Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts
Open accessAbstract
Background Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking.Methods Influenza A, B and coronavirus antibody titers were measured in 257 subjects with recurrent unipolar and bipolar disorder and healthy controls, by SCID. Pearson's χ² tests and logistic regression models were used to analyze associations between seropositivity for coronaviruses, influenza A and B viruses and the following: a) history of recurrent mood disorders b) having attempted suicide in the past c) uni- vs. bi-polarity and d) presence of psychotic symptoms during mood episodes.Results Seropositivity for influenza A (p=0.004), B (p<0.0001) and coronaviruses (p<0.0001) were associated with history of mood disorders but not with the specific diagnosis of unipolar or bipolar depression. Seropositivity for influenza B was significantly associated with a history of suicide attempt (p=0.001) and history of psychotic symptoms (p=0.005).Limitations The design was cross-sectional. Socioeconomic factors, inflammatory markers, and axis II psychopathology were not assessed.Conclusions The association of seropositivity for influenza and coronaviruses with a history of mood disorders, and influenza B with suicidal behavior require replication in larger longitudinal samples. The need for these studies is additionally supported by the high incidence of these viral infections, the high prevalence of mood disorders, and resilience of suicide epidemics.
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Seropositivity for coronaviruses is associated with suicide and psychosis persisting one year after SARS.
“Moreover, seropositivity for coronaviruses associated with suicide and psychosis persisting one year after SARS (Okusaga et al., 2011).”
From Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors (2020) · cites this paper as Okusaga et al., 2011
Okusaga et al. connected seropositivity for human coronavirus strain L63 with mood disorders and suicide attempts.
“Further indication for psychiatric implications of coronaviruses infections came from a study of Okusaga et al. [160], who connected seropositivity for human coronavirus strain L63 with mood disorders and suicide attempts.”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [160]
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Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Harrison's principles of internal medicine
(2008) · Choice Reviews Online · doi:10.5860/choice.46-0330 · Cited by 3,058 · see citing works
Harrison's Principles of Internal Medicine.
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-1-167_1 · Cited by 1,527 · see citing works
Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones
Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519 · see citing works
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works
Neurobiology of suicidal behaviour
Mann, J. J. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1220 · Cited by 1,260 · see citing works
Cytokine-induced sickness behavior: where do we stand?
Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862 · see citing works
Nicholson, K. G., Wood, J., & Zambon, M. C. F. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14854-4 · Cited by 690 · see citing works
Beautrais, A. L., Joyce, P. R., Mulder, R. T., Fergusson, D. M., Deavoll, B. J., & Nightingale, S. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.8.1009 · Cited by 654 · see citing works
Gelder, M. (1983) · Cited by 557 · see citing works
Neuroinvasion by Human Respiratory Coronaviruses
Arbour, N., Day, R. W., Newcombe, J., & Talbot, P. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.8913-8921.2000 · Cited by 518 · see citing works
Interferon-alpha–induced changes in tryptophan metabolism
Capuron, L., Neurauter, G., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Fuchs, D., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00173-2 · Cited by 493 · see citing works
Xu, J., Zhong, S., Liu, J., Li, L., Li, Y., Wu, X., Li, Z., Deng, P., Zhang, J., Zhong, N. S., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/444461 · Cited by 492 · see citing works
Organic Psychiatry: The Psychological Consequences of Cerebral Disorder
Lishman, W. (1978) · Cited by 483 · see citing works
Measuring the global burden of disease and epidemiological transitions: 2002–2030
López, A. D., & Mathers, C. D. (2006) · Annals of Tropical Medicine and Parasitology · doi:10.1179/136485906x97417 · Cited by 462 · see citing works
Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000586 · Cited by 380 · see citing works
Jawetz, Melnick & Adelberg's Medical Microbiology
Brooks, G. F. (2001) · Cited by 377 · see citing works
The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans
Wichers, M., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003103 · Cited by 329 · see citing works
Yeh, E. A., Collins, A. R., Cohen, M. E., Duffner, P. K., & Faden, H. S. (2004) · PEDIATRICS · doi:10.1542/peds.113.1.e73 · Cited by 329 · see citing works
Seasonal Patterns of Stress, Immune Function, and Disease
Nelson, R. J., Demas, G. E., Klein, S. L., Kriegsfeld, L. J., & Bronson, F. H. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546341 · Cited by 316 · see citing works
Cytokines as modulators of the hypothalamus-pituitary-adrenal axis
Besedovsky, H. O., Del Rey, A., Klusman, I., Furukawa, H., Monge Arditi, G., & Kabiersch, A. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90284-c · Cited by 314 · see citing works
Review of Medical Microbiology and Immunology
Levinson, W. E. (2002) · Repository of the University of Ljubljana (University of Ljubljana) · Cited by 256 · see citing works
Dictionary of Psychological Medicine
WOK (1893) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-189309000-00024 · Cited by 227 · see citing works
PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis
Fujimoto, S., Kobayashi, M., Uemura, O., Iwasa, M., 安藤, 恒., Katoh, T., Nakamura, C., Maki, N., Togari, H., & Wada, Y. (1998) · The Lancet · doi:10.1016/s0140-6736(98)12449-2 · Cited by 227 · see citing works
Gold, P. W., Licinio, J., Wong, M., & Chrousos, G. P. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44723.x · Cited by 199 · see citing works
Determinants and Outcomes of Serious Attempted Suicide: A Nationwide Study in Finland, 1996-2003
Haukka, J. K., Suominen, K. H., Partonen, T., & Lönnqvist, J. K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn017 · Cited by 194 · see citing works
Coronavirus Immunoreactivity in Individuals With a Recent Onset of Psychotic Symptoms
Severance, E. G., Dickerson, F., Viscidi, R. P., Bossis, I., Stallings, C. R., Origoni, A. E., Sullens, A., & Yolken, R. H. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp052 · Cited by 190 · see citing works
Self-citationOrganic Psychiatry The Psychological Consequences of Cerebral Disorder
Durward, W. F. (1979) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.42.8.772-a · Cited by 168 · see citing works
Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.02.017 · Cited by 164 · see citing works
Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism
Wang, J., & Dunn, A. J. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00016-3 · Cited by 144 · see citing works
dictionary of psychological medicine
Tuke, D. H. (2016) · Medical Entomology and Zoology · Cited by 139 · see citing works
Brain-immune interactions and disease susceptibility
Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 132 · see citing works
Hiroi, N., Wong, M. L., Licinio, J., Park, C., Young, M., Gold, P. W., Chrousos, G. P., & Bornstein, S. R. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000908 · Cited by 124 · see citing works
Ellman, L. M., Yolken, R. H., Buka, S. L., Torrey, E. F., & Cannon, T. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.015 · Cited by 114 · see citing works
Self-citationShorter Oxford Textbook of Psychiatry
Ford, P. (2011) · Occupational Medicine · doi:10.1093/occmed/kqq186 · Cited by 114 · see citing works
Postolache, T. T., Mortensen, P. B., Tonelli, L. H., Jiao, X., Frangakis, C., Soriano, J. J., & Qin, P. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.05.015 · Cited by 105 · see citing works
Self-citationSeverance, E. G., Bossis, I., Dickerson, F., Stallings, C. R., Origoni, A. E., Sullens, A., Yolken, R. H., & Viscidi, R. P. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00124-08 · Cited by 101 · see citing works
Self-citationInfluenza B Virus Encephalitis
McCullers, J. A., Facchini, S., Chesney, P. J., & Webster, R. G. (1999) · Clinical Infectious Diseases · doi:10.1086/515214 · Cited by 93 · see citing works
Azorin, J., Kaladjian, A., Besnier, N., Adida, M., Hantouche, E. G., Lancrenon, S., & Akiskal, H. S. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.09.004 · Cited by 82 · see citing works
Orthomyxoviruses (influenza viruses)
Hermodsson, S. (1983) · Elsevier eBooks · doi:10.1016/b978-0-407-00253-1.50032-3 · Cited by 52 · see citing works
Acute sickness behaviour: an immune system-to-brain communication?
Vollmer-Conna, U. S. (2001) · Psychological Medicine · doi:10.1017/s0033291701003841 · Cited by 52 · see citing works
Coronaviruses in brain tissue from patients with multiple sclerosis
Dessau, R. B., Lisby, G., & Frederiksen, J. L. (2001) · Acta Neuropathologica · doi:10.1007/s004010000331 · Cited by 51 · see citing works
Skok, M. V. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209106 · Cited by 48 · see citing works
Airborne inflammatory factors from the nose to the brain
Tonelli, L. H. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s52 · Cited by 47 · see citing works
The widening scope of coronaviruses
Kahn, J. S. (2006) · Current Opinion in Pediatrics · doi:10.1097/01.mop.0001110940.57894.90 · Cited by 46 · see citing works
Influenza Infection Causing Manic Psychosis
Steinberg, D., Hirsch, S. R., Marston, S. D., Reynolds, K., & Sutton, R. N. P. (1972) · The British Journal of Psychiatry · doi:10.1192/bjp.120.558.531 · Cited by 44 · see citing works
An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap
Dursun, S. M., Blackburn, J., & Kutcher, S. (2001) · Medical Hypotheses · doi:10.1054/mehy.2000.1187 · Cited by 31 · see citing works
Reversible Splenial Lesion in Influenza Virus Encephalopathy
Matsubara, K., Kodera, M., Nigami, H., Yura, K., & Fukaya, T. (2007) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2007.08.008 · Cited by 29 · see citing works
Host-pathogen interactions during coronavirus infection of primary alveolar epithelial cells
Miura, T. A., & Holmes, K. V. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209078 · Cited by 25 · see citing works
Influenza and Mania: A Possible Connection With the Locus Ceruleus
MAURIZI, C. P. (1985) · Southern Medical Journal · doi:10.1097/00007611-198502000-00025 · Cited by 24 · see citing works
Harrison, R. M. (1958) · BMJ · doi:10.1136/bmj.1.5068.460 · Cited by 15 · see citing works
The Neurology of Affective Disorder and Suicide
Whitlock, F. A. (1982) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048678209159465 · Cited by 15 · see citing works
M-Protein as a Possible Inducer of Depressive State in Influenza
Zhilinskaya, I. N., Маклакова, А. С., & Ашмарин, И. П. (2002) · Doklady Biological Sciences · doi:10.1023/a:1021749810319 · Cited by 2 · see citing works
Shorter Oxford Textbook of Psychiatry
Harrison, P., Cowen, P., Fazel, M., & Bhui, K. (2026) · Oxford University Press eBooks · doi:10.1093/med/9780192871053.001.0001
Flagged first, then by citations
Research works printed but not linked: 2
- Basco M.R. Is there a place for research diagnostic methods in clinic settings? First M.B. Standardized Evaluation in Clinical Practice (Review of Psychiatry Series) 2003 American Psychiatric Publishing Washington, D.C. 1 28
- Oquendo M.A. Halberstam B. Mann J.J. Risk factors for suicidal behavior: the utility and limitations of research instruments First M.B. Standardized Evaluation in Clinical Practice (Review of Psychiatry Series) 2003 American Psychiatric Publishing Washington, DC 103 130
Cited by
Sorted by citations
Fegert, J. M., Vitiello, B., Plener, P. L., & Clemens, V. (2020) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-020-00329-3 · Cited by 1,807 · see citing works
Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors
Mazza, M. G., De Lorenzo, R., Conte, C., Poletti, S., Vai, B., Bollettini, I., Melloni, E. M. T., Furlan, R., Ciceri, F., Rovere-Querini, P., et al. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.037 · Cited by 1,804 · see citing works
Troyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964 · see citing works
Autoimmune Diseases and Severe Infections as Risk Factors for Mood Disorders: A Nationwide Study
Benros, M. E., Waltoft, B. L., Nordentoft, M., Østergaard, S. D., Eaton, W. W., Krogh, J., & Mortensen, P. B. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1111 · Cited by 572 · see citing works
Consideraciones sobre la salud mental en la pandemia de COVID-19
Huarcaya-Victoria, J. (2020) · Revista Peruana de Medicina Experimental y Salud Pública · doi:10.17843/rpmesp.2020.372.5419 · Cited by 496 · see citing works
Role of Inflammation in Suicide: From Mechanisms to Treatment
Brundin, L., Bryleva, E. Y., & Thirtamara Rajamani, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.116 · Cited by 257 · see citing works
“A study by Okusaga et al (2011) found higher seropositivity for influenza B virus in patients with a history of suicide attempt, whereas seropositivity for all three types of viruses (influenza A, B, and coronaviruses) was associated with the history of mood disorders.”
Zortea, T. C., Brenna, C. T. A., Joyce, M., McClelland, H., Tippett, M., Tran, M. M., Arensman, E., Corcoran, P., Hatcher, S., Heise, M. J., et al. (2021) · Crisis · doi:10.1027/0227-5910/a000753 · Cited by 190 · see citing works
Seasonality of Suicidal Behavior
Woo, J., Okusaga, O. O., & Postolache, T. T. (2012) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph9020531 · Cited by 178 · see citing works
Self-citationde Ávila, M. A. G., Filho, P. T. H., Jacob, F. L. D. S., Alcântara, L. R. D. S., Berghammer, M. C., Nolbris, M. J., Olaya‐Contreras, P., & Nilsson, S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17165757 · Cited by 168 · see citing works
Steiner, J. H., Bogerts, B., Sarnyai, Z., Walter, M., Gos, T., Bernstein, H., & Myint, A.-M. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.583941 · Cited by 159 · see citing works
Zandifar, A., Badrfam, R., Yazdani, S., Arzaghi, S. M., Rahimi, F., Ghasemi, S., Khamisabadi, S., Mohammadian Khonsari, N., & Qorbani, M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00667-1 · Cited by 154 · see citing works
The SARS-CoV-2 and mental health: From biological mechanisms to social consequences
Szcześniak, D. M., Gładka, A., Misiak, B., Cyran, A., & Rymaszewska, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110046 · Cited by 152 · see citing works
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
Environmental factors, life events, and trauma in the course of bipolar disorder
Aldinger, F., & Schulze, T. G. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12433 · Cited by 139 · see citing works
Lund-Sørensen, H., Benros, M. E., Madsen, T., Sørensen, H. J., Eaton, W. W., Postolache, T. T., Nordentoft, M., & Erlangsen, A. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.1594 · Cited by 131 · see citing works
Self-citationBenedetti, F., Palladini, M., Paolini, M., Melloni, E. M. T., Vai, B., LORENZO, R. D., Furlan, R., Rovere, P. Q., Falini, A., & Mazza, M. G. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100387 · Cited by 127 · see citing works
Leaune, E., Samuel, M., Oh, H., Poulet, E., & Brunelin, J. (2020) · Preventive Medicine · doi:10.1016/j.ypmed.2020.106264 · Cited by 116 · see citing works
The pandemic exposes human nature: 10 evolutionary insights
Seitz, B. M., Aktipis, A., Buss, D. M., Alcock, J., Bloom, P. A., Gelfand, M. J., Harris, S., Lieberman, D., Natterson-Horowitz, B., Pinker, S. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009787117 · Cited by 103 · see citing works
COVID-19 and psychosis risk: real or delusional concern?
Watson, C. J., Thomas, R. H., Solomon, T., Michael, B. D., Nicholson, T. R., & Pollak, T. A. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135491 · Cited by 103 · see citing works
An inflammatory profile linked to increased suicide risk
Keaton, S. A., Madaj, Z. B., Heilman, P., Smart, L., Grit, J., Gibbons, R., Postolache, T. T., Roaten, K., Achtyes, E. D., & Brundin, L. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.12.100 · Cited by 95 · see citing works
Self-citationIs it time for immunopsychiatry in psychotic disorders?
Leboyer, M., Oliveira, J., Tamouza, R., & Groc, L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4266-1 · Cited by 96 · see citing works
Banerjee, D., & Viswanath, B. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102350 · Cited by 96 · see citing works
Oh, H. Y., Marinovich, C., Rajkumar, R. P., Besecker, M., Zhou, S., Jacob, L., Koyanagi, A., & Smith, L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.121 · Cited by 91 · see citing works
Orsini, A. A., Corsi, M., Santangelo, A., Riva, A., Peroni, D. G., Foiadelli, T., Savasta, S., & Striano, P. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04544-w · Cited by 86 · see citing works
Neurological manifestations of coronavirus infections – a systematic review
Almqvist, J., Granberg, T., Tzortzakakis, A., Klironomos, S., Kollia, E., Öhberg, C., Martinꝉ, R., Piehl, F., Ouellette, R., & Ineichen, B. V. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51166 · Cited by 84 · see citing works
SARS-CoV-2 Dissemination Through Peripheral Nerves Explains Multiple Organ Injury
Fenrich, M., Mrdenovic, S., Balog, M., Tomic, S., Zjalic, M., Roncevic, A., Mandic, D., Debeljak, Z., & Heffer, M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00229 · Cited by 95 · see citing works
Animal models to improve our understanding and treatment of suicidal behavior
Gould, T. D., Georgiou, P., Brenner, L. A., Brundin, L., Can, A., Courtet, P., Donaldson, Z. R., Dwivedi, Y., Guillaume, S., Gottesman, I. I., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.50 · Cited by 81 · see citing works
Self-citationHanson, B. A., Visvabharathy, L., Ali, S. T., Kang, A. K., Patel, T. R., Clark, J. R., Lim, P. H., Orban, Z. S., Hwang, S., Mattoon, D., et al. (2022) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001151 · Cited by 60 · see citing works
Suicide during COVID-19 and other major international respiratory outbreaks: A systematic review
Kahil, K., Cheaito, M. A., Hayek, R. E., Nofal, M., Halabi, S. E., Kundadak, G. K., Pereira-Sánchez, V., & Hayek, S. E. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102509 · Cited by 61 · see citing works
A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks
Zhou, X., Lei, L., Liu, J. H., Halu, A., Zhang, Y., Li, B., Guo, Z., Liu, G., Sun, C., Loscalzo, J., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.04.002 · Cited by 55 · see citing works
Mortensen, P. B., Pedersen, C. B., McGrath, J. J., HOUGAARD, D. M., Nørgaard‐Petersen, B., Mors, O. N., Børglum, A. D., & Yolken, R. H. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00962.x · Cited by 55 · see citing works
Self-citationInfectious and immunogenetic factors in bipolar disorder
Oliveira, J., Oliveira-Maia, A. J., Tamouza, R., Brown, A. S., & Leboyer, M. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12791 · Cited by 52 · see citing works
Postolache, T. T., Benros, M. E., & Brenner, L. A. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.2795 · Cited by 53 · see citing works
Self-citationÉpidémie de COVID-19 et prise en charge des conduites suicidaires : challenge et perspectives
Conejero, I., Berrouiguet, S., Ducasse, D., Leboyer, M., Jardon, V., Olié, É., & Courtet, P. (2020) · L Encéphale · doi:10.1016/j.encep.2020.05.001 · Cited by 53 · see citing works
Alpert, O., Begun, L., Garren, P. A., & Solhkhah, R. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100173 · Cited by 47 · see citing works
Toxoplasma gondii, Suicidal Behavior, and Intermediate Phenotypes for Suicidal Behavior
Postolache, T. T., Wadhawan, A., Rujescu, D., Hoisington, A. J., Dagdag, A., Baca‐García, E., Lowry, C. A., Okusaga, O. O., & Brenner, L. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.665682 · Cited by 44 · see citing works
Self-citationFallout from the COVID-19 pandemic – should we prepare for a tsunami of post viral depression?
Lyons, D., Frampton, M., Naqvi, S. S., Donohoe, D., Adams, G., & GLYNN, K. P. (2020) · Irish Journal of Psychological Medicine · doi:10.1017/ipm.2020.40 · Cited by 41 · see citing works
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Serafini, G., Costanza, A., Aguglia, A., Amerio, A., Trabucco, A., Escelsior, A., Sher, L., & Amore, M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.09.001 · Cited by 47 · see citing works
Abdoli, A., Taghipour, A., Pirestani, M., Jahromi, M. A. M., Roustazadeh, A., Mir, H., Ardakani, H. M., Kenarkoohi, A., Falahi, S., & Karimi, M. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05645 · Cited by 38 · see citing works
Coronaviruses and Central Nervous System Manifestations
Khateb, M., Bosak, N., & Muqary, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00715 · Cited by 38 · see citing works
Suicide and Lyme and associated diseases
Bransfield, R. C. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s136137 · Cited by 37 · see citing works
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Conejero, I., Nobile, B., Olié, É., & Courtet, P. (2021) · Current Psychiatry Reports · doi:10.1007/s11920-021-01227-x · Cited by 85 · see citing works
Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19
Tizenberg, B., Brenner, L. A., Lowry, C. A., Okusaga, O. O., Benavides, D. R., Hoisington, A. J., Benros, M. E., Stiller, J. W., Kessler, R. C., & Postolache, T. T. (2021) · Current Psychiatry Reports · doi:10.1007/s11920-021-01275-3 · Cited by 33 · see citing works
Self-citationNobile, B., Durand, M., Olié, É., Guillaume, S., Molès, J., Haffen, É., & Courtet, P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.615695 · Cited by 31 · see citing works
Identification of anti-tuberculosis agents that target the cell-division protein FtsZ
Lin, Y., Zhu, N., Han, Y., Jiang, J., & Si, S. (2014) · The Journal of Antibiotics · doi:10.1038/ja.2014.89 · Cited by 29 · see citing works
Xiao, X., Zhang, H., Ning, W., Yang, Z. R., Wang, Y., & Zhang, T. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114060 · Cited by 29 · see citing works
Porcelli, B., Verdino, V., Bossini, L., Terzuoli, L., & Fagiolini, A. M. (2014) · Autoimmunity Highlights · doi:10.1007/s13317-014-0064-0 · Cited by 28 · see citing works
Bipolar disorder, COVID‐19, and the risk of relapse
Rajkumar, R. P. (2020) · Bipolar Disorders · doi:10.1111/bdi.12947 · Cited by 28 · see citing works
Psychiatric sequelae in COVID-19 survivors: A narrative review
Putri, C., Arisa, J., Hananto, J. E., Hariyanto, T. I., & Kurniawan, A. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i10.821 · Cited by 28 · see citing works
Wu, C., Lee, M., Hương, P. T. T., Chan, C., Chen, C.-Y., & Liao, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-06511-1 · Cited by 25 · see citing works
Hansen, H. G., Köhler‐Forsberg, O., Petersen, L. V., Nordentoft, M., Postolache, T. T., Erlangsen, A., & Benros, M. E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.11.008 · Cited by 26 · see citing works
Self-citationBöhmwald, K., Andrade, C. A., & Kalergis, A. M. (2021) · Pharmaceuticals · doi:10.3390/ph14040340 · Cited by 28 · see citing works
Wierenga, K. L., Moore, S. E., Pressler, S. J., Hacker, E. D., & Perkins, S. M. (2021) · Nursing Outlook · doi:10.1016/j.outlook.2021.03.020 · Cited by 22 · see citing works
Three insights on psychoneuroimmunology of mood disorders to be taken from the COVID-19 pandemic
Brietzke, E. M., Magee, T., Freire, R. C. R., Gomes, F. A., & Milev, R. V. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100076 · Cited by 22 · see citing works
Brain and COVID-19 Crosstalk: Pathophysiological and Psychological Manifestations
Verma, K., Amitabh, Prasad, D. N., Kumar, B., & Kohli, E. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00446 · Cited by 22 · see citing works
Ahn, S., Kim, J. L., Kim, J. R., Lee, S. H., Yim, H. W., Jeong, H., Chae, J., Park, H. Y., Lee, J. J., & Lee, H. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.02.029 · Cited by 21 · see citing works
Microbes and Mental Illness: Past, Present, and Future
Bransfield, R. C., Mao, C., & Greenberg, R. (2023) · Healthcare · doi:10.3390/healthcare12010083 · Cited by 23 · see citing works
Mood disturbance after infection
Gunaratne, P., Lloyd, A. R., & Vollmer-Conna, U. S. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413503718 · Cited by 18 · see citing works
Pollen counts and suicide rates. Association not replicated
Woo, J., Gibbons, R. D., Rogers, C. A., Qin, P., Kim, J. B., Roberts, D. W., Noh, E. S., Mann, J. J., & Postolache, T. T. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01813.x · Cited by 18 · see citing works
Self-citationAustgen, G., Meyers, M. S., Gordon, M., & Livingston, R. (2021) · Journal of the Academy of Consultation-Liaison Psychiatry · doi:10.1016/j.jaclp.2021.07.010 · Cited by 18 · see citing works
Postolache, T. T., Akram, F., Lee, E., Lowry, C. A., Stiller, J. W., Brenner, L. A., Streeten, E. A., Turecki, G., & Dwivedi, Y. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.027 · Cited by 18 · see citing works
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Peper, M., & Schott, J. (2021) · Zeitschrift für Neuropsychologie · doi:10.1024/1016-264x/a000342 · Cited by 17 · see citing works
An overview of the neurological aspects in COVID-19 infection
Singh, D., & Singh, E. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102101 · Cited by 17 · see citing works
Clinical Aspects of Manic Episodes After SARS-CoV-2 Contagion or COVID-19
CASALE, A. D., Modesti, M. N., Rapisarda, L., Girardi, P., & Tambelli, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.926084 · Cited by 17 · see citing works
Hickie, I. B., Merikangas, K. R., Carpenter, J. S., Iorfino, F., Scott, E. M., Scott, J. L., & Crouse, J. J. (2023) · Bipolar Disorders · doi:10.1111/bdi.13304 · Cited by 16 · see citing works
Pandemics throughout the centuries
Schwartz, R. A., & Kapila, R. (2020) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2020.12.006 · Cited by 16 · see citing works
Proposed Pathway Linking Respiratory Infections with Depression
Karimi, Z., Chenari, M., Rezaie, F., Karimi, S., Parhizgari, N., & Mokhtari‐Azad, T. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.2.199 · Cited by 16 · see citing works
Coronavirus Disease 2019 (COVID-19) and Psychiatric Sequelae in South Africa: Anxiety and Beyond
Subramaney, U., Kim, A. W., Chetty, I., Chetty, S., Jayrajh, P., Govender, M., Maharaj, P., & Pak, E. (2020) · Wits Journal of Clinical Medicine · doi:10.18772/26180197.2020.v2n2a2 · Cited by 15 · see citing works
Problem gambling during Covid-19
Frisone, F., Alibrandi, A., & Settineri, S. (2020) · Mediterranean Journal of Clinical Psychology · doi:10.6092/2282-1619/mjcp-2457 · Cited by 15 · see citing works
Legacy of neuropsychiatric symptoms associated with past COVID-19 infection: A cause of concern
Berardis, D. D., Carlo, F. D., Giannantonio, M. D., & Pettorruso, M. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i6.773 · Cited by 14 · see citing works
Volk, P., Manesh, M. R., Warren, M. E., Besko, K., de Andrade, E. G., Wicki‐Stordeur, L. E., & Swayne, L. A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16016 · Cited by 13 · see citing works
The role of neurotropism in psychiatric patients with COVID-19
Diaz, A. D., & Baweja, R. K. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01197-w · Cited by 13 · see citing works
Jung, S. J., Lim, S., & Yoon, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244596 · Cited by 13 · see citing works
François, M., Schaefer, J. M., Bôle‐Feysot, C., Déchelotte, P., Verhulst, F. C., & Fetissov, S. O. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.12.011 · Cited by 13 · see citing works
SARS-CoV-2 Psychiatric Sequelae: A Review of Neuroendocrine Mechanisms and Therapeutic Strategies
Hornick, M. G., Olson, M. E., & Jadhav, A. L. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab069 · Cited by 13 · see citing works
Ramalho, S., Martins‐Mendes, D., Macedo, J. M., Barros, C. E. C., Luís, C., Sá, S., Gestoso, Á., Pereira, A. C., Baylina, P., & Fernandes, R. (2023) · Healthcare · doi:10.3390/healthcare11172463 · Cited by 17 · see citing works
The Role of the SARS-CoV-2 Pandemic on Suicide Rates
Karakasi, M., Kevrekidis, D. P., & Pavlidis, P. (2020) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0000000000000598 · Cited by 12 · see citing works
Smith, C. J., Renshaw, P. F., Yurgelun-Todd, D. A., & Sheth, C. S. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.772335 · Cited by 12 · see citing works
Daou, M. A. Z., Rached, G., & Geller, J. L. (2021) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001338 · Cited by 11 · see citing works
Telles-Garcia, N., Zahrli, T. A., Aggarwal, G., Bansal, S., Richards, L., & Aggarwal, S. (2020) · Case Reports in Psychiatry · doi:10.1155/2020/8897454 · Cited by 10 · see citing works
Chenthamara, D., Prasathkumar, M., Robert, B., Anisha, S., Sadhasivam, S., Essa, M. M., Chidambaram, S. B., Al-Balushi, B., Guillemin, G. J., & Qoronfleh, M. W. (2020) · International Journal of Tryptophan Research · doi:10.1177/1178646920978243 · Cited by 10 · see citing works
Coronavirus infections from 2002 to 2021: neuropsychiatric manifestations
Barthorpe, A., & Rogers, J. P. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.11.013 · Cited by 10 · see citing works
Sinyor, M., Zaheer, R., Webb, R. T., Knipe, D. W., Eyles, E., Higgins, J. P. T., McGuinness, L. A., Schmidt, L., Macleod-Hall, C., Dekel, D., et al. (2022) · The Canadian Journal of Psychiatry · doi:10.1177/07067437221094552 · Cited by 10 · see citing works
Loneliness, internalizing symptoms, and inflammatory markers in adolescent COVID‐19 survivors
Akçay, E., Çöp, E., Dinç, G. Ş., Göker, Z., Parlakay, A. Ö., Demirel, B. D., Mutlu, M., & Kırmızı, B. (2022) · Child Care Health and Development · doi:10.1111/cch.13043 · Cited by 11 · see citing works
Coronavirus disease 2019 pandemic: Do not forget patients with severe mental illness
Mousavi, S. B. (2020) · International Journal of Social Psychiatry · doi:10.1177/0020764020939982 · Cited by 8 · see citing works
Jegede, O. O., Raman, A. A., Tiongson, B. C., Garlapati, P. R., Hershberger, J., & Gayam, V. B. R. (2020) · International Journal of Mental Health · doi:10.1080/00207411.2020.1845567 · Cited by 8 · see citing works
Benros, M. E., & Mortensen, P. B. (2015) · Current topics in neurotoxicity · doi:10.1007/978-3-319-13602-8_6 · Cited by 8 · see citing works
Pandemia COVID‑19 e Perturbação Mental: Breve Revisão da Literatura
Nascimento, S., Pereira, C. F. P., Caldas, I., Silva, M., Mendonça, T., Lourenço, B., & Gonçalves, M. A. C. (2020) · Revista Portuguesa de Psiquiatria e Saúde Mental · doi:10.51338/rppsm.2020.v6.i2.146 · Cited by 8 · see citing works
Sarchiapone, M., López‐Castromán, J., Gramaglia, C. M., Baca‐García, E., Baralla, F., Barrigón, M. L., Bartollino, S., Beezhold, J., Bobes, J., Calati, R., et al. (2021) · GLOBAL PSYCHIATRY ARCHIVES · doi:10.52095/gp.2021.8114 · Cited by 8 · see citing works
Lorkiewicz, P., & Waszkiewicz, N. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1423739 · Cited by 9 · see citing works
Increased Suicide of Iranian Resident Physicians in the COVID-19 Pandemic
Nazari, S., Ghazvini, H., Tamijani, S. M. S., & Rafaiee, R. (2021) · international journal high risk behaviors & addiction · doi:10.5812/ijhrba.117651 · Cited by 7 · see citing works
Ascertaining Whether Suicides Are Caused by Infections
Brundin, L., & Grit, J. L. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.1470 · Cited by 7 · see citing works
Postolache, T. T., Duncan, E., Yen, P., Potocki, E., Barnhart, M. C., Federline, A., Massa, N., Dagdag, A., Joseph, J., Wadhawan, A., et al. (2025) · Folia Parasitologica · doi:10.14411/fp.2025.002 · Cited by 6 · see citing works
Self-citationPsychotropics and COVID-19: An analysis of safety and prophylaxis
Javelot, H., Straczek, C., Meyer, G., Faria, C. G. F., Weiner, L., Drapier, D., Fakra, É., Fossati, P., Weibel, S., Dizet, S., et al. (2021) · L Encéphale · doi:10.1016/j.encep.2021.08.002 · Cited by 6 · see citing works
Gkatsa, T. (2021) · International Journal Of Scientific Advances · doi:10.51542/ijscia.spi2.02 · Cited by 6 · see citing works
Leone, M., Kuja‐Halkola, R., Levál, A., D'Onofrio, B. M., Larsson, H., Lichtenstein, P., & Bergen, S. E. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.004 · Cited by 6 · see citing works
A case of Sars-Cov-2-related mania with prominent psychosis>
Russo, M., Consoli, S., Rosa, M. A. D., Calisi, D., Dono, F., Carrarini, C., ONOFRJ, M. C., Angelis, M. V. D., & Sensi, S. L. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114266 · Cited by 5 · see citing works
Meinlschmidt, G., Guemghar, S., Roemmel, N., Battegay, E., Hunziker, S., & Schaefert, R. (2022) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796021000676 · Cited by 5 · see citing works
Mechanisms of New-Onset Psychosis during the Covid-19 Pandemic: What Ignited the Fire?
Mourani, S. C., Khoury, R., & Ghossoub, E. (2022) · Annals of Clinical Psychiatry · doi:10.12788/acp.0065 · Cited by 6 · see citing works
Psychiatric Manifestations of COVID-19: A Literature Review
Khatun, A., Tamilanban, T., & Chitra, V. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220701152821 · Cited by 5 · see citing works
- Authors
- Okusaga, O., Yolken, R. H., Langenberg, P., Lapidus, M., Arling, T. A., Dickerson, F. B., Scrandis, D. A., Severance, E., Cabassa, J. A., Balis, T., & Postolache, T. T.
- Affiliations
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Sheppard Pratt Health System (US)
- Corresponding author
- Postolache, Teodor T.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 130
- Issue
- 1-2
- Pages
- 220-225
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC3043161
- OpenAlex
- W1965020733
- Cited by
- 163
- References
- 55
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 29 · 2021: 36 · 2020: 44 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH074891, R21MH075891)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- influenza A virus, influenza B, coronavirus, seropositivity, mood disorders, bipolar disorder, major depressive disorder, suicide attempts, psychotic symptoms, neurotropic viruses
- MeSH terms
- Adolescent, Adult, Aged, Bipolar Disorder, Major Depressive Disorder, Depressive Disorder, Female, Humans, Influenza, Human, Male, Middle Aged, Influenza A virus, Influenza B virus, Suicide, Attempted, Chi-Square Distribution, Logistic Models, Coronavirus, Coronavirus Infections, Mood Disorders, Young Adult
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