Gender difference, sex hormones, and immediate type hypersensitivity reactions
Abstract
Gender differences in the development and prevalence of human diseases have long been recognized. Immense interest grows in the understanding of the role of sex hormones in the homeostasis of immunity. Asthma predominates in boys before puberty and this gender preference reverses after puberty and in adulthood, when adult women tend to have a more severe disease, often recalcitrant to treatment. Atopic eczema in preschool children shows insignificant gender difference or male preponderance in different studies, with more adult females suffering from atopic eczema. The limited data on the prevalence of immediate hypersensitivity to hymenoptera venom show controversial results. Discrepancy exists regarding the gender difference in food allergy, with females reporting significantly more allergic reactions in questionnaire studies. In general, adverse reactions to nonionic iodinated radiocontrast media are more commonly observed in females. The course of allergic diseases varies unpredictably during pregnancy, whereas hormone replacement therapy in postmenopausal women usually has a favorable influence on the course of asthma. Experiments in rodents confirm an effect of estrogens on mast cell activation and allergic sensitization, while progesterone is shown to suppress histamine release but potentiate IgE induction. Dehydroepiandrosterone may antagonize the production of Th2 cytokines but the effect of testosterone and the other androgens remains less defined. Actual data from human studies are lacking.
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A relationship between female hormones, mast cell-derived mediators, and development of asthma and other allergic and inflammatory diseases has been suggested.
“In this regard, a relationship between female hormones, MC-derived mediators and development of asthma and other allergic and inflammatory diseases has been suggested [4, 16, 19].”
From Gender-Related Effects of Sex Steroids on Histamine Release and Fc<i>ε</i>RI Expression in Rat Peritoneal Mast Cells (2015) · cites this paper as [19]
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- Authors
- Chen, W., Mempel, M., Schober, W., Behrendt, H., & Ring, J.
- Affiliations
- Technical University of Munich (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Chen, W.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2008-10-10
- Volume
- 63
- Issue
- 11
- Pages
- 1418-1427
- ISSN
- 0105-4538 (ISSN-L)
- 1398-9995
- OpenAlex
- W2033825102
- Cited by
- 370
- References
- 119
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 19 · 2023: 24 · 2022: 23 · 2021: 28 · 2020: 20 · 2019: 24 · 2018: 22 · 2017: 20 · 2016: 18 · 2015: 19 · 2014: 24 · 2013: 14 · 2012: 21
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- sex hormones, gender differences, immediate hypersensitivity, asthma, atopic dermatitis, hymenoptera venom allergy, food allergy, pregnancy, hormone replacement therapy, estrogen, progesterone, dehydroepiandrosterone, testosterone, mast cell activation, IgE, Th2 cytokines, histamine release
- MeSH terms
- Anaphylaxis, Angioedema, Animals, Asthma, Conjunctivitis, Allergic, Contraceptives, Oral, Dermatitis, Atopic, Female, Food Hypersensitivity, Humans, Hypersensitivity, Male, Menopause, Menstruation, Sex Characteristics, Gonadal Steroid Hormones, Urticaria
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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