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Indications for antidepressant drug prescribing in general practice in the Netherlands
Open accessAbstract
Background The intensity of the use of antidepressants in large populations can nowadays relatively easily be estimated using databases encompassing prescription data. There are shortcomings when using prescription databases as they contain no clinical data on patient illness. Antidepressants are prescribed for different illnesses, thus information on the indications could help when interpreting results from database studies on antidepressant drug use. The aim of this study is to investigate for which indications antidepressants are being prescribed in general practice in the Netherlands. Methods Data were obtained from the Second Dutch National Survey of General Practice, carried out by NIVEL (N=385,461). Patients, 18 years and older, who received an antidepressant prescription from a general practitioner in 2001 were selected (N=13,835). Indications for antidepressant drug prescribing were identified using time windows of different lengths. Results Antidepressants are most often being prescribed for depression (45.5%) and anxiety/panic disorders (17.2%). For these indications lengthening the time window around prescription date from 0 to 180 days resulted in an increase of 20-40% in antidepressant drug users identified with these indications. Limitation None of our selected indications could be identified in the physician-patient contact file for about a third of the antidepressant drug users. The study was performed in a general practice setting and did not include antidep…
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The indications for antidepressant usage have been extended for various anxiety/panic disorders, not only for mood disorders.
“Besides that, the indications for antidepressant usage have been extended for various anxiety/panic disorders, not only for mood disorders [45].”
From Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan (2017) · cites this paper as [45]
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Metadata
- Authors
- Gardarsdottir, H., Heerdink, E. R., van Dijk, L., & Egberts, A. C. G.
- Affiliations
- Utrecht University (NL)
- Netherlands Institute for Health Services Research (NL)
- Corresponding author
- Heerdink, E.R.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 98
- Issue
- 1-2
- Pages
- 109-115
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2171870329
- Cited by
- 170
- References
- 3
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 8 · 2015: 15 · 2014: 10 · 2013: 17 · 2012: 7
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.nivel.nl
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- antidepressant prescribing, depression, anxiety disorders, panic disorder, general practice, prescription database, antidepressant use
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Antidepressive Agents, Data Collection, Depression, Family Practice, Female, Humans, Male, Middle Aged, Netherlands, Drug Prescriptions
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