The effect of FTO rs9939609 on major depression differs across MDD subtypes
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A correlation is reported between FTO variants and the severity of MDD.
“A correlation is reported between FTO variants and the severity of MDD.359”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [359]
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“The FTO variant rs9939609 in human trials was associated with a lower risk of developing MDD. 358 A correlation is reported between FTO variants and the severity of MDD. 359 Lack of the FTO gene impacts anxiety-depression-like behavior in mice.”
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- Authors
- Milaneschi, Y., Lamers, F., Mbarek, H., Hottenga, J.-J., Boomsma, D. I., & Penninx, B. W. J. H.
- Affiliations
- Amsterdam Public Health (NL)
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Milaneschi, Y
- Venue
- Molecular Psychiatry
- Published
- 2014-02-04
- Volume
- 19
- Issue
- 9
- Pages
- 960-962
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- OpenAlex
- W2322676809
- Cited by
- 78
- References
- 8
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 10 · 2016: 7 · 2015: 8 · 2014: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- VU Research Portal (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- University of Texas Southwestern Medical Center
- National Institutes of Health (5r01hd042157-05, 1r01mh081802-01)
- National Institute of Mental Health (MH-081802, RC2MH089995, U24MH068457, RC2MH089951)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD042157-01A1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- FTO, rs9939609, major depressive disorder, depression subtypes, genetic susceptibility, body mass index, obesity
- MeSH terms
- Depression, Female, Humans, Male, Obesity, Proteins, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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