Cited by 370Asthma and respiratory diseasesAllergic Rhinitis and SensitizationFood Allergy and Anaphylaxis Research

Gender difference, sex hormones, and immediate type hypersensitivity reactions

Chen, W., Mempel, M., Schober, W., Behrendt, H., Ring, J.·2008·Allergy

Abstract

Gender differences in the development and prevalence of human diseases have long been recognized. Immense interest grows in the understanding of the role of sex hormones in the homeostasis of immunity. Asthma predominates in boys before puberty and this gender preference reverses after puberty and in adulthood, when adult women tend to have a more severe disease, often recalcitrant to treatment. Atopic eczema in preschool children shows insignificant gender difference or male preponderance in different studies, with more adult females suffering from atopic eczema. The limited data on the prevalence of immediate hypersensitivity to hymenoptera venom show controversial results. Discrepancy exists regarding the gender difference in food allergy, with females reporting significantly more allergic reactions in questionnaire studies. In general, adverse reactions to nonionic iodinated radiocontrast media are more commonly observed in females. The course of allergic diseases varies unpredictably during pregnancy, whereas hormone replacement therapy in postmenopausal women usually has a favorable influence on the course of asthma. Experiments in rodents confirm an effect of estrogens on mast cell activation and allergic sensitization, while progesterone is shown to suppress histamine release but potentiate IgE induction. Dehydroepiandrosterone may antagonize the production of Th2 cytokines but the effect of testosterone and the other androgens remains less defined. Actual data from human studies are lacking.

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Registry

Crossref · 10.1111/j.1398-9995.2008.01880.x

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119 of 119 references verified0 citation errors · 0 not checkable

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Authors
Chen, W., Mempel, M., Schober, W., Behrendt, H., & Ring, J.
Affiliations
  • Technical University of Munich (DE)
  • Helmholtz Munich (DE)
Corresponding author
Chen, W.
Venue
Allergy
Publisher
Wiley
Published
2008-10-10
Volume
63
Issue
11
Pages
1418-1427
ISSN
  • 0105-4538 (ISSN-L)
  • 1398-9995
OpenAlex
W2033825102
Cited by
370
References
119
Citations by year
2026: 16 · 2025: 14 · 2024: 19 · 2023: 24 · 2022: 23 · 2021: 28 · 2020: 20 · 2019: 24 · 2018: 22 · 2017: 20 · 2016: 18 · 2015: 19 · 2014: 24 · 2013: 14 · 2012: 21
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Locations
  • Allergy (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • Site cant be reached (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
sex hormones, gender differences, immediate hypersensitivity, asthma, atopic dermatitis, hymenoptera venom allergy, food allergy, pregnancy, hormone replacement therapy, estrogen, progesterone, dehydroepiandrosterone, testosterone, mast cell activation, IgE, Th2 cytokines, histamine release
MeSH terms
Anaphylaxis, Angioedema, Animals, Asthma, Conjunctivitis, Allergic, Contraceptives, Oral, Dermatitis, Atopic, Female, Food Hypersensitivity, Humans, Hypersensitivity, Male, Menopause, Menstruation, Sex Characteristics, Gonadal Steroid Hormones, Urticaria

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