Altered brain network modules induce helplessness in major depressive disorder
Open accessAbstract
Objective The abnormal brain functional connectivity (FC) has been assumed to be a pathophysiological aspect of major depressive disorder (MDD). However, it is poorly understood, regarding the underlying patterns of global FC network and their relationships with the clinical characteristics of MDD.Methods Resting-state functional magnetic resonance imaging data were acquired from 16 first episode, medication-naïve MDD patients and 16 healthy control subjects. The global FC network was constructed using 90 brain regions. The global topological patterns, e.g., small-worldness and modularity, and their relationships with depressive characteristics were investigated. Furthermore, the participant coefficient and module degree of MDD patients were measured to reflect the regional roles in module network, and the impairment of FC was examined by network based statistic.Results Small-world property was not altered in MDD. However, MDD patients exhibited 5 atypically reorganized modules compared to the controls. A positive relationship was also found among MDD patients between the intra-module I and helplessness factor evaluated via the Hamilton Depression Scale. Specifically, eight regions exhibited the abnormal participant coefficient or module degree, e.g., left superior orbital frontal cortex and right amygdala. The decreased FC was identified among the sub-network of 24 brain regions, e.g., frontal cortex, supplementary motor area, amygdala, thalamus, and hippocampus.Limitation The limited size of MDD samples precluded meaningful study of distinct clinical characteristics in relation to aberrant FC.Conclusions The results revealed altered patterns of brain module network at the global level in MDD patients, which might contribute to the feelings of helplessness.
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In MDD, resting-state functional connectivity strength within a module involving several PFC regions correlates positively with self-reported helplessness.
“In a study using graph analyses, rsFC strength within a module involving several PFC regions (e.g., dorsal and medial superior frontal gyrus; OFC; middle frontal gyrus, anterior cingulum gyrus) correlated positively with self-reported helplessness in MDD [209].”
From Prefrontal cortex and depression (2022) · cites this paper as [209]
Results §3.5 reports a positive correlation between intra-module I connectivity and helplessness in MDD (r = 0.54, p < 0.05). However, the Introduction describes the helplessness measure as a clinician-rated HAMD interview, not a self-report. Results §3.2 also places the middle frontal gyrus in module II, rather than the correlated module I, among MDD patients. Page numbers are unavailable in our copy. (LLM, conf=0.91)
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- Authors
- Peng, D., Shi, F., Shen, T., Peng, Z., Zhang, C., Liu, X., Qiu, M., Liu, J., Jiang, K., Fang, Y., & Shen, D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Corresponding author
- Fang, Yiru
- Shen, Dinggang
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 168
- Pages
- 21-29
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC5321069
- OpenAlex
- W2108482200
- Cited by
- 76
- References
- 61
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 3 · 2014: 1
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University College London
- National Institute on Aging (R01AG042599, R01AG041721, AG 042599, AG041721)
- National Institute of Mental Health (MH100217, R01MH100217)
- National Institute of Biomedical Imaging and Bioengineering (EB006733, EB009634, EB008374, R01EB008374, R01EB009634, R01EB006733)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- major depressive disorder, brain functional connectivity, helplessness, network modularity, small-world property, first-episode depression, amygdala, network-based statistics, resting-state fMRI
- MeSH terms
- Adult, Brain, Depressive Disorder, Major, Major Depressive Disorder, Emotions, Female, Helplessness, Learned, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Research Design, Case-Control Studies
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