Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression: an exploratory approach
Abstract
Abnormalities in regional cerebral blood flow (rCBF) have been reported to characterize depressive episodes; they are at least partly reversed by antidepressant treatment. Treatment-specific as well as response-related changes in rCBF have been reported. We explored the changes in rCBF induced by vagus nerve stimulation (VNS), a recently proposed antidepressant strategy, by application of single photon emission-computed tomography with (99m)Tc-hexamethyl-propylene amine oxime in otherwise treatment-refractory patients. Both region-of-interest (ROI) and statistical parametric mapping (SPM) analytic approaches were used. Decreases of rCBF in the amygdala, left hippocampus, left subgenual cingulate cortex, left and right ventral anterior cingulum, right thalamus and brain stem were observed; the only increase of rCBF was found by SPM analysis in the middle frontal gyrus. This pattern shares features with changes of rCBF previously associated with the administration of selective serotonin reuptake inhibitors. Similarities to other brain-stimulation strategies in antidepressant treatment were less pronounced.
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Decreased hippocampal activity after VNS has been reported in depression and schizophrenia.
“Decreased hippocampal activity after VNS has been reported in a number of other studies in other conditions such as depression (77, 167) or schizophrenia (168).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [167]
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- Authors
- Zobel, A., Joe, A., Freymann, N., Clusmann, H., Schramm, J., Reinhardt, M., Biersack, H.-J., Maier, W., & Broich, K.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Zobel, Astrid
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 139
- Issue
- 3
- Pages
- 165-179
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1994953919
- Cited by
- 117
- References
- 61
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 10
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- vagus nerve stimulation, regional cerebral blood flow, depression, treatment-resistant depression, amygdala, hippocampus, subgenual anterior cingulate cortex, anterior cingulate cortex, thalamus, brainstem, selective serotonin reuptake inhibitors, antidepressant response, brain stimulation
- MeSH terms
- Mirtazapine, Adult, Amygdala, Antidepressive Agents, Tricyclic, Brain, Cerebrovascular Circulation, Combined Modality Therapy, Major Depressive Disorder, Transcutaneous Electric Nerve Stimulation, Female, Gyrus Cinguli, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Mianserin, Oximes, Thalamus, Vagus Nerve, Citalopram, Tomography, Emission-Computed, Single-Photon, Selective Serotonin Reuptake Inhibitors, Radiopharmaceuticals
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