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Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels
Open accessAbstract
Background Anaphylaxis after Hymenoptera stings has been reported in subjects with mastocytosis, but few data exist regarding disease prevalence in populations allergic to these insects.Objective The incidence of clonal mast cell (MC) disorders in subjects with both systemic reactions to Hymenoptera stings and increased serum baseline tryptase (sBT) levels was assessed by using bone marrow (BM) aspirates and biopsy specimens.Methods Subjects with a history of a systemic reaction caused by a Hymenoptera sting underwent the standard diagnostic work-up for Hymenoptera allergy, and sBT levels were measured. Subjects with an increased sBT level had BM evaluation that included histology/cytology, flow cytometry, and detection of KIT mutations.Results Forty-four (11.6%) of 379 subjects with systemic reactions had increased sBT levels (>11.4 ng/mL), and 31 (70.5%) of these had a history of anaphylaxis. Thirty-four subjects with increased sBT levels underwent a BM analysis. Histology detected diagnostic or subdiagnostic MC infiltrates in 22 (65%) of 34 patients. Abnormal MCs were identified by means of flow cytometry and cytology in 26 (78.8%) of 33 and 20 (58.8%) of 34 subjects, respectively. A KIT mutation was detected in 17 (54.8%) of 31 subjects. The diagnosis was indolent systemic mastocytosis in 21 (61.7%) of 34 subjects and monoclonal MC activation syndrome in 9 (26.5%) of 34 subjects. All subjects with anaphylaxis had one of those 2 disorders.Conclusion The concomitant presence of systemic reactions (especially anaphylaxis) after Hymenoptera stings and increased sBT levels strongly suggests that a BM examination is indicated for the diagnosis of clonal MC disease.
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“in patients with systemic mastocytosis (SM) and MCAS, an IgE-dependent allergy (e.g., against insect venom) is frequently documented.”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [23]
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“These patients suffer from a combination of primary and secondary MCAS, and, as a result, they are at high risk to develop recurrent life-threatening anaphylaxis (21-23).”
From Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome (2019) · cites this paper as [23]
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“thus, they are at high risk for developing recurrent life-threatening anaphylaxis, particularly after Hymenoptera stings, 23,100-102 but they might also be after exposure to food, drugs, and other allergens. 103-105”
From Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review (2021) · cites this paper as [100]
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Self-citationPicard, M., Junior, P. F. G.-B., Mezzano, V., & Castells, M. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.04.001 · Cited by 77
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Golden, D. B. K. (2015) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2015.01.007 · Cited by 75
Bonadonna, P., Zanotti, R., Pagani, M., Bonifacio, M., Scaffidi, L., Olivieri, E., Franchini, M., Reccardini, F., Costantino, M. T., Roncallo, C., et al. (2018) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2017.11.025 · Cited by 73
Self-citationSerum total tryptase levels are increased in patients with active chronic urticaria
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Carter, M. C., Metcalfe, D. D., Matito, A., Escribano, L., Butterfield, J. H., Schwartz, L. B., Bonadonna, P., Zanotti, R., Triggiani, M., Castells, M., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.10.063 · Cited by 72
Self-citationDiagnosis and treatment of Hymenoptera venom allergy
Ruëff, F., Bauer, A., Becker, S., Brehler, R., Brockow, K., Chaker, A. M., Darsow, U. G., Fischer, J., Fuchs, T., Gerstlauer, M., et al. (2023) · Allergologie select · doi:10.5414/alx02430e · Cited by 72
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Hymenoptera Allergy and Mast Cell Activation Syndromes
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Epidemiology, Diagnosis, and Treatment of Hymenoptera Venom Allergy in Mastocytosis Patients
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Self-citationMastocytosis and allergic diseases.
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Self-citationClinical relevance of inherited genetic differences in human tryptases
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Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis
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Self-citationPathogenesis and Pathology of Mastocytosis
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Self-citationMast cell activation disorders
Akin, C. (2014) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2014.03.007 · Cited by 56
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Venom Immunotherapy in Patients with Mastocytosis and Hymenoptera Venom Anaphylaxis
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Mast cell activation syndromes: Collegium Internationale Allergologicum update 2022
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Self-citationMastocytosis and Mast Cell Activation Disorders: Clearing the Air
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Anaphylaxis and Mast Cell Disease: What Is the Risk?
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Spectrum of mast cell activation disorders
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Metadata
- Authors
- Bonadonna, P., Perbellini, O., Passalacqua, G., Caruso, B., Colarossi, S., Dal Fior, D., Castellani, L., Bonetto, C., Frattini, F., Dama, A., Martinelli, G., Chilosi, M., Senna, G., Pizzolo, G., & Zanotti, R.
- Affiliations
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- University of Verona (IT)
- University of Genoa (IT)
- University of Bologna (IT)
- Corresponding author
- Passalacqua, Giovanni
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 123
- Issue
- 3
- Pages
- 680-686
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2095523733
- Cited by
- 392
- References
- 36
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 16 · 2021: 21 · 2020: 18 · 2019: 36 · 2018: 17 · 2017: 19 · 2016: 23 · 2015: 30 · 2014: 39 · 2013: 31 · 2012: 16
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Rheumatology › Eosinophilic Disorders and Syndromes
- Keywords
- clonal mast cell disorders, systemic anaphylaxis, serum tryptase, indolent systemic mastocytosis, KIT mutations, mastocytosis diagnosis
- MeSH terms
- Adolescent, Adult, Aged, Anaphylaxis, Animals, Bone Marrow, Child, Clone Cells, Female, Humans, Hymenoptera, Insect Bites and Stings, Male, Mast Cells, Mastocytosis, Middle Aged, Skin Tests, Incidence, Point Mutation, Proto-Oncogene Proteins c-kit, Tryptases, Young Adult
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