Cited by 142Asthma and respiratory diseasesImmunodeficiency and Autoimmune DisordersDermatology and Skin Diseases

Risks for infection in patients with asthma (or other atopic conditions): Is asthma more than a chronic airway disease

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Juhn, Young J.·2014·Journal of Allergy and Clinical Immunology

Abstract

Most of the research effort regarding asthma has been devoted to its causes, therapy, and prognosis. There is also evidence that the presence of asthma can influence patients' susceptibility to infections, yet research in this aspect of asthma has been limited. There is additional debate in this field, with current literature tending to view the increased risk of infection among atopic patients as caused by opportunistic infections secondary to airway inflammation, especially in patients with severe atopic diseases. However, other evidence suggests that such risk and its underlying immune dysfunction might be a phenotypic or clinical feature of atopic conditions. This review argues (1) that improved understanding of the effects of asthma or other atopic conditions on the risk of microbial infections will bring important and new perspectives to clinical practice, research, and public health concerning atopic conditions and (2) that research efforts into the causes and effects of asthma must be juxtaposed because they are likely to guide each other.

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Crossref · 10.1016/j.jaci.2014.04.024

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  • Epidemiological studies show an association between cesarean section delivery and chronic immune disorders such as asthma, which are associated with an increased risk of viral infections.

    “Epidemiological studies have shown an association between CS delivery and chronic immune disorders, such as asthma (Sevelsted et al., 2015), which are associated with an increased risk of viral infections (Juhn, 2014).”

    From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Juhn, 2014

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Authors
Juhn, Y. J.
Affiliations
Mayo Clinic (US)
Corresponding author
Juhn, Young J.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2014-08
Volume
134
Issue
2
Pages
247-257.e3
ISSN
0091-6749 (ISSN-L)
OpenAlex
W2002394995
Cited by
142
References
175
Citations by year
2026: 8 · 2025: 4 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 20 · 2020: 18 · 2019: 18 · 2018: 13 · 2017: 12 · 2016: 6 · 2015: 8 · 2014: 3
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Agency for Healthcare Research and Quality (R01HS018431-01A1, R01HS018431)
  • National Institute of Allergy and Infectious Diseases (R21AI101277)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
asthma, atopic diseases, infection risk, microbial infection, opportunistic infections, airway inflammation, immune dysfunction, allergic asthma
MeSH terms
Asthma, Bacterial Infections, Chronic Disease, Dermatitis, Atopic, Disease Susceptibility, Rhinitis, Allergic, Seasonal, Humans, Immunity, Innate, Mycoses, Rhinitis, Allergic, Perennial, Risk Factors, Virus Diseases

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