A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression.
Open accessAbstract
Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood cytokine levels; however, neither the pattern of cytokine alterations nor the impact of clinical status have been compared across disorders. We performed a meta-analysis of blood cytokines in acutely and chronically ill patients with these major psychiatric disorders. Articles were identified by searching the PubMed, PsycInfo and Web of Science, and the reference lists of these studies. Sixty-eight studies met the inclusion criteria (40 schizophrenia, 10 bipolar disorder and 18 MDD) for acutely ill patients. Forty-six studies met the inclusion criteria (18 schizophrenia, 16 bipolar disorder and 12 MDD) for chronically ill patients. Levels of two cytokines (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)), one soluble cytokine receptor (sIL-2R), and one cytokine receptor antagonist (IL-1RA) were significantly increased in acutely ill patients with schizophrenia, bipolar mania and MDD compared with controls (P<0.01). Following treatment of the acute illness, IL-6 levels significantly decreased in both schizophrenia and MDD (P<0.01); sIL-2R levels increased in schizophrenia; and IL-1RA levels in bipolar mania decreased. In chronically ill patients, the levels of IL-6 were significantly increased in schizophrenia, euthymic (but not depressed) bipolar disorder and MDD compared with controls (P<0.01). The levels of IL-1β and sIL-2R were significantly increased in both chronic schizophrenia and euthymic bipolar disorder. Overall, there were similarities in the pattern of cytokine alterations in schizophrenia, bipolar disorder and MDD during acute and chronic phases of illness, raising the possibility of common underlying pathways for immune dysfunction. Effects of treatment on cytokines were more robust for schizophrenia and MDD, but were more frequently studied than for acute mania. These findings have important implications for our understanding of the pathophysiology and treatment of major psychiatric disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A meta-analysis of cytokines in psychiatric disorders found that IL-6, TNF-alpha, IL-1RA, and sIL-2R were significantly elevated in peripheral blood of both acutely ill patients with schizophrenia and bipolar disorder compared to healthy controls.
“A meta-analysis of cytokines in psychiatric disorders found that IL-6, TNF-α, IL-1RA, and sIL-2R were significantly elevated in peripheral blood of both acutely ill patients with SCZ and BD compared to those in healthy controls (16).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [16]
Following treatment of acute illness, IL-6 levels significantly decreased in schizophrenia, sIL-2R levels increased in schizophrenia, and IL-1RA levels decreased in bipolar mania.
“Following treatment of the acute illness, IL-6 levels significantly decreased in SCZ, sIL-2R levels increased in SCZ, and IL-1RA levels decreased in bipolar mania (16).”
From Investigation of systemic immune-inflammation index, neutrophil/high-density lipoprotein ratio, lymphocyte/high-density lipoprotein ratio, and monocyte/high-density lipoprotein ratio as indicators of inflammation in patients with schizophrenia and bipolar disorder (2022) · cites this paper as [16]
That recent meta-analysis also investigated the effects of antidepressant treatment on blood cytokine levels in patients with MDD.
“This recent meta-analysis also investigated the effects of antidepressant treatment on blood cytokine levels in patients with MDD (50).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [50]
A recent meta-analysis compared peripheral cytokine levels among patients with schizophrenia, bipolar disorder, and MDD.
“A recent meta-analysis aimed to compare peripheral levels of cytokines among patients with schizophrenia, bipolar disorder, and also MDD (50).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [50]
That recent meta-analysis included only 30 studies.
“However, this meta-analysis included only 30 studies.”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [50]
A previous meta-analysis found suggestive differences in peripheral cytokine levels between acute and chronic MDD relative to healthy controls.
“Notwithstanding we could not investigate whether length of disease and number of affective episodes as possible moderators of ESs estimates due to the lack of data across studies, a previous meta-analysis, which used a different definition had found suggestive that some differences in peripheral levels of cytokines may occur in acute compared to chronic MDD relative to HCs (50).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [50]
Previous evidence indicates that antidepressant drugs may impact peripheral cytokine levels at follow-up.
“However, our exploratory metaregressions could have limited power to detect this effect, and previous evidence indicates that antidepressant drugs may impact peripheral cytokine levels at follow-up (50).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [50]
The levels of neutrophils, monocytes, lymphocytes and platelets are known to change in inflammation.
“The levels of neutrophils, monocytes, lymphocytes and platelets, which are cheap and easy to get from a complete blood count, are known to change in inflammation 18,19 .”
Successful treatment to achieve euthymia after an acute illness could reverse inflammation and normalize peripheral levels of inflammatory mediators.
“The data also indicated that successful treatment to achieve euthymia after an acute illness could reverse inflammation and normalize peripheral levels of inflammatory mediators 17,18 .”
Low-grade systemic inflammation is increasingly recognized as a significant factor in the pathogenesis and progression of both BD and MDD.
“In recent years, low-grade systemic inflammation has been increasingly recognized as a significant factor in the pathogenesis and progression of both BD and MDD [3, 4].”
From Complete Blood-Count-Derived Inflammatory Markers Across Acute Mood Episodes (2026) · cites this paper as [3]
Cytokines have been shown to be altered in other psychiatric disorders.
“they have also been shown to be altered in other psychiatric disorders.”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [38]
Elevated levels of tumor necrosis factor-alpha have also been found in PTSD studies, in patients with anorexia nervosa and in patients with acute relapse of schizophrenia.
“For example, elevated levels of TNF-α have also been found in PTSD studies (34), in patients with anorexia nervosa (37) and in patients with acute relapse of schizophrenia (31, 38).”
From Cytokine Research in Depression: Principles, Challenges, and Open Questions (2019) · cites this paper as [38]
Two recent meta-analyses found different results regarding changes in peripheral levels of immune mediators after antidepressant treatment.
“Furthermore, two recent metaanalysis found different results regarding changes in peripheral levels immune mediators after antidepressant treatment [31,32].”
That meta-analysis included relatively few studies and estimated effect sizes through fixed-effects modelling, which can provide unreliable results when heterogeneity across studies is high.
“However, this meta-analysis included relatively few studies, and estimated ES through fixed-effects modelling, which can provide unreliable results when heterogeneity across studies is high [32,21].”
One recent meta-analysis verified that antidepressant drug treatment decreased levels of IL-6, IL-10 and IL-12, and increased levels of IL-1β and IL-4.
“One of this meta-analysis verified that antidepressant drug treatment decreased levels of IL-6, IL-10 and IL-12, and increased levels of IL-1β and IL-4 [32].”
Recent evidence suggests a possible role of immune dysregulation in the etiopathogenesis of depression.
“Furthermore, recent evidence suggested a possible role of immune dysregulation in the etiopathogenesis of depression [13,14,15,16].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [14]
Studies comparing first-episode SCZ patients with controls contain the most consistent results as reported in the two meta-analyses by Miller and collaborators.
“Studies comparing patients with first-episode SCZ patients with controls contain the most consistent results as reported in the two meta-analyses by Miller and collaborators13,45,”
From Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses (2019) · cites this paper as [45]
IL-12 significantly increased in the blood of patients with SCZ.
“however, IL-12 significantly increased in the blood of patients with SCZ13,45.”
From Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses (2019) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works
Funnel plots for detecting bias in meta-analysis
Sterne, J. A. C., & Egger, M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00377-8 · Cited by 3,779 · see citing works
IL-6 as a keystone cytokine in health and disease
Hunter, C. A., & Jones, S. A. (2015) · Nature Immunology · doi:10.1038/ni.3153 · Cited by 2,511 · see citing works
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
Meta-Analysis of Cytokine Alterations in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Buckley, P., Seabolt, W., Mellor, A., & Kirkpatrick, B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.013 · Cited by 1,742 · see citing works
Self-citationTHE COMPARISON OF PERCENTAGES IN MATCHED SAMPLES
COCHRAN, W. G. (1950) · Biometrika · doi:10.1093/biomet/37.3-4.256 · Cited by 1,465 · see citing works
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197 · see citing works
Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review
Potvin, S., Stip, É., Sepehry, A. A., Gendron, A., Bah, R., & Kouassi, É. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.024 · Cited by 989 · see citing works
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works
Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works
Higgins, J. (2011) · Medical Entomology and Zoology · Cited by 815 · see citing works
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772 · see citing works
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015) · Nature Neuroscience · doi:10.1038/nn.3922 · Cited by 755 · see citing works
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works
Maes, M., Meltzer, H. Y., Bosmans, E., Bergmans, R., Vandoolaeghe, E., Ranjan, R., & Desnyder, R. (1995) · Journal of Affective Disorders · doi:10.1016/0165-0327(95)00028-l · Cited by 622 · see citing works
Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies
Modabbernia, A., Taslimi, S., Brietzke, E., & Ashrafi, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.007 · Cited by 596 · see citing works
Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works
ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research
Leng, S. X., McElhaney, J. E., Walston, J. D., Xie, D., Fedarko, N. S., & Kuchel, G. A. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.8.879 · Cited by 521 · see citing works
Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis
Upthegrove, R., Manzanares-Teson, N., & Barnes, N. M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.005 · Cited by 501 · see citing works
O’Connor, M.-F., Bower, J. E., Cho, H. J., Creswell, J. D., Dimitrov, S., Hamby, M. E., Hoyt, M. A., Martin, J. L., Robles, T. F., Sloan, E. K., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.04.005 · Cited by 500 · see citing works
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays
de Jager, W., Bourcier, K., Rijkers, G. T., Prakken, B. J., & Seyfert‐Margolis, V. (2009) · BMC Immunology · doi:10.1186/1471-2172-10-52 · Cited by 428 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works
Indicators of immune activation in major depression
Sluzewska, A., RYBAKOWSKI, J. K., Bosmans, E., Sobieska, M., Berghmans, R., Maes, M. H. J., & Wiktorowicz, K. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02783-7 · Cited by 384 · see citing works
Frommberger, U. H., Bauer, J., Haselbauer, P., Fräulin, A., Riemann, D., & Berger, M. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02900219 · Cited by 362 · see citing works
O’Brien, S. M., Scully, P., Fitzgerald, P., Scott, L. V., & Dinan, T. G. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.05.013 · Cited by 355 · see citing works
Efficacy of Anti-inflammatory Agents to Improve Symptoms in Patients With Schizophrenia: An Update
Sommer, I. E., van Westrhenen, R., Begemann, M., de Witte, L. D., Leucht, S., & Kahn, R. S. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt139 · Cited by 342 · see citing works
Cytokines and Glucocorticoid Receptor Signaling
Pace, T. W. W., & Miller, A. H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04984.x · Cited by 339 · see citing works
Haack, M., Hinze‐Selch, D., Fenzel, T., Kraus, T., Kühn, M., Schuld, A., & Pollmächer, T. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00021-7 · Cited by 329 · see citing works
The inflammatory response system in treatment-resistant schizophrenia: increased serum interleukin-6
Lin, A., Kenis, G., Bignotti, S., Tura, G. J. B., Jong, R. D., Bosmans, E., Pioli, R., Altamura, C. A., Scharpé, S., & Maes, M. H. J. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00034-6 · Cited by 321 · see citing works
Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315 · see citing works
Mikovа, O. E., Yakimova, R., Bosmans, E., Kenis, G., & Maes, M. H. J. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00081-5 · Cited by 299 · see citing works
Chronic stress, daily stressors, and circulating inflammatory markers
Gouin, J.-P., Glaser, R., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. (2012) · Health Psychology · doi:10.1037/a0025536 · Cited by 293 · see citing works
Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder
Eller, T., Vasar, V., Shlik, J., & Maron, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.015 · Cited by 290 · see citing works
A detailed examination of cytokine abnormalities in Major Depressive Disorder
Simon, N. M., McNamara, K., Chow, C. W., Maser, R. S., Papakostas, G. I., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K. K. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.06.004 · Cited by 286 · see citing works
Inflammatory Markers and Sleep Disturbance in Major Depression
Motivala, S. J., Sarfatti, A., Olmos, L., & Irwin, M. R. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000149259.72488.09 · Cited by 286 · see citing works
Cytokine profiles in bipolar affective disorder: focus on acutely ill patients.
O'Brien, S. M., Scully, P., Scott, L. V., & Dinan, T. G. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.11.015 · Cited by 285 · see citing works
Cytokines in bipolar disorder: A systematic review and meta-analysis
Munkholm, K., Vinberg, M., & Vedel Kessing, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.010 · Cited by 256 · see citing works
Methods for Exploring Heterogeneity in Meta-Analysis
Song, F., Sheldon, T., Sutton, A. J., Abrams, K. R., & Jones, D. R. (2001) · Evaluation & the Health Professions · doi:10.1177/016327870102400203 · Cited by 253 · see citing works
Metabolic profile of antipsychotic-naive individuals with non-affective psychosis
Fernández-Egea, E., Bernardo, M., Donner, T. W., Conget, I., Parellada, E., Justicia, A., Esmatjes, E., García‐Rizo, C., & Kirkpatrick, B. W. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.052605 · Cited by 242 · see citing works
Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders
Gibney, S. M., & Drexhage, H. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9462-8 · Cited by 237 · see citing works
Peripheral biomarkers and illness activity in bipolar disorder
Kapczinski, F. P., Dal‐Pizzol, F., Teixeira, A. L., Magalhães, P. V. D. S., Kauer‐Sant’Anna, M., Klamt, F., Moreira, J. C. F., Pasquali, M. A. D. B., Fries, G. R., Quevedo, J., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.015 · Cited by 236 · see citing works
Meta-Analysis of Lymphocytes in Schizophrenia: Clinical Status and Antipsychotic Effects
Miller, B. J., Gassama, B., Sebastian, D., Buckley, P. F., & Mellor, A. L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.007 · Cited by 232 · see citing works
Self-citationNF-IL6 and NF-kappa B in cytokine gene regulation.
Akira, S., & Kishimoto, T. (1997) · PubMed · Cited by 231 · see citing works
Dhabhar, F. S., Burke, H. M., Epel, E. S., Mellon, S. H., Rosser, R., Reus, V. I., & Wolkowitz, O. M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.05.010 · Cited by 225 · see citing works
Kim, Y.-K., Suh, I.-B., Kim, H., Han, C.-S., Lim, C.-S., Choi, S.-H., & Licinio, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001084 · Cited by 224 · see citing works
Antipsychotics' effects on blood levels of cytokines in schizophrenia: A meta-analysis
Tourjman, V., Kouassi, É., Koué, M.-È., Rocchetti, M., Fortin-Fournier, S., Fusar-Poli, P., & Potvin, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.10.011 · Cited by 224 · see citing works
Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness
Ganguli, R., Yang, Z., Shurin, G. V., Chengappa, K. N. R., Brar, J. S., Gubbi, A. V., & Rabin, B. S. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90042-6 · Cited by 222 · see citing works
IL-6 levels decrease with SSRI treatment in patients with major depression
Başterzi, A. D., Aydemir, Ç., Kısa, C., Aksaray, S., Tüzer, V., Yazıcı, K., & Göka, E. (2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.717 · Cited by 219 · see citing works
Serum and gene expression profile of cytokines in first-episode psychosis
Di Nicola, M., Cattaneo, A., Hepgul, N., Di Forti, M., Aitchison, K. J., Janiri, L., Murray, R. M., Dazzan, P., Pariante, C. M., & Mondelli, V. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.06.010 · Cited by 217 · see citing works
Acute phase proteins in major depression
Berk, M., Wadee, A. A., Kuschke, R. H., & O’Neill-Kerr, A. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00139-6 · Cited by 215 · see citing works
Nitta, M., Kishimoto, T., Müller, N., Weiser, M., Davidson, M., Kane, J. M., & Correll, C. U. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt070 · Cited by 204 · see citing works
NF-IL6 and NF-κB in Cytokine Gene Regulation
Akira, S., & Kishimoto, T. (1997) · Advances in immunology · doi:10.1016/s0065-2776(08)60740-3 · Cited by 201 · see citing works
Sasayama, D., Hattori, K., Wakabayashi, C., Teraishi, T., Hori, H., Ota, M., Yoshida, S., Arima, K., Higuchi, T., Amano, N., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.12.001 · Cited by 198 · see citing works
de Witte, L. D., Tomasik, J., Schwarz, E., Guest, P. C., Rahmoune, H., Kahn, R. S., & Bahn, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.02.005 · Cited by 188 · see citing works
Theodoropoulou, S., Spanakos, G., Baxevanis, C. N., Economou, M., Gritzapis, A. D., Papamichail, M., & Stefanis, C. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00007-4 · Cited by 187 · see citing works
Th2 Cytokine Response in Major Depressive Disorder Patients before Treatment
Pavón, L., Sandoval-López, G., Eugenia Hernández, M., Loría, F., Estrada, I., Pérez, M., Moreno, J., Ávila, U., Leff, P., Antón, B., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.014 · Cited by 187 · see citing works
Th1, Th2 and Th3 cytokine alteration in schizophrenia
Kim, Y., Myint, A.-M., Lee, B.-H., Han, C.-S., Lee, H., Kim, D.-J., & Leonard, B. E. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.047 · Cited by 187 · see citing works
The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia
Song, X., Lv, L., Li, W., Hao, Y., & Zhao, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.018 · Cited by 187 · see citing works
Maes, M. H. J. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00094-3 · Cited by 179 · see citing works
Immunology of Major Depression
Müller, N. (2014) · NeuroImmunoModulation · doi:10.1159/000356540 · Cited by 175 · see citing works
Stojanovic, A., Martorell, L., Montalvo, I., Ortega, L., Monseny, R., Vilella, E., & Labad, J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.12.005 · Cited by 170 · see citing works
Drexhage, R. C., Hoogenboezem, T. A., Cohen, D., Versnel, M. A., Nolen, W. A., van Beveren, N. J. M., & Drexhage, H. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001653 · Cited by 169 · see citing works
Cytokine assays: An assessment of the preparation and treatment of blood and tissue samples
Keustermans, G., Hoeks, S. B. E. A., Meerding, J., Prakken, B. J., & de Jager, W. (2013) · Methods · doi:10.1016/j.ymeth.2013.04.005 · Cited by 166 · see citing works
Hope, S., Dieset, I., Agartz, I., Steen, N. E., Ueland, T., Melle, I., Aukrust, P., & Andreassen, O. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.08.003 · Cited by 164 · see citing works
Beumer, W., Drexhage, R. C., de Wit, H., Versnel, M. A., Drexhage, H. A., & Cohen, D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.001 · Cited by 161 · see citing works
Kim, Y., Kim, L., & Lee, M. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00171-1 · Cited by 159 · see citing works
Borovčanin, M., Jovanović, I., Radosavljevic, G. D., Dejanovic, S. D., Banković, D., Arsenijević, N., & Lukić, M. L. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.016 · Cited by 151 · see citing works
The role of IL-12 and TGF-β1 in the pathophysiology of major depressive disorder
Lee, K.-M., & Kim, Y.-K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.015 · Cited by 150 · see citing works
The secretion of IL-1β and options for release
Piccioli, P., & Rubartelli, A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.007 · Cited by 142 · see citing works
Pedrini, M., Massuda, R., Fries, G. R., Pasquali, M. A. D. B., Schnorr, C. E., Moreira, J. C. F., Teixeira, A. L., Lobato, M. I. R., Walz, J. C., Belmonte-de-Abreu, P. S., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.03.019 · Cited by 142 · see citing works
Hernández, M. E., Mendieta, D., Martínez-Fong, D., Loría, F., Moreno, J., Estrada, I., Bojalil, R., & Pavón, L. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.08.001 · Cited by 140 · see citing works
The Immunology of Bipolar Disorder
Barbosa, I. G., Machado‐Vieira, R., Soares, J. C., & Teixeira, A. L. (2014) · NeuroImmunoModulation · doi:10.1159/000356539 · Cited by 140 · see citing works
Kim, Y., Myint, A.-M., Verkerk, R. M., Scharpé, S., Steinbusch, H. W. M., & Leonard, B. E. (2009) · Neuropsychobiology · doi:10.1159/000213565 · Cited by 136 · see citing works
Biological significance of soluble IL‐2 receptor
Caruso, C., Candore, G., Cigna, D., Colucci, A. T., & Modica, M. A. (1993) · Mediators of Inflammation · doi:10.1155/s0962935193000018 · Cited by 130 · see citing works
Müller, N., Empl, M., Riedel, M. J., Schwarz, M., & Ackenheil, M. (1997) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02922260 · Cited by 127 · see citing works
Abnormalities in serum chemokine levels in euthymic patients with Bipolar Disorder
Brietzke, E. M., Kauer‐Sant’Anna, M., Teixeira, A. L., & Kapczinski, F. P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.04.008 · Cited by 127 · see citing works
Activation of Th17 cells in drug naïve, first episode schizophrenia
Ding, M., Song, X., Zhao, J., Gao, J., Li, X., Ge, Y., Wang, X., Harrington, A., Fan, X., & Lv, L. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.001 · Cited by 127 · see citing works
Increased Serum Interleukin 2 Receptor Concentration in Schizophrenic and Brain-Damaged Subjects
Ganguli, R. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810030098018 · Cited by 124 · see citing works
Pearlman, D. M., & Najjar, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.05.001 · Cited by 123 · see citing works
Maes, M. H. J., Bosmans, E., Ranjan, R., Vandoolaeghe, E., Meltzer, H. Y., LEY, M. D., Berghmans, R., Stans, G., & Desnyder, R. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(96)00029-1 · Cited by 120 · see citing works
Immunologic variables in acute mania of bipolar disorder
Liu, H., Yang, Y., Chou, Y.-M., Chen, K.-P., Shen, W. W., & Leu, S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.01.006 · Cited by 118 · see citing works
Bai, Y., Su, T., Tsai, S., Chiou, W., Li, C., Tu, P., & Mu-Hong, C. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.05.009 · Cited by 117 · see citing works
Maes, M., Ringel, K., Kubera, M., Berk, M., & Rybakowski, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.11.016 · Cited by 116 · see citing works
A systematic, quantitative review of blood autoantibodies in schizophrenia
Ezeoke, A., Mellor, A. L., Buckley, P. F., & Miller, B. J. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.029 · Cited by 115 · see citing works
Self-citationDimitrov, D. H., Lee, S., Yantis, J., Valdez, C., Paredes, R. M., Braida, N., Velligan, D. I., & Walss‐Bass, C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.10.019 · Cited by 114 · see citing works
Activation of indices of cell-mediated immunity in bipolar mania
Tsai, S., Chen, K.-P., Yang, Y., Chen, C., Lee, J.-C., Singh, V. K., & Leu, S.-J. C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00159-0 · Cited by 111 · see citing works
Kubera, M., Kenis, G., Bosmans, E., Zieba, A., Dudek, D., Nowak, G., & Maes, M. H. J. (2000) · PubMed · Cited by 110 · see citing works
Akiyama, K. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00140-6 · Cited by 109 · see citing works
Leo, R., Lorenzo, G. D., Tesauro, M., Razzini, C., Forleo, G. B., Chiricolo, G., Cola, C., Zanasi, M., Troisi, A., Siracusano, A., et al. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1114 · Cited by 107 · see citing works
Tsai, S., Chung, K., Wu, J.-Y., Kuo, C., Lee, H., & Huang, S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.022 · Cited by 102 · see citing works
Cytokine levels in euthymic bipolar patients
Guloksuz, S., Aktas Cetin, E., Cetin, T., Deniz, G., Oral, E. T., & Nutt, D. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.027 · Cited by 102 · see citing works
Lower subjective social status exaggerates interleukin-6 responses to a laboratory stressor
Derry, H. M., Fagundes, C. P., Andridge, R., Glaser, R., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.026 · Cited by 102 · see citing works
Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder
Pike, J. L., & Irwin, M. R. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.05.004 · Cited by 101 · see citing works
T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients.
Kim, Y.-K., Myint, A.-M., Lee, B.-H., Han, C.-S., Lee, S.-W., Leonard, B. E., & Steinbusch, H. W. M. (2004) · Psychiatry Research · doi:10.1016/j.psychres.2004.08.005 · Cited by 100 · see citing works
Rapaport, M. H., & Lohr, J. B. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb01599.x · Cited by 99 · see citing works
Self-citationT‐helper 1/T‐helper 2 cytokine imbalance and clinical phenotypes of acute‐phase major depression
HUANG, T., & Lee, C. (2007) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2007.01686.x · Cited by 97 · see citing works
Kynurenine pathway in psychosis: evidence of increased tryptophan degradation
Barry, S., Clarke, G., Scully, P., & Dinan, T. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108089583 · Cited by 96 · see citing works
Song, X., Fan, X., Li, X., Zhang, W., Gao, J., Zhao, J., Harrington, A., Ziedonis, D. M., & Lv, L. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3382-4 · Cited by 95 · see citing works
Tsai, S., Yang, Y.-Y., Kuo, C.-J., Chen, C., & Leu, S.-J. C. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00252-4 · Cited by 95 · see citing works
O’Brien, S. M., Scully, P., & Dinan, T. G. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.11.014 · Cited by 93 · see citing works
Kagaya, A., Kugaya, A., Takebayashi, M., Fukue, M., Saeki, T., Yamawaki, S., & Uchitomi, Y. (2001) · Neuropsychobiology · doi:10.1159/000054867 · Cited by 92 · see citing works
Levels of TNF‐α, soluble TNF receptors (sTNFR1, sTNFR2), and cognition in bipolar disorder
Baysal, Ö. D., Ci̇nemre, B., Aksoy, U. M., Akbas, H. S., Metin, Ö., Fettahoğlu, E. Ç., Gökmen, Z., & Davran, F. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2301 · Cited by 84 · see citing works
Lotrich, F. E., Butters, M. A., Aizenstein, H. J., Marron, M. M., Reynolds, C. F., & Gildengers, A. G. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4048 · Cited by 83 · see citing works
Munkholm, K., Weikop, P., Kessing, L. V., & Vinberg, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.021 · Cited by 83 · see citing works
Association between Insulin Resistance and Breast Carcinoma: A Systematic Review and Meta-Analysis
Hernández, A. V., Guarnizo, M., Miranda, Y., Pasupuleti, V., Deshpande, A., Paico-Palacios, S., Lenti, H., Ganoza, S., Montalvo, L., Thota, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099317 · Cited by 83 · see citing works
Increased levels of adipokines in bipolar disorder
Barbosa, I. G., Rocha, N. P., de Miranda, A. S., Magalhães, P. V. D. S., Huguet, R. B., de Souza, L. P., Kapczinski, F. P., & Teixeira, A. L. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.010 · Cited by 83 · see citing works
Borovčanin, M., Jovanović, I., Radosavljevic, G. D., Dejanovic, S. D., Stefanović, V., Arsenijević, N., & Lukić, M. L. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.03.027 · Cited by 82 · see citing works
Song, X., Fan, X., Song, X., Zhang, J., Zhang, W., Li, X., Gao, J., Harrington, A., Ziedonis, D. M., & Lv, L. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.044 · Cited by 82 · see citing works
Cytokines, epilepsy and epileptic drugs--is there a mutual influence?
Młodzikowska-Albrecht, J., Steinborn, B., & Żarowski, M. (2007) · PubMed · Cited by 80 · see citing works
Xiu, M. H., Yang, G. G., Tan, Y., Chen, D. C., Tan, S., Wang, Z. R., Yang, F. D., Okusaga, O. O., Soares, J. C., & Zhang, X. Y. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.024 · Cited by 79 · see citing works
Berardis, D. D., Conti, C. M., Serroni, N., Moschetta, F. S., Olivieri, L., Carano, A., Salerno, R. M., Cavuto, M., Farina, B., Alessandrini, M., et al. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300204 · Cited by 78 · see citing works
The essential roles of TGFB1 in reproduction
Ingman, W. V., & Robertson, S. A. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.05.003 · Cited by 74 · see citing works
Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines
Pae, C., Yoon, C., Kim, T., Kim, J.-J., Park, S., Lee, C., Lee, S.-J., Lee, C., & Paik, I. (2005) · International Immunopharmacology · doi:10.1016/j.intimp.2005.10.004 · Cited by 73 · see citing works
Kamińska, T., Wysocka, A., Marmurowska-Michałowska, H., Dubas-Ślemp, H., & Kandefer‐Szerszeń, M. (2001) · PubMed · Cited by 72 · see citing works
Interleukin-1β Serum Levels is Increased in Antidepressant-Free Elderly Depressed Patients
Diniz, B. S., Teixeira, A. L., Talib, L. L., Gattaz, W. F., & Forlenza, O. V. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181c2947f · Cited by 69 · see citing works
Kalmady, S. V., Venkatasubramanian, G., Shivakumar, V., Gautham, S., Subramaniam, A., Jose, D. A., Maitra, A., Ravi, V., & Gangadhar, B. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096021 · Cited by 69 · see citing works
Cytokine and adipokine alterations in patients with schizophrenia treated with clozapine
Klemettilä, J.-P., Kampman, O., Seppälä, N., Viikki, M., Hämäläinen, M., Moilanen, E., & Leinonen, E. V. J. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.049 · Cited by 68 · see citing works
Gattaz, W. F., Dalgalarrondo, P., & Schröder, H. C. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90006-q · Cited by 64 · see citing works
Asevedo, E. D. M., Rizzo, L. B., Gadelha, A., Mansur, R. B., Ota, V., Berberian, A. D. A., Scarpato, B. S., Teixeira, A. L., Bressan, R. A., & Brietzke, E. M. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.02.032 · Cited by 63 · see citing works
Li, H., Hong, W., Zhang, C., Wu, Z., Wang, Z., Yuan, C., Li, Z., Huang, J., Lin, Z., & Fang, Y. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.033 · Cited by 63 · see citing works
Immune parameters in euthymic bipolar patients and normal volunteers
Rapaport, M. H. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90012-4 · Cited by 62 · see citing works
Self-citationKuo, F.-C., Lee, C.-H., Hsieh, C., Kuo, P., Chen, Y.-C., & Hung, Y. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.11.020 · Cited by 59 · see citing works
Fornaro, M., Rocchi, G., Escelsior, A., Contini, P., & Martino, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.08.007 · Cited by 59 · see citing works
Kubistova, A., Horáček, J., & Novák, T. (2012) · PubMed · Cited by 59 · see citing works
Inflammation in psychotic disorders: A population-based study
Suvisaari, J., Loo, B.-M., Saarni, S. E., Haukka, J. K., Perälä, J., Saarni, S. I., Viertiö, S., Partti, K., Lönnqvist, J. K., & Jula, A. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.07.006 · Cited by 57 · see citing works
Crespo‐Facorro, B., Carrasco-Marı́n, E., Pérez‐Iglesias, R., Pelayo‐Terán, J. M., Fernández-Prieto, L., Leyva‐Cobián, F., & Vázquez‐Barquero, J. L. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2006.08.005 · Cited by 55 · see citing works
Inflammation and schizophrenia
Al-Asmari, A., & Khan, M. W. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113493305 · Cited by 55 · see citing works
Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology
Xiu, M. H., Chen, D. C., Wang, D., Zhang, K., Dong, A., Tang, W., Zhang, F., Liu, L. J., Liu, J. H., Liu, H. B., et al. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.04.026 · Cited by 53 · see citing works
Ayorech, Z., Tracy, D. K., Baumeister, D., & Giaroli, G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.015 · Cited by 53 · see citing works
Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients
Singh, B., Bera, N. K., Nayak, C. R., & Chaudhuri, T. K. (2009) · Cytokine · doi:10.1016/j.cyto.2009.05.005 · Cited by 52 · see citing works
Sirota, P., Meiman, M. E., Hershko, R., & Bessler, H. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2004.04.012 · Cited by 51 · see citing works
Increased Interleukin-17 and decreased BAFF serum levels in drug-free acute schizophrenia
Kissi, Y. E., Samoud, S., Mtiraoui, A., Letaief, L., Hannachi, N., Ayachi, M., Ali, B. B. H., & Boukadida, J. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.10.007 · Cited by 51 · see citing works
Effect of Risperidone on Serum Cytokines
Kim, D., Kim, W. B., Yoon, S.-J., Go, H.-J., Choi, B., Jun, T., & Kim, Y. (2001) · International Journal of Neuroscience · doi:10.3109/00207450108986549 · Cited by 50 · see citing works
Su, S., Sun, M.-T., Wen, M.-J., Lin, C.-J., Chen, Y.-C., & Hung, Y. (2011) · The International Journal of Psychiatry in Medicine · doi:10.2190/pm.42.3.a · Cited by 50 · see citing works
Interleukin-1β is associated with depressive episode in major depression but not in bipolar disorder
Mota, R., Gazal, M., Acosta, B. A., de Leon, P. B., Jansen, K., Pinheiro, R. T., Souza, L. D. D. M., Silva, R. A., Oses, J. P., Quevedo, L. D. Á., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.020 · Cited by 49 · see citing works
Drexhage, R. C., Padmos, R. C., de Wit, H., Versnel, M. A., Hooijkaas, H., van der Lely, A. J., van Beveren, N. J. M., DeRijk, R. H., & Cohen, D. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.03.018 · Cited by 49 · see citing works
Baek, D., & Park, Y. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.008 · Cited by 49 · see citing works
Zhang, X. Y., Tang, W., Xiu, M. H., Chen, D. C., Yang, F. D., Tan, Y., Wang, Z. R., Zhang, F., Liu, J., Liu, L., et al. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.03.001 · Cited by 48 · see citing works
Bresee, C. J., & Rapaport, M. H. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000315 · Cited by 48 · see citing works
Self-citationAltered intracellular signaling cascades in peripheral blood mononuclear cells from BD patients
Barbosa, I. G., Nogueira, C. R. C., Rocha, N. P., Queiroz, A. L. L., Vago, J. P., Tavares, L. P., Assis, F., Fagundes, C. T., Huguet, R. B., Bauer, M. E., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.019 · Cited by 46 · see citing works
Chen, S., Lee, S.-Y., Chang, Y.-H., Chen, S., Chu, C.-H., Tzeng, N., Lee, I., Chen, P. S., Yeh, T. L., Huang, S., et al. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9382-z · Cited by 46 · see citing works
Autoantibodies against 60-kDa heat shock protein in schizophrenia
Schwarz, M., Riedel, M. J., Gruber, R., Müller, N., & Ackenheil, M. (1998) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050051 · Cited by 46 · see citing works
Selected Cytokine Profiles during Remission in Bipolar Patients
Remlinger-Molenda, A., Wójciak, P., Michalak, M., Karczewski, J., & RYBAKOWSKI, J. K. (2012) · Neuropsychobiology · doi:10.1159/000339949 · Cited by 46 · see citing works
Circulating levels of sTNFR1 as a marker of severe clinical course in schizophrenia
Noto, C. D. S., Gadelha, A., Belangero, S. I., Spíndola, L., Rocha, N. P., de Miranda, A. S., Teixeira, A. L., Smith, M. D. A. C., Mari, J. D. J., Bressan, R. A., et al. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.12.010 · Cited by 41 · see citing works
Francesconi, L. P., Ceresér, K. M., Mascarenhas, R., Stertz, L., Gama, C. S., & Belmonte-de-Abreu, P. S. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.06.042 · Cited by 39 · see citing works
Dunjić-Kostić, B., Jašović‐Gašić, M., Ivković, M., Radonjić, N. V., Pantović-Stefanović, M., Damjanović, A., Poznanović, S. T., Jovanović, A., Nikolić, T., & Petronijević, N. (2013) · PubMed · Cited by 37 · see citing works
Chiang, S. S. W., Riedel, M. J., Schwarz, M., & Mueller, N. (2013) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12040 · Cited by 35 · see citing works
The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation.
Thomas, R. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1784 · Cited by 33 · see citing works
Yoshimura, R., Umene‐Nakano, W., Hoshuyama, T., Ikenouchi‐Sugita, A., Hori, H., Katsuki, A., Hayashi, K., Atake, K., & Nakamura, J. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1155 · Cited by 31 · see citing works
Einvik, G., Vistnes, M., Hrubos‐Strøm, H., Randby, A., Namtvedt, S. K., Nordhus, I. H., Somers, V. K., Dammen, T., & Omland, T. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.01.017 · Cited by 31 · see citing works
Cetin, T., Gülöksüz, S., Çetin, E. A., Gazioğlu, S. B., Deniz, G., Oral, E., & van Os, J. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-158 · Cited by 30 · see citing works
Increased interleukin-6 level in Taiwanese schizophrenic patients.
Lin, C.-C., Chang, C., Chang, P.-Y., & Huang, T. (2011) · PubMed · Cited by 29 · see citing works
Sasayama, D., Wakabayashi, C., Hori, H., Teraishi, T., Hattori, K., Ota, M., Ishikawa, M., Arima, K., Higuchi, T., Amano, N., et al. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.06.003 · Cited by 28 · see citing works
Hsu, J.-W., Lirng, J., Wang, S., Lin, C.-L., Yang, K., Liao, M., & Chou, Y. H. (2013) · Bipolar Disorders · doi:10.1111/bdi.12164 · Cited by 27 · see citing works
Döme, P., Halmai, Z., Dobos, J., Lazáry, J., Gonda, X., Kenessey, I., Sallai, T., Makkos, Z., & Faludi, G. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.027 · Cited by 26 · see citing works
Lower serum interleukin-2 levels in schizophrenic patients with tardive dyskinesia
Liu, H., Kang, Y., Liang, J., Li, C., Xiu, M., Chen, D., Yang, F., Wang, F., Wu, G., Haile, C. N., et al. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.01.002 · Cited by 26 · see citing works
Soluble interleukin-2 receptor and tumor necrosis factor levels in depressed patients in Estonia
Eller, T., Aluoja, A., Maron, E., & Vasar, V. (2009) · Medicina · doi:10.3390/medicina45120124 · Cited by 25 · see citing works
Regulation of Macrophage Biology by Lithium: A New Look at an Old Drug
Raghavendra, P. B., Lee, E. H., & Parameswaran, N. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9516-y · Cited by 24 · see citing works
Tsai, S., Lee, H., Chen, C., & Lee, C.-H. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00103-6 · Cited by 17 · see citing works
Brietzke, E. M., & Teixeira, A. L. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00822.x · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Bidirectional Relationship of Depression and Inflammation: Double Trouble
Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136 · see citing works
Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies
Köhler, C. A., Freitas, T. H., Maes, M., de Andrade, N. Q., Liu, C. S., Fernandes, B. S., Stubbs, B., Solmi, M., Veronese, N., Herrmann, N., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12698 · Cited by 1,443 · see citing works
Self-citationOsimo, E. F., Pillinger, T., Rodriguez, I. M., Khandaker, G. M., Pariante, C. M., & Howes, O. D. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.02.010 · Cited by 937 · see citing works
Osimo, E. F., Baxter, L. J., Lewis, G., Jones, P. B., & Khandaker, G. M. (2019) · Psychological Medicine · doi:10.1017/s0033291719001454 · Cited by 774 · see citing works
Kappelmann, N., Lewis, G., Dantzer, R., Jones, P. B., & Khandaker, G. M. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.167 · Cited by 659 · see citing works
Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations.
Müller, N. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby024 · Cited by 648 · see citing works
Barnes, T. R. E., Drake, R., Paton, C., Cooper, S. J., Deakin, J. F. W., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I. R., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 607 · see citing works
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584 · see citing works
Inflammation in psychiatric disorders: what comes first?
Bauer, M. E., & Teixeira, A. L. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13712 · Cited by 500 · see citing works
Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders
Fiorentino, M., Sapone, A., Senger, S., Camhi, S. S., Kadzielski, S. M., Buie, T. M., Kelly, D. L., Cascella, N., & Fasano, A. (2016) · Molecular Autism · doi:10.1186/s13229-016-0110-z · Cited by 494 · see citing works
Bidirectional Microglia–Neuron Communication in Health and Disease
Szepesi, Z., Manouchehrian, O., Bachiller, S., & Deierborg, T. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00323 · Cited by 459 · see citing works
Inflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
Köhler, C. A., Freitas, T. H., Stubbs, B., Maes, M., Solmi, M., Veronese, N., de Andrade, N. Q., Morris, G., Fernandes, B. S., Brunoni, A. R., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0632-1 · Cited by 449 · see citing works
Self-citationImaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 432 · see citing works
Yuan, N., Chen, Y., Xia, Y., Dai, J., & Liu, C. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0570-y · Cited by 428 · see citing works
Rheumatoid arthritis and depression: an inflammatory perspective
Nerurkar, L., Siebert, S., McInnes, I. B., & Cavanagh, J. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30255-4 · Cited by 417 · see citing works
Wang, A. K., & Miller, B. J. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx035 · Cited by 389 · see citing works
Self-citationNLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings
Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works
Milaneschi, Y., Kappelmann, N., Ye, Z., Lamers, F., Moser, S., Jones, P. B., Burgess, S., Penninx, B. W. J. H., & Khandaker, G. M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01188-w · Cited by 369 · see citing works
Non-Genetic Factors in Schizophrenia
Stilo, S. A., & Murray, R. M. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1091-3 · Cited by 322 · see citing works
Dopamine, Immunity, and Disease
Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J. R., & Gaskill, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 319 · see citing works
Cytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
The blood–brain barrier in psychosis
Pollak, T. A., Drndarski, S., Stone, J. M., David, A. S., McGuire, P. K., & Abbott, N. J. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30293-6 · Cited by 304 · see citing works
Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum
Kotov, R., Jonas, K. G., Carpenter, W. T., Dretsch, M. N., Eaton, N. R., Forbes, M. K., Forbush, K. T., Hobbs, K. A., Reininghaus, U., Slade, T. N., et al. (2020) · World Psychiatry · doi:10.1002/wps.20730 · Cited by 310 · see citing works
The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder
Maes, M., & Carvalho, A. F. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1016-x · Cited by 306 · see citing works
Inflammatory Biomarkers and Risk of Schizophrenia
Hartwig, F. P., Borges, M. C., Horta, B. L., Bowden, J., & Smith, G. D. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3191 · Cited by 304 · see citing works
Ortelli, P., Ferrazzoli, D., Sebastianelli, L., Engl, M., Romanello, R., Nardone, R., Bonini, I., Koch, G., Saltuari, L. L., Quartarone, A., et al. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117271 · Cited by 302 · see citing works
Leighton, S. P., Nerurkar, L., Krishnadas, R., Johnman, C., Graham, G. J., & Cavanagh, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.205 · Cited by 291 · see citing works
Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization
Howes, O. D., & McCutcheon, R. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.278 · Cited by 288 · see citing works
Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L. A., Mason, A. M., Foley, C. N., Gkatzionis, A., Jones, P. B., & Burgess, S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0395-3 · Cited by 279 · see citing works
Watson, D., Levin‐Aspenson, H. F., Waszczuk, M. A., Conway, C. C., Dalgleish, T., Dretsch, M. N., Eaton, N. R., Forbes, M. K., Forbush, K. T., Hobbs, K. A., et al. (2022) · World Psychiatry · doi:10.1002/wps.20943 · Cited by 285 · see citing works
The origin of NMDA receptor hypofunction in schizophrenia
Nakazawa, K., & Sapkota, K. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107426 · Cited by 277 · see citing works
Cytokine Alterations in Schizophrenia: An Updated Review
Momtazmanesh, S., Zare-Shahabadi, A., & Rezaei, N. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00892 · Cited by 277 · see citing works
Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Meyer, J. H., Červenka, S., Kim, M.-J., Kreisl, W. C., Henter, I. D., & Innis, R. B. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30255-8 · Cited by 274 · see citing works
Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis
Fraguas, D., Díaz‐Caneja, C. M., Ayora, M., Hernández-Álvarez, F., Rodríguez-Quiroga, A., Recio, S., Leza, J. C., & Arango, C. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby125 · Cited by 272 · see citing works
Depression and inflammation among children and adolescents: A meta-analysis
Colasanto, M., Madigan, S. L., & Korczak, D. J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.025 · Cited by 278 · see citing works
Li, W., Ali, T., He, K., Liu, Z., Shah, F. A., Ren, Q., Liu, Y., Jiang, A., & Li, S. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.008 · Cited by 263 · see citing works
Rosenblat, J., & McIntyre, R. (2017) · Brain Sciences · doi:10.3390/brainsci7110144 · Cited by 258 · see citing works
Costello, H., Gould, R. L., Abrol, E., & Howard, R. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027925 · Cited by 248 · see citing works
Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway
Tanaka, M., Tóth, F., Polyák, H., Szabó, Á., Mándi, Y., & Vécsei, L. (2021) · Biomedicines · doi:10.3390/biomedicines9070734 · Cited by 252 · see citing works
Allen, A. P., Curran, E. A., Duggan, Á., Cryan, J. F., Chorcoráin, A. N., Dinan, T. G., Molloy, D. W., Kearney, P. M., & Clarke, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.006 · Cited by 244 · see citing works
Halstead, S., Siskind, D. J., Amft, M., Wagner, E. M., Yakimov, V., Liu, Z. S.-J., Walder, K. R., & Warren, N. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00025-1 · Cited by 245 · see citing works
Liu, R. T., Rowan-Nash, A. D., Sheehan, A. E., Walsh, R. F. L., Sanzari, C. M., Korry, B. J., & Belenky, P. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.026 · Cited by 244 · see citing works
Biological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 247 · see citing works
Orlovska‐Waast, S., Köhler‐Forsberg, O., Brix, S. W., Nordentoft, M., Kondziella, D., Krogh, J., & Benros, M. E. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0220-4 · Cited by 233 · see citing works
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
Pillinger, T., D’Ambrosio, E., McCutcheon, R., & Howes, O. D. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0058-9 · Cited by 230 · see citing works
The Emerging Neurobiology of Bipolar Disorder
Harrison, P. J., Geddes, J. R., & Tunbridge, E. M. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.006 · Cited by 235 · see citing works
On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?
Roohi, E., Jaafari, N., & Hashemian, F. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02100-7 · Cited by 235 · see citing works
Cytokines, Oxidative Stress and Cellular Markers of Inflammation in Schizophrenia
Upthegrove, R., & Khandaker, G. M. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_88 · Cited by 230 · see citing works
Steardo, L., Steardo, L., & Verkhratsky, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00949-5 · Cited by 222 · see citing works
Renna, M. E., O'Toole, M. S., Spaeth, P. E., Lekander, M., & Mennin, D. S. (2018) · Depression and Anxiety · doi:10.1002/da.22790 · Cited by 220 · see citing works
Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology
Goldsmith, D. R., Bekhbat, M., Mehta, N. D., & Felger, J. C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.11.003 · Cited by 220 · see citing works
Self-citationKouba, B. R., Borba, L. A., de Souza, P. B., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2024) · Cells · doi:10.3390/cells13050423 · Cited by 232 · see citing works
Tolkien, K., Bradburn, S., & Murgatroyd, C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.11.007 · Cited by 215 · see citing works
Sabé, M., Pillinger, T., Kaiser, S., Chen, C., Taipale, H. T., Tanskanen, A. J., Tiihonen, J., Leucht, S., Correll, C. U., & Solmi, M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104608 · Cited by 215 · see citing works
Zhang, J., Ma, L., Chang, L., Pu, Y., Qu, Y., & Hashimoto, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00878-3 · Cited by 209 · see citing works
Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders
Carvalho, A. F., Solmi, M., Sanches, M., Machado, M. O., Stubbs, B., Ajnakina, O., Sherman, C., Sun, Y. R., Liu, C. S., Brunoni, A. R., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0835-5 · Cited by 204 · see citing works
Solmi, M., Sharma, M. S., Osimo, E. F., Fornaro, M., Bortolato, B., Croatto, G., Miola, A., Vieta, E., Pariante, C. M., Smith, L., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.014 · Cited by 198 · see citing works
Cheng, J., Hu, H., Ju, Y., Liu, J., Wang, M., Liu, B., & Zhang, Y. (2024) · General Psychiatry · doi:10.1136/gpsych-2023-101374 · Cited by 216 · see citing works
Misiak, B., Stańczykiewicz, B., Kotowicz, K., RYBAKOWSKI, J. K., Samochowiec, J., & Frydecka, D. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.015 · Cited by 198 · see citing works
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works
The impact of machine learning techniques in the study of bipolar disorder: A systematic review
Librenza‐Garcia, D., Kotzian, B. J., Yang, J. M. K., Mwangi, B., Cao, B., Lima, L. N. P., Bermúdez, M. B., Boeira, M. V., Kapczinski, F. P., & Passos, I. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.004 · Cited by 195 · see citing works
Immunopsychiatry: important facts
Khandaker, G. M., Dantzer, R., & Jones, P. B. (2017) · Psychological Medicine · doi:10.1017/s0033291717000745 · Cited by 200 · see citing works
Pillinger, T., Osimo, E. F., Brugger, S., Mondelli, V., McCutcheon, R. A., & Howes, O. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sby160 · Cited by 190 · see citing works
Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia
Notter, T., Coughlin, J. M., Gschwind, T., Weber-Stadlbauer, U., Wang, Y.-C., Kassiou, M., Vernon, A., Benke, D., Pomper, M., Sawa, A., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2016.248 · Cited by 195 · see citing works
de Melo, Nunes, S. O. V., Anderson, G., Vargas, H. O., Barbosa, D. S., Gałecki, P., Carvalho, A. F., & Maes, M. H. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.027 · Cited by 189 · see citing works
Perry, B. I., Upthegrove, R., Kappelmann, N., Jones, P. B., Burgess, S., & Khandaker, G. M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.07.009 · Cited by 187 · see citing works
How inflammation affects the brain in depression: a review of functional and structural MRI studies
Han, K.-M., & Ham, B.-J. (2021) · Journal of Clinical Neurology · doi:10.3988/jcn.2021.17.4.503 · Cited by 187 · see citing works
Wang, L., Wang, R., Liu, L., Qiao, D., Baldwin, D. S., & Hou, R. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.021 · Cited by 192 · see citing works
Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions
Miller, B. J., & Goldsmith, D. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.211 · Cited by 182 · see citing works
Self-citationImmune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives
Ermakov, E. A., Melamud, M. M., Buneva, V. N., & Ivanova, S. А. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.880568 · Cited by 184 · see citing works
Zhang, J.-C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.112 · Cited by 182 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Omega-3 fatty acids for depression in adults
Appleton, K. M., Sallis, H., Perry, R. E., Ness, A., & Churchill, R. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004692.pub4 · Cited by 181 · see citing works
Abautret-Daly, Á., Dempsey, E., Parra‐Blanco, A., Medina, C., & Harkin, A. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.3 · Cited by 185 · see citing works
Profiling inflammatory signatures of schizophrenia: A cross-sectional and meta-analysis study
Frydecka, D., Krzystek‐Korpacka, M., Lubeiro, A., Stramecki, F., Stańczykiewicz, B., Beszłej, J. A., Piotrowski, P., Kotowicz, K., Szewczuk-Bogusławska, M., Pawlak, E., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.002 · Cited by 179 · see citing works
Neuroinflammation and Oxidative Stress in Psychosis and Psychosis Risk
Barron, H., Hafizi, S., Andreazza, A. C., & Mizrahi, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030651 · Cited by 176 · see citing works
Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 179 · see citing works
C-Reactive protein as a biomarker for major depressive disorder?
Orsolini, L., Pompili, S., Tempia Valenta, S., Salvi, V., & Volpe, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031616 · Cited by 171 · see citing works
Lizano, P. L., Lutz, O., Ling, G., Lee, A. M., Eum, S., Bishop, J. R., Kelly, S., Pasternak, O., Clementz, B. A., Pearlson, G. D., et al. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18070825 · Cited by 164 · see citing works
The Role of Intercellular Adhesion Molecule-1 in the Pathogenesis of Psychiatric Disorders
Müller, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01251 · Cited by 169 · see citing works
Dunleavy, C., Elsworthy, R. J., Upthegrove, R., Wood, S. J., & Aldred, S. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13416 · Cited by 169 · see citing works
Klawonn, A. M., Fritz, M., Castany, S., Pignatelli, M., Canal, C., Similä, F., Tejeda, H. A., Levinsson, J., Jaarola, M., Jakobsson, J., et al. (2021) · Immunity · doi:10.1016/j.immuni.2020.12.016 · Cited by 161 · see citing works
Autoimmune Diseases and Psychotic Disorders
Jeppesen, R., & Benros, M. E. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00131 · Cited by 165 · see citing works
Roomruangwong, C., Noto, C. D. S., Kanchanatawan, B., Anderson, G., Kubera, M., Carvalho, A. F., & Maes, M. H. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01737-z · Cited by 162 · see citing works
Neutrophil-to-lymphocyte ratio in schizophrenia: A systematic review and meta-analysis
Karageorgiou, V., Milas, G. P., & Michopoulos, I. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.017 · Cited by 163 · see citing works
Role of inflammation in depression relapse
Liu, C., Zhang, G., Li, B., Li, M., Woelfer, M., Walter, M., & Wang, L. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1475-7 · Cited by 166 · see citing works
Çakici, N., Sutterland, A. L., Penninx, B. W. J. H., Dalm, V. A. S. H., de Haan, L., & van Beveren, N. J. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.039 · Cited by 161 · see citing works
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Belbasis, L., Köhler, C. A., Stefanis, N. C., Stubbs, B., van Os, J., Vieta, E., Seeman, M. V., Arango, C., Carvalho, A. F., & Εvangelou, Ε. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12847 · Cited by 149 · see citing works
Lesh, T. A., Careaga, M., Rose, D. R., McAllister, A. K., de Water, J. V., Carter, C. S., & Ashwood, P. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1197-2 · Cited by 149 · see citing works
Schizophrenia and inflammation research: a bibliometric analysis
Sun, H.-L., Bai, W., Li, X.-H., Huang, H., Cui, X.-L., Cheung, T., Su, Z.-H., Yuan, Z., Ng, C. H., & Xiang, Y.-T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907851 · Cited by 148 · see citing works
Bora, E. (2019) · Psychological Medicine · doi:10.1017/s0033291719001685 · Cited by 150 · see citing works
Neuroinflammation in Schizophrenia: The Key Role of the WNT/β-Catenin Pathway
Vallée, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052810 · Cited by 153 · see citing works
The Role of Inflammation in the Treatment of Schizophrenia
Fond, G. B., Lançon, C., Korchia, T., Auquier, P., & Boyer, L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00160 · Cited by 147 · see citing works
New and emerging approaches to treat psychiatric disorders
Scangos, K. W., State, M. W., Miller, A. H., Baker, J. T., & Williams, L. M. (2023) · Nature Medicine · doi:10.1038/s41591-022-02197-0 · Cited by 147 · see citing works
Inflammatory markers and treatment outcome in treatment resistant depression: A systematic review
Yang, C., Wardenaar, K. J., Bosker, F. J., Li, J., & Schoevers, R. A. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.045 · Cited by 145 · see citing works
Goldsmith, D. R., Haroon, E., Woolwine, B. J., Jung, M. Y., Wommack, E. C., Harvey, P. D., Treadway, M. T., Felger, J. C., & Miller, A. H. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.025 · Cited by 142 · see citing works
Self-citationSuda, K., & Matsuda, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031172 · Cited by 147 · see citing works
- Authors
- Goldsmith, D. R., Rapaport, M. H., & Miller, B. J.
- Affiliations
- Emory University (US)
- Augusta University (US)
- Corresponding author
- Goldsmith, D R
- Venue
- Molecular Psychiatry
- Published
- 2016-02-23
- Volume
- 21
- Issue
- 12
- Pages
- 1696-1709
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC6056174
- OpenAlex
- W2399060753
- Cited by
- 1,683
- References
- 164
- Citations by year
- 2026: 133 · 2025: 163 · 2024: 172 · 2023: 206 · 2022: 218 · 2021: 224 · 2020: 168 · 2019: 146 · 2018: 124 · 2017: 89 · 2016: 35 · 2015: 1
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Mental Health (K23MH098014, R25MH101079)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- blood cytokines, schizophrenia, bipolar disorder, major depressive disorder, interleukin-6, TNF-α, IL-1β, soluble interleukin-2 receptor, interleukin-1 receptor antagonist, immune dysfunction, acute mania, chronic disease, antipsychotic treatment effects
- MeSH terms
- Adult, Bipolar Disorder, Depression, Major Depressive Disorder, Female, Humans, Male, Psychotic Disorders, Schizophrenia, Tumor Necrosis Factor-alpha, Receptors, Interleukin-2, Interleukin-6, Cytokines, Interleukin 1 Receptor Antagonist Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
