Cited by 121RNA modifications and cancerGenetic Associations and EpidemiologyTreatment of Major Depression

An association study of the m6A genes with major depressive disorder in Chinese Han population

Du, Tingfu, Rao, Shuquan, Wu, Lin, Ye, Ning, Liu, Zeyue, Hu, Huiling, Xiu, Jianbo, Shen, Yan +1 more·2015·Journal of Affective Disorders

Abstract

Background Major depressive disorder (MDD) is a common, chronic and recurrent mental disease but the precise mechanism behind this disorder remains unknown. FTO is one of the N6-methyladenosine (m6A) modification genes and has recently been found to be associated with depression. N6-methyladenosine (m6A) is the most abundant internal modification on RNA, which is highly enriched within the brain. There are five genes involved in m6A modification including FTO, but whether these m6A modification genes could confer a risk of MDD is still unclear. This study aimed to investigate the genetic influence of the m6A modification genes on risk of MDD.Methods We genotyped 23 SNPs in 5 modification genes among 738 patients with MDD and 1098 controls. The UNPHASED program was applied to analyze the genotyping data for allelic and genotypic association with MDD.Results Of the 23 SNPs selected, rs12936694 from the m6A demethylase gene ALKBH5 showed allelic association (χ(2)=11.19, p=0.0008, OR=1.491, 95%CI 1.179-1.887) and genotypic association (χ(2)=12.26, df=2, p=0.0022) with MDD.Limitations Replication and functional study are required to draw a firm conclusion.Conclusions The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population.

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Crossref · 10.1016/j.jad.2015.05.025

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Authors
Du, T., Rao, S., Wu, L., Ye, N., Liu, Z., Hu, H., Xiu, J., Shen, Y., & Xu, Q.
Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author
Xu, Qi
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2015-09
Volume
183
Pages
279-286
ISSN
0165-0327 (ISSN-L)
OpenAlex
W1885991053
Cited by
121
References
50
Citations by year
2026: 10 · 2025: 6 · 2024: 12 · 2023: 15 · 2022: 12 · 2021: 14 · 2020: 17 · 2019: 10 · 2018: 7 · 2017: 12 · 2016: 4 · 2015: 1 · 2014: 1
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, China
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
major depressive disorder, N6-methyladenosine, RNA methylation, ALKBH5, FTO, genetic susceptibility, single nucleotide polymorphisms, Han Chinese, genetic association
MeSH terms
AlkB Homolog 5, RNA Demethylase, Adenosine, Adult, Alleles, China, Depressive Disorder, Major, Major Depressive Disorder, Female, Genotype, Humans, Male, Membrane Proteins, Middle Aged, Risk Factors, Case-Control Studies, Polymorphism, Single Nucleotide, Asian People, Dioxygenases

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