Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior

Psychopharmacology: The third generation of progress

O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020 · see citing works

Psychopharmacology: The Third Generation of Progress.

(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021 · see citing works

Limbic-cortical dysregulation: a proposed model of depression

(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works

The amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction.

Aggleton, J. P. (1992) · Wiley-Liss eBooks · Cited by 1,536 · see citing works

Neuroimaging studies of mood disorders

Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works

The amygdala: Neurobiological aspects of emotion, memory and mental dysfunction

Scheel-Krüger, J. (1993) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(93)90037-5 · Cited by 1,277 · see citing works

Cytochrome oxidase: an endogenous metabolic marker for neuronal activity

Wong-Riley, M. T. T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90165-3 · Cited by 1,238 · see citing works

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works

Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems

EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708 · see citing works

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674 · see citing works

Depression, intellectual impairment, and Parkinson disease

Mayeux, R. P., Stern, Y., Rosen, J. J., & Leventhal, J. (1981) · Neurology · doi:10.1212/wnl.31.6.645 · Cited by 571 · see citing works

The dorsal diencephalic conduction system: A review of the anatomy and functions of the habenular complex

Sutherland, R. J. (1982) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(82)90003-3 · Cited by 537 · see citing works

PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review

Videbech, P. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101001011.x · Cited by 419 · see citing works

Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat

Christoph, G., Leonzio, R., & Wilcox, K. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-03-00613.1986 · Cited by 418 · see citing works

Physiological Evidence for Habenula as Major Link Between Forebrain and Midbrain Raphe

Wang, R. Y., & Aghajanian, G. K. (1977) · Science · doi:10.1126/science.194312 · Cited by 411 · see citing works

Zur Serotonin-Hypothese der Depression*

Lesch, K., & Beckmann, H. (1990) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-2007-1001206 · Cited by 392 · see citing works

Magnetic Resonance Imaging of the Caudate Nuclei in Depression: Preliminary Observations

Krishnan, K. R. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070047007 · Cited by 365 · see citing works

Metabolic rate in the right amygdala predicts negative affect in depressed patients

Abercrombie, H., Schaefer, S., Larson, C., Oakes, T., Lindgren, K. A., Holden, J., Perlman, S. B., Turski, P., Krahn, D., Benca, R., et al. (1998) · NeuroReport · doi:10.1097/00001756-199810050-00028 · Cited by 345 · see citing works

Regional cerebral glucose utilization in patients with a range of severities of unipolar depression

Kimbrell, T. A., Ketter, T. A., George, M. S., Little, J. T., Benson, B. E., Willis, M. W., Herscovitch, P., & Post, R. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01216-1 · Cited by 300 · see citing works

Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion

Morris, J. S., Smith, K. A., Cowen, P. J., Friston, K. J., & Dolan, R. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0455 · Cited by 288 · see citing works

Functional Magnetic Resonance Imaging of Brain Reward Circuitry in the Human

BREITER, H. C., & Rosen, B. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09287.x · Cited by 231 · see citing works

Cerebral correlates of depressed behavior in rats, visualized using 14C- 2-deoxyglucose autoradiography

Caldecott-Hazard, S., Mazziotta, J. C., & Phelps, M. E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01951.1988 · Cited by 194 · see citing works

Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta-analysis

Steffens, D. C., Krishnan, K. R., & Helms, M. J. (1997) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1997)6:1 · Cited by 194 · see citing works

The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress

Amat, J., Sparks, P., Matus-Amat, P., Griggs, J., Watkins, L. R., & Maier, S. F. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02934-1 · Cited by 187 · see citing works

Dopaminergic abnormalities in amygdaloid nuclei in major depression: a postmortem study

Klimek, V., Schenck, J. E., Han, H., Stockmeier, C. A., & Ordway, G. A. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01383-5 · Cited by 176 · see citing works

Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat

Maswood, S., Barter, J. E., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01313-9 · Cited by 173 · see citing works

Evidence for, and nature of, the tonic inhibitory influence of habenulointerpeduncular pathways upon cerebral dopaminergic transmission in the rat

Nishikawa, T., Fage, D., & Scatton, B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90347-1 · Cited by 166 · see citing works

Cytochrome oxidase activity in the auditory system of the mouse: A qualitative and quantitative histochemical study

Gonzalez-Lima, F., & Cada, A. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90550-9 · Cited by 163 · see citing works

Intellectual changes in patients with MPTP‐induced parkinsonism

Stern, Y., & Langston, J. W. (1985) · Neurology · doi:10.1212/wnl.35.10.1506 · Cited by 150 · see citing works

Possible excitatory amino acid afferents to nucleus raphe dorsalis of the rat investigated with retrograde wheat germ agglutinin and d-[3H]aspartate tracing

Kalén, P., Karlson, M., & Wiklund, L. (1985) · Brain Research · doi:10.1016/0006-8993(85)91244-2 · Cited by 148 · see citing works

Frontostriatal deficits in unipolar major depression

Rogers, M. A., Bradshaw, J. L., Pantelis, C., & Phillips, J. G. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00126-9 · Cited by 147 · see citing works

Quantitative mapping of cytovhrome oxidase activity in the central auditory system of the gerbil: a study with calibrated activity standards and metal-intensified histochemistry

Gonzalez-Lima, F., & Jones, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90836-2 · Cited by 145 · see citing works

Brain Glucose Metabolism During Non—Rapid Eye Movement Sleep in Major Depression

Ho, A. P. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070095014 · Cited by 131 · see citing works

Selective activation of the mesocortico-frontal dopaminergic neurons induced by lesion of the habenula in the rat

Lisoprawski, A., Herve, D., Blanc, G., Glowinski, J., & Tassin, J. P. (1980) · Brain Research · doi:10.1016/0006-8993(80)90135-3 · Cited by 130 · see citing works

Prevention of learned helplessness: In vivo correlation with cortical serotonin

Petty, F., Kramer, G. L., & Wilson, L. B. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90163-a · Cited by 123 · see citing works

Forebrain origins and terminations of the medial forebrain bundle metabolically activated by rewarding stimulation or by reward-blocking doses of pimozide

Gallistel, C. R., Gomita, Y., Yadin, E., & Campbell, K. J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01246.1985 · Cited by 119 · see citing works

Metabolic Mapping of the Brain During Rewarding Self-Stimulation

Porrino, L. J., Esposito, R., Seeger, T., Crane, A. M., Pert, A., & Sokoloff, L. (1984) · Science · doi:10.1126/science.6710145 · Cited by 118 · see citing works

Cells of the rat lateral habenula respond to high-threshold somatosensory inputs

Benabid, A. L., & Jeaugey, L. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90393-5 · Cited by 94 · see citing works

Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease

Gonzalez-Lima, F. (1998) · Springer eBooks · doi:10.1007/978-1-4757-9936-1 · Cited by 92 · see citing works

Habenula and thalamus cell transplants restore normal sleep behaviors disrupted by denervation of the interpeduncular nucleus

Haun, F., Eckenrode, T. C., & Murray, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-08-03282.1992 · Cited by 91 · see citing works

Plasticity of [14C]2-deoxy-d-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement

Kozlowski, M. R., & Marshall, J. F. (1980) · Brain Research · doi:10.1016/0006-8993(80)90442-4 · Cited by 89 · see citing works

The fasciculus retroflexus controls the integrity of REM sleep by supporting the generation of hippocampal theta rhythm and rapid eye movements in rats

Valjakka, A., Vartiainen, J., Tuomisto, L. M., Tuomisto, J. T., Olkkonen, H., & Airaksinen, M. M. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00006-9 · Cited by 86 · see citing works

Quantitative histochemistry of cytochrome oxidase in rat brain

Gonzalez-Lima, F., & Garrosa, M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90943-n · Cited by 83 · see citing works

Self-stimulation of the habenular complex in the rat.

Sutherland, R. J., & Nakajima, S. (1981) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077833 · Cited by 77 · see citing works

Ascending reticular activating system in the rat: A 2-deoxyglucose study

Gonzalez-Lima, F., & Scheich, H. (1985) · Brain Research · doi:10.1016/0006-8993(85)91190-4 · Cited by 76 · see citing works

Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease

Gonzalez-Lima, F. (2013) · Medical Entomology and Zoology · Cited by 74 · see citing works

Role of lateral habenula in the regulation of exploratory behavior and its relationship to stress in rats

Lee, E. H. Y., & Huang, S.-P. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90169-6 · Cited by 73 · see citing works

Relevance of the Habenular Complex to Neuropsychiatry: A Review and Hypothesis

Sandyk, R. (1991) · International Journal of Neuroscience · doi:10.3109/00207459108990738 · Cited by 70 · see citing works

Haloperidol and Cerebral Metabolism in the Conscious Rat: Relation to Pharmacokinetics

Pizzolato, G., Soncrant, T. T., & Rapoport, S. I. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12792.x · Cited by 67 · see citing works

Congenital helpless rats as a genetic model for cortex metabolism in depression

Shumake, J., Poremba, A., Edwards, E., & Gonzalez-Lima, F. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00040 · Cited by 65 · see citing works

Genetic predisposition and the development of posttraumatic stress disorder in an animal model

King, J. A., Abend, S., & Edwards, E. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01071-x · Cited by 65 · see citing works

Neurochemical and behavioral consequences of mild, uncontrollable shock: Effects of PCPA

Edwards, E., Johnson, J., Anderson, D. C., Turano, P., & Henn, F. A. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90018-3 · Cited by 58 · see citing works

Regional brain effects of sodium azide treatment on cytochrome oxidase activity: a quantitative histochemical study

Cada, A. M., Gonzalez-Lima, F., Rose, G. M., & Bennett, M. C. (1995) · Metabolic Brain Disease · doi:10.1007/bf02109361 · Cited by 58 · see citing works

Early Stress and Genetic Influences on Hypothalamic–Pituitary–Adrenal Axis Functioning in Adulthood

King, J. A., & Edwards, E. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1525 · Cited by 57 · see citing works

Further evidence for excitatory amino acid transmission in the lateral habenular projection to the rostral raphe nuclei: Lesion-induced decrease of high affinity glutamate uptake

Kalén, P., Pritzel, M., Nieoullon, A. L., & Wiklund, L. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90225-9 · Cited by 57 · see citing works

Effect of some brain lesions on intracranial self-stimulation in the rat

Boyd, E., & Gardner, L. C. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.213.4.1044 · Cited by 56 · see citing works

Quantitative Histochemistry of Cytochrome Oxidase Activity

Gonzalez-Lima, F., & Cada, A. M. (1998) · Springer eBooks · doi:10.1007/978-1-4757-9936-1_2 · Cited by 53 · see citing works

D1/D2 DOPAMINE RECEPTOR STIMULATION BY L-DOPA: A[14C]-2-DEOXYGLUCOSE AUTORADIOGRAPHIC STUDY

Trugman, J. M., JAMES, C. L., & Wooten, G. F. (1991) · Brain · doi:10.1093/brain/114.3.1429 · Cited by 50 · see citing works

Melancholia in rodents: neurobiology and pharmacology.

Henn, F. A., Johnson, J., Edwards, E., & Anderson, D. (1985) · PubMed · Cited by 49 · see citing works

Withdrawal following cocaine self‐administration decreases regional cerebral metabolic rate in critical brain reward regions

Hammer, R. P., Pires, W. S., Markou, A., & Koob, G. F. (1993) · Synapse · doi:10.1002/syn.890140110 · Cited by 49 · see citing works

Dissociation of septo-hippocampal metabolism in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00297-x · Cited by 48 · see citing works

First and second order maternal behavior related afferents of the lateral habenula

Felton, T. M., Linton, L., Rosenblatt, J. S., & Morell, J. I. (1999) · Neuroreport · doi:10.1097/00001756-199903170-00039 · Cited by 48 · see citing works

Untitled work

(2001) · PubMed · Cited by 47 · see citing works

Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02142-5 · Cited by 41 · see citing works

Genetic Studies in Affective Disorders

PAPOLOS, DEMITRI, F., LACHMAN, & HERBERT, M. (1995) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199509000-00014 · Cited by 38 · see citing works

Habenular modulation of raphe indoleamine metabolism

Speciale, S. G., Neckers, L., & Wyatt, R. J. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90506-8 · Cited by 35 · see citing works

Alterations in glucocorticoid inducible RNAs in the limbic system of learned helpless rats

Lachman, H. M., Papolos, D. F., Boyle, A., Sheftel, G., Juthani, M., Edwards, E., & Henn, F. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90862-h · Cited by 34 · see citing works

Effects of reinforcement-blocking doses of pimozide on neural system driven by rewarding stimulation of the MFB: A 14C-2-deoxyglucose analysis

Gomita, Y., & Gallistel, C. R. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90369-0 · Cited by 34 · see citing works

Action of habenular efferents on ventral tegmental area neurons studied in vitro

Matsuda, Y., & Fujimura, K. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90254-u · Cited by 33 · see citing works

Effects of methylenedioxymethamphetamine on local cerebral glucose utilization in the rat

Wilkerson, G., & London, E. D. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90128-7 · Cited by 33 · see citing works

Network operations revealed by brain metabolic mapping in a genetic model of hyperactivity and attention deficit: the Naples high- and low-excitability rats

Gonzalez-Lima, F., & Sadile, A. G. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00049-4 · Cited by 30 · see citing works

Lateral habenula and hippocampus: A complex interaction raphe cells-mediated

Ferraro, G., Montalbano, M. E., Sardo, P., & Grutta, V. L. (1997) · Journal of Neural Transmission · doi:10.1007/bf01291880 · Cited by 29 · see citing works

Habenula lesions attenuate lateral hypothalamic analgesia in the formalin test

Fuchs, P. N., & Cox, V. C. (1993) · Neuroreport · doi:10.1097/00001756-199302000-00001 · Cited by 26 · see citing works

Effect of some brain lesions on septal intracranial self-stimulation in the rat

Boyd, E., & Celso, M. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.219.3.734 · Cited by 19 · see citing works

Cytochrome Oxidase Atlas of Rat Brain

Gonzalez-Lima, F., & Cada, A. M. (1998) · Springer eBooks · doi:10.1007/978-1-4757-9936-1_10 · Cited by 16 · see citing works

Melancholia as a Neurological Disorder

Austin, M., & Mitchell, P. (1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511759024.016 · Cited by 15 · see citing works

Genetic Studies in Affective Disorders: Overview of Basic Methods, Current Directions, and Critical Research Issues

Dünner, D. L. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.6.948-a · Cited by 13 · see citing works

Effects of self-administered phencyclidine on regional uptake of 2-deoxy-d-[1-14C]glucose in brain

Weissman, A. D., Marquis, K. L., Moreton, J. E., & London, E. D. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90136-6 · Cited by 10 · see citing works

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

Yang, Y., Cui, Y., Sang, K., Dong, Y., Ni, Z., Ma, S., & Hu, H. (2018) · Nature · doi:10.1038/nature25509 · Cited by 1,036 · see citing works

The habenula: from stress evasion to value-based decision-making

Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955 · see citing works

Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient

Sartorius, A., Kiening, K. L., Kirsch, P., von Gall, C. C., Haberkorn, U., Unterberg, A. W., Henn, F. A., & Meyer-Lindenberg, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.027 · Cited by 611 · see citing works

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works

Reward processing by the lateral habenula in normal and depressive behaviors

Proulx, C. D., Hikosaka, O., & Malinow, R. (2014) · Nature Neuroscience · doi:10.1038/nn.3779 · Cited by 461 · see citing works

βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression

Li, K., Zhou, T., Liao, L., Yang, Z., Wong, C., Henn, F., Malinow, R., Yates, J. R., & Hu, H. (2013) · Science · doi:10.1126/science.1240729 · Cited by 411 · see citing works

Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression

Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

Shabel, S. J., Proulx, C. D., Piriz, J., & Malinow, R. (2014) · Science · doi:10.1126/science.1250469 · Cited by 369 · see citing works

Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response.

Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.018 · Cited by 281 · see citing works

Stress models of depression: forming genetically vulnerable strains

Henn, F. A., & Vollmayr, B. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.019 · Cited by 274 · see citing works

Lateral habenula in the pathophysiology of depression

Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254 · see citing works

Neuronal Dynamics Regulating Brain and Behavioral State Transitions

Andalman, A. S., Burns, V. M., Lovett-Barron, M., Broxton, M. J., Poole, B., Yang, S., Grosenick, L., Lerner, T. N., Chen, R., Benster, T., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.037 · Cited by 246 · see citing works

Reward and aversion

Hu, H. (2016) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014106 · Cited by 253 · see citing works

The SEEKING mind: Primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression

Alcaro, A., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.03.002 · Cited by 240 · see citing works

Lateral habenula lesions improve the behavioral response in depressed rats via increasing the serotonin level in dorsal raphe nucleus

Yang, L.-M., Hu, B., Xia, Y.-H., Zhang, B.-L., & Zhao, H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.10.022 · Cited by 236 · see citing works

The ‘resting-state hypothesis’ of major depressive disorder—A translational subcortical–cortical framework for a system disorder

Northoff, G., Wiebking, C., Feinberg, T., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.007 · Cited by 222 · see citing works

The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation

McLaughlin, I., Dani, J. A., & Biasi, M. D. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14008 · Cited by 230 · see citing works

Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes

Morishita, T., Fayad, S. M., Higuchi, M.-A., Nestor, K. A., & Foote, K. D. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0282-1 · Cited by 216 · see citing works

PERIL AND PLEASURE: AN RDOC-INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION: Neighborhood Characteristics and Mental Health

Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209 · see citing works

Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb

Ma, S., Chen, M., Jiang, Y., Xiang, X., Wang, S., Wu, Z., Li, S., Cui, Y., Wang, J., Zhu, Y., et al. (2023) · Nature · doi:10.1038/s41586-023-06624-1 · Cited by 213 · see citing works

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

Vadnie, C. A., & McClung, C. A. (2017) · Neural Plasticity · doi:10.1155/2017/1504507 · Cited by 199 · see citing works

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

Lecca, S., Meye, F. J., & Mameli, M. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12480 · Cited by 196 · see citing works

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

Cerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187 · see citing works

Habenula Volume in Bipolar Disorder and Major Depressive Disorder: A High-Resolution Magnetic Resonance Imaging Study

Savitz, J. B., Nugent, A. C., Bogers, W., Roiser, J. P., Bain, E., Neumeister, A., Zarate, C. A., Manji, H. K., Cannon, D. M., Marrett, S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.027 · Cited by 182 · see citing works

Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

Ranft, K., Dobrowolny, H., Krell, D., Bielau, H., Bogerts, B., & Bernstein, H.-G. (2010) · Psychological Medicine · doi:10.1017/s0033291709990821 · Cited by 183 · see citing works

Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice

Lecca, S., Pelosi, A., Tchenio, A., Moutkine, I., Lujan, R., Hervé, D., & Mameli, M. (2016) · Nature Medicine · doi:10.1038/nm.4037 · Cited by 176 · see citing works

Deep brain stimulation for depression.

Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works

Neural Correlates of Rapid Antidepressant Response to Ketamine in Treatment-Resistant Unipolar Depression: A Preliminary Positron Emission Tomography Study

Carlson, P. J., Diazgranados, N., Nugent, A. C., Ibrahim, L., Luckenbaugh, D. A., Brutsche, N., Herscovitch, P., Manji, H. K., Zarate, C. A., & Drevets, W. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.008 · Cited by 168 · see citing works

Translating the habenula-from rodents to humans

Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164 · see citing works

Learned helplessness: unique features and translational value of a cognitive depression model

Vollmayr, B., & Gass, P. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1654-2 · Cited by 155 · see citing works

Habenular and interpeduncularis nuclei: shared components in multiple-function networks.

Klemm, W. R. (2004) · PubMed · Cited by 153 · see citing works

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

Winter, C., Vollmayr, B., Djodari-Irani, A., Klein, J., & Sartorius, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.034 · Cited by 145 · see citing works

The Lateral Habenula:No Longer Neglected

Geisler, S., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900016710 · Cited by 149 · see citing works

The role of lateral habenula–dorsal raphe nucleus circuits in higher brain functions and psychiatric illness

Zhao, H., Zhang, B., Yang, S., & Rusak, B. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.09.016 · Cited by 147 · see citing works

Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety

Okamoto, H., Agetsuma, M., & Aizawa, H. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20913 · Cited by 142 · see citing works

Negative learning bias is associated with risk aversion in a genetic animal model of depression

Shabel, S. J., Murphy, R. T., & Malinow, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00001 · Cited by 148 · see citing works

Is subcortical–cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach

Alcaro, A., Panksepp, J., Witczak, J., Hayes, D. J., & Northoff, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.023 · Cited by 144 · see citing works

Learning shapes the aversion and reward responses of lateral habenula neurons

Wang, D., Li, Y., Feng, Q., Guo, Q., Zhou, J., & Luo, M. (2017) · eLife · doi:10.7554/elife.23045 · Cited by 141 · see citing works

Brain Systems Underlying Susceptibility to Helplessness and Depression

Shumake, J., & Gonzalez-Lima, F. (2003) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582303259057 · Cited by 135 · see citing works

Differential projections from the lateral habenula to the rostromedial tegmental nucleus and ventral tegmental area in the rat

Gonçalves, L., Sego, C., & Metzger, M. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22787 · Cited by 134 · see citing works

Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat

Kim, U., & Lee, T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08030.x · Cited by 133 · see citing works

The medial habenula: still neglected

Viswanath, H., Carter, A. Q., Baldwin, P. R., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00931 · Cited by 141 · see citing works

Lateral habenula and the rostromedial tegmental nucleus innervate neurochemically distinct subdivisions of the dorsal raphe nucleus in the rat

Sego, C., Gonçalves, L., Lima, L. B., Furigo, I. C., Donato, J., & Metzger, M. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23533 · Cited by 126 · see citing works

The Effects of Tryptophan Depletion on Neural Responses to Emotional Words in Remitted Depression

Roiser, J. P., Levy, J., Fromm, S. J., Nugent, A. C., Talagala, S. L., Hasler, G., Henn, F. A., Sahakian, B. J., & Drevets, W. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.002 · Cited by 123 · see citing works

Neurobiological Mechanisms of Nicotine Reward and Aversion

Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 132 · see citing works

Genetics and genomics of depression

Hamet, P., & Tremblay, J. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.006 · Cited by 110 · see citing works

Depression, Olfaction, and Quality of Life: A Mutual Relationship

Rochet, M., el-Hage, W., Richa, S., Kazour, F., & Atanasova, B. (2018) · Brain Science · doi:10.3390/brainsci8050080 · Cited by 104 · see citing works

Behavioral characteristics of rats predisposed to learned helplessness: Reduced reward sensitivity, increased novelty seeking, and persistent fear memories

Shumake, J., Barrett, D. W., & Gonzalez-Lima, F. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.016 · Cited by 107 · see citing works

The role of the habenula in the transition from reward to misery in substance use and mood disorders

Batalla, A., Homberg, J. R., Lipina, T. V., Sescousse, G., Luijten, M., Ivanova, S. А., Schellekens, A., & LOONEN, A. J. M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.019 · Cited by 100 · see citing works

Morphological and electrophysiological characteristics of neurons within identified subnuclei of the lateral habenula in rat brain slices

Weiss, T., & Veh, R. W. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.047 · Cited by 100 · see citing works

Deep brain stimulation for psychiatric disorders: where we are now

Cleary, D. R., Ozpinar, A., Raslan, A. M. T., & Ko, A. L. (2015) · Neurosurgical FOCUS · doi:10.3171/2015.3.focus1546 · Cited by 99 · see citing works

Dysregulation of the Lateral Habenula in Major Depressive Disorder

Browne, C. A., Hammack, R. J., & Lucki, I. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00046 · Cited by 93 · see citing works

The habenula in psychiatric disorders: More than three decades of translational investigation

Fakhoury, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.010 · Cited by 90 · see citing works

Striatal structure and function in mood disorders: a comprehensive review

Marchand, W. R., & Yurgelun‐Todd, D. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00874.x · Cited by 91 · see citing works

Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving

Zahm, D. S., & Root, D. H. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.004 · Cited by 91 · see citing works

Topographic commissural and descending projections of the habenula in the rat

Kim, U. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.21951 · Cited by 85 · see citing works

Increased metabolic activity in the septum and habenula during stress is linked to subsequent expression of learned helplessness behavior

Mirrione, M. M., Schulz, D., Lapidus, K. A. B., Zhang, S., Goodman, W. K., & Henn, F. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00029 · Cited by 86 · see citing works

Role of the Lateral Habenula in Pain-Associated Depression

Li, Y., Wang, Y., Xuan, C., Li, Y., Piao, L., Li, J., & Zhao, H. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00031 · Cited by 85 · see citing works

The lateral habenula and the serotonergic system

Metzger, M., Bueno, D., & Lima, L. B. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.007 · Cited by 81 · see citing works

Differential Neuromodulation of Acquisition and Retrieval of Avoidance Learning by the Lateral Habenula and Ventral Tegmental Area

Shumake, J., Ilango, A., Scheich, H., Wetzel, W., & Ohl, F. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3604-09.2010 · Cited by 82 · see citing works

Brain glucose metabolism in an animal model of depression

Detka, J., Kurek, A., Kucharczyk, M. W., Głombik, K., Basta‐Kaim, A., Kubera, M., Lasoń, W., & Budziszewska, B. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.046 · Cited by 86 · see citing works

Hyperactivation of the habenula as a link between depression and sleep disturbance

Aizawa, H., Cui, W., Tanaka, K., & Okamoto, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00826 · Cited by 81 · see citing works

Afferent and efferent connections of the interpeduncular nucleus with special reference to circuits involving the habenula and raphe nuclei

Lima, L. B., Bueno, D., Leite, F., Souza, S., Gonçalves, L., Furigo, I. C., Donato, J., & Metzger, M. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24217 · Cited by 80 · see citing works

GPR3 Receptor, a Novel Actor in the Emotional-Like Responses

Valverde, O., Célèrier, E., Baranyi, M., Vanderhaeghen, P., Maldonado, R. J., Sperlágh, B., Vassart, G., & Ledent, C. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004704 · Cited by 78 · see citing works

Elevation of p11 in lateral habenula mediates depression-like behavior

Seo, J.-S., Zhong, P., Liu, A., Yan, Z., & Greengard, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.96 · Cited by 77 · see citing works

Altered brain network modules induce helplessness in major depressive disorder

Peng, D., Shi, F., Shen, T., Peng, Z., Zhang, C., Liu, X., Qiu, M., Liu, J., Jiang, K., Fang, Y., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.061 · Cited by 76 · see citing works

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

Metzger, M., Souza, R., Lima, L. B., Bueno, D., Gonçalves, L., Sego, C., Donato, J., & Shammah‐Lagnado, S. J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14647 · Cited by 77 · see citing works

Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect

Mällo, T., Matrov, D., Kõiv, K., & Harro, J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.041 · Cited by 74 · see citing works

Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats

Li, J., Kang, S., Fu, R., Wu, L., Wu, W., Liu, H., Gregor, D. M., Zuo, W., Bekker, A., & Ye, J.-H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.035 · Cited by 73 · see citing works

Behavioral correlates of differences in neural metabolic capacity

Sakata, J. T., Crews, D., & Gonzalez-Lima, F. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.017 · Cited by 73 · see citing works

Sex Differences in the Neuroadaptations of Reward-related Circuits in Response to Subchronic Variable Stress

Zhang, S., Zhang, H., Ku, S. M., Juarez, B., Morel, C., Tzavaras, N., Montgomery, S. E., Hodes, G. E., Brancato, A., Russo, S. J., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.021 · Cited by 70 · see citing works

Brain responses to chronic social defeat stress: Effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats

Kanarik, M., O’Leary, A., Matrov, D., Kõiv, K., Sharp, T., Panksepp, J., & Harro, J. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.06.015 · Cited by 71 · see citing works

Habenular Kiss1 Neurons Modulate the Serotonergic System in the Brain of Zebrafish

Ogawa, S., Ng, K. W., Ramadasan, P. N., Nathan, F. M., & Parhar, I. S. (2012) · Endocrinology · doi:10.1210/en.2012-1062 · Cited by 66 · see citing works

The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System

Berger, A. L., Henricks, A. M., Lugo, J. M., Wright, H. R., Warrick, C. R., Sticht, M. A., Morena, M., Río, I. B., Laredo, S. A., Craft, R. M., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.018 · Cited by 66 · see citing works

Beyond depression: Toward a process‐based approach to research, diagnosis, and treatment.

Forgeard, M. J. C., Haigh, E. A. P., Beck, A. T., Davidson, R. J., Henn, F. A., Maier, S. F., Mayberg, H. S., & Seligman, M. E. P. (2011) · Clinical Psychology Science and Practice · doi:10.1111/j.1468-2850.2011.01259.x · Cited by 63 · see citing works

Why depression and pain often coexist and mutually reinforce: Role of the lateral habenula

Li, J., Li, Y., Zhang, B., Shen, X., & Zhao, H. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.08.010 · Cited by 63 · see citing works

An emerging role for the lateral habenula in aggressive behavior

Flanigan, M. E., Aleyasin, H., Takahashi, A., Golden, S. A., & Russo, S. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.003 · Cited by 61 · see citing works

Activation of serotonin2C receptors in the lateral habenular nucleus increases the expression of depression-related behaviors in the hemiparkinsonian rat

Han, L., Zhang, L., Li, L., Sun, Y., Wang, Y., Chen, L., Guo, Y., Zhang, Y., Zhang, Q.-J., & Liu, J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.024 · Cited by 62 · see citing works

Medial Habenula-Interpeduncular Nucleus Circuit Contributes to Anhedonia-Like Behavior in a Rat Model of Depression

Xu, C., Sun, Y., Cai, X., You, T., Zhao, H., Li, Y., & Zhao, H. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00238 · Cited by 62 · see citing works

Habenula

Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001937 · Cited by 58 · see citing works

Inter-individual differences in neurobiology as vulnerability factors for affective disorders: Implications for psychopharmacology

Harro, J. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.11.006 · Cited by 59 · see citing works

Differential projections from subfields in the lateral preoptic area to the lateral habenular complex of the rat

Kowski, A. B., Geisler, S., Krauss, M. I., & Veh, R. W. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21610 · Cited by 58 · see citing works

Functional integrity of the habenula is necessary for social play behaviour in rats

van Kerkhof, L. W. M., Damsteegt, R., Trezza, V., Voorn, P., & Vanderschuren, L. J. M. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12353 · Cited by 56 · see citing works

Brain differences in newborn rats predisposed to helpless and depressive behavior

Shumake, J., Conejo, N. M., González‐Pardo, H., & Gonzalez-Lima, F. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.015 · Cited by 57 · see citing works

Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?

Puryear, C. B., Brooks, J. M., Tan, L. A., Smith, K. L., Li, Y., Cunningham, J. I., Todtenkopf, M. S., Dean, R. L., & Sánchez, C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.007 · Cited by 56 · see citing works

Habenula responses to potential and actual loss in major depression: preliminary evidence for lateralized dysfunction

Furman, D. J., & Gotlib, I. H. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw019 · Cited by 53 · see citing works

S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: III. Actions in Models of Potential Antidepressive and Anxiolytic Activity in Comparison with Ropinirole

Millan, M. J., Brocco, M., Papp, M., Serres, F., Rochelle, C. D. L., Sharp, T., Péglion, J.-L., & Dekeyne, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.062463 · Cited by 53 · see citing works

The Critical Role of Nurr1 as a Mediator and Therapeutic Target in Alzheimer’s Disease-related Pathogenesis

Jeon, S. G., Yoo, A., Chun, D. W., Hong, S. B., Chung, H., Kim, J.-I., & Moon, M. (2020) · Aging and Disease · doi:10.14336/ad.2019.0718 · Cited by 55 · see citing works

The neurophysiology of ketamine: an integrative review

McMillan, R. L., & Muthukumaraswamy, S. D. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0090 · Cited by 49 · see citing works

Different brain networks underlying the acquisition and expression of contextual fear conditioning: a metabolic mapping study

González‐Pardo, H., Conejo, N. M., Lana, G., & Arias, J. L. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.064 · Cited by 50 · see citing works

Classifying suicidal behavior with resting-state functional connectivity and structural neuroimaging

Gosnell, S. N., Fowler, J. C., & Salas, R. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13029 · Cited by 49 · see citing works

The habenula couples the dopaminergic and the serotonergic systems: application to depression in Parkinson’s disease

Sourani, D., Eitan, R., Gordon, N., & Goelman, G. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08200.x · Cited by 51 · see citing works

A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression

Hines, L. M., Hoffman, P. L., Bhave, S. V., Saba, L. M., Kaiser, A., Snell, L. D., Goncharov, I., Legault, L., Dongier, M., Grant, B. F., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1040-06.2006 · Cited by 50 · see citing works

5HT1B receptor-mediated pre-synaptic depression of excitatory inputs to the rat lateral habenula

Hwang, E.-K., & Chung, J.-M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.046 · Cited by 46 · see citing works

Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels

Zuo, W., Zhang, Y., Xie, G., Gregor, D. M., Bekker, A., & Ye, J.-H. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.10.012 · Cited by 45 · see citing works

Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: Relevance of animal affective systems to human disorders, with a focus on resilience to adverse events

Harro, J., Kanarik, M., Matrov, D., & Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.016 · Cited by 45 · see citing works

Lateral habenula as a link between dopaminergic and serotonergic systems contributes to depressive symptoms in Parkinson's disease

Luo, X., Zhang, B. L., Li, J. C., Yang, Y., Sun, Y., & Zhao, H. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.11.006 · Cited by 42 · see citing works

Involvement of lateral habenula α1 subunit-containing GABAA receptor-mediated inhibitory transmission in the regulation of depression-related behaviors in experimental Parkinson's disease

Wang, T., Zhang, L., Zhang, Q.-J., Wang, Y., Du, C., Sun, Y., Zhang, J., Lv, S.-X., Chen, L., & Liu, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.015 · Cited by 42 · see citing works

Deep Brain Stimulation of the Lateral Habenular Complex in Treatment-Resistant Depression

Schneider, T. M., Beynon, C., Sartorius, A., Unterberg, A. W., & Kiening, K. L. (2012) · Operative Neurosurgery · doi:10.1227/neu.0b013e318277a5aa · Cited by 40 · see citing works

Fear and Anxiety Regulation by Conserved Affective Circuits

Okamoto, H., & Aizawa, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.031 · Cited by 38 · see citing works

Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02142-5 · Cited by 41 · see citing works

Brain differences in newborn rats predisposed to helpless and depressive behavior

Shumake, J., Conejo, N. M., González‐Pardo, H., & Gonzalez-Lima, F. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.015 · Cited by 57 · see citing works

Dissociation of septo-hippocampal metabolism in the congenitally helpless rat

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00297-x · Cited by 48 · see citing works

Congenital helpless rats as a genetic model for cortex metabolism in depression

Shumake, J., Poremba, A., Edwards, E., & Gonzalez-Lima, F. (2000) · Neuroreport · doi:10.1097/00001756-200011270-00040 · Cited by 65 · see citing works

The functional neuroanatomy of helplessness vulnerability

Shumake, J. (2004) · Texas ScholarWorks (Texas Digital Library)