Cited by 232Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolTreatment of Major Depression

Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior

Shumake, J., Edwards, E., Gonzalez-Lima, F.·2003·Brain Research

Abstract

Congenitally helpless rats have been selectively bred to display an immediate helpless response to stress in order to model hereditary brain differences that contribute to depression vulnerability. Differences in regional brain metabolism between congenitally helpless and non-helpless rats were investigated using quantitative cytochrome oxidase histochemistry. The results indicated that congenitally helpless rats had 64-71% elevated metabolism in the habenula and a 25% elevation in the related interpeduncular nucleus. In contrast, helpless rats had 28% reduced metabolism in the ventral tegmental area (VTA) and 14-16% reductions in the basal ganglia and basolateral and central amygdala. The opposite metabolic changes in the habenula and ventral tegmental area may be especially important for determining the congenitally helpless rat's global pattern of brain activity, which resembles the metabolic activity pattern produced by dopamine antagonism.

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Crossref · 10.1016/s0006-8993(02)04048-9

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78 of 78 references verified0 citation errors · 0 not checkable

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  • The lateral habenula is implicated in negative mood states in both animal and human research.

    “The LHb is implicated in negative mood states in both animal and human research.”

    From Deep brain stimulation for depression. (2022) · cites this paper as [41]

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Authors
Shumake, J., Edwards, E., & Gonzalez-Lima, F.
Affiliations
  • The University of Texas at Austin (US)
  • University of Maryland, Baltimore (US)
Corresponding author
Gonzalez-Lima, F.
Venue
Brain Research
Publisher
Elsevier BV
Published
2003-02
Volume
963
Issue
1-2
Pages
274-281
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1999881677
Cited by
232
References
78
Citations by year
2026: 1 · 2025: 4 · 2024: 11 · 2023: 2 · 2022: 10 · 2021: 9 · 2020: 14 · 2019: 18 · 2018: 21 · 2017: 20 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 16 · 2012: 6
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (T32MH18837, T32MH018837)
  • National Institute of Neurological Disorders and Stroke (R01NS037755, R01 NS-37755)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
brain regional metabolism, habenula, ventral tegmental area, interpeduncular nucleus, amygdala, basal ganglia, depression vulnerability, stress response, dopamine antagonism, cytochrome oxidase histochemistry
MeSH terms
Animals, Basal Ganglia, Behavior, Animal, Electron Transport Complex IV, Histocytochemistry, Male, Phenotype, Stress, Psychological, Rats, Sprague-Dawley, Ventral Tegmental Area, Habenula, Rats

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