., Brown-Whitehorn, T. F., Nadeau, K. C., Cheema, A. S., Leonard, S. A., Pongracic, J. A., Sauvage-Delebarre, C., et al. (2017) · JAMA · doi:10.1001/jama.2017.16591 · Cited by 214
Molecular, Genetic, and Cellular Bases for Treating Eosinophilic Esophagitis
Rothenberg, M. E. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.002 · Cited by 212
A new look at the pathogenesis of asthma
Holgate, S. T., Arshad, H. S., Roberts, G. C., Howarth, P. H., Thurner, P. J., & Davies, D. E. (2009) · Clinical Science · doi:10.1042/cs20090474 · Cited by 215
Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis
Schlievert, P. M., Strandberg, K. L., Lin, Y., Peterson, M. L., & Leung, D. Y. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.039 · Cited by 198
The Skin Microbiome: Current Landscape and Future Opportunities
Smythe, P., & Wilkinson, H. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043950 · Cited by 218
Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases
Searing, D. A., & Leung, D. Y. M. (2010) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2010.05.005 · Cited by 190
Skin Barrier and Immune Dysregulation in Atopic Dermatitis: An Evolving Story with Important Clinical Implications
Czarnowicki, T., Krueger, J. G., & Guttman‐Yassky, E. (2014) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2014.03.006 · Cited by 184
Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173
“5 areas, are similar to those of European ancestry despite FLG mutations being more uncommon in Chinese and Korean ancestry (20, 67, 73, 74).”
Background
Natural moisturizing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods
Kežić, S., Kammeyer, A., Calkoen, F., Fluhr, J. W., & Bos, J. D. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09342.x · Cited by 165
Allergic Asthma: Influence of Genetic and Environmental Factors
Mukherjee, A. B., & Zhang, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.197046 · Cited by 172
The Microbiome and Food Allergy
Iweala, O. I., & Nagler‐Anderson, C. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041621 · Cited by 171
FLGmutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics
Akiyama, M. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09582.x · Cited by 157
Contact dermatitis: Allergic and irritant
Tan, C.-H., Rasool, S., & Johnston, G. A. (2013) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2013.05.033 · Cited by 155
Protease and Protease-Activated Receptor-2 Signaling in the Pathogenesis of Atopic Dermatitis
Lee, S. E., Jeong, S. K., & Lee, S. H. (2010) · Yonsei Medical Journal · doi:10.3349/ymj.2010.51.6.808 · Cited by 157
Ten warning signs of primary immunodeficiency: a new paradigm is needed for the 21st century
Arkwright, P. D., & Gennery, A. R. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06206.x · Cited by 156
Allergic skin diseases
Fonacier, L. S., Dreskin, S. C., & Leung, D. Y. M. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.039 · Cited by 139
Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown
Ogonowska, P., Gilaberte, Y., Barańska‐Rybak, W., & Nakonieczna, J. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.567090 · Cited by 142
Endophenotypic Variations of Atopic Dermatitis by Age, Race, and Ethnicity
Nomura, T., Wu, J., Kabashima, K., & Guttman‐Yassky, E. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.02.022 · Cited by 130
Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children
Brown, S., Relton, C. L., Liao, H., Zhao, Y., Sandilands, A., McLean, W. H. I., Cordell, H. J., & Reynolds, N. J. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09339.x · Cited by 127
Self-citation
Sensitization via Healthy Skin Programs Th2 Responses in Individuals with Atopic Dermatitis
Newell, L., Polak, M. E., Perera, J., Owen, C. L., Boyd, P., Pickard, C., Howarth, P. H., Healy, E., Holloway, J. W., Friedmann, P. S., et al. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.148 · Cited by 123
Upregulation of Aquaporin-3 Is Involved in Keratinocyte Proliferation and Epidermal Hyperplasia
Nakahigashi, K., Kabashima, K., Ikoma, A., Verkman, A. S., Miyachi, Y., & Hara‐Chikuma, M. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.395 · Cited by 121
The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population
Thyssen, J. P., Johansen, J. D., Linneberg, A. R., Menné, T., Nielsen, N. H., Meldgaard, M., Szecsi, P. B., Stender, S., & Carlsen, B. C. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09708.x · Cited by 120
Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches
Swindle, E. J., Collins, J. E., & Davies, D. E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.037 · Cited by 120
Epidermal Barrier in Atopic Dermatitis
Kim, B. E., & Leung, D. Y. (2012) · Allergy, Asthma and Immunology Research · doi:10.4168/aair.2012.4.1.12 · Cited by 114
Skin barrier in atopic dermatitis
Kezic, S. (2014) · Frontiers in Bioscience · doi:10.2741/4225 · Cited by 115
Skin Exposure and Asthma: Is There a Connection?
Redlich, C. A. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201002-025rm · Cited by 115
Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis
Molin, S., Vollmer, S., Weiss, E., Ruzicka, T., & Prinz, J. C. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09245.x · Cited by 112
Epithelial origin of eosinophilic esophagitis
Rochman, M., Azouz, N. P., & Rothenberg, M. E. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.008 · Cited by 111
Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model
Briot, A., Lacroix, M., Robin, A., Steinhoff, M. S., Deraison, C., & Hovnanian, A. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.233 · Cited by 111
Abnormal skin barrier in the etiopathogenesis of atopic dermatitis
Elias, P. M., & Schmuth, M. (2009) · Current Allergy and Asthma Reports · doi:10.1007/s11882-009-0037-y · Cited by 107
Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study
Thyssen, J. P., Carlsen, B. C., Menné, T., Linneberg, A. R., Nielsen, N. H., Meldgaard, M., Szecsi, P. B., Stender, S., & Johansen, J. D. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09822.x · Cited by 105
Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis
Elias, P. M., & Wakefield, J. S. (2011) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-010-8231-1 · Cited by 103
Protease Activity Enhances Production of Thymic Stromal Lymphopoietin and Basophil Accumulation in Flaky Tail Mice
Moniaga, C. S., Jeong, S. K., Egawa, G., Nakajima, S., Hara‐Chikuma, M., Jeon, J. E., Lee, S. H., Hibino, T., Miyachi, Y., & Kabashima, K. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.039 · Cited by 102
The role of filaggrin in the atopic diathesis
O’Regan, G. M., & Irvine, A. D. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03522.x · Cited by 101
Self-citation
Staphylococcus aureus and the Cutaneous Microbiota Biofilms in the Pathogenesis of Atopic Dermatitis
Domenico, E. G. D., Cavallo, I., Capitanio, B., Ascenzioni, F., Pimpinelli, F., Morrone, A., & Ensoli, F. (2019) · Microorganisms · doi:10.3390/microorganisms7090301 · Cited by 101
The epidemiology of eczema in children and adults in England: A population‐based study using primary care data
de Lusignan, S., Alexander, H., Broderick, C., Dennis, J., McGovern, A. P., Feeney, C., & Flohr, C. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13784 · Cited by 102
Eczema Herpeticum: Clinical and Pathophysiological Aspects
Damour, A., Garcia, M., Sénéschal, J., Lévêque, N., & Bodet, C. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08768-3 · Cited by 103
Nickel and cobalt allergy before and after nickel regulation – evaluation of a public health intervention
Thyssen, J. P. (2011) · Contact Dermatitis · doi:10.1111/j.1600-0536.2011.01957.x · Cited by 96
CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23/IL-17–Mediated Psoriasiform Skin Inflammation In Vivo
Mellett, M., Meier-Schiesser, B., Mohanan, D., Schairer, R., Cheng, P. F., Satoh, T. K., Kiefer, B., Ospelt, C., Nobbe, S., Thome, M., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.03.1525 · Cited by 93
Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review
Demessant‐Flavigny, A., Connétable, S., Kérob, D., Moreau, M., Aguilar, L., & Wollenberg, A. (2023) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.19125 · Cited by 105
Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor
Simpson, E. L., Böhling, A., Bielfeldt, S., Bosc, C., & Kerrouche, N. (2012) · Journal of Dermatological Treatment · doi:10.3109/09546634.2012.713461 · Cited by 90
Atopic Dermatitis (Atopic Eczema)
Leung, D. Y. M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0755-7.00139-1 · Cited by 90
Update on atopic dermatitis
Meledathu, S., Naidu, M. P., & Brunner, P. M. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.01.013 · Cited by 90
Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: a pivotal interplay in the pathogenesis of Atopic Dermatitis
Domenico, E. G. D., Cavallo, I., Bordignon, V., Prignano, G., Sperduti, I., Gurtner, A., Trento, E., Toma, L., Pimpinelli, F., Capitanio, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27421-1 · Cited by 87
A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis
Holgate, S. T. (2010) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2010.2.3.165 · Cited by 89
Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options
Bieber, T. R. M., Paller, A. S., Kabashima, K., Feely, M. A., Rueda, M. J., Terres, J. A. R., & Wollenberg, A. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18225 · Cited by 90
The Discovery and Function of Filaggrin
Hoober, J. K., & Eggink, L. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031455 · Cited by 90
Role of the epidermal barrier in atopic dermatitis
Proksch, E., Fölster‐Holst, R., Bräutigam, M., Sepehrmanesh, M., Pfeiffer, S., & Jensen, J. (2009) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2009.07157.x · Cited by 86
Lipid abnormalities and lipid-based repair strategies in atopic dermatitis
Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.001 · Cited by 78
Infectious Complications in Atopic Dermatitis
Sun, D., & Ong, P. Y. (2016) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2016.08.015 · Cited by 80
Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema
Zeller, S., Rhyner, C., Meyer, N., Schmid‐Grendelmeier, P., Akdiş, C. A., & Crameri, R. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.015 · Cited by 77
The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis
Danby, S. G., Chittock, J., Brown, K., Albenali, L., & Cork, M. J. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12778 · Cited by 77
FLGmutation p.Lys4021X in the C-terminal imperfect filaggrin repeat in Japanese patients with atopic eczema
Nemoto‐Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H. I., & Shimizu, H. (2009) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2009.09406.x · Cited by 77
Self-citation
Guidance on the diagnosis and clinical management of atopic eczema
Baron, S. E., Cohen, S. N., & Archer, C. B. (2012) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2012.04336.x · Cited by 75
IL-25 Enhances HSV-1 Replication by Inhibiting Filaggrin Expression, and Acts Synergistically with Th2 Cytokines to Enhance HSV-1 Replication
Kim, B. E., Bin, L., Ye, Y., Ramamoorthy, P., & Leung, D. Y. M. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.223 · Cited by 74
Atopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review
Mohammad, S., Karim, M. R., Iqbal, S., Lee, J. H., Mathiyalagan, R., Kim, Y. J., Yang, D. U., & Yang, D. (2024) · Microbiological Research · doi:10.1016/j.micres.2023.127595 · Cited by 83
Keratosis Pilaris Revisited: Is It More Than Just a Follicular Keratosis?
Thomas, M., & Khopkar, U. (2012) · International Journal of Trichology · doi:10.4103/0974-7753.111215 · Cited by 73
Abnormal epidermal barrier in the pathogenesis of atopic dermatitis
Wolf, R., & Wolf, D. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.08.023 · Cited by 87
Evaluation of an HPLC Method for the Determination of Natural Moisturizing Factors in the Human Stratum Corneum
Đapić, I., Jakaša, I., Yau, N. L. H., Kežić, S., & Kammeyer, A. (2013) · Analytical Letters · doi:10.1080/00032719.2013.789881 · Cited by 68
Functional profiling of the gut microbiome in disease-associated inflammation
Börnigen, D., Morgan, X. C., Franzosa, E. A., Ren, B., Xavier, R. J., Garrett, W. S., & Huttenhower, C. (2013) · Genome Medicine · doi:10.1186/gm469 · Cited by 72
Therapeutic Implications of a Barrier-based Pathogenesis of Atopic Dermatitis
Elias, P. M. (2010) · Annals of Dermatology · doi:10.5021/ad.2010.22.3.245 · Cited by 65
Filaggrin mutations and atopy: consequences for future therapeutics
Heimall, J. R., & Spergel, J. M. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.11.100 · Cited by 67
Hallmarks of Atopic Skin Mimicked In Vitro by Means of a Skin Disease Model Based on FLG Knock-down
Küchler, S., Henkes, D., Eckl, K., Ackermann, K., Plendl, J., Korting, H.-C., Hennies, H.-C., & Schäfer‐Korting, M. (2011) · Alternatives to Laboratory Animals · doi:10.1177/026119291103900508 · Cited by 66
Chromosome 11q13.5 variant associated with childhood eczema: An effect supplementary to filaggrin mutations
O’Regan, G. M., Campbell, L., Cordell, H. J., Irvine, A. D., McLean, W. H. I., & Brown, S. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.10.046 · Cited by 64
Self-citation
Ethnicity and stratum corneum ceramides
Jungersted, J. M., Høgh, J. K., Hellgren, L. I., Jemec, G. B. E., & Agner, T. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10080.x · Cited by 62

Authors: O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D.
Affiliations: University of Dundee (GB)
Trinity College Dublin (IE)
Corresponding author: Irvine, Alan D.
ORCID: Sandilands, Aileen
McLean, W.H. Irwin
Irvine, Alan D.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2008-10
Volume: 122
Issue: 4
Pages: 689-693
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2008.08.002
OpenAlex: W4296927509
Cited by: 350
References: 25
Citations by year: 2026: 8 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 20 · 2021: 20 · 2020: 29 · 2019: 22 · 2018: 9 · 2017: 15 · 2016: 14 · 2015: 11 · 2014: 17 · 2013: 23 · 2012: 25
FWCI: 37.11
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: filaggrin, FLG gene, atopic dermatitis, loss-of-function mutations, epithelial barrier function, chronic inflammation, autoimmune mechanisms, atopic diseases, genetic susceptibility
MeSH terms: Filaggrin Proteins, Animals, Chronic Disease, Dermatitis, Atopic, Eczema, Flagellin, Humans, Inflammation, Mutation, Autoimmunity, Th2 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Filaggrin in atopic dermatitis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks