Reduced left subgenual anterior cingulate cortical activity during withdrawal-related emotions in melancholic depressed female patients
Open accessAbstract
Background Research regarding the neurocircuitry in mood disorders suggests an important role for affective information processing of the subgenual part of the anterior cingulate cortex (Cg25: Brodmann area 25).Objective In this study, we focused on Cg25 neuronal responses in depressed females using a paradigm in which emotions are elicited without explicit cognitive control, relying on the salient nature of the mood inducing stimuli eliciting approach-related emotions (like happiness) or withdrawal-related emotions (like disgust).Methods Twelve treatment-resistant melancholic depressed women and 12 healthy female control subjects were asked to passively view blocks of emotionally valenced baby faces while undergoing functional magnetic resonance imaging (fMRI).Results Compared to the healthy females, the depressed patients displayed significantly higher bilateral Cg25 neuronal activities in both emotional conditions. In melancholically depressed women, we found significantly less left-sided than right-sided Cg25 neuronal activity during the withdrawal-related emotions, while right-sided Cg25 activity was comparable for both emotional responses.Conclusions Our results indicate that in depressed women the left Cg25 modulates intense visceral emotional responses to aversive visual stimuli. This could help explain why the left Cg25 provides a valid target region for antidepressant treatment strategies in unipolar melancholic depression.
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Increased subgenual cingulate activity suggests that MDD patients have stronger autonomic emotional responses than controls.
“Increased activity in the subgenual cingulate cortex suggests that individuals with MDD show stronger autonomic emotional responses than controls.63”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [63]
During passive viewing paradigms, patients with bipolar disorder and those with MDD demonstrate hypoactivity in the DLPFC and OFC and hyperactivity in the amygdala and anterior cingulate (subgenual and pregenual), although evidence is less consistent for subcortical regions such as the amygdala and paralimbic regions.
“During passive viewing paradigms, patients with bipolar disorder and those with MDD demonstrate hypoactivity in the DLPFC and OFC and hyperactivity in the amygdala and anterior cingulate (subgenual and pregenual), although evidence is less consistent for subcortical regions such as the amygdala and paralimbic regions.”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [63]
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- Authors
- Baeken, C., Van Schuerbeek, P., De Raedt, R., Ramsey, N. F., Bossuyt, A., De Mey, J., Vanderhasselt, M. A., Leyman, L., & Luypaert, R.
- Affiliations
- Vrije Universiteit Brussel (BE)
- University Medical Center Utrecht (NL)
- Ghent University (BE)
- Corresponding author
- Baeken, C.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 127
- Issue
- 1-3
- Pages
- 326-331
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W1982755413
- Cited by
- 22
- References
- 44
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- biblio.ugent.be
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- Vrije Universiteit Brussel
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- subgenual anterior cingulate cortex, endogenous depression, depression in women, treatment-resistant depression, disgust, hemispheric lateralization, antidepressant targets, mood disorders, emotional processing
- MeSH terms
- Adult, Brain Mapping, Depressive Disorder, Dominance, Cerebral, Emotions, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Neurons, Occipital Lobe, Pattern Recognition, Visual
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