Cited by 193Neurological disorders and treatmentsTreatment of Major DepressionElectroconvulsive Therapy Studies

Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression

Dougherty, Darin D., Weiss, Anthony P., Cosgrove, G. Rees, Alpert, Nathaniel M., Cassem, Edwin H., Nierenberg, Andrew A., Price, Bruce H., Mayberg, Helen S. +2 more·2003·Journal of Neurosurgery

Abstract

Object Neurosurgical procedures are a viable intervention for severe, treatment-refractory major depression, although they have been associated with only modest rates of efficacy. The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression. Methods Thirteen patients underwent stereotactic anterior cingulotomy for treatment-refractory major depression. Symptom severity was measured using the Beck Depression Inventory (BDI) both before and approximately 12 months after surgery. The authors performed [18F]fluorodeoxyglucose-positron emission tomography (PET) studies in all patients preoperatively. Statistical parametric mapping methods were used to test for loci of significant correlation between preoperative regional cerebral metabolism and postoperative reduction in BDI scores. The mean (+/- standard deviation) change in the BDI score from the preoperative period (43.7 +/- 7.8) to the postoperative period (30.5 +/- 21.3) was 33.1 +/- 45.4%. Two loci--the left subgenual prefrontal cortex and left thalamus--were identified as sites at which preoperative metabolism was significantly correlated with subsequent improvement in depressive symptom severity following cingulotomy. Specifically, higher preoperative rates of metabolism at these loci were associated with better postoperative results. Conclusions Possible PET scanning predictors of treatment response were identified in patients wi…

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Crossref · 10.3171/jns.2003.99.6.1010

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  • Hypermetabolism in the subgenual cingulate and prefrontal cortex may predict favourable responses to anterior cingulotomies in major depression.

    “while hypermetabolism in the subgenual cingulate and prefrontal cortex may predict favourable responses to anterior cingulotomies in this disorder (Dougherty et al., 2003).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Dougherty et al., 2003

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Authors
Dougherty, D. D., Weiss, A. P., Cosgrove, G. R., Alpert, N. M., Cassem, E. H., Nierenberg, A. A., Price, B. H., Mayberg, H. S., Fischman, A. J., & Rauch, S. L.
Affiliations
Harvard University (US)
Venue
Journal of Neurosurgery
Published
2003-12
Volume
99
Issue
6
Pages
1010-1017
ISSN
0022-3085 (ISSN-L)
OpenAlex
W1992186274
Cited by
193
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 4 · 2016: 7 · 2015: 15 · 2014: 18 · 2013: 11 · 2012: 14
FWCI
2.15
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
anterior cingulotomy, major depressive disorder, treatment-resistant depression, neurosurgery, treatment response prediction, subgenual prefrontal cortex, thalamus, 18F-FDG PET, regional cerebral glucose metabolism, stereotactic neurosurgery
MeSH terms
Adult, Aged, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Stereotaxic Techniques, Telencephalon, Tomography, Emission-Computed, Treatment Outcome

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