CoChat
Sign Up
Cited by 166Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression

Kumari, Veena, Mitterschiffthaler, Martina T, Teasdale, John D, Malhi, Gin S, Brown, Richard G, Giampietro, Vincent, Brammer, Michael J, Poon, Lucia +4 more·2003·Biological Psychiatry
DOI 10.1016/s0006-3223(02)01785-7
Open this paper in CoChat — free account

Abstract

Background Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness.Methods Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.Results Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.Conclusions Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.

Integrity signals

Registry

Crossref · 10.1016/s0006-3223(02)01785-7

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Functional neuroimaging studies in MDD consistently indicate hypoactivation in reward-processing regions, including the dorsal and ventral striatum, medial prefrontal cortex, pregenual and subgenual anterior cingulate, and medial frontal gyrus.

    “Functional neuroimaging studies in MDD have consistently indicated hypoactivation in reward-processing regions, including the dorsal and ventral striatum [210-214] and a host of other reward structures, including the medial prefrontal cortex [215,216], the pregenual and subgenual anterior cingulate, and the medial frontal gyrus [217,218].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [215]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Kumari, V., Mitterschiffthaler, M. T., Teasdale, J. D., Malhi, G. S., Brown, R. G., Giampietro, V., Brammer, M. J., Poon, L., Simmons, A., Williams, S. C. R., Checkley, S. A., & Sharma, T.
Affiliations
  • King's College London (GB)
  • MRC Cognition and Brain Sciences Unit (GB)
  • UNSW Sydney (AU)
Corresponding author
Sharma, Tonmoy
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-10
Volume
54
Issue
8
Pages
777-791
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(02)01785-7
OpenAlex
W2048350205
Cited by
166
References
71
Citations by year
2025: 5 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 3 · 2013: 5 · 2012: 10
FWCI
7.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
treatment-resistant depression, rostral anterior cingulate cortex, medial prefrontal cortex, hippocampus, subgenual cingulate, striatum, parahippocampal gyrus, inferior frontal gyrus, brainstem
MeSH terms
Adult, Affect, Antidepressive Agents, Brain, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Female, Humans, Magnetic Resonance Imaging, Middle Aged

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review