Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder
Open accessAbstract
Patients with subthreshold hypomania (SBP; subthreshold bipolar disorder) were indistinguishable from those with bipolar disorder (BP)-II on clinical bipolar validators, but their analyses lacked biological and pharmacological treatment data. Because inflammation and neuroprogression underlies BP, we hypothesized that cytokines and brain-derived neurotrophic factor (BDNF) are biomarkers for BP. We enrolled 41 drug-naïve patients with SBP and 48 with BP-II undergoing 12 weeks of pharmacological treatment (valproic acid, fluoxetine, risperidone, lorazepam). The Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) were used to evaluate clinical responses at baseline and at weeks 0, 1, 2, 4, 8, and 12. Inflammatory cytokines (tumour necrosis factor [TNF]-α, transforming growth factor [TGF]-β1, interleukin [IL]-6, IL-8 and IL-1β) and BDNF levels were also measured. Mixed models repeated measurement was used to examine the therapeutic effect and changes in BDNF and cytokine levels between the groups. HDRS and YMRS scores significantly (P < 0.001) declined in both groups, the SBP group had significantly lower levels of BDNF (P = 0.005) and TGF-β1 (P = 0.02). Patients with SBP and BP-II respond similarly to treatment, but SBP patients may have different neuroinflammation marker expression.
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Wang and colleagues have found an association for serum BDNF levels, but not for IL-1β or IL-6.
“while Wang and colleagues have found an association for serum BDNF levels, but not for IL-1β or IL-6 [98].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [98]
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- Authors
- Wang, T.-Y., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Wang, L.-J., Chen, P. S., Chen, S.-H., Chu, C.-H., Huang, S.-Y., Tzeng, N.-S., Li, C.-L., Chung, Y.-L., Hsieh, T.-H., Lee, I. H., Chen, K. C., Yang, Y. K., Hong, J.-S., & Lu, R.-B.
- Affiliations
- National Cheng Kung University Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
- Kaohsiung Medical University (TW)
- Asia University (TW)
- Chang Gung University (TW)
- National Cheng Kung University (TW)
- Tri-Service General Hospital (TW)
- National Institute of Environmental Health Sciences (US)
- National Health Research Institutes (TW)
- Corresponding author
- Lu, Ru-Band
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-06-07
- Volume
- 6
- Issue
- 1
- Pages
- 27431-27431
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4895208
- OpenAlex
- W2416078335
- Cited by
- 21
- References
- 59
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Science Council (NSC100-2314-B-075B-010-MY3, NSC 100, NSC98-2314-B-006–022-MY3)
- National Health Research Institutes
- National Cheng Kung University Hospital
- National Cheng Kung University
- Tri-Service General Hospital
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar II disorder, brain-derived neurotrophic factor, inflammatory cytokines, neuroinflammation, biomarkers, TNF-α, TGF-β1, interleukin-6, interleukin-8, IL-1β, valproic acid, fluoxetine, risperidone, lorazepam, treatment response, drug-naive patients
- MeSH terms
- Adolescent, Adult, Bipolar Disorder, Dextromethorphan, Double-Blind Method, Female, Humans, Male, Memantine, Placebos, Valproic Acid, Biomarkers, Cytokines, Treatment Outcome, Brain-Derived Neurotrophic Factor, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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